LOCUS       NM_080683               8548 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 13
            (PTPN13), transcript variant 1, mRNA.
ACCESSION   NM_080683
VERSION     NM_080683.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8548)
  AUTHORS   Peng,W., Fu,J., Zhou,L. and Duan,H.
  TITLE     METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib
            resistance by inhibiting PTPN13 expression
  JOURNAL   Cancer Med 13 (13), e7420 (2024)
   PUBMED   38967523
  REMARK    GeneRIF: METTL1/FOXM1 promotes lung adenocarcinoma progression and
            gefitinib resistance by inhibiting PTPN13 expression.
REFERENCE   2  (bases 1 to 8548)
  AUTHORS   Tu,R., Zhong,D., Li,P., Li,Y., Chen,Z., Hu,F., Yuan,G., Chen,Z.,
            Yu,S. and Song,J.
  TITLE     PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal
            cancer
  JOURNAL   Ann Med 55 (2), 2281659 (2023)
   PUBMED   38039548
  REMARK    GeneRIF: PTPN13 rs989902 and CHEK2 rs738722 are associated with
            esophageal cancer.
REFERENCE   3  (bases 1 to 8548)
  AUTHORS   Wang,J., Li,S., Zhang,X., Zhu,N., Yiminniyaze,R., Dong,L., Li,C.,
            Gulinuer,W., Xia,J., Li,J., Zhou,D., Liu,X., Zhang,Y., Zhang,Y. and
            Li,S.
  TITLE     Protein tyrosine phosphatase PTPL1 suppresses lung cancer through
            Src/ERK/YAP1 signaling
  JOURNAL   Thorac Cancer 13 (21), 3042-3051 (2022)
   PUBMED   36193770
  REMARK    GeneRIF: Protein tyrosine phosphatase PTPL1 suppresses lung cancer
            through Src/ERK/YAP1 signaling.
REFERENCE   4  (bases 1 to 8548)
  AUTHORS   Moshiri,H., Cabrera Riofrio,D.A., Lim,Y.J., Lauhasurayotin,S.,
            Manisterski,M., Elhasid,R., Bonilla,F.A., Dhanraj,S.,
            Armstrong,R.N., Li,H., Scherer,S.W., Hernandez-Hernandez,A. and
            Dror,Y.
  TITLE     Germline PTPN13 mutations in patients with bone marrow failure and
            acute lymphoblastic leukemia
  JOURNAL   Leukemia 36 (8), 2132-2135 (2022)
   PUBMED   35643866
  REMARK    GeneRIF: Germline PTPN13 mutations in patients with bone marrow
            failure and acute lymphoblastic leukemia.
REFERENCE   5  (bases 1 to 8548)
  AUTHORS   Zhu,N., Zhang,X.J., Zou,H., Zhang,Y.Y., Xia,J.W., Zhang,P.,
            Zhang,Y.Z., Li,J., Dong,L., Wumaier,G. and Li,S.Q.
  TITLE     PTPL1 suppresses lung cancer cell migration via inhibiting
            TGF-beta1-induced activation of p38 MAPK and Smad 2/3 pathways and
            EMT
  JOURNAL   Acta Pharmacol Sin 42 (8), 1280-1287 (2021)
   PUBMED   33536603
  REMARK    GeneRIF: PTPL1 suppresses lung cancer cell migration via inhibiting
            TGF-beta1-induced activation of p38 MAPK and Smad 2/3 pathways and
            EMT.
REFERENCE   6  (bases 1 to 8548)
  AUTHORS   Inazawa,J., Ariyama,T., Abe,T., Druck,T., Ohta,M., Huebner,K.,
            Yanagisawa,J., Reed,J.C. and Sato,T.
  TITLE     PTPN13, a fas-associated protein tyrosine phosphatase, is located
            on the long arm of chromosome 4 at band q21.3
  JOURNAL   Genomics 31 (2), 240-242 (1996)
   PUBMED   8824809
REFERENCE   7  (bases 1 to 8548)
  AUTHORS   Sato,T., Irie,S., Kitada,S. and Reed,J.C.
  TITLE     FAP-1: a protein tyrosine phosphatase that associates with Fas
  JOURNAL   Science 268 (5209), 411-415 (1995)
   PUBMED   7536343
REFERENCE   8  (bases 1 to 8548)
  AUTHORS   Saras,J., Claesson-Welsh,L., Heldin,C.H. and Gonez,L.J.
