LOCUS       NM_002835               3384 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 12
            (PTPN12), transcript variant 1, mRNA.
ACCESSION   NM_002835
VERSION     NM_002835.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Sarmasti Emami,S., Ge,A., Zhang,D., Hao,Y., Ling,M., Rubino,R.,
            Nicol,C.J.B., Wang,W. and Yang,X.
  TITLE     Identification of PTPN12 Phosphatase as a Novel Negative Regulator
            of Hippo Pathway Effectors YAP/TAZ in Breast Cancer
  JOURNAL   Int J Mol Sci 25 (7), 4064 (2024)
   PUBMED   38612874
  REMARK    GeneRIF: Identification of PTPN12 Phosphatase as a Novel Negative
            Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3384)
  AUTHORS   Wang,X., Wang,X., Lai,J., Xu,W., Zhu,W. and Chen,G.
  TITLE     Protein tyrosine phosphatase non-receptor type 12 suppresses tumor
            progression in osteosarcoma cells
  JOURNAL   J Orthop Sci 28 (2), 468-475 (2023)
   PUBMED   35063332
  REMARK    GeneRIF: Protein tyrosine phosphatase non-receptor type 12
            suppresses tumor progression in osteosarcoma cells.
REFERENCE   3  (bases 1 to 3384)
  AUTHORS   Niu,Y., Guo,Y., Li,Y., Shen,S., Liang,J., Guo,W. and Dong,Z.
  TITLE     LncRNA GATA2-AS1 suppresses esophageal squamous cell carcinoma
            progression via the mir-940/PTPN12 axis
  JOURNAL   Exp Cell Res 416 (2), 113130 (2022)
   PUBMED   35364057
  REMARK    GeneRIF: LncRNA GATA2-AS1 suppresses esophageal squamous cell
            carcinoma progression via the mir-940/PTPN12 axis.
REFERENCE   4  (bases 1 to 3384)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3384)
  AUTHORS   Manso,J.A., Marcos,T., Ruiz-Martin,V., Casas,J., Alcon,P., Sanchez
            Crespo,M., Bayon,Y., de Pereda,J.M. and Alonso,A.
  TITLE     PSTPIP1-LYP phosphatase interaction: structural basis and
            implications for autoinflammatory disorders
  JOURNAL   Cell Mol Life Sci 79 (2), 131 (2022)
   PUBMED   35152348
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3384)
  AUTHORS   Habib,T., Herrera,R. and Decker,S.J.
  TITLE     Activators of protein kinase C stimulate association of Shc and the
            PEST tyrosine phosphatase
  JOURNAL   J Biol Chem 269 (41), 25243-25246 (1994)
   PUBMED   7929214
REFERENCE   7  (bases 1 to 3384)
  AUTHORS   Garton,A.J. and Tonks,N.K.
  TITLE     PTP-PEST: a protein tyrosine phosphatase regulated by serine
            phosphorylation
  JOURNAL   EMBO J 13 (16), 3763-3771 (1994)
   PUBMED   7520867
REFERENCE   8  (bases 1 to 3384)
  AUTHORS   Takekawa,M., Itoh,F., Hinoda,Y., Adachi,M., Ariyama,T., Inazawa,J.,
            Imai,K. and Yachi,A.
  TITLE     Chromosomal localization of the protein tyrosine phosphatase G1
            gene and characterization of the aberrant transcripts in human
            colon cancer cells
  JOURNAL   FEBS Lett 339 (3), 222-228 (1994)
   PUBMED   7509295
REFERENCE   9  (bases 1 to 3384)
  AUTHORS   Takekawa,M., Itoh,F., Hinoda,Y., Arimura,Y., Toyota,M., Sekiya,M.,
            Adachi,M., Imai,K. and Yachi,A.
  TITLE     Cloning and characterization of a human cDNA encoding a novel
            putative cytoplasmic protein-tyrosine-phosphatase
  JOURNAL   Biochem Biophys Res Commun 189 (2), 1223-1230 (1992)
   PUBMED   1472029
REFERENCE   10 (bases 1 to 3384)
  AUTHORS   Yi,T., Cleveland,J.L. and Ihle,J.N.
