LOCUS       NM_080684               7975 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 13
            (PTPN13), transcript variant 3, mRNA.
ACCESSION   NM_080684
VERSION     NM_080684.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7975)
  AUTHORS   Peng,W., Fu,J., Zhou,L. and Duan,H.
  TITLE     METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib
            resistance by inhibiting PTPN13 expression
  JOURNAL   Cancer Med 13 (13), e7420 (2024)
   PUBMED   38967523
  REMARK    GeneRIF: METTL1/FOXM1 promotes lung adenocarcinoma progression and
            gefitinib resistance by inhibiting PTPN13 expression.
REFERENCE   2  (bases 1 to 7975)
  AUTHORS   Tu,R., Zhong,D., Li,P., Li,Y., Chen,Z., Hu,F., Yuan,G., Chen,Z.,
            Yu,S. and Song,J.
  TITLE     PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal
            cancer
  JOURNAL   Ann Med 55 (2), 2281659 (2023)
   PUBMED   38039548
  REMARK    GeneRIF: PTPN13 rs989902 and CHEK2 rs738722 are associated with
            esophageal cancer.
REFERENCE   3  (bases 1 to 7975)
  AUTHORS   Wang,J., Li,S., Zhang,X., Zhu,N., Yiminniyaze,R., Dong,L., Li,C.,
            Gulinuer,W., Xia,J., Li,J., Zhou,D., Liu,X., Zhang,Y., Zhang,Y. and
            Li,S.
  TITLE     Protein tyrosine phosphatase PTPL1 suppresses lung cancer through
            Src/ERK/YAP1 signaling
  JOURNAL   Thorac Cancer 13 (21), 3042-3051 (2022)
   PUBMED   36193770
  REMARK    GeneRIF: Protein tyrosine phosphatase PTPL1 suppresses lung cancer
            through Src/ERK/YAP1 signaling.
REFERENCE   4  (bases 1 to 7975)
  AUTHORS   Moshiri,H., Cabrera Riofrio,D.A., Lim,Y.J., Lauhasurayotin,S.,
            Manisterski,M., Elhasid,R., Bonilla,F.A., Dhanraj,S.,
            Armstrong,R.N., Li,H., Scherer,S.W., Hernandez-Hernandez,A. and
            Dror,Y.
  TITLE     Germline PTPN13 mutations in patients with bone marrow failure and
            acute lymphoblastic leukemia
  JOURNAL   Leukemia 36 (8), 2132-2135 (2022)
   PUBMED   35643866
  REMARK    GeneRIF: Germline PTPN13 mutations in patients with bone marrow
            failure and acute lymphoblastic leukemia.
REFERENCE   5  (bases 1 to 7975)
  AUTHORS   Zhu,N., Zhang,X.J., Zou,H., Zhang,Y.Y., Xia,J.W., Zhang,P.,
            Zhang,Y.Z., Li,J., Dong,L., Wumaier,G. and Li,S.Q.
  TITLE     PTPL1 suppresses lung cancer cell migration via inhibiting
            TGF-beta1-induced activation of p38 MAPK and Smad 2/3 pathways and
            EMT
  JOURNAL   Acta Pharmacol Sin 42 (8), 1280-1287 (2021)
   PUBMED   33536603
  REMARK    GeneRIF: PTPL1 suppresses lung cancer cell migration via inhibiting
            TGF-beta1-induced activation of p38 MAPK and Smad 2/3 pathways and
            EMT.
REFERENCE   6  (bases 1 to 7975)
  AUTHORS   Inazawa,J., Ariyama,T., Abe,T., Druck,T., Ohta,M., Huebner,K.,
            Yanagisawa,J., Reed,J.C. and Sato,T.
  TITLE     PTPN13, a fas-associated protein tyrosine phosphatase, is located
            on the long arm of chromosome 4 at band q21.3
  JOURNAL   Genomics 31 (2), 240-242 (1996)
   PUBMED   8824809
REFERENCE   7  (bases 1 to 7975)
  AUTHORS   Sato,T., Irie,S., Kitada,S. and Reed,J.C.
