LOCUS       NM_005401              13360 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 14
            (PTPN14), mRNA.
ACCESSION   NM_005401
VERSION     NM_005401.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13360)
  AUTHORS   Blakely,W.J., Hatterschide,J. and White,E.A.
  TITLE     HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading
            PTPN14
  JOURNAL   mBio 15 (10), e0181124 (2024)
   PUBMED   39248565
  REMARK    GeneRIF: HPV18 E7 inhibits LATS1 kinase and activates YAP1 by
            degrading PTPN14.
REFERENCE   2  (bases 1 to 13360)
  AUTHORS   Ma,Q., He,X., Wang,X., Zhao,G., Zhang,Y., Su,C., Wei,M., Zhang,K.,
            Liu,M., Zhu,Y. and He,J.
  TITLE     PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta
            signaling in smooth muscle cells
  JOURNAL   Nat Commun 15 (1), 7398 (2024)
   PUBMED   39191789
  REMARK    GeneRIF: PTPN14 aggravates neointimal hyperplasia via boosting
            PDGFRbeta signaling in smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13360)
  AUTHORS   Zhou,J.K., Li,J. and Peng,Y.
  TITLE     circPTPN14 promotes renal fibrosis through its interaction with
            FUBP1 to enhance MYC transcription
  JOURNAL   Cell Mol Life Sci 80 (4), 115 (2023)
   PUBMED   37014433
  REMARK    GeneRIF: circPTPN14 promotes renal fibrosis through its interaction
            with FUBP1 to enhance MYC transcription.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13360)
  AUTHORS   Li,H., Guan,B., Liu,S., Liu,H., Song,L., Zhang,G., Zhao,R., Zhou,C.
            and Gao,P.
  TITLE     PTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR
            pathway
  JOURNAL   Cell Death Dis 14 (3), 188 (2023)
   PUBMED   36898991
  REMARK    GeneRIF: PTPN14 promotes gastric cancer progression by
            PI3KA/AKT/mTOR pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13360)
  AUTHORS   Russell-Goldman,E., Dong,F. and Hanna,J.
  TITLE     Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct
            Pathways of Molecular Pathogenesis
  JOURNAL   Am J Dermatopathol 44 (8), 545-552 (2022)
   PUBMED   35830698
  REMARK    GeneRIF: Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for
            Distinct Pathways of Molecular Pathogenesis.
REFERENCE   6  (bases 1 to 13360)
  AUTHORS   Wadham,C., Gamble,J.R., Vadas,M.A. and Khew-Goodall,Y.
  TITLE     Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to
            the nucleus is associated with induction of cell proliferation
  JOURNAL   J Cell Sci 113 (Pt 17), 3117-3123 (2000)
   PUBMED   10934049
REFERENCE   7  (bases 1 to 13360)
  AUTHORS   Aoyama,K., Matsuda,T. and Aoki,N.
  TITLE     Characterization of newly identified four isoforms for a putative
            cytosolic protein tyrosine phosphatase PTP36
  JOURNAL   Biochem Biophys Res Commun 266 (2), 523-531 (1999)
   PUBMED   10600535
REFERENCE   8  (bases 1 to 13360)
  AUTHORS   Ogata,M., Takada,T., Mori,Y., Uchida,Y., Miki,T., Okuyama,A.,
            Kosugi,A., Sawada,M., Oh-hora,M. and Hamaoka,T.
  TITLE     Regulation of phosphorylation level and distribution of PTP36, a
            putative protein tyrosine phosphatase, by cell-substrate adhesion
  JOURNAL   J Biol Chem 274 (29), 20717-20724 (1999)
   PUBMED   10400706
REFERENCE   9  (bases 1 to 13360)
  AUTHORS   Ogata,M., Takada,T., Mori,Y., Oh-hora,M., Uchida,Y., Kosugi,A.,
            Miyake,K. and Hamaoka,T.
