LOCUS       NM_014369               3616 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 18
            (PTPN18), transcript variant 1, mRNA.
ACCESSION   NM_014369
VERSION     NM_014369.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3616)
  AUTHORS   Zhou,Z., Yu,W., Li,H., Shi,J., Meng,S., Yan,Y., Chen,R., Liu,H.,
            Wang,J., Sun,J., Xiao,Z. and Zhang,J.
  TITLE     Hepatitis B Virus X Protein Represses Expression of Tumor
            Suppressor PTPN18 in Hepatocellular Carcinoma
  JOURNAL   Mol Cancer Res 22 (9), 891-901 (2024)
   PUBMED   38787319
  REMARK    GeneRIF: Hepatitis B Virus X Protein Represses Expression of Tumor
            Suppressor PTPN18 in Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 3616)
  AUTHORS   Wang,T., Yu,Y., Ba,X., Zhang,X., Zhang,N., Wang,G., Bai,B., Li,T.,
            Zhao,J., Zhao,Y. and Wang,B.
  TITLE     PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing
            Immune Suppression
  JOURNAL   Oxid Med Cell Longev 2023, 2994316 (2023)
   PUBMED   36846716
  REMARK    GeneRIF: PTPN18 Serves as a Potential Oncogene for Glioblastoma by
            Enhancing Immune Suppression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3616)
  AUTHORS   Manso,J.A., Marcos,T., Ruiz-Martin,V., Casas,J., Alcon,P., Sanchez
            Crespo,M., Bayon,Y., de Pereda,J.M. and Alonso,A.
  TITLE     PSTPIP1-LYP phosphatase interaction: structural basis and
            implications for autoinflammatory disorders
  JOURNAL   Cell Mol Life Sci 79 (2), 131 (2022)
   PUBMED   35152348
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3616)
  AUTHORS   Held,M.A., Greenfest-Allen,E., Su,S., Stoeckert,C.J., Stokes,M.P.
            and Wojchowski,D.M.
  TITLE     Phospho-PTM proteomic discovery of novel EPO- modulated kinases and
            phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2
            Signaling
  JOURNAL   Cell Signal 69, 109554 (2020)
   PUBMED   32027948
  REMARK    GeneRIF: Phospho-PTM proteomic discovery of novel EPO- modulated
            kinases and phosphatases, including PTPN18 as a positive regulator
            of EPOR/JAK2 Signaling.
REFERENCE   5  (bases 1 to 3616)
  AUTHORS   Cai,J., Huang,S., Yi,Y. and Bao,S.
  TITLE     Downregulation of PTPN18 can inhibit proliferation and metastasis
            and promote apoptosis of endometrial cancer
  JOURNAL   Clin Exp Pharmacol Physiol 46 (8), 734-742 (2019)
   PUBMED   31034093
  REMARK    GeneRIF: Downregulation of PTPN18 can inhibit proliferation and
            metastasis and promote apoptosis of endometrial cancer
REFERENCE   6  (bases 1 to 3616)
  AUTHORS   Blanchetot,C., Chagnon,M., Dube,N., Halle,M. and Tremblay,M.L.
  TITLE     Substrate-trapping techniques in the identification of cellular PTP
            targets
  JOURNAL   Methods 35 (1), 44-53 (2005)
   PUBMED   15588985
REFERENCE   7  (bases 1 to 3616)
  AUTHORS   Gandhi,T.K., Chandran,S., Peri,S., Saravana,R., Amanchy,R.,
            Prasad,T.S. and Pandey,A.
  TITLE     A bioinformatics analysis of protein tyrosine phosphatases in
            humans
  JOURNAL   DNA Res 12 (2), 79-89 (2005)
   PUBMED   16303740
  REMARK    GeneRIF: novel isoform of PTPN18 based on analysis of expressed
            sequence tags was discovered; deletion of 4 exons in the catalytic
            domain of the isoform may alter enzymatic activity; 2 of the novel
            isoform predictions were experimentally validated through RT-PCR
REFERENCE   8  (bases 1 to 3616)
  AUTHORS   Gensler,M., Buschbeck,M. and Ullrich,A.
  TITLE     Negative regulation of HER2 signaling by the PEST-type
            protein-tyrosine phosphatase BDP1
  JOURNAL   J Biol Chem 279 (13), 12110-12116 (2004)
   PUBMED   14660651
  REMARK    GeneRIF: BDP1 has a role in negative regulation of HER2 signaling
REFERENCE   9  (bases 1 to 3616)
  AUTHORS   Wang,B., Lemay,S., Tsai,S. and Veillette,A.
  TITLE     SH2 domain-mediated interaction of inhibitory protein tyrosine
            kinase Csk with protein tyrosine phosphatase-HSCF
  JOURNAL   Mol Cell Biol 21 (4), 1077-1088 (2001)
   PUBMED   11158295
REFERENCE   10 (bases 1 to 3616)
  AUTHORS   Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and
            Ullrich,A.