  TITLE     Cloning and characterization of PTPL1, a protein tyrosine
            phosphatase with similarities to cytoskeletal-associated proteins
  JOURNAL   J Biol Chem 269 (39), 24082-24089 (1994)
   PUBMED   7929060
REFERENCE   9  (bases 1 to 8548)
  AUTHORS   Banville,D., Ahmad,S., Stocco,R. and Shen,S.H.
  TITLE     A novel protein-tyrosine phosphatase with homology to both the
            cytoskeletal proteins of the band 4.1 family and
            junction-associated guanylate kinases
  JOURNAL   J Biol Chem 269 (35), 22320-22327 (1994)
   PUBMED   8071359
  REMARK    Erratum:[J Biol Chem 1995 Apr 28;270(17):10359]
REFERENCE   10 (bases 1 to 8548)
  AUTHORS   Maekawa,K., Imagawa,N., Nagamatsu,M. and Harada,S.
  TITLE     Molecular cloning of a novel protein-tyrosine phosphatase
            containing a membrane-binding domain and GLGF repeats
  JOURNAL   FEBS Lett 337 (2), 200-206 (1994)
   PUBMED   8287977
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA625835.1, D21209.1 and
            BG202767.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_080683.2.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are signaling
            molecules that regulate a variety of cellular processes including
            cell growth, differentiation, mitotic cycle, and oncogenic
            transformation. This PTP is a large intracellular protein. It has a
            catalytic PTP domain at its C-terminus and two major structural
            domains: a region with five PDZ domains and a FERM domain that
            binds to plasma membrane and cytoskeletal elements. This PTP was
            found to interact with, and dephosphorylate, Fas receptor and
            IkappaBalpha through the PDZ domains. This suggests it has a role
            in Fas mediated programmed cell death. This PTP was also shown to
            interact with GTPase-activating protein, and thus may function as a
            regulator of Rho signaling pathways. Four alternatively spliced
            transcript variants, which encode distinct proteins, have been
            reported. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) lacks an in-frame segment of a
            coding exon, compared to variant 4. The encoded protein (isoform 1)
            lacks 5 internal amino acids, compared to isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D21209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000411767.7/ ENSP00000407249.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               DA625835.1         1-417
            418-8536            D21209.1           1-8119
            8537-8548           BG202767.1         699-710
FEATURES             Location/Qualifiers
     source          1..8548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.3"
     gene            1..8548
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /note="protein tyrosine phosphatase non-receptor type 13"
                     /db_xref="GeneID:5783"
                     /db_xref="HGNC:HGNC:9646"
                     /db_xref="MIM:600267"
     exon            1..475
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            476..595
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..7938
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein-tyrosine phosphatase PTPL1; hPTPE1;
                     protein-tyrosine phosphatase 1E; fas-associated
                     protein-tyrosine phosphatase 1; protein tyrosine
                     phosphatase, non-receptor type 13 (APO-1/CD95
                     (Fas)-associated phosphatase)"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     13 isoform 1"
                     /protein_id="NP_542414.1"
                     /db_xref="CCDS:CCDS47094.1"
                     /db_xref="GeneID:5783"
                     /db_xref="HGNC:HGNC:9646"
                     /db_xref="MIM:600267"
                     /translation="MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADP
                     AALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIY
                     SLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNS
                     NCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSD
                     VLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQ
                     FKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTS
                     TTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLR
                     EAMNVEEPVRRYKTYHGDVFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVD
                     ETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDT
                     IKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGK
                     NEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYF
                     FVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQ
                     LRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDL
                     SYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVC
                     SKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQY
                     LLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS
                     STLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHD
                     LSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASL
                     NRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPE
                     REITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS
                     VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSS
                     YMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVN
                     GFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD
                     SDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSL
                     GISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE
                     TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFV
                     TEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGD
                     VILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQV
                     LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPA
                     NISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPS
                     PLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELE
                     VELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDV
                     TNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGG
                     HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSL
                     VLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE
                     ISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLN
                     ENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKS
                     ESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSG
                     KYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILP
                     YDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIA
                     MMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE
                     VRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICID
                     VVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQ
                     PQLLK"
     exon            596..774
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            775..840
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1026
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1114
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1675
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1771
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1865
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2088
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2163
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2338
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2492
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2631
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2784
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2967
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3130
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3548
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3646
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3703
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3793
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3901
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4033
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4497
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4498..4629
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4630..4723
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..4809
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4810..4969
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            4970..5184
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5185..5283
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5284..5648
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5649..5829
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5830..5988
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            5989..6160
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6161..6371
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6372..6442
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6443..6504
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6505..6598
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6599..6736
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6737..6825
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6826..6881
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6882..6985
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            6986..7134
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            7135..7225
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            7226..7563
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            7564..7779
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            7780..7842
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     exon            7843..8548
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8513..8518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /note="hexamer: AATAAA"
     polyA_site      8548
                     /gene="PTPN13"
                     /gene_synonym="FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL;
                     PTP1E; PTPL1; PTPLE"
                     /note="major polyA site"
ORIGIN      
        1 gagtagctcc agcggccacg ctgaggcgag ggtgacacac catgctcacg gcccctggag
       61 accgtcgtgc tggcgagccg tgctccgtag ctccccggtc cgcctcggca gcggtcagag
      121 tcgcctacag gagttgagcc gcccgcgcca gaaggttttg gcgaagctct tggagaggcg
      181 tcgagcacag tagggcggcg ggggtgcgtt gagcgctcgg gggtcaggca gtcggccggg
      241 atcgccgctg gggagcgttt ccgaggcgag gaggaggagg aggagatgct gctcctcttc
      301 tccccctccc caggctcctt ctacagctcc ttcagcccac gcccgcagcc gcttgtggga
      361 gaagtggtgg tggctctcgg cgcccgcggc ggctgccggc ggcccgcccc gacgccgcgt
      421 ccctgcagcc ctcgcccggc gctccagtag caggacccgg tctcgggacc agccggtaat
      481 atgcacgtgt cactagctga ggccctggag gttcggggtg gaccacttca ggaggaagaa
      541 atatgggctg tattaaatca aagtgctgaa agtctccaag aattattcag aaaagtaagc
      601 ctagctgatc ctgctgccct tggcttcatc atttctccat ggtctctgct gttgctgcca
      661 tctggtagtg tgtcatttac agatgaaaat atttccaatc aggatcttcg agcattcact
      721 gcaccagagg ttcttcaaaa tcagtcacta acttctctct cagatgttga aaagatccac
      781 atttattctc ttggaatgac actgtattgg ggggctgatt atgaagtgcc tcagagccaa
      841 cctattaagc ttggagatca tctcaacagc atactgcttg gaatgtgtga ggatgttatt
      901 tacgctcgag tttctgttcg gactgtgctg gatgcttgca gtgcccacat taggaatagc
      961 aattgtgcac cctcattttc ctacgtgaaa cacttggtaa aactggttct gggaaatctt
     1021 tctgggacag atcagctttc ctgtaacagt gaacaaaagc ctgatcgaag ccaggctatt
     1081 cgagatcgat tgcgaggaaa aggattacca acaggaagaa gctctacttc tgatgtacta
     1141 gacatacaaa agcctccact ctctcatcag acctttctta acaaagggct tagtaaatct
     1201 atgggatttc tgtccatcaa agatacacaa gatgagaatt atttcaagga cattttatca
     1261 gataattctg gacgtgaaga ttctgaaaat acattctccc cttaccagtt caaaactagt
     1321 ggcccagaaa aaaaacccat ccctggcatt gatgtgcttt ctaagaagaa gatctgggct
     1381 tcatccatgg acttgctttg tacagctgac agagacttct cttcaggaga gactgccaca
     1441 tatcgtcgtt gtcaccctga ggcagtaaca gtgcggactt caactactcc tagaaaaaag
     1501 gaggcaagat actcagatgg aagtatagcc ttggatatct ttggccctca gaaaatggat
     1561 ccaatatatc acactcgaga attgcccacc tcctcagcaa tatcaagtgc tttggaccga
     1621 atccgagaga gacaaaagaa acttcaggtt ctgagggaag ccatgaatgt agaagaacca
     1681 gttcgaagat acaaaactta tcatggtgat gtctttagta cctccagtga aagtccatct
     1741 attatttcct ctgaatcaga tttcagacaa gtgagaagaa gtgaagcctc aaagaggttt