  TITLE     Effects of overexpression of PTP36, a putative protein tyrosine
            phosphatase, on cell adhesion, cell growth, and cytoskeletons in
            HeLa cells
  JOURNAL   J Biol Chem 274 (18), 12905-12909 (1999)
   PUBMED   10212280
REFERENCE   10 (bases 1 to 13360)
  AUTHORS   Smith,A.L., Mitchell,P.J., Shipley,J., Gusterson,B.A., Rogers,M.V.
            and Crompton,M.R.
  TITLE     Pez: a novel human cDNA encoding protein tyrosine phosphatase- and
            ezrin-like domains
  JOURNAL   Biochem Biophys Res Commun 209 (3), 959-965 (1995)
   PUBMED   7733990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA738908.1, AK291641.1,
            AL445305.11, AL603838.6 and AL929236.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005401.4.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an N-terminal
            noncatalytic domain similar to that of band 4.1 superfamily
            cytoskeleton-associated proteins, which suggested the membrane or
            cytoskeleton localization of this protein. It appears to regulate
            lymphatic development in mammals, and a loss of function mutation
            has been found in a kindred with a lymphedema-choanal atresia.
            [provided by RefSeq, Sep 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291641.1, X82676.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366956.10/ ENSP00000355923.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               DA738908.1         80-356
            278-548             AK291641.1         289-559
            549-748             AL445305.11        3979-4178           c
            749-2100            AK291641.1         760-2111
            2101-3118           AL603838.6         25863-26880         c
            3119-4312           AK291641.1         3130-4323
            4313-13360          AL929236.4         107760-116807       c
FEATURES             Location/Qualifiers
     source          1..13360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3-q41"
     gene            1..13360
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /note="protein tyrosine phosphatase non-receptor type 14"
                     /db_xref="GeneID:5784"
                     /db_xref="HGNC:HGNC:9647"
                     /db_xref="MIM:603155"
     exon            1..420
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..748
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..4138
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /EC_number="3.1.3.48"
                     /note="cytoskeletal-associated protein tyrosine
                     phosphatase; protein-tyrosine phosphatase pez"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     14"
                     /protein_id="NP_005392.2"
                     /db_xref="CCDS:CCDS1514.1"
                     /db_xref="GeneID:5784"
                     /db_xref="HGNC:HGNC:9647"
                     /db_xref="MIM:603155"
                     /translation="MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQ
                     ECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFY
                     VPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQD
                     FLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQE
                     IFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEE
                     TALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQP
                     YILPPVHVQCGEHYSETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVH
                     SVNSLNCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMR
                     QMKRGILHTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVPYGPQGVYSN
                     KLVSPSDQRNPKNNVVPSKPGASAISHTVSTPELANMQLQGSHNYSTAHMLKNYLFRP
                     PPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEV
                     SEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHLPMARRNTLREQGPPEEGSG
                     SHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAA
                     LARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARVLRHGPAKAISMSRTDPPA
                     VNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMA
                     GLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYE
                     QIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVV
                     GGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKH
                     SSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQG
                     FLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEK
                     VEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI"
     exon            749..918
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1016
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1084
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1155
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1243
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1332
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1420
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1503
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1561
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1640
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..3118
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3262
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3481
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3610
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3845
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..4009
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..13360
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13337..13342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /note="hexamer: AATAAA"
     polyA_site      13360
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /note="major polyA site"
ORIGIN      
        1 ctttccaact ttttctcggc ggagtgagcg cagcgggcgc agactcgggg gcaggttgct
       61 gtgcttctcc gggctcagcc gcctgctctc ctggctcagg tcctcgggga gccctagaca
      121 gacatcaagt ggccactggc gctccttccc ctcccagctg agccatcctc cccggcctcc
      181 tcgggcggga cagccccgtg cttaggtttt tctccttttc tcccccggtg cgcctctgct
      241 cggactctcg cgccgggatc gcggcggaaa cctccctccc ctttcgcctc ctgcggctcc
      301 ttcccttcgc ccctcctccg ccagtcactg gaatcaattc cgtggggaat cggctccgcc
      361 gccgcgaagg acagcctttc cgcgcgggac tccggggcgc cacgggggcc atgtaagcag
      421 ctatcttcca gagggccaca ctgggcatgg acaccctttt ccctgcctgg aggagcacag