  TITLE     FAP-1: a protein tyrosine phosphatase that associates with Fas
  JOURNAL   Science 268 (5209), 411-415 (1995)
   PUBMED   7536343
REFERENCE   8  (bases 1 to 7975)
  AUTHORS   Saras,J., Claesson-Welsh,L., Heldin,C.H. and Gonez,L.J.
  TITLE     Cloning and characterization of PTPL1, a protein tyrosine
            phosphatase with similarities to cytoskeletal-associated proteins
  JOURNAL   J Biol Chem 269 (39), 24082-24089 (1994)
   PUBMED   7929060
REFERENCE   9  (bases 1 to 7975)
  AUTHORS   Banville,D., Ahmad,S., Stocco,R. and Shen,S.H.
  TITLE     A novel protein-tyrosine phosphatase with homology to both the
            cytoskeletal proteins of the band 4.1 family and
            junction-associated guanylate kinases
  JOURNAL   J Biol Chem 269 (35), 22320-22327 (1994)
   PUBMED   8071359
  REMARK    Erratum:[J Biol Chem 1995 Apr 28;270(17):10359]
REFERENCE   10 (bases 1 to 7975)
  AUTHORS   Maekawa,K., Imagawa,N., Nagamatsu,M. and Harada,S.
  TITLE     Molecular cloning of a novel protein-tyrosine phosphatase
            containing a membrane-binding domain and GLGF repeats
  JOURNAL   FEBS Lett 337 (2), 200-206 (1994)
   PUBMED   8287977
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA625835.1, D21211.1 and
            BG202767.1.
            
            On May 31, 2019 this sequence version replaced NM_080684.2.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are signaling
            molecules that regulate a variety of cellular processes including
            cell growth, differentiation, mitotic cycle, and oncogenic
            transformation. This PTP is a large intracellular protein. It has a
            catalytic PTP domain at its C-terminus and two major structural
            domains: a region with five PDZ domains and a FERM domain that
            binds to plasma membrane and cytoskeletal elements. This PTP was
            found to interact with, and dephosphorylate, Fas receptor and
            IkappaBalpha through the PDZ domains. This suggests it has a role
            in Fas mediated programmed cell death. This PTP was also shown to
            interact with GTPase-activating protein, and thus may function as a
            regulator of Rho signaling pathways. Four alternatively spliced
            transcript variants, which encode distinct proteins, have been
            reported. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (3) lacks multiple in-frame
            segments of the coding region, compared to variant 4. The encoded
            protein (isoform 3) lacks 191 internal amino acids, compared to
            isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D21211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               DA625835.1         1-417
            418-7963            D21211.1           1-7546
            7964-7975           BG202767.1         699-710
FEATURES             Location/Qualifiers
     source          1..7975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.3"
     gene            1..7975
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /note="protein tyrosine phosphatase non-receptor type 13"
                     /db_xref="GeneID:5783"
                     /db_xref="HGNC:HGNC:9646"
                     /db_xref="MIM:600267"
     exon            1..475
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            476..595
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..7365
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /EC_number="3.1.3.48"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein-tyrosine phosphatase PTPL1; hPTPE1;
                     protein-tyrosine phosphatase 1E; fas-associated
                     protein-tyrosine phosphatase 1; protein tyrosine
                     phosphatase, non-receptor type 13 (APO-1/CD95
                     (Fas)-associated phosphatase)"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     13 isoform 3"
                     /protein_id="NP_542415.1"
                     /db_xref="CCDS:CCDS47096.1"
                     /db_xref="GeneID:5783"
