LOCUS       NP_055184                460 aa            linear   PRI 29-OCT-2024
DEFINITION  tyrosine-protein phosphatase non-receptor type 18 isoform 1 [Homo
            sapiens].
ACCESSION   NP_055184
VERSION     NP_055184.2
DBSOURCE    REFSEQ: accession NM_014369.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 460)
  AUTHORS   Zhou,Z., Yu,W., Li,H., Shi,J., Meng,S., Yan,Y., Chen,R., Liu,H.,
            Wang,J., Sun,J., Xiao,Z. and Zhang,J.
  TITLE     Hepatitis B Virus X Protein Represses Expression of Tumor
            Suppressor PTPN18 in Hepatocellular Carcinoma
  JOURNAL   Mol Cancer Res 22 (9), 891-901 (2024)
   PUBMED   38787319
  REMARK    GeneRIF: Hepatitis B Virus X Protein Represses Expression of Tumor
            Suppressor PTPN18 in Hepatocellular Carcinoma.
REFERENCE   2  (residues 1 to 460)
  AUTHORS   Wang,T., Yu,Y., Ba,X., Zhang,X., Zhang,N., Wang,G., Bai,B., Li,T.,
            Zhao,J., Zhao,Y. and Wang,B.
  TITLE     PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing
            Immune Suppression
  JOURNAL   Oxid Med Cell Longev 2023, 2994316 (2023)
   PUBMED   36846716
  REMARK    GeneRIF: PTPN18 Serves as a Potential Oncogene for Glioblastoma by
            Enhancing Immune Suppression.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 460)
  AUTHORS   Manso,J.A., Marcos,T., Ruiz-Martin,V., Casas,J., Alcon,P., Sanchez
            Crespo,M., Bayon,Y., de Pereda,J.M. and Alonso,A.
  TITLE     PSTPIP1-LYP phosphatase interaction: structural basis and
            implications for autoinflammatory disorders
  JOURNAL   Cell Mol Life Sci 79 (2), 131 (2022)
   PUBMED   35152348
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 460)
  AUTHORS   Held,M.A., Greenfest-Allen,E., Su,S., Stoeckert,C.J., Stokes,M.P.
            and Wojchowski,D.M.
  TITLE     Phospho-PTM proteomic discovery of novel EPO- modulated kinases and
            phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2
            Signaling
  JOURNAL   Cell Signal 69, 109554 (2020)
   PUBMED   32027948
  REMARK    GeneRIF: Phospho-PTM proteomic discovery of novel EPO- modulated
            kinases and phosphatases, including PTPN18 as a positive regulator
            of EPOR/JAK2 Signaling.
REFERENCE   5  (residues 1 to 460)
  AUTHORS   Cai,J., Huang,S., Yi,Y. and Bao,S.
  TITLE     Downregulation of PTPN18 can inhibit proliferation and metastasis
            and promote apoptosis of endometrial cancer
  JOURNAL   Clin Exp Pharmacol Physiol 46 (8), 734-742 (2019)
   PUBMED   31034093
  REMARK    GeneRIF: Downregulation of PTPN18 can inhibit proliferation and
            metastasis and promote apoptosis of endometrial cancer
REFERENCE   6  (residues 1 to 460)
  AUTHORS   Blanchetot,C., Chagnon,M., Dube,N., Halle,M. and Tremblay,M.L.
  TITLE     Substrate-trapping techniques in the identification of cellular PTP
            targets
  JOURNAL   Methods 35 (1), 44-53 (2005)
   PUBMED   15588985
REFERENCE   7  (residues 1 to 460)
  AUTHORS   Gandhi,T.K., Chandran,S., Peri,S., Saravana,R., Amanchy,R.,
            Prasad,T.S. and Pandey,A.
  TITLE     A bioinformatics analysis of protein tyrosine phosphatases in
            humans
  JOURNAL   DNA Res 12 (2), 79-89 (2005)
   PUBMED   16303740
  REMARK    GeneRIF: novel isoform of PTPN18 based on analysis of expressed
            sequence tags was discovered; deletion of 4 exons in the catalytic
            domain of the isoform may alter enzymatic activity; 2 of the novel
            isoform predictions were experimentally validated through RT-PCR
REFERENCE   8  (residues 1 to 460)
  AUTHORS   Gensler,M., Buschbeck,M. and Ullrich,A.