      481 gtgatagtgt aattttccag tcacgaaact gctaaggcca tctcaggggc gtgtgcgcca
      541 ggataggcgg gcggcgtccg aggaccacat agccatgcct tttggtctga agctccgccg
      601 gacacggcgc tacaacgtcc tgagcaagaa ctgctttgtc acacggattc gcctgctgga
      661 cagcaatgtt atcgagtgca cgctgtcggt ggaaagcaca gggcaagaat gcctggaggc
      721 tgtggcccag aggctggagc tgcgagagac gcactacttt ggcctttggt ttctcagcaa
      781 gagccagcaa gcacgatggg tggagctgga gaaacctctg aagaaacatc tggacaaatt
      841 cgctaatgag cctttgcttt tctttggagt catgttctat gtgccaaatg tgtcatggct
      901 tcagcaagag gccacaagat atcagtatta cctgcaagtc aaaaaagatg tgcttgaagg
      961 gcgattacga tgtacattgg accaggtgat tcggctagcc ggcctagctg tgcaagctga
     1021 ttttggagac tataatcagt ttgattctca agatttcctc agagagtatg tgctatttcc
     1081 tatggatttg gccctggaag aggctgttct ggaggagctg acccagaagg tagcccaaga
     1141 acacaaagcc cacagtggaa tcctgccagc agaagctgaa ctgatgtaca tcaatgaagt
     1201 tgaacgtttg gatggatttg gacaggaaat cttccctgta aaggacaatc atggaaactg
     1261 tgtacacctt ggcattttct ttatggggat tttcgtgagg aacagaattg gaagacaagc
     1321 ggtaatatac aggtggaatg acatggggaa tatcactcat aacaagtcga ccattctagt
     1381 ggagctcatc aacaaagaag agactgccct ctttcacacg gatgatatcg aaaatgccaa
     1441 gtatatttct cggttgtttg ccacacgaca caagttttac aaacaaaaca aaatctgcac
     1501 tgaacagtca aattctccac cccccatcag acgccagccc acctggagcc gatcctctct
     1561 gcccaggcag cagccgtaca tcctgcctcc cgttcacgtc cagtgtggtg agcactactc
     1621 ggaaacgcac acctcgcaag acagcatttt tcatgggaat gaagaagcct tgtattgcaa
     1681 ctctcacaac agcctggact taaattattt aaatggcact gtcaccaatg gcagcgtgtg
     1741 tagcgttcac agcgtcaact ccctcaactg ctcgcaaagt ttcatccagg cctcccctgt
     1801 atcctccaac ctcagtatcc ctgggagtga catcatgcgg gccgactaca tcccgagcca
     1861 ccggcacagc gcgatcatcg tgccctcgta caggccaacc cccgattatg agacagtcat
     1921 gcgccagatg aagaggggga tcctgcatac agacagccag agccagtctc tgagaaacct
     1981 caacattatc aacacccatg cctacaacca gccagaggat ctggtgtaca gccaaccgga
     2041 gatgcgggag aggcacccct acactgtccc ttatgggcca cagggggtct acagcaacaa
     2101 acttgtcagt ccatctgacc agaggaaccc aaagaataat gtggtaccaa gcaagccggg
     2161 ggcaagcgcc atctcgcaca cggtgagcac cccagagctg gccaacatgc agctgcaggg
     2221 cagccataac tacagcacgg cccacatgct taagaactat ctcttcaggc caccgccccc
     2281 ctacccacgg ccacgacctg ccaccagcac cccagacctg gccagccacc gccacaagta
     2341 cgtcagcggc agcagcccgg acctggtgac ccggaaggtg cagctctcgg tgaagacctt
     2401 ccaagaggac agctctccgg tggttcatca gtctctccag gaggtgagcg agcccctcac
     2461 ggccaccaag caccacggca ctgtgaacaa gcgccacagc ctggaggtga tgaacagcat
     2521 ggtgcggggc atggaggcca tgacgctcaa gtcgctccac ctccccatgg ctcgccgcaa
     2581 cacgctccgg gagcagggac cgcccgagga ggggtcaggc agccacgagg tcccccagct
     2641 ccctcagtat caccacaaga agaccttctc tgatgccact atgctaatcc acagcagcga
     2701 gagtgaggag gaggaggagg aggctccaga atcggtgccc cagatcccca tgctccggga
     2761 gaagatggag tacagtgccc agctgcaggc ggccctggcc cgcatcccca acaagccccc
     2821 gcctgagtac cccggtccaa ggaagagtgt gagcaatggg gctctgaggc aggaccaagc
     2881 cagccttcct cccgccatgg ccagagccag ggtgctgagg catgggccag ccaaggccat
     2941 cagcatgtct cggactgacc cgccggctgt caacggggcc tctctcggcc catccatctc
     3001 ggaacccgac ctgactagtg tgaaggagcg ggtcaaaaaa gagcctgtga aggagagacc
