LOCUS       NM_002834               6073 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 11
            (PTPN11), transcript variant 1, mRNA.
ACCESSION   NM_002834 NM_032904
VERSION     NM_002834.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6073)
  AUTHORS   Huang,M., Zhang,F., Zhu,Y., Zeng,H. and Li,S.
  TITLE     MEST promotes immune escape in gastric cancer by downregulating
            MHCI expression via SHP2
  JOURNAL   Int J Biochem Cell Biol 174, 106621 (2024)
   PUBMED   39181599
  REMARK    GeneRIF: MEST promotes immune escape in gastric cancer by
            downregulating MHCI expression via SHP2.
REFERENCE   2  (bases 1 to 6073)
  AUTHORS   Sheng,L., Liu,Y.J., Zhou,J.F., Chao,H.Y., Hua,H.Y., Zhou,X. and
            Zhao,X.H.
  TITLE     [Characteristic Analysis of Adult Acute Myeloid Leukemia Patients
            with PTPN11 Gene Mutation]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (4), 1063-1070 (2024)
   PUBMED   39192399
  REMARK    GeneRIF: [Characteristic Analysis of Adult Acute Myeloid Leukemia
            Patients with PTPN11 Gene Mutation].
REFERENCE   3  (bases 1 to 6073)
  AUTHORS   Chouhan,S., Sridaran,D., Weimholt,C., Luo,J., Li,T., Hodgson,M.C.,
            Santos,L.N., Le Sommer,S., Fang,B., Koomen,J.M., Seeliger,M.,
            Qu,C.K., Yart,A., Kontaridis,M.I., Mahajan,K. and Mahajan,N.P.
  TITLE     SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54
            to amend androgen receptor homeostasis
  JOURNAL   Nat Commun 15 (1), 5629 (2024)
   PUBMED   38965223
  REMARK    GeneRIF: SHP2 as a primordial epigenetic enzyme expunges histone H3
            pTyr-54 to amend androgen receptor homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6073)
  AUTHORS   Perrin,S., Protic,S., Bretegnier,V., Laurendeau,I., de
            Lageneste,O.D., Panara,N., Ruckebusch,O., Luka,M., Masson,C.,
            Maillard,T., Coulpier,F., Pannier,S., Wicart,P., Hadj-Rabia,S.,
            Radomska,K.J., Zarhrate,M., Menager,M., Vidaud,D., Topilko,P.,
            Parfait,B. and Colnot,C.
  TITLE     MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1
            loss in Schwann cells and skeletal stem/progenitor cells
  JOURNAL   Sci Transl Med 16 (753), eadj1597 (2024)
   PUBMED   38924432
  REMARK    GeneRIF: MEK-SHP2 inhibition prevents tibial pseudarthrosis caused
            by NF1 loss in Schwann cells and skeletal stem/progenitor cells.
            Erratum:[Sci Transl Med. 2024 Aug 28;16(762):eads3171. doi:
            10.1126/scitranslmed.ads3171.. PMID: 39196963]
REFERENCE   5  (bases 1 to 6073)
  AUTHORS   Gelb,B.D. and Tartaglia,M.
  TITLE     Noonan Syndrome with Multiple Lentigines
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301557
REFERENCE   6  (bases 1 to 6073)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
REFERENCE   7  (bases 1 to 6073)
  AUTHORS   Adachi,M., Sekiya,M., Miyachi,T., Matsuno,K., Hinoda,Y., Imai,K.
            and Yachi,A.
  TITLE     Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3
            with sequence similarity to the src-homology region 2
  JOURNAL   FEBS Lett 314 (3), 335-339 (1992)
   PUBMED   1281790
REFERENCE   8  (bases 1 to 6073)
  AUTHORS   Freeman,R.M. Jr., Plutzky,J. and Neel,B.G.
  TITLE     Identification of a human src homology 2-containing
            protein-tyrosine-phosphatase: a putative homolog of Drosophila
            corkscrew
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11239-11243 (1992)
   PUBMED   1280823
REFERENCE   9  (bases 1 to 6073)
  AUTHORS   Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y.,
            Imai,K. and Yachi,A.
  TITLE     Protein-tyrosine phosphatase expression in pre-B cell NALM-6
  JOURNAL   Cancer Res 52 (3), 737-740 (1992)
   PUBMED   1370651
REFERENCE   10 (bases 1 to 6073)
  AUTHORS   Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M.,
            Adachi,M., Imai,K. and Yachi,A.
  TITLE     cDNA cloning of new protein tyrosine phosphatases in the human
            colon
  JOURNAL   Tumour Biol 13 (3), 180-186 (1992)
   PUBMED   1626183
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004086.14 and AC004216.1.