  TITLE     Characterization of the PEST family protein tyrosine phosphatase
            BDP1
  JOURNAL   Oncogene 13 (10), 2275-2279 (1996)
   PUBMED   8950995
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN995571.1, X79568.1,
            AK303804.1, AC132479.2, BM789073.1 and CA310199.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014369.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, the mitotic cycle, and
            oncogenic transformation. This PTP contains a PEST motif, which
            often serves as a protein-protein interaction domain, and may be
            related to protein intracellular half-live. This protein can
            differentially dephosphorylate autophosphorylated tyrosine kinases
            that are overexpressed in tumor tissues, and it appears to regulate
            HER2, a member of the epidermal growth factor receptor family of
            receptor tyrosine kinases. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X79568.1, SRR1163658.227597.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000175756.10/ ENSP00000175756.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DN995571.1         58-80
            24-1118             X79568.1           15-1109
            1119-1771           AK303804.1         770-1422
            1772-2754           AC132479.2         49557-50539
            2755-3359           BM789073.1         3-607
            3360-3616           CA310199.1         22-278              c
FEATURES             Location/Qualifiers
     source          1..3616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..3616
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /note="protein tyrosine phosphatase non-receptor type 18"
                     /db_xref="GeneID:26469"
                     /db_xref="HGNC:HGNC:9649"
                     /db_xref="MIM:606587"
     exon            1..145
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1435
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     brain-derived phosphatase; tyrosine-protein phosphatase
                     non-receptor type 18; protein tyrosine phosphatase,
                     non-receptor type 18 (brain-derived)"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     18 isoform 1"
                     /protein_id="NP_055184.2"
                     /db_xref="CCDS:CCDS2161.1"
                     /db_xref="GeneID:26469"
                     /db_xref="HGNC:HGNC:9649"
                     /db_xref="MIM:606587"
                     /translation="MSRSLDSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADG
                     VCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYI
                     ATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCIT
                     LIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQ
                     GSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQ
                     TEEQYRFLYHTVAQMFCSTLQNASPHYQNIKENCAPLYDDALFLRTPQALLAIPRPPG
                     GVLRSISVPGSPGHAMADTYAVVQKRGAPAGAGSGTQTGTGTGTGARSAEEAPLYSKV
                     TPRAQRPGAHAEDARGTLPGRVPADQSPAGSGAYEDVAGGAQTGGLGFNLRIGRPKGP
                     RDPPAEWTRV"
     exon            146..254
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            255..331
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            332..427
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            428..466
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            467..535
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            536..598
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            599..741
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            742..808
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            809..886
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            887..976
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1065
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1292
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1367
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..3616
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3595..3600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /note="hexamer: AATAAA"
     polyA_site      3616
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /note="major polyA site"
ORIGIN      
        1 acactcgccg cgcgcgcggc ggccgggctg gaccttgctg gcccgcggcg ccatgagccg