     3061 tgtgtctgaa atgttttccc tggaagacag cattatagag agagagatga tgatcaggaa
     3121 tctagagaag cagaagatgg caggcctgga ggcacagaag aggccgctga tgttggcagc
     3181 attgaatggg ctctcggtgg ctcgagtctc agggcgggaa gagaatcgag ttgatgccac
     3241 ccgggttccc atggacgaga ggttcagaac cctgaagaag aaactagaag agggaatggt
     3301 gttcacagaa tatgagcaaa ttccaaagaa aaaggcgaat ggcattttca gcacagcagc
     3361 tctgccagaa aacgccgagc gcagccgaat ccgtgaagtt gtcccctatg aggagaatcg
     3421 agtagagctg ataccaacca aagaaaataa cacaggatac attaatgcct cccacatcaa
     3481 ggtggtggtt ggcggggcag aatggcacta catagccacc caggggcccc tgccacacac
     3541 gtgccacgac ttctggcaga tggtgtggga gcagggagtg aatgtgattg ccatggtcac
     3601 tgcagaggag gagggtggac gaaccaaaag ccaccgatac tggcccaaac taggttcaaa
     3661 gcacagctca gccacctatg gcaagttcaa ggtcaccacg aagtttcgaa cggattctgt
     3721 ttgctatgca accacgggct tgaaggtcaa gcaccttttg tctgggcaag aaaggacggt
     3781 gtggcattta caatatactg actggccaga tcacggctgt ccagaagatg tccaaggatt
     3841 tttatcctac ttggaggaga tccagtcggt ccgtcgccat accaacagca tgctggaagg
     3901 caccaagaac cggcacccgc ccatcgtggt ccactgtagt gctggggtgg gaaggaccgg
     3961 cgtgctcatt ctttctgagc tgatgatcta ctgcttggaa cataacgaaa aggtggaagt
     4021 gcccatgatg ctgaggctcc tcagggagca gaggatgttc atgatccaga ctatcgctca
     4081 gtacaagttt gtctaccaag tcctcatcca gttcctccaa aactccagac tcatttaatc
     4141 accccaatcc agctcctgga ggagggaccc agctccatcg cgctggagga gagtcacctc
     4201 cagacaacat ctgctccccc cacaggggtg caggtggctg gcagcaaaca ggctctctga
     4261 agacagtagc caagattatt cacacatacc atgtattatt ttatatgaga taatttattt
     4321 ttttcccctt tggaataact tttgtgaatt attataatgc agtttcccta gtaatatagt
     4381 acttttcatt tgaaccacat cttgactgat ctgtattgta atatatgtca gcaggtaagg
     4441 ttgcctgctg gatcattttg aggacagagg catgagggag cacatctctt gtgaagttgc
     4501 agccagattt gtaaccaacc ctgaaattca tcagcttaat tcatttatca gcttgattca
     4561 ttcatcattc attgcttata tccaaagcaa agacggtaag aaaatgaatt catcctgaaa
     4621 tataaagaaa agggtctgaa ggaacaaaca cgattctctt atattttggg gctcatgagc
     4681 cttgatagac agtttcctct cgtcttcatt tccacccctc atcctcagta gtctcctctc
     4741 ccccacgccc caccccaact tcccccccaa gcttgagtta aagacagaat agctaaagac
     4801 agtgctgcct ttacaatgca gtaattgcca tctttggggc cgaaagacaa gctctgtgtt
     4861 gtgcttttct tgaccacccc ttatcctggg ctctggagct tgtgtttccc tgctggcgac
     4921 tgtaccttgg gtatttgttg ctacctctcc tgtttgctca gtaggaccct gtctggtggc
     4981 attgaggctc tggaccagac catctgtgca gttaaggctc taccctgatt gagagaggat
     5041 agcagaccta gaaagagaaa ggagttgggc agggcctttg aggattgtgt ttttcaggca
     5101 gggccttgat gatcattgtt ttttatttaa ataagatgtg tgtgctggac agagacctaa
     5161 aagttgaggt cactaagtca ttggaaaggc catcaaggaa acagatgggg aagctgattt
     5221 atgggagctg taaggcattt agctacataa caggggtcct ggccaggaaa cacatcaaat
     5281 gtgacccccg ctgtgctgat atcatcttca ggctttggtc tgcaagatca gaattaatcc
     5341 cactcgggac cccatagtcc aaacttgggg ccacttgatg aacgatggta gaattgtcat
     5401 tggcagagcc ctgtgcttct ttccttttct tcataaaatc cactcgctgg tcagttatct
     5461 tcactttgaa gcccagttct tagtttcttc ctatggcttc attggtcagt gtccttctga
     5521 atttccaagg atggtacaca ataaatcatg ttttgtactt ttttcctctt actgcatttt
     5581 gggggattta tcattctatg tctacctttt cttgagtaca gctttgatat gcacctgttg