     1801 gaatccagca gtggtctccc aggggtagat gaaaccttaa gtcaaggcca gtcacagaga
     1861 ccgagcagac aatatgaaac accctttgaa ggcaacttaa ttaatcaaga gatcatgcta
     1921 aaacggcaag aggaagaact gatgcagcta caagccaaaa tggcccttag acagtctcgg
     1981 ttgagcctat atccaggaga cacaatcaaa gcgtccatgc ttgacatcac cagggatccg
     2041 ttaagagaaa ttgccctaga aacagccatg actcaaagaa aactgaggaa tttctttggc
     2101 cctgagtttg tgaaaatgac aattgaacca tttatatctt tggatttgcc acggtctatt
     2161 cttactaaga aagggaagaa tgaggataac cgaaggaaag taaacataat gcttctgaac
     2221 gggcaaagac tggaactgac ctgtgatacc aaaactatat gtaaagatgt gtttgatatg
     2281 gttgtggcac atattggctt agtagagcat catttgtttg ctttagctac cctcaaagat
     2341 aatgaatatt tctttgttga tcctgactta aaattaacca aagtggcccc agagggatgg
     2401 aaagaagaac caaagaaaaa gaccaaagcc actgttaatt ttactttgtt tttcagaatt
     2461 aaatttttta tggatgatgt tagtctaata caacatactc tgacgtgtca tcagtattac
     2521 cttcagcttc gaaaagatat tttggaggaa aggatgcact gtgatgatga gacttcctta
     2581 ttgctggcat ccttggctct ccaggctgag tatggagatt atcaaccaga ggttcatggt
     2641 gtgtcttact ttagaatgga gcactatttg cccgccagag tgatggagaa acttgattta
     2701 tcctatatca aagaagagtt acccaaattg cataatacct atgtgggagc ttctgaaaaa
     2761 gagacagagt tagaattttt aaaggtctgc caaagactga cagaatatgg agttcatttt
     2821 caccgagtgc accctgagaa gaagtcacaa acaggaatat tgcttggagt ctgttctaaa
     2881 ggtgtccttg tgtttgaagt tcacaatgga gtgcgcacat tggtccttcg ctttccatgg
     2941 agggaaacca agaaaatatc tttttctaaa aagaaaatca cattgcaaaa tacatcagat
     3001 ggaataaaac atggcttcca gacagacaac agtaagatat gccagtacct gctgcacctc
     3061 tgctcttacc agcataagtt ccagctacag atgagagcaa gacagagcaa ccaagatgcc
     3121 caagatattg agagagcttc gtttaggagc ctgaatctcc aagcagagtc tgttagagga
     3181 tttaatatgg gacgagcaat cagcactggc agtctggcca gcagcaccct caacaaactt
     3241 gctgttcgac ctttatcagt tcaagctgag attctgaaga ggctatcctg ctcagagctg
     3301 tcgctttacc agccattgca aaacagttca aaagagaaga atgacaaagc ttcatgggag
     3361 gaaaagccta gagagatgag taaatcatac catgatctca gtcaggcctc tctctatcca
     3421 catcggaaaa atgtcattgt taacatggaa cccccaccac aaaccgttgc agagttggtg
     3481 ggaaaacctt ctcaccagat gtcaagatct gatgcagaat ctttggcagg agtgacaaaa
     3541 cttaataatt caaagtctgt tgcgagttta aatagaagtc ctgaaaggag gaaacatgaa
     3601 tcagactcct catccattga agaccctggg caagcatatg ttctaggaat gactatgcat
     3661 agttctggaa actcttcatc ccaagtaccc ttaaaagaaa atgatgtgct acacaaaaga
     3721 tggagcatag tatcttcacc agaaagggag atcaccttag tgaacctgaa aaaagatgca
     3781 aagtatggct tgggatttca aattattggt ggggagaaga tgggaagact ggacctaggc
     3841 atatttatca gttcagttgc ccctggagga ccagctgact tggatggatg cttgaagcca
     3901 ggagaccgtt tgatatctgt gaatagtgtg agtctggagg gagtcagcca ccatgctgca
     3961 attgaaattt tgcaaaatgc acctgaagat gtgacacttg ttatctctca gccaaaagaa
     4021 aagatatcca aagtgccttc tactcctgtg catctcacca atgagatgaa aaactacatg
     4081 aagaaatctt cctacatgca agacagtgct atagattctt cttccaagga tcaccactgg
     4141 tcacgtggta ccctgaggca catctcggag aactcctttg ggccatctgg gggcctgcgg
     4201 gaaggaagcc tgagttctca agattccagg actgagagtg ccagcttgtc tcaaagccag
     4261 gtcaatggtt tctttgccag ccatttaggt gaccaaacct ggcaggaatc acagcatggc
     4321 agcccttccc catctgtaat atccaaagcc accgagaaag agactttcac tgatagtaac
     4381 caaagcaaaa ctaaaaagcc aggcatttct gatgtaactg attactcaga ccgtggagat
     4441 tcagacatgg atgaagccac ttactccagc agtcaggatc atcaaacacc aaaacaggaa
     4501 tcttcctctt cagtgaatac atccaacaag atgaatttta aaactttttc ttcatcacct
     4561 cctaagcctg gagatatctt tgaggttgaa ctggctaaaa atgataacag cttggggata
     4621 agtgtcacgg gaggtgtgaa tacgagtgtc agacatggtg gcatttatgt gaaagctgtt
     4681 attccccagg gagcagcaga gtctgatggt agaattcaca aaggtgatcg cgtcctagct
     4741 gtcaatggag ttagtctaga aggagccacc cataagcaag ctgtggaaac actgagaaat
     4801 acaggacagg tggttcatct gttattagaa aagggacaat ctccaacatc taaagaacat
     4861 gtcccggtaa ccccacagtg taccctttca gatcagaatg cccaaggtca aggcccagaa
     4921 aaagtgaaga aaacaactca ggtcaaagac tacagctttg tcactgaaga aaatacattt
     4981 gaggtaaaat tatttaaaaa tagctcaggt ctaggattca gtttttctcg agaagataat
     5041 cttataccgg agcaaattaa tgccagcata gtaagggtta aaaagctctt tcctggacag
     5101 ccagcagcag aaagtggaaa aattgatgta ggagatgtta tcttgaaagt gaatggagcc