       61 cagcctggac tcggcgcgga gcttcctgga gcggctggaa gcgcggggcg gccgggaggg
      121 ggcagtcctc gccggcgagt tcagcgacat ccaggcctgc tcggccgcct ggaaggctga
      181 cggcgtgtgc tccaccgtgg ccggcagtcg gccagagaac gtgaggaaga accgctacaa
      241 agacgtgctg ccttatgatc agacgcgagt aatcctctcc ctgctccagg aagagggaca
      301 cagcgactac attaatggca acttcatccg gggcgtggat ggaagcctgg cctacattgc
      361 cacgcaagga cccttgcctc acaccctgct agacttctgg agactggtct gggagtttgg
      421 ggtcaaggtg atcctgatgg cctgtcgaga gatagagaat gggcggaaaa ggtgtgagcg
      481 gtactgggcc caggagcagg agccactgca gactgggctt ttctgcatca ctctgataaa
      541 ggagaagtgg ctgaatgagg acatcatgct caggaccctc aaggtcacat tccagaagga
      601 gtcccgttct gtgtaccagc tacagtatat gtcctggcca gaccgtgggg tccccagcag
      661 tcctgaccac atgctcgcca tggtggagga agcccgtcgc ctccagggat ctggccctga
      721 acccctctgt gtccactgca gtgcgggttg tgggcgaaca ggcgtcctgt gcaccgtgga
      781 ttatgtgagg cagctgctcc tgacccagat gatcccacct gacttcagtc tctttgatgt
      841 ggtccttaag atgaggaagc agcggcctgc ggccgtgcag acagaggagc agtacaggtt
      901 cctgtaccac acggtggctc agatgttctg ctccacactc cagaatgcca gcccccacta
      961 ccagaacatc aaagagaatt gtgccccact ctacgacgat gccctcttcc tccggactcc
     1021 ccaggcactt ctcgccatac cccgcccacc aggaggggtc ctcaggagca tctctgtgcc
     1081 cgggtccccg ggccacgcca tggctgacac ctacgcggtg gtgcagaagc gcggggctcc
     1141 agcgggcgcc gggagtggga cgcagacggg gacggggacg gggacggggg cgcgcagcgc
     1201 ggaggaggcg ccgctctaca gcaaggtgac gccgcgcgcc cagcgacccg gggcgcacgc
     1261 ggaggacgcg agggggacgc tgcctggccg cgttcctgct gaccaaagtc ctgccggatc
     1321 tggcgcctac gaggacgtgg cgggtggagc tcagaccggt gggctaggtt tcaacctgcg
     1381 cattgggagg ccgaagggtc cccgggaccc gcctgctgag tggacccggg tgtaagtcta
     1441 acgccagttc ctgcctgttg cctcttgtga gctcggactg ctgatgcccc ggtgctgctg
     1501 agcgccgtgc gcagaatgga aacagtgggc ctggatcaaa gttaaagttt ctcagggtgg
     1561 gaaatgtggg ggctttgccc caatgactgt agcattcaag gcttgaggct ggaggaggta
     1621 gctagggtat agtggctggt gaggctgcac agagcagatt caagaaagaa gatcaggaag
     1681 gggcatgacc cctgagttat gaaggggaga agggacagat gagcttccgg agactgctct
     1741 cctcaccaca cagcactagt ccatcctcag cacctgagcc tccctcactt ggacactcag
     1801 gggaccacac agagaagtgg atggacactt cgccatccag gcagaactaa gccaggcata
     1861 accacagcca agcagattaa ccccaggcag accgataaaa agacctccag ataggcagac
     1921 agacagatgg accaccaacc tggacagaca gccaaagctt cagagataca gtccacaggt
     1981 ggacaaaggg atccccagcc agagagagag agaccagcca acagcttgat agaccagtgc
     2041 agccagagag accaccaaac agagccccca aaagacagac atctctgcta gctggacagc
     2101 caggtggacc ccctaagtta gattactaga cagatataaa cagatcccct gctgaacaga
     2161 tacacagagt tctcagaccc cacccccacc ctcaggtggg ctggctggct gacagacctt
     2221 ctggccagac agactcctaa ccaaccagat ggactgccag acaggcagac atcagccaca
     2281 tggaatcctg acatcccagc cagccggcca gactctcatc ttgatgtctt gatggatgga
     2341 ccccagctag tcagacatga tcctccagat tgacagacaa gtcccccaaa tgagtacaca
     2401 tctccagcta ttcagacaga tggaccccca gcaaatcagg acctatctag gcagacccca
     2461 gccagacccc cgccagacag actcccaacc agactgaccc cttactattc acacagcctg
     2521 ccgagtagct gggactacag gtctaatttt tttttttttt aagaaatgag tttttgccat
     2581 gttgcccaga ctggtcttga actcccaacc tcaagcaatc ctcctgcctc agcctcccaa
     2641 agtgctgaga ttacaggtgt gagccaccag gctcagcccc ctaagatttg aaacacttta
     2701 aatggcccat ggtagggttc ctgctaggat aaaacattaa gcggctgtta aaagaaataa
     2761 aaggaggaca cgtctctgtg cactggtgtg gacaaatctc caagtcactg caaaatggaa
     2821 aaagtataag atgctctttc cctgaacctc aagggtcccg cccctctcac tttcaggtct
     2881 ctggacctct gactgacact gtgcctgccc aggtccctgt atgcactgcc acagtgccct
     2941 gggccccatg tccacccctg tcctgccctt ctctgggata gggctggcct tcctctgcct
     3001 ctgcctggct gcatccatgg tcgatctcaa gtgccttggc atgaactcca ctctcctgca
     3061 gccttcaatc aaggaatgat ggggatgtgt acatacccca ccccacccct tggcagggtg
     3121 atgctgaggt gtggattttt aacagttccc agactttccc aggaggcttg ggtttgggtg
     3181 cccacagtgg gagctggtgt gatatcatac cttcgccggc cgcctttcct tcctgttctc
     3241 tgtgccccta ctcccactct agagctgccc cgtttctctg ttttcgtgaa agagctgacc
     3301 ctgtgctgcc tcccactctc ccaatgcccc tgccactcct gtgagcctgc tgctggtgag
     3361 gtcggtgctg acctctgtgt tgctggataa tgagtcatct atctctggag gagaagaaag
     3421 gcaggtcctc cacagccctg ataaaatctc caagtctccc agtttcgggt ccctctcctg
     3481 ggatgcagac ccactgcctg cccagctggt acgatccaca tgccctcttc ttgggaatag
     3541 gggcatggga aagtgactaa agatactgtt ctggctgctg tgttcactgt gagtaataaa
     3601 ctgtccattt ctccga
//