     5641 ttacgtggtg atgggaagtc acaggcgtgc tctttctagt taatttgatg ccacatcttc
     5701 cttgtctttt cagcttggga aaaaggcggc agtggaggaa ggcatggaat gcccacagtg
     5761 gtcagttcaa agaacaaacg tgcaattaaa aaactgtagt cagccaggca cggtggttca
     5821 cacctgtaat cccagcactt tgaaaggcca aggcgggcag attgcttgag ctaaggagtt
     5881 cgagaccagc ctgagcaaca tgatgaaacc ccgtctctac aaaaagtaca aaaattagcc
     5941 aggcgtggtg gtatgccctg gtagtcccag ctgctcggga ggctgaggca ggaggatcac
     6001 ctgattctaa gaattcgaga ctgcagtgag ccgtgatctt gccactgtag tccaggctgg
     6061 gctacggaga gaccctgcct ccaaaaaaaa aaaaaaaaaa ggaaaaaagg ttgtcaagaa
     6121 aaactagatg ttaggagaaa ggaaaattta attgcagttt tttttcttag aattgactgc
     6181 tgtgagagtt ccatatgcct ttcttcattg ctgcttttgt cccccgtgag ctaaaaagat
     6241 ggagtgacat caaatcaacc agaaaaagta tgcctttgtg acatcccatc accacatgcc
     6301 aacaggtata tattccccat taagttcttc ggaataggaa tcctctgttt caacctggcc
     6361 aggtgttgtg gtggctgtac tctagttaga ctcggaatat ctggggatgg agggcttccc
     6421 ctgtgtcttc tacttcaagg tctgaaggct cagtgaagga gtataatctg ctgatctttg
     6481 tagattctgg agttttgttg tatgtcctgg aaagaaaccc attagtatta catgtatttt
     6541 cagtgaacag agcttataac ccttattata agaagctcat caataagcaa aaagatactt
     6601 gtttcctttc cttggaggtt tttccatcct tgggatattc tgctgttagg gatgttttag
     6661 caagtggtct cagttactgg tttattgcgt gatgaacaac atcagtattt atcttttatc
     6721 tctaagcccc aaggtgggca ctgttagaat atgtctcatg tggacagcat atagatctgg
     6781 tgcgtctttg aggtcgtcag agctcatggg cttccctgaa attcatccac tgtccctgcc
     6841 gtatgctacg ggaatattca ttagtgtaca aaatgcaggg aggaagtagg tttaatattc
     6901 aactttctag ccaaagttta tattgaaacc caaaagaaaa catttaagag ttgttccaca
     6961 tatttcactt ttaaaaacaa atgcctttgg ttctttagca cattttgcat tccttttcac
     7021 atctccagta aatgccaaca tatctcctgt taaattagca gcagccattt aaagtccttt
     7081 cggtggcatc tgcataataa ttgcccagag atgctttata tctgggaagc aagccaagga
     7141 ataaaccttg aagcaaagtg tattaaatta gttatctagt tagagctttt ggaatgattt
     7201 cctgatgatg tatcaagtct gaagctggag ctgtcagtgt ctattgctgc agtttggatt
     7261 tgaagggaga aaatgtaaaa tggaggaaaa aaaagttacc atctcacaac aaagccatca
     7321 aacattttcc agccgctgtt ttcgaggttt tccagttgaa ctgtttggtt tctttcatcc
     7381 acactcattt ggatacattg acccgaggta ttcatccttg tttactgtgg tccctgaatc
     7441 atgggggctg aatttgatgt cttcatcctt gagatgagcc tgctggctta gctgaggaat
     7501 gtcctgctga ggtttcttag gtttccttgg gttctaagga tatactggat ataccatctt
     7561 ttagcaagag tatctggtag catttacaga tagcatagac attggtatgc acttctttcc
     7621 ccagatagga agtaaaggag gatttagttg catgaaaaaa ggatgttaaa cattgattac
     7681 ataggagtaa agatgaatga gctgcaatat tcagtcggag ctaaacaata agatcaggga
     7741 aggtaaaaat acctatgtgg aatattttga atcgtaagct tttgaggagc ttaaattgag
     7801 agaattttac ttttaatttt gtagattgag aagaggaacc gctttttaaa attatagcta
     7861 aactgtcatt gttttcctaa gagtcacttg gccatctctg gccccctctt tcatcagcct
     7921 gaagagaggg tctttgtaga ctgctgaggg tgggccttgt aggacttgac catggcttac
     7981 acctacttaa cctttatcct gctttctttc agcttgtgct tttcagttat aaactccagt
     8041 gggtacagca ggctggcctt ttcatccagc tgattatttt tccagcttaa tatagattga
     8101 cccatatgaa atttccaata atggaccata ttttctgcaa atagacagta ctcgcatgga
     8161 tcacctatat cttccccctg atacactgtg ggtcccaaca ccagatgtca tttctccaga