                     /db_xref="HGNC:HGNC:9646"
                     /db_xref="MIM:600267"
                     /translation="MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADP
                     AALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIY
                     SLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNS
                     NCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSD
                     VLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQ
                     FKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTS
                     TTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLR
                     EAMNVEEPVRRYKTYHGDVFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVD
                     ETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDT
                     IKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGK
                     NEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYF
                     FVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQ
                     LRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDL
                     SYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVC
                     SKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQY
                     LLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREITLVNLKKDAKYGLG
                     FQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEI
                     LQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWS
                     RGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQH
                     GSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTP
                     KQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGI
                     YVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ
                     SPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGL
                     GFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQE
                     VISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQS
                     TSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSN
                     MVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSE
                     SASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGF
                     TVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASK
                     TVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS
                     VAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR
                     SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP
                     NLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMN
                     GKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEI
                     TWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGL
                     LDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINA
                     SFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYW
                     PNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDT
                     PSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDL
                     VRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK"
     exon            596..774
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            775..840
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1026
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1114
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1675
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1771
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1865
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2088
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2163
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2338
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2492
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2631
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2784
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2967
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3130
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3220
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3328
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3460
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3924
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4056
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4150
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4236
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4396
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4397..4611
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4612..4710
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4711..5075
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5076..5256
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5415
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5416..5587
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5588..5798
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5799..5869
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5870..5931
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5932..6025
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6026..6163
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6164..6252
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6253..6308
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6309..6412
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6413..6561
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6562..6652
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6653..6990
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6991..7206
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            7207..7269
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            7270..7975
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7940..7945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /note="hexamer: AATAAA"
     polyA_site      7975
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /note="major polyA site"
ORIGIN      
        1 gagtagctcc agcggccacg ctgaggcgag ggtgacacac catgctcacg gcccctggag
       61 accgtcgtgc tggcgagccg tgctccgtag ctccccggtc cgcctcggca gcggtcagag
      121 tcgcctacag gagttgagcc gcccgcgcca gaaggttttg gcgaagctct tggagaggcg
      181 tcgagcacag tagggcggcg ggggtgcgtt gagcgctcgg gggtcaggca gtcggccggg
      241 atcgccgctg gggagcgttt ccgaggcgag gaggaggagg aggagatgct gctcctcttc
      301 tccccctccc caggctcctt ctacagctcc ttcagcccac gcccgcagcc gcttgtggga
      361 gaagtggtgg tggctctcgg cgcccgcggc ggctgccggc ggcccgcccc gacgccgcgt
      421 ccctgcagcc ctcgcccggc gctccagtag caggacccgg tctcgggacc agccggtaat
      481 atgcacgtgt cactagctga ggccctggag gttcggggtg gaccacttca ggaggaagaa
      541 atatgggctg tattaaatca aagtgctgaa agtctccaag aattattcag aaaagtaagc
      601 ctagctgatc ctgctgccct tggcttcatc atttctccat ggtctctgct gttgctgcca
      661 tctggtagtg tgtcatttac agatgaaaat atttccaatc aggatcttcg agcattcact
      721 gcaccagagg ttcttcaaaa tcagtcacta acttctctct cagatgttga aaagatccac
      781 atttattctc ttggaatgac actgtattgg ggggctgatt atgaagtgcc tcagagccaa
      841 cctattaagc ttggagatca tctcaacagc atactgcttg gaatgtgtga ggatgttatt
      901 tacgctcgag tttctgttcg gactgtgctg gatgcttgca gtgcccacat taggaatagc
      961 aattgtgcac cctcattttc ctacgtgaaa cacttggtaa aactggttct gggaaatctt
     1021 tctgggacag atcagctttc ctgtaacagt gaacaaaagc ctgatcgaag ccaggctatt
     1081 cgagatcgat tgcgaggaaa aggattacca acaggaagaa gctctacttc tgatgtacta
     1141 gacatacaaa agcctccact ctctcatcag acctttctta acaaagggct tagtaaatct
     1201 atgggatttc tgtccatcaa agatacacaa gatgagaatt atttcaagga cattttatca
     1261 gataattctg gacgtgaaga ttctgaaaat acattctccc cttaccagtt caaaactagt
     1321 ggcccagaaa aaaaacccat ccctggcatt gatgtgcttt ctaagaagaa gatctgggct
     1381 tcatccatgg acttgctttg tacagctgac agagacttct cttcaggaga gactgccaca
     1441 tatcgtcgtt gtcaccctga ggcagtaaca gtgcggactt caactactcc tagaaaaaag
     1501 gaggcaagat actcagatgg aagtatagcc ttggatatct ttggccctca gaaaatggat
