LOCUS       NP_005392               1187 aa            linear   PRI 12-NOV-2024
DEFINITION  tyrosine-protein phosphatase non-receptor type 14 [Homo sapiens].
ACCESSION   NP_005392
VERSION     NP_005392.2
DBSOURCE    REFSEQ: accession NM_005401.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1187)
  AUTHORS   Blakely,W.J., Hatterschide,J. and White,E.A.
  TITLE     HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading
            PTPN14
  JOURNAL   mBio 15 (10), e0181124 (2024)
   PUBMED   39248565
  REMARK    GeneRIF: HPV18 E7 inhibits LATS1 kinase and activates YAP1 by
            degrading PTPN14.
REFERENCE   2  (residues 1 to 1187)
  AUTHORS   Ma,Q., He,X., Wang,X., Zhao,G., Zhang,Y., Su,C., Wei,M., Zhang,K.,
            Liu,M., Zhu,Y. and He,J.
  TITLE     PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta
            signaling in smooth muscle cells
  JOURNAL   Nat Commun 15 (1), 7398 (2024)
   PUBMED   39191789
  REMARK    GeneRIF: PTPN14 aggravates neointimal hyperplasia via boosting
            PDGFRbeta signaling in smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1187)
  AUTHORS   Zhou,J.K., Li,J. and Peng,Y.
  TITLE     circPTPN14 promotes renal fibrosis through its interaction with
            FUBP1 to enhance MYC transcription
  JOURNAL   Cell Mol Life Sci 80 (4), 115 (2023)
   PUBMED   37014433
  REMARK    GeneRIF: circPTPN14 promotes renal fibrosis through its interaction
            with FUBP1 to enhance MYC transcription.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1187)
  AUTHORS   Li,H., Guan,B., Liu,S., Liu,H., Song,L., Zhang,G., Zhao,R., Zhou,C.
            and Gao,P.
  TITLE     PTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR
            pathway
  JOURNAL   Cell Death Dis 14 (3), 188 (2023)
   PUBMED   36898991
  REMARK    GeneRIF: PTPN14 promotes gastric cancer progression by
            PI3KA/AKT/mTOR pathway.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1187)
  AUTHORS   Russell-Goldman,E., Dong,F. and Hanna,J.
  TITLE     Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct
            Pathways of Molecular Pathogenesis
  JOURNAL   Am J Dermatopathol 44 (8), 545-552 (2022)
   PUBMED   35830698
  REMARK    GeneRIF: Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for
            Distinct Pathways of Molecular Pathogenesis.
REFERENCE   6  (residues 1 to 1187)
  AUTHORS   Wadham,C., Gamble,J.R., Vadas,M.A. and Khew-Goodall,Y.
  TITLE     Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to
            the nucleus is associated with induction of cell proliferation
  JOURNAL   J Cell Sci 113 (Pt 17), 3117-3123 (2000)
   PUBMED   10934049
REFERENCE   7  (residues 1 to 1187)
  AUTHORS   Aoyama,K., Matsuda,T. and Aoki,N.
  TITLE     Characterization of newly identified four isoforms for a putative
            cytosolic protein tyrosine phosphatase PTP36
  JOURNAL   Biochem Biophys Res Commun 266 (2), 523-531 (1999)
   PUBMED   10600535
REFERENCE   8  (residues 1 to 1187)
  AUTHORS   Ogata,M., Takada,T., Mori,Y., Uchida,Y., Miki,T., Okuyama,A.,
            Kosugi,A., Sawada,M., Oh-hora,M. and Hamaoka,T.
  TITLE     Regulation of phosphorylation level and distribution of PTP36, a
            putative protein tyrosine phosphatase, by cell-substrate adhesion
  JOURNAL   J Biol Chem 274 (29), 20717-20724 (1999)
   PUBMED   10400706
REFERENCE   9  (residues 1 to 1187)
  AUTHORS   Ogata,M., Takada,T., Mori,Y., Oh-hora,M., Uchida,Y., Kosugi,A.,
            Miyake,K. and Hamaoka,T.
  TITLE     Effects of overexpression of PTP36, a putative protein tyrosine
            phosphatase, on cell adhesion, cell growth, and cytoskeletons in
            HeLa cells
  JOURNAL   J Biol Chem 274 (18), 12905-12909 (1999)
   PUBMED   10212280
REFERENCE   10 (residues 1 to 1187)
  AUTHORS   Smith,A.L., Mitchell,P.J., Shipley,J., Gusterson,B.A., Rogers,M.V.
            and Crompton,M.R.
  TITLE     Pez: a novel human cDNA encoding protein tyrosine phosphatase- and
            ezrin-like domains
  JOURNAL   Biochem Biophys Res Commun 209 (3), 959-965 (1995)
   PUBMED   7733990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA738908.1, AK291641.1,
            AL445305.11, AL603838.6 and AL929236.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 28, 2003 this sequence version replaced NP_005392.1.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an N-terminal
            noncatalytic domain similar to that of band 4.1 superfamily
            cytoskeleton-associated proteins, which suggested the membrane or
            cytoskeleton localization of this protein. It appears to regulate
            lymphatic development in mammals, and a loss of function mutation
            has been found in a kindred with a lymphedema-choanal atresia.