  TITLE     Identification of novel protein tyrosine phosphatases of
            hematopoietic cells by polymerase chain reaction amplification
  JOURNAL   Blood 78 (9), 2222-2228 (1991)
   PUBMED   1932742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006451.5, CN395133.1,
            AB209524.1 and BC050008.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002835.3.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are signaling
            molecules that regulate a variety of cellular processes including
            cell growth, differentiation, mitotic cycle, and oncogenic
            transformation. This PTP contains a C-terminal PEST motif, which
            serves as a protein-protein interaction domain, and may regulate
            protein intracellular half-life. This PTP was found to bind and
            dephosphorylate the product of the oncogene c-ABL and thus may play
            a role in oncogenesis. This PTP was also shown to interact with,
            and dephosphorylate, various products related to cytoskeletal
            structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B,
            PSTPIP1, and paxillin. This suggests it has a regulatory role in
            controlling cell shape and mobility. Alternative splicing results
            in multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M93425.1, SRR1660809.52468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248594.11/ ENSP00000248594.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC006451.5         33328-33488
            162-170             CN395133.1         4-12
            171-2979            AB209524.1         1-2809
            2980-3384           BC050008.1         3004-3408
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..3384
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /note="protein tyrosine phosphatase non-receptor type 12"
                     /db_xref="GeneID:5782"
                     /db_xref="HGNC:HGNC:9645"
                     /db_xref="MIM:600079"
     exon            1..351
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2595
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein-tyrosine phosphatase G1; tyrosine-protein
                     phosphatase non-receptor type 12"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     12 isoform 1"
                     /protein_id="NP_002826.3"
                     /db_xref="CCDS:CCDS5592.1"
                     /db_xref="GeneID:5782"
                     /db_xref="HGNC:HGNC:9645"
                     /db_xref="MIM:600079"
                     /translation="MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRT
                     EKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKA
                     YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPF
                     KISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK
                     YQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSA
                     VQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPP
                     PKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPV
                     LHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSF
                     DGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSV
                     TPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTV
                     SLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNI
                     STASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTP
                     ESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECP
                     PTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT"
     exon            352..460
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..537
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..633
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..672
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..744
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..804
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..947
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1014
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1092
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1191
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1277
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..2248
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2326
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2394
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2425
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2533