  TITLE     Negative regulation of HER2 signaling by the PEST-type
            protein-tyrosine phosphatase BDP1
  JOURNAL   J Biol Chem 279 (13), 12110-12116 (2004)
   PUBMED   14660651
  REMARK    GeneRIF: BDP1 has a role in negative regulation of HER2 signaling
REFERENCE   9  (residues 1 to 460)
  AUTHORS   Wang,B., Lemay,S., Tsai,S. and Veillette,A.
  TITLE     SH2 domain-mediated interaction of inhibitory protein tyrosine
            kinase Csk with protein tyrosine phosphatase-HSCF
  JOURNAL   Mol Cell Biol 21 (4), 1077-1088 (2001)
   PUBMED   11158295
REFERENCE   10 (residues 1 to 460)
  AUTHORS   Kim,Y.W., Wang,H., Sures,I., Lammers,R., Martell,K.J. and
            Ullrich,A.
  TITLE     Characterization of the PEST family protein tyrosine phosphatase
            BDP1
  JOURNAL   Oncogene 13 (10), 2275-2279 (1996)
   PUBMED   8950995
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN995571.1, X79568.1,
            AK303804.1, AC132479.2, BM789073.1 and CA310199.1.
            
            On Jan 25, 2002 this sequence version replaced NP_055184.1.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, the mitotic cycle, and
            oncogenic transformation. This PTP contains a PEST motif, which
            often serves as a protein-protein interaction domain, and may be
            related to protein intracellular half-live. This protein can
            differentially dephosphorylate autophosphorylated tyrosine kinases
            that are overexpressed in tumor tissues, and it appears to regulate
            HER2, a member of the epidermal growth factor receptor family of
            receptor tyrosine kinases. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X79568.1, SRR1163658.227597.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000175756.10/ ENSP00000175756.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     Protein         1..460
                     /product="tyrosine-protein phosphatase non-receptor type
                     18 isoform 1"
                     /EC_number="3.1.3.48"
                     /note="brain-derived phosphatase; tyrosine-protein
                     phosphatase non-receptor type 18; protein tyrosine
                     phosphatase, non-receptor type 18 (brain-derived)"
                     /calculated_mol_wt=50351
     Region          27..292
                     /region_name="PTPc-N18"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 18; cd14603"
                     /db_xref="CDD:350451"
     Region          361..460
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99952.2)"
     Site            389
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q61152; propagated from
                     UniProtKB/Swiss-Prot (Q99952.2)"
     Site            393
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99952.2)"
     Site            426
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q61152; propagated from
                     UniProtKB/Swiss-Prot (Q99952.2)"
     CDS             1..460
                     /gene="PTPN18"
                     /gene_synonym="BDP1; PTP-HSCF"
                     /coded_by="NM_014369.4:53..1435"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS2161.1"
                     /db_xref="GeneID:26469"
                     /db_xref="HGNC:HGNC:9649"
                     /db_xref="MIM:606587"
ORIGIN      
        1 msrsldsars flerleargg regavlagef sdiqacsaaw kadgvcstva gsrpenvrkn
       61 rykdvlpydq trvilsllqe eghsdyingn firgvdgsla yiatqgplph tlldfwrlvw
      121 efgvkvilma creiengrkr cerywaqeqe plqtglfcit likekwlned imlrtlkvtf
      181 qkesrsvyql qymswpdrgv psspdhmlam veearrlqgs gpeplcvhcs agcgrtgvlc
      241 tvdyvrqlll tqmippdfsl fdvvlkmrkq rpaavqteeq yrflyhtvaq mfcstlqnas
      301 phyqnikenc aplyddalfl rtpqallaip rppggvlrsi svpgspgham adtyavvqkr
      361 gapagagsgt qtgtgtgtga rsaeeaplys kvtpraqrpg ahaedargtl pgrvpadqsp
      421 agsgayedva ggaqtgglgf nlrigrpkgp rdppaewtrv
//