            [provided by RefSeq, Sep 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291641.1, X82676.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366956.10/ ENSP00000355923.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3-q41"
     Protein         1..1187
                     /product="tyrosine-protein phosphatase non-receptor type
                     14"
                     /EC_number="3.1.3.48"
                     /note="cytoskeletal-associated protein tyrosine
                     phosphatase; protein-tyrosine phosphatase pez"
                     /calculated_mol_wt=135131
     Region          24..220
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          215..305
                     /region_name="FERM_C_PTPN14_PTPN21"
                     /note="FERM domain C-lobe of Protein tyrosine phosphatase
                     non-receptor proteins 14 and 21 (PTPN14 and 21); cd13188"
                     /db_xref="CDD:270009"
     Site            order(224,241,243,250)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270009"
     Site            order(254,259..262,292,296,299..300)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Site            292..303
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Site            314
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62130; propagated from
                     UniProtKB/Swiss-Prot (Q15678.2)"
     Site            461
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62130; propagated from
                     UniProtKB/Swiss-Prot (Q15678.2)"
     Site            486
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17525332; propagated from
                     UniProtKB/Swiss-Prot (Q15678.2)"
     Region          510..531
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15678.2)"
     Site            591
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q15678.2)"
     Site            593
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62130; propagated from
                     UniProtKB/Swiss-Prot (Q15678.2)"
     Site            594
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q15678.2)"
     Site            642
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q15678.2)"
     Region          671..690
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15678.2)"
     Region          787..824
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15678.2)"
     Site            831
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62130; propagated from
                     UniProtKB/Swiss-Prot (Q15678.2)"
     Region          896..1182
                     /region_name="PTPc-N14"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 14; cd14599"
                     /db_xref="CDD:350447"
     CDS             1..1187
                     /gene="PTPN14"
                     /gene_synonym="CATLPH; PEZ; PTP36; PTPD2"
                     /coded_by="NM_005401.5:575..4138"
                     /db_xref="CCDS:CCDS1514.1"
                     /db_xref="GeneID:5784"
                     /db_xref="HGNC:HGNC:9647"
                     /db_xref="MIM:603155"
ORIGIN      
        1 mpfglklrrt rrynvlsknc fvtrirllds nviectlsve stgqecleav aqrlelreth
       61 yfglwflsks qqarwvelek plkkhldkfa nepllffgvm fyvpnvswlq qeatryqyyl
      121 qvkkdvlegr lrctldqvir laglavqadf gdynqfdsqd flreyvlfpm dlaleeavle
      181 eltqkvaqeh kahsgilpae aelmyineve rldgfgqeif pvkdnhgncv hlgiffmgif
      241 vrnrigrqav iyrwndmgni thnkstilve linkeetalf htddienaky isrlfatrhk
      301 fykqnkicte qsnspppirr qptwsrsslp rqqpyilppv hvqcgehyse thtsqdsifh
      361 gneealycns hnsldlnyln gtvtngsvcs vhsvnslncs qsfiqaspvs snlsipgsdi
      421 mradyipshr hsaiivpsyr ptpdyetvmr qmkrgilhtd sqsqslrnln iinthaynqp
      481 edlvysqpem rerhpytvpy gpqgvysnkl vspsdqrnpk nnvvpskpga saishtvstp
      541 elanmqlqgs hnystahmlk nylfrppppy prprpatstp dlashrhkyv sgsspdlvtr
      601 kvqlsvktfq edsspvvhqs lqevseplta tkhhgtvnkr hslevmnsmv rgmeamtlks
      661 lhlpmarrnt lreqgppeeg sgshevpqlp qyhhkktfsd atmlihsses eeeeeeapes
      721 vpqipmlrek meysaqlqaa laripnkppp eypgprksvs ngalrqdqas lppamararv
      781 lrhgpakais msrtdppavn gaslgpsise pdltsvkerv kkepvkerpv semfsledsi
      841 ieremmirnl ekqkmaglea qkrplmlaal nglsvarvsg reenrvdatr vpmderfrtl
      901 kkkleegmvf teyeqipkkk angifstaal penaersrir evvpyeenrv eliptkennt
      961 gyinashikv vvggaewhyi atqgplphtc hdfwqmvweq gvnviamvta eeeggrtksh
     1021 rywpklgskh ssatygkfkv ttkfrtdsvc yattglkvkh llsgqertvw hlqytdwpdh
     1081 gcpedvqgfl syleeiqsvr rhtnsmlegt knrhppivvh csagvgrtgv lilselmiyc
     1141 lehnekvevp mmlrllreqr mfmiqtiaqy kfvyqvliqf lqnsrli
//