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..3384
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /note="hexamer: ATTAAA"
     polyA_site      3384
                     /gene="PTPN12"
                     /gene_synonym="PTP-PEST; PTPG1"
                     /note="major polyA site"
ORIGIN      
        1 gctagcgcag cggctcgcct ggtactgtgg gagagcggcg gctgctcctg gaagttgtgg
       61 tgtcgggagc ccagccggtg ccgccgcagc cgccgcctag ggcggtgggg aggaggaggg
      121 agccgcgggg cttggcgggg tcgggaggga gggacgtgct gggggaacga gctggggaag
      181 acggagcggg ctctgtgccg ggcgggcggg cggcgggggg gccagcgacc gcagccgggg
      241 ggacgcggga ggatggagca agtggagatc ctgaggaaat tcatccagag ggtccaggcc
      301 atgaagagtc ctgaccacaa tggggaggac aacttcgccc gggacttcat gcggttaaga
      361 agattgtcta ccaaatatag aacagaaaag atatatccca cagccactgg agaaaaagaa
      421 gaaaatgtta aaaagaacag atacaaggac atactgccat ttgatcacag ccgagttaaa
      481 ttgacattaa agactccttc acaagattca gactatatca atgcaaattt tataaagggc
      541 gtctatgggc caaaagcata tgtagcaact caaggacctt tagcaaatac agtaatagat
      601 ttttggagga tgatatggga gtataatgtt gtgatcattg taatggcctg ccgagaattt
      661 gagatgggaa ggaaaaaatg tgagcgctat tggcctttgt atggagaaga ccccataacg
      721 tttgcaccat ttaaaatttc ttgtgaggat gaacaagcaa gaacagacta cttcatcagg
      781 acactcttac ttgaatttca aaatgaatct cgtaggctgt atcagtttca ttatgtgaac
      841 tggccagacc atgatgttcc ttcatcattt gattctattc tggacatgat aagcttaatg
      901 aggaaatatc aagaacatga agatgttcct atttgtattc attgcagtgc aggctgtgga
      961 agaacaggtg ccatttgtgc catagattat acgtggaatt tactaaaagc tgggaaaata
     1021 ccagaggaat ttaatgtatt taatttaata caagaaatga gaacacaaag gcattctgca
     1081 gtacaaacaa aggagcaata tgaacttgtt catagagcta ttgcccaact gtttgaaaaa
     1141 cagctacaac tatatgaaat tcatggagct cagaaaattg ctgatggagt gaatgaaatt
     1201 aacactgaaa acatggtcag ctccatagag cctgaaaaac aagattctcc tcctccaaaa
     1261 ccaccaagga cccgcagttg ccttgttgaa ggggatgcta aagaagaaat actgcagcca
     1321 ccggaacctc atccagtgcc acccatcttg acaccttctc ccccttcagc ttttccaaca
     1381 gtcactactg tgtggcagga caatgataga taccatccaa agccagtgtt gcatatggtt
     1441 tcatcagaac aacattcagc agacctcaac agaaactata gtaaatcaac agaacttcca
     1501 gggaaaaatg aatcaacaat tgaacagata gataaaaaat tggaacgaaa tttaagtttt
     1561 gagattaaga aggtccctct ccaagaggga ccaaaaagtt ttgatgggaa cacacttttg
     1621 aataggggac atgcaattaa aattaaatct gcttcacctt gtatagctga taaaatctct
     1681 aagccacagg aattaagttc agatctaaat gtcggtgata cttcccagaa ttcttgtgtg
     1741 gactgcagtg taacacaatc aaacaaagtt tcagttactc caccagaaga atcccagaat
     1801 tcagacacac ctccaaggcc agaccgcttg cctcttgatg agaaaggaca tgtaacgtgg
     1861 tcatttcatg gacctgaaaa tgccataccc atacctgatt tatctgaagg caattcctca
     1921 gatatcaact atcaaactag gaaaactgtg agtttaacac caagtcctac aacacaagtt
     1981 gaaacacctg atcttgtgga tcatgataac acttcaccac tcttcagaac acccctcagt
     2041 tttactaatc cacttcactc tgatgactca gactcagatg aaagaaactc tgatggtgct
     2101 gtgacccaga ataaaactaa tatttcaaca gcaagtgcca cagtttctgc tgccactagt
     2161 actgaaagca tttctactag gaaagtattg ccaatgtcca ttgctagaca taatatagca
     2221 ggaacaacac attcaggtgc tgaaaaagat gttgatgtta gtgaagattc acctcctccc
     2281 ctacctgaaa gaactcctga atcgtttgtg ttagcaagtg aacataatac acctgtaaga
     2341 tcggaatgga gtgaacttca aagtcaggaa cgatctgaac aaaaaaagtc tgaaggcttg
     2401 ataacctctg aaaatgagaa atgtgatcat ccagcgggag gtattcacta tgaaatgtgc
     2461 atagaatgtc cacctacttt cagtgacaag agagaacaaa tatcagaaaa tccaacagaa
     2521 gccacagata ttggttttgg taatcgatgt ggaaaaccca aaggaccaag agatccacct
     2581 tcagaatgga catgattcag ggagctagaa gacactttaa gttatactgg aaaattcagg
     2641 tgccactgaa agccagattt atagtattcc atctttaata tgtgggacta acagcagtgt
     2701 agattgttac cttaatattt tttgctggga ccatctacct gccttatact acacttagga
     2761 aaaagtatta catatggttt attttgaaac ttcaagtatt attgccttaa tgtctcttaa
     2821 ccctgttaca cgctgcttgt agacatgtta atatagtaat acctttatga tatattgagt
     2881 ttaaggacta ctctttttct gttttatcat gtatgcatta ttttgtatat gtacagggca
     2941 agtaggtata taatttgata aagttgcaat tgaaatatta ttaacagaag atgtaagaaa
     3001 tttctgcatg gtctaaatct ttgtgtactt tatttgtaaa ttatttgccc tggagtttta
     3061 gaaaatagtt tctgaatttt aaacttgctg gattcatgca gccagctttg caggttatca
     3121 gagatcaaag attgtaataa taattttgta aattgtaagc aaaaagttat ttttatatta
     3181 tatacagtct aattgttcat cctaattgtt cctgttttca tctagtcaga gattcagtaa
     3241 gtgccttgga acaatattga attctcttag cttgtgtgtg tttctttaat atttgaactc
     3301 aagtgggatt agaagactat caaaatacat gtatgtttca ggatatttga cctgtcatta
     3361 aaaaaaacaa acagttttac agtg
//