     1561 ccaatatatc acactcgaga attgcccacc tcctcagcaa tatcaagtgc tttggaccga
     1621 atccgagaga gacaaaagaa acttcaggtt ctgagggaag ccatgaatgt agaagaacca
     1681 gttcgaagat acaaaactta tcatggtgat gtctttagta cctccagtga aagtccatct
     1741 attatttcct ctgaatcaga tttcagacaa gtgagaagaa gtgaagcctc aaagaggttt
     1801 gaatccagca gtggtctccc aggggtagat gaaaccttaa gtcaaggcca gtcacagaga
     1861 ccgagcagac aatatgaaac accctttgaa ggcaacttaa ttaatcaaga gatcatgcta
     1921 aaacggcaag aggaagaact gatgcagcta caagccaaaa tggcccttag acagtctcgg
     1981 ttgagcctat atccaggaga cacaatcaaa gcgtccatgc ttgacatcac cagggatccg
     2041 ttaagagaaa ttgccctaga aacagccatg actcaaagaa aactgaggaa tttctttggc
     2101 cctgagtttg tgaaaatgac aattgaacca tttatatctt tggatttgcc acggtctatt
     2161 cttactaaga aagggaagaa tgaggataac cgaaggaaag taaacataat gcttctgaac
     2221 gggcaaagac tggaactgac ctgtgatacc aaaactatat gtaaagatgt gtttgatatg
     2281 gttgtggcac atattggctt agtagagcat catttgtttg ctttagctac cctcaaagat
     2341 aatgaatatt tctttgttga tcctgactta aaattaacca aagtggcccc agagggatgg
     2401 aaagaagaac caaagaaaaa gaccaaagcc actgttaatt ttactttgtt tttcagaatt
     2461 aaatttttta tggatgatgt tagtctaata caacatactc tgacgtgtca tcagtattac
     2521 cttcagcttc gaaaagatat tttggaggaa aggatgcact gtgatgatga gacttcctta
     2581 ttgctggcat ccttggctct ccaggctgag tatggagatt atcaaccaga ggttcatggt
     2641 gtgtcttact ttagaatgga gcactatttg cccgccagag tgatggagaa acttgattta
     2701 tcctatatca aagaagagtt acccaaattg cataatacct atgtgggagc ttctgaaaaa
     2761 gagacagagt tagaattttt aaaggtctgc caaagactga cagaatatgg agttcatttt
     2821 caccgagtgc accctgagaa gaagtcacaa acaggaatat tgcttggagt ctgttctaaa
     2881 ggtgtccttg tgtttgaagt tcacaatgga gtgcgcacat tggtccttcg ctttccatgg
     2941 agggaaacca agaaaatatc tttttctaaa aagaaaatca cattgcaaaa tacatcagat
     3001 ggaataaaac atggcttcca gacagacaac agtaagatat gccagtacct gctgcacctc
     3061 tgctcttacc agcataagtt ccagctacag atgagagcaa gacagagcaa ccaagatgcc
     3121 caagatattg atgtgctaca caaaagatgg agcatagtat cttcaccaga aagggagatc
     3181 accttagtga acctgaaaaa agatgcaaag tatggcttgg gatttcaaat tattggtggg
     3241 gagaagatgg gaagactgga cctaggcata tttatcagtt cagttgcccc tggaggacca
     3301 gctgacttgg atggatgctt gaagccagga gaccgtttga tatctgtgaa tagtgtgagt
     3361 ctggagggag tcagccacca tgctgcaatt gaaattttgc aaaatgcacc tgaagatgtg
     3421 acacttgtta tctctcagcc aaaagaaaag atatccaaag tgccttctac tcctgtgcat
     3481 ctcaccaatg agatgaaaaa ctacatgaag aaatcttcct acatgcaaga cagtgctata
     3541 gattcttctt ccaaggatca ccactggtca cgtggtaccc tgaggcacat ctcggagaac
     3601 tcctttgggc catctggggg cctgcgggaa ggaagcctga gttctcaaga ttccaggact
     3661 gagagtgcca gcttgtctca aagccaggtc aatggtttct ttgccagcca tttaggtgac
     3721 caaacctggc aggaatcaca gcatggcagc ccttccccat ctgtaatatc caaagccacc
     3781 gagaaagaga ctttcactga tagtaaccaa agcaaaacta aaaagccagg catttctgat
     3841 gtaactgatt actcagaccg tggagattca gacatggatg aagccactta ctccagcagt
     3901 caggatcatc aaacaccaaa acaggaatct tcctcttcag tgaatacatc caacaagatg
     3961 aattttaaaa ctttttcttc atcacctcct aagcctggag atatctttga ggttgaactg
     4021 gctaaaaatg ataacagctt ggggataagt gtcacgggag gtgtgaatac gagtgtcaga
     4081 catggtggca tttatgtgaa agctgttatt ccccagggag cagcagagtc tgatggtaga
     4141 attcacaaag gtgatcgcgt cctagctgtc aatggagtta gtctagaagg agccacccat
     4201 aagcaagctg tggaaacact gagaaataca ggacaggtgg ttcatctgtt attagaaaag
     4261 ggacaatctc caacatctaa agaacatgtc ccggtaaccc cacagtgtac cctttcagat
     4321 cagaatgccc aaggtcaagg cccagaaaaa gtgaagaaaa caactcaggt caaagactac
     4381 agctttgtca ctgaagaaaa tacatttgag gtaaaattat ttaaaaatag ctcaggtcta
     4441 ggattcagtt tttctcgaga agataatctt ataccggagc aaattaatgc cagcatagta
     4501 agggttaaaa agctctttcc tggacagcca gcagcagaaa gtggaaaaat tgatgtagga
     4561 gatgttatct tgaaagtgaa tggagcctct ttgaaaggac tatctcagca ggaagtcata
     4621 tctgctctca ggggaactgc tccagaagta ttcttgcttc tctgcagacc tccacctggt
     4681 gtgctaccgg aaattgatac tgcgcttttg accccacttc agtctccagc acaagtactt