            
            On Oct 7, 2019 this sequence version replaced NM_002834.4.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains two tandem Src
            homology-2 domains, which function as phospho-tyrosine binding
            domains and mediate the interaction of this PTP with its
            substrates. This PTP is widely expressed in most tissues and plays
            a regulatory role in various cell signaling events that are
            important for a diversity of cell functions, such as mitogenic
            activation, metabolic control, transcription regulation, and cell
            migration. Mutations in this gene are a cause of Noonan syndrome as
            well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.76044.1,
                                           SRR18074967.2448050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000351677.7/ ENSP00000340944.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC004086.14        30059-30237         c
            180-302             AC004086.14        2786-2908           c
            303-497             AC004216.1         177692-177886       c
            498-690             AC004216.1         174817-175009       c
            691-807             AC004216.1         173524-173640       c
            808-921             AC004216.1         172141-172254       c
            922-1018            AC004216.1         155164-155260       c
            1019-1098           AC004216.1         150474-150553       c
            1099-1257           AC004216.1         150189-150347       c
            1258-1389           AC004216.1         145999-146130       c
            1390-1544           AC004216.1         141575-141729       c
            1545-1612           AC004216.1         139694-139761       c
            1613-1764           AC004216.1         139029-139180       c
            1765-1877           AC004216.1         125948-126060       c
            1878-1979           AC004216.1         123408-123509       c
            1980-6073           AC004216.1         118286-122379       c
FEATURES             Location/Qualifiers
     source          1..6073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..6073
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /note="protein tyrosine phosphatase non-receptor type 11"
                     /db_xref="GeneID:5781"
                     /db_xref="HGNC:HGNC:9644"
                     /db_xref="MIM:176876"
     exon            1..179
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1947
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein-tyrosine phosphatase 2C; protein-tyrosine
                     phosphatase 1D; SH2 domain-containing protein tyrosine
                     phosphatase 2"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     11 isoform 1"
                     /protein_id="NP_002825.3"
                     /db_xref="CCDS:CCDS9163.1"
                     /db_xref="GeneID:5781"
                     /db_xref="HGNC:HGNC:9644"
                     /db_xref="MIM:176876"
                     /translation="MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLS
                     VRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
                     NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGES
                     NDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNT
                     TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNK
                     NRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCL
                     QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA
                     AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIM
                     DAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE
                     AQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPT
                     PPCAEMREDSARVYENVGLMQQQKSFR"
     exon            180..302
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            303..497
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..690
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..807
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..921
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1018
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1098
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1257
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1389
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1544
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1612
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1764
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1877
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1979
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..6073
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5892..5897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /note="hexamer: ATTAAA"
     polyA_site      5918
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /note="major polyA site"
     regulatory      6046..6051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /note="hexamer: AATAAA"
     polyA_site      6073