     8221 gcagtgctaa tgaacacaaa aggtataccc tgggtggccc agctcttttc acgaacgtgc
     8281 tgccctgctc atagtgatcc ttgcatcact tggtgaatgg gccatctcct gggacatgga
     8341 agttgcagag gtagatagtg cactgcagct tctcttaagc cggattggcc atcaggcata
     8401 tcactctgga gtttttagct gctgtccttt cccgatgaac agtctgtatt agctgacctc
     8461 agcctacttg ttacgtgacg tatgggtccc aaaagtgtcc tttgtcaaaa agcagaatgt
     8521 gccttctagt ctccctttcc ccatctaatg gtgtattcga tggtgaagat gagtacagtt
     8581 gaccacccct atctgtgggt tccacatccc tatattcaac caagtacaga ttgaaaaata
     8641 tttggggaag aggggaaacc cacaaagttc caaaaagcaa aagttgaatt tgccacatgc
     8701 tgaatactac attgaattca cacaaatgaa gtgatgtgta ggcattgagt taggtattgt
     8761 aaataatcta gagatgattt aaagtatgca agagatgtgc ataggttata tgcaaatact
     8821 gtgctatttt atataaaaga cttgaacatc catggattct ggtattctca gagggtcctt
     8881 gattgccccc tttggtaaag gacaactatt tcgttactga ttttcgtttg gggaagatct
     8941 gtcaatccct tgaggtgcgg gggttggggg gatggagggt acagggcatt ctaggatgtg
     9001 tgccagggag cacagattca agggatggga ttgagtcaga cctgtgttct tactcagtgt
     9061 cagaaataac tctgtggagc tcctagagta agacatttcc ggaagcacca cataattact
     9121 gttgggctct tagggtagcc cttttaggga attgagcatt cccatgtttt accaacaatt
     9181 attctgctgc tgtgttttat tatattgcca atggttttga gacactcatc atgctcttat
     9241 ttagtgattt cttttcatga gcagagcaac agctcatcca gcatggtttc caaatggaga
     9301 aatttgggtc ttctgtagaa accacacaaa ttctccaatg gcctacagcc ttatggttgg
     9361 cacactagtt ggccctatag ggtggaaata aagctgtaag atgttaaact gcatttgata
     9421 cttctcttga acgctgagca aggaagcaaa atagttcttg tctttactta agcttctaag
     9481 acattttggg gcaaaggacc ttacagatgg cgtctgttga aagtaacagc aacgtgccag
     9541 ggagaaatgt gggggaaatc tcatcaaatt ctgccacctc aaatgtgttg tccagaagtc
     9601 agtgttattc agggggccct gtgaaacttg accaccagct tgcgccatca acactcagcc
     9661 tttatccagc ctgctctcag cttttgtgtt tctgttagaa actcagatag gtaagtattt
     9721 ttattcagta gactaccttt cttatctttt cagcttaata tagctgcatc ttctttctca
     9781 aagccaaact aagatattct ctattaaaat gtccatgagc ctagcattga gtgtctggca
     9841 tccatcaatt tcatagactg gaaaatgatt gttgtttggt acagtaaaga agaggatgtg
     9901 catcagttcc taccgtttgc agctttgttt ttagccttcc cattttaaaa ataaattcaa
     9961 ggacattgag ttacaaggca ggagggctgg agctactggg cagcctgaat atgacaagca
    10021 tttgtgtgga aagtcattgc tccttctgcc acactttggg ccatcaggat cattctttcc
    10081 cagaagtgcc ataaacttgc tcaaaagttt ctataaatgg gaagagggag aggaaggatt
    10141 tttgcatcag tcctgaagtt gctatccaaa agttctctgt ttcacaaata attttctgaa
    10201 ctctggaatg cctctcctac tccctgcctc cctttctgta atgtcagagt gatggaaacc
    10261 accaagtggc atgctaggga aagcctgcag cagtgttgga gtctatttca ccctagctca
    10321 tagttttaaa ctgtcttcac tgttgaggta gagcttgatg aatgtcatgg attatgatgt
    10381 gtggtttatc atatttgcct ggatttgctg atcaaaagca ccatcttccc tcgcctgctg
    10441 ctggcagcct ttccttgcct tgcttgttag cagagcattc tgcttaccca tgtggctccc
    10501 agagttagca gccccggctc ttggatttct tgattcttct cccctgtgat ctcagaggtg
    10561 ctgcagagga cattcccctt tagagcaagt catgtttcta ttcaggccac aaaactggga
    10621 tgtacatgca gtgactttgg tgttccttgt cttgttcagg ggaacgggtg ggactgttgt
    10681 gtgctgtcac cctcttcatt ccatgagcac cttgttcact tagggtctgc tgcctttttt
    10741 tttttctttt tctttttttt ttttttttta gtttttgaga tcgtgtctca ctcctgttgc