     4741 ccaaacagca gtaaagactc ttctcagcca tcatgtgtgg agcaaagcac cagctcagat
     4801 gaaaatgaaa tgtcagacaa aagcaaaaaa cagtgcaagt ccccatccag aagagacagt
     4861 tacagtgaca gcagtgggag tggagaagat gacttagtga cagctccagc aaacatatca
     4921 aattcgacct ggagttcagc tttgcatcag actctaagca acatggtatc acaggcacag
     4981 agtcatcatg aagcacccaa gagtcaagaa gataccattt gtaccatgtt ttactatcct
     5041 cagaaaattc ccaataaacc agagtttgag gacagtaatc cttcccctct accaccggat
     5101 atggctcctg ggcagagtta tcaaccccaa tcagaatctg cttcctctag ttcgatggat
     5161 aagtatcata tacatcacat ttctgaacca actagacaag aaaactggac acctttgaaa
     5221 aatgacttgg aaaatcacct tgaagacttt gaactggaag tagaactcct cattacccta
     5281 attaaatcag aaaaaggaag cctgggtttt acagtaacca aaggcaatca gagaattggt
     5341 tgttatgttc atgatgtcat acaggatcca gccaaaagtg atggaaggct aaaacctggg
     5401 gaccggctca taaaggttaa tgatacagat gttactaata tgactcatac agatgcagtt
     5461 aatctgctcc gggctgcatc caaaacagtc agattagtta ttggacgagt tctagaatta
     5521 cccagaatac caatgttgcc tcatttgcta ccggacataa cactaacgtg caacaaagag
     5581 gagttgggtt tttccttatg tggaggtcat gacagccttt atcaagtggt atatattagt
     5641 gatattaatc caaggtccgt cgcagccatt gagggtaatc tccagctatt agatgtcatc
     5701 cattatgtga acggagtcag cacacaagga atgaccttgg aggaagttaa cagagcatta
     5761 gacatgtcac ttccttcatt ggtattgaaa gcaacaagaa atgatcttcc agtggtcccc
     5821 agctcaaaga ggtctgctgt ttcagctcca aagtcaacca aaggcaatgg ttcctacagt
     5881 gtggggtctt gcagccagcc tgccctcact cctaatgatt cattctccac ggttgctggg
     5941 gaagaaataa atgaaatatc gtaccccaaa ggaaaatgtt ctacttatca gataaaggga
     6001 tcaccaaact tgactctgcc caaagaatct tatatacaag aagatgacat ttatgatgat
     6061 tcccaagaag ctgaagttat ccagtctctg ctggatgttg tggatgagga agcccagaat
     6121 cttttaaacg aaaataatgc agcaggatac tcctgtggtc caggtacatt aaagatgaat
     6181 gggaagttat cagaagagag aacagaagat acagactgcg atggttcacc tttacctgag
     6241 tattttactg aggccaccaa aatgaatggc tgtgaagaat attgtgaaga aaaagtaaaa
     6301 agtgaaagct taattcagaa gccacaagaa aagaagactg atgatgatga aataacatgg
     6361 ggaaatgatg agttgccaat agagagaaca aaccatgaag attctgataa agatcattcc
     6421 tttctgacaa acgatgagct cgctgtactc cctgtcgtca aagtgcttcc ctctggtaaa
     6481 tacacgggtg ccaacttaaa atcagtcatt cgagtcctgc ggggtttgct agatcaagga
     6541 attccttcta aggagctgga gaatcttcaa gaattaaaac ctttggatca gtgtctaatt
     6601 gggcaaacta aggaaaacag aaggaagaac agatataaaa atatacttcc ctatgatgct
     6661 acaagagtgc ctcttggaga tgaaggtggc tatatcaatg ccagcttcat taagatacca
     6721 gttgggaaag aagagttcgt ttacattgcc tgccaaggac cactgcctac aactgttgga
     6781 gacttctggc agatgatttg ggagcaaaaa tccacagtga tagccatgat gactcaagaa
     6841 gtagaaggag aaaaaatcaa atgccagcgc tattggccca acatcctagg caaaacaaca
     6901 atggtcagca acagacttcg actggctctt gtgagaatgc agcagctgaa gggctttgtg
     6961 gtgagggcaa tgacccttga agatattcag accagagagg tgcgccatat ttctcatctg
     7021 aatttcactg cctggccaga ccatgataca ccttctcaac cagatgatct gcttactttt
     7081 atctcctaca tgagacacat ccacagatca ggcccaatca ttacgcactg cagtgctggc
     7141 attggacgtt cagggaccct gatttgcata gatgtggttc tgggattaat cagtcaggat
     7201 cttgattttg acatctctga tttggtgcgc tgcatgagac tacaaagaca cggaatggtt
     7261 cagacagagg atcaatatat tttctgctat caagtcatcc tttatgtcct gacacgtctt
     7321 caagcagaag aagagcaaaa acagcagcct cagcttctga agtgacatga aaagagcctc
     7381 tggatgcatt tccatttctc tccttaacct ccagcagact cctgctctct atccaaaata
     7441 aagatcacag agcagcaagt tcatacaaca tgcatgttct cctctatctt agaggggtat
     7501 tcttcttgaa aataaaaaat attgaaatgc tgtattttta cagctacttt aacctatgat
     7561 aattatttac aaaattttaa cactaaccaa acaatgcaga tcttagggat gattaaaggc
     7621 agcatttgat gatagcagac attgttacaa ggacatggtg agtctatttt taatgcacca
     7681 atcttgttta tagcaaaaat gttttccaat attttaataa agtagttatt ttatagggga
     7741 tacttgaaac cagtatttaa gctttaaatg acagtaatat tggcatagaa aaaagtagca
     7801 aatgtttact gtatcaattt ctaatgttta ctatatagaa tttcctgtaa tatatttata
     7861 tactttttca tgaaaatgga gttatcagtt atctgtttgt tactgcatca tctgtttgta
     7921 atcattatct cactttgtaa ataaaaacac accttaaaac atgaacaagc caaaa
//