     5161 tctttgaaag gactatctca gcaggaagtc atatctgctc tcaggggaac tgctccagaa
     5221 gtattcttgc ttctctgcag acctccacct ggtgtgctac cggaaattga tactgcgctt
     5281 ttgaccccac ttcagtctcc agcacaagta cttccaaaca gcagtaaaga ctcttctcag
     5341 ccatcatgtg tggagcaaag caccagctca gatgaaaatg aaatgtcaga caaaagcaaa
     5401 aaacagtgca agtccccatc cagaagagac agttacagtg acagcagtgg gagtggagaa
     5461 gatgacttag tgacagctcc agcaaacata tcaaattcga cctggagttc agctttgcat
     5521 cagactctaa gcaacatggt atcacaggca cagagtcatc atgaagcacc caagagtcaa
     5581 gaagatacca tttgtaccat gttttactat cctcagaaaa ttcccaataa accagagttt
     5641 gaggacagta atccttcccc tctaccaccg gatatggctc ctgggcagag ttatcaaccc
     5701 caatcagaat ctgcttcctc tagttcgatg gataagtatc atatacatca catttctgaa
     5761 ccaactagac aagaaaactg gacacctttg aaaaatgact tggaaaatca ccttgaagac
     5821 tttgaactgg aagtagaact cctcattacc ctaattaaat cagaaaaagg aagcctgggt
     5881 tttacagtaa ccaaaggcaa tcagagaatt ggttgttatg ttcatgatgt catacaggat
     5941 ccagccaaaa gtgatggaag gctaaaacct ggggaccggc tcataaaggt taatgataca
     6001 gatgttacta atatgactca tacagatgca gttaatctgc tccgggctgc atccaaaaca
     6061 gtcagattag ttattggacg agttctagaa ttacccagaa taccaatgtt gcctcatttg
     6121 ctaccggaca taacactaac gtgcaacaaa gaggagttgg gtttttcctt atgtggaggt
     6181 catgacagcc tttatcaagt ggtatatatt agtgatatta atccaaggtc cgtcgcagcc
     6241 attgagggta atctccagct attagatgtc atccattatg tgaacggagt cagcacacaa
     6301 ggaatgacct tggaggaagt taacagagca ttagacatgt cacttccttc attggtattg
     6361 aaagcaacaa gaaatgatct tccagtggtc cccagctcaa agaggtctgc tgtttcagct
     6421 ccaaagtcaa ccaaaggcaa tggttcctac agtgtggggt cttgcagcca gcctgccctc
     6481 actcctaatg attcattctc cacggttgct ggggaagaaa taaatgaaat atcgtacccc
     6541 aaaggaaaat gttctactta tcagataaag ggatcaccaa acttgactct gcccaaagaa
     6601 tcttatatac aagaagatga catttatgat gattcccaag aagctgaagt tatccagtct
     6661 ctgctggatg ttgtggatga ggaagcccag aatcttttaa acgaaaataa tgcagcagga
     6721 tactcctgtg gtccaggtac attaaagatg aatgggaagt tatcagaaga gagaacagaa
     6781 gatacagact gcgatggttc acctttacct gagtatttta ctgaggccac caaaatgaat
     6841 ggctgtgaag aatattgtga agaaaaagta aaaagtgaaa gcttaattca gaagccacaa
     6901 gaaaagaaga ctgatgatga tgaaataaca tggggaaatg atgagttgcc aatagagaga
     6961 acaaaccatg aagattctga taaagatcat tcctttctga caaacgatga gctcgctgta
     7021 ctccctgtcg tcaaagtgct tccctctggt aaatacacgg gtgccaactt aaaatcagtc
     7081 attcgagtcc tgcggggttt gctagatcaa ggaattcctt ctaaggagct ggagaatctt
     7141 caagaattaa aacctttgga tcagtgtcta attgggcaaa ctaaggaaaa cagaaggaag
     7201 aacagatata aaaatatact tccctatgat gctacaagag tgcctcttgg agatgaaggt
     7261 ggctatatca atgccagctt cattaagata ccagttggga aagaagagtt cgtttacatt
     7321 gcctgccaag gaccactgcc tacaactgtt ggagacttct ggcagatgat ttgggagcaa
     7381 aaatccacag tgatagccat gatgactcaa gaagtagaag gagaaaaaat caaatgccag
     7441 cgctattggc ccaacatcct aggcaaaaca acaatggtca gcaacagact tcgactggct
     7501 cttgtgagaa tgcagcagct gaagggcttt gtggtgaggg caatgaccct tgaagatatt
     7561 cagaccagag aggtgcgcca tatttctcat ctgaatttca ctgcctggcc agaccatgat
     7621 acaccttctc aaccagatga tctgcttact tttatctcct acatgagaca catccacaga
     7681 tcaggcccaa tcattacgca ctgcagtgct ggcattggac gttcagggac cctgatttgc
     7741 atagatgtgg ttctgggatt aatcagtcag gatcttgatt ttgacatctc tgatttggtg
     7801 cgctgcatga gactacaaag acacggaatg gttcagacag aggatcaata tattttctgc
     7861 tatcaagtca tcctttatgt cctgacacgt cttcaagcag aagaagagca aaaacagcag
     7921 cctcagcttc tgaagtgaca tgaaaagagc ctctggatgc atttccattt ctctccttaa
     7981 cctccagcag actcctgctc tctatccaaa ataaagatca cagagcagca agttcataca
     8041 acatgcatgt tctcctctat cttagagggg tattcttctt gaaaataaaa aatattgaaa
     8101 tgctgtattt ttacagctac tttaacctat gataattatt tacaaaattt taacactaac
     8161 caaacaatgc agatcttagg gatgattaaa ggcagcattt gatgatagca gacattgtta
     8221 caaggacatg gtgagtctat ttttaatgca ccaatcttgt ttatagcaaa aatgttttcc
     8281 aatattttaa taaagtagtt attttatagg ggatacttga aaccagtatt taagctttaa
     8341 atgacagtaa tattggcata gaaaaaagta gcaaatgttt actgtatcaa tttctaatgt
     8401 ttactatata gaatttcctg taatatattt atatactttt tcatgaaaat ggagttatca
     8461 gttatctgtt tgttactgca tcatctgttt gtaatcatta tctcactttg taaataaaaa
     8521 cacaccttaa aacatgaaca agccaaaa
//