    10801 gcaggctgga gtgcagcctc caaagtagct gggattatag gcgtgcacca ccacacccgg
    10861 ctaattttta tatttttagt agagacgggg ttttgccatg ttggccagac tggtctcaaa
    10921 cctctgacct cgtgatgacc cccctcggcc tcccaaagtg ctgggattac acccagcctc
    10981 tgctgccttt tcatatttcc ccatctgctt tatggatcaa ctctcaacag tacacttttt
    11041 cttttcttta cctaccctat gagtgcaacc cagatgtaag agttaatcct cgtcagagaa
    11101 tcattgcctt aaacctctca gaaatatgta attaggaaat cttattttaa ttttttaaaa
    11161 attgcttgta tagtttcaaa gaataagatc tggcaaatgg ccagatgtgg tggctcacac
    11221 ctgtaatcaa accagcactt tgggaggctg aggcaggcag atcacctgag gtcaggcgtt
    11281 caagaccagc ctggccaaca tggtgaaatc ccgtctctac taaaaataca aaaaaaaaaa
    11341 aaaaaaaaaa aattagccag gcatggtggc acatgcctgt aatcccagct actcaggagg
    11401 ctgaggcagg ataattgctt gaacccggga ggtggaggtt gcagtgagcc gagatcatgc
    11461 cactgcactc cagcctgggc aacagagtga gactttgtct caaaaaaaaa aaaaaaaaaa
    11521 aaaaaagatc tggcggatga aaataaccag aatgaaaata gctagaaaac tcagcaagca
    11581 ggaagctccc tttctcaccc ttttgttccc ttgccgatag aatcagtcac tattagaaaa
    11641 aatgaaagac gctctgttta aaacaatgat gacagcagta cttaatatgt atttcgaggt
    11701 gaacttatat agattgagag aggctgcatt tggcagactg atgtatagga agacccattt
    11761 gtttctagct tctccctgca gggaaaatgc tttcgtcatt atagcctctt tacacagact
    11821 ggccattcta gtgaaacagg tggtaaacct ttgggctgcc cagaaacatt ttatctgttt
    11881 tcacttacct aggaagggga aagattagcg ggtcatccaa aatctgtatg taagctatct
    11941 tcattttctt ccccaacctt ctcctcctgg gaaacacaaa tgctatctca tctgacaaaa
    12001 ggttttagag gataaagctg aaaagattgg attgggatct ttttgtggct tggggcggag
    12061 ccttttgcta aaatctcaag aatgctgctt tgagtttagc tagggtggct ctcagaactg
    12121 gggtgcctgg cattctcagc atttctcagg ggcctcccac ctctgacaac tgcagtgtta
    12181 gctaatacat accttgagca tagaactgaa tgctgtaatt cagagccatt ttttttttca
    12241 acttgaacat tgtacaattt tactgcaatt tcctttgaac tttcttgcca ctgtttggaa
    12301 tcttaaaaat tcattagcct tctcctttct gacataaagc tactcttcat cagagatgag
    12361 ttcctatgta tgtcctttgt tccttcaata gctaattaat gtgcttgagg atacttcagt
    12421 ggaaaaaaag gtttaaatat gcaaattact aataaatgtg taaccttatg taacttgtgt
    12481 tacatcaagt aacaagctaa tctagtttgt ttcactggac taggcttgtg ctccctactt
    12541 cagtattttg atgctttcct tgatctttgt ttcacaaaat gttgtgaatt ttggtatcat
    12601 tcaaaacaaa tgacatttat taggtttcat tttgaaacga tgtacagaca agtccccaac
    12661 ttagaaaccg gtttgttctt aaggttcttg cgtcagccca tagaagccca ctgacctcca
    12721 ccacagccca aatggagggc tgtgatagcc agatctggtt ggcttttgtg ggctgaccca
    12781 gacatttaat caccatctct tatgttgttg ccgtaagaaa tgcattccag gttgggactt
    12841 gggatcctga gagcacattc gccccctgtg gtggccgctt gccaccttgc aagatggaag
    12901 cccagtctcc ttactaccaa actgtagttg taagcagagg gaggggtgag atgtttatag
    12961 gacattccct aagctgggga gtgattttta tcactattca tgtcaactgt actttggtat
    13021 agactcccta tcaatttaat aatatgaaaa gcctaaaata aaactatgca tgctattcta
    13081 tgtgctattt tatatcagta aataagctta tgcttgccag ttgtatacac agttatgagg
    13141 tgtatagaac tgactttgac agtatttttt gcactgtttc ctatctgttt ttataaagtc
    13201 ttatttagat attggacctt gttgatgttc tcactgccct tgtgcttgct ataaaatgtt
    13261 tcatatgtgc ctttacaaat gtgagatctt tattctaacc tttttttgta aaagatatct
    13321 attgatttcc atatgcaata aacctttttt tcagagaaaa
//