                     /gene="PTPN11"
                     /gene_synonym="BPTP3; CFC; JMML; METCDS; NS1; PTP-1D;
                     PTP2C; SH-PTP2; SH-PTP3; SHP2"
                     /note="major polyA site"
ORIGIN      
        1 agtctccggg atccccaggc ctggaggggg gtctgtgcgc ggccggctgg ctctgccccg
       61 cgtccggtcc cgagcgggcc tccctcgggc cagcccgatg tgaccgagcc cagcggagcc
      121 tgagcaagga gcgggtccgt cgcggagccg gagggcggga ggaacatgac atcgcggaga
      181 tggtttcacc caaatatcac tggtgtggag gcagaaaacc tactgttgac aagaggagtt
      241 gatggcagtt ttttggcaag gcctagtaaa agtaaccctg gagacttcac actttccgtt
      301 agaagaaatg gagctgtcac ccacatcaag attcagaaca ctggtgatta ctatgacctg
      361 tatggagggg agaaatttgc cactttggct gagttggtcc agtattacat ggaacatcac
      421 gggcaattaa aagagaagaa tggagatgtc attgagctta aatatcctct gaactgtgca
      481 gatcctacct ctgaaaggtg gtttcatgga catctctctg ggaaagaagc agagaaatta
      541 ttaactgaaa aaggaaaaca tggtagtttt cttgtacgag agagccagag ccaccctgga
      601 gattttgttc tttctgtgcg cactggtgat gacaaagggg agagcaatga cggcaagtct
      661 aaagtgaccc atgttatgat tcgctgtcag gaactgaaat acgacgttgg tggaggagaa
      721 cggtttgatt ctttgacaga tcttgtggaa cattataaga agaatcctat ggtggaaaca
      781 ttgggtacag tactacaact caagcagccc cttaacacga ctcgtataaa tgctgctgaa
      841 atagaaagca gagttcgaga actaagcaaa ttagctgaga ccacagataa agtcaaacaa
      901 ggcttttggg aagaatttga gacactacaa caacaggagt gcaaacttct ctacagccga
      961 aaagagggtc aaaggcaaga aaacaaaaac aaaaatagat ataaaaacat cctgcccttt
     1021 gatcatacca gggttgtcct acacgatggt gatcccaatg agcctgtttc agattacatc
     1081 aatgcaaata tcatcatgcc tgaatttgaa accaagtgca acaattcaaa gcccaaaaag
     1141 agttacattg ccacacaagg ctgcctgcaa aacacggtga atgacttttg gcggatggtg
     1201 ttccaagaaa actcccgagt gattgtcatg acaacgaaag aagtggagag aggaaagagt
     1261 aaatgtgtca aatactggcc tgatgagtat gctctaaaag aatatggcgt catgcgtgtt
     1321 aggaacgtca aagaaagcgc cgctcatgac tatacgctaa gagaacttaa actttcaaag
     1381 gttggacaag ggaatacgga gagaacggtc tggcaatacc actttcggac ctggccggac
     1441 cacggcgtgc ccagcgaccc tgggggcgtg ctggacttcc tggaggaggt gcaccataag
     1501 caggagagca tcatggatgc agggccggtc gtggtgcact gcagtgctgg aattggccgg
     1561 acagggacgt tcattgtgat tgatattctt attgacatca tcagagagaa aggtgttgac
     1621 tgcgatattg acgttcccaa aaccatccag atggtgcggt ctcagaggtc agggatggtc
     1681 cagacagaag cacagtaccg atttatctat atggcggtcc agcattatat tgaaacacta
     1741 cagcgcagga ttgaagaaga gcagaaaagc aagaggaaag ggcacgaata tacaaatatt
     1801 aagtattctc tagcggacca gacgagtgga gatcagagcc ctctcccgcc ttgtactcca
     1861 acgccaccct gtgcagaaat gagagaagac agtgctagag tctatgaaaa cgtgggcctg
     1921 atgcaacagc agaaaagttt cagatgagaa aacctgccaa aacttcagca cagaaataga
     1981 tgtggacttt caccctctcc ctaaaaagat caagaacaga cgcaagaaag tttatgtgaa
     2041 gacagaattt ggatttggaa ggcttgcaat gtggttgact accttttgat aagcaaaatt
     2101 tgaaaccatt taaagaccac tgtattttaa ctcaacaata cctgcttccc aattactcat
     2161 ttcctcagat aagaagaaat catctctaca atgtagacaa cattatattt tatagaattt
     2221 gtttgaaatt gaggaagcag ttaaattgtg cgctgtattt tgcagattat ggggattcaa
     2281 attctagtaa taggcttttt tatttttatt tttataccct taaccagttt aatttttttt
     2341 ttcctcattg ttggggatga tgagaagaaa tgatttggga aaattaagta acaacgacct
     2401 agaaaagtga gaacaatctc atttaccatc atgtatccag tagtggataa ttcattttga
     2461 tggcttctat ttttggccaa atgagaatta agccagtgcc tgagactgtc agaagttgac
     2521 ctttgcactg gcattaaaga gtcatagaaa aagaatcatg gatatttatg aattaaggta
     2581 agaggtgtgg cttttttttt tttctttttt ccagccgttg accaattata gttcggctgt
     2641 tgactgagaa gtttgtggtg ggaaaacgtt tgccatattt tctttgcatt tgaataattg
     2701 tcttgtactt agaaaaaagg cgtctatgaa tgaccagtgt ttttggtcgc caaatgttgc
     2761 tgacaaactt atcccaaaac tttagtggct taaaaaaacc tgcccccaac tgttagtcaa
     2821 tctgagctgg gctcagctgg gctgttcttc tgccagcctg caggtggcca ctcatgtggt
     2881 cagcaggtcg gcggagagac tgggatggct gggcttctct ctctgcctgc agtcctgagt
     2941 ctctccttct tcgtgtagtc tctttcagtg gcctggctgg cagggtagct agacctctca
     3001 catgcagctc agagctccca agagctcaaa agcagaaatg gccaggcctt ctgaaaactt
     3061 aagtccagaa ttgtcacagt gtcccttcta cttccctcta ttgatgatga tgatgatgat
     3121 gatgatgatg atgatgatga tgatgatggt tttttctaat cagaagaaag ctggggtatg
     3181 ccctctactt actaaacaag tcacaagccc agctcagatt caagaaaagg gtgtgaagta
     3241 gaggtgcagt taagtggggg gccactagtc taacagacgg tcacaaccag tgccatggaa
     3301 aaccaaggat attagcaaaa gcagaagttg ctagtgacct tgggaagccg aagctgctta
     3361 cagtagctgg gacaagctga aagtcagact aagaaataaa gagagggcct tcaagaagct
     3421 tcctgaatga tttctgctag ccctgagcct atttttggaa ccagcacttg gggaaactga
     3481 tcttgtgagg atggatgtgt ttagggacac agggcttttg agagcagcac caccccactg
     3541 gggcatcccc agacttggga aacgtgactc tttcttaatg ccactgggtt ttagtcaggc
     3601 cacagtgaga aggaacagcc ctaacaggcc tccagccagg ttgaatgagc tcatttttgt
     3661 tgtagccaac cagtaagatt tgctaatgtt ctacattaag tgccttctcc aaagacatcc
     3721 ctctttgcct catatgttga atcatccagt gcggatattt caatgaaaat atcattggtt
     3781 gacttttgtg atggtaataa tgctatggca tctttgccat gaagttgtgg cctccttgga
     3841 ttcttctgac tttggcttct gaaaggaagg cctagatcca gccctggtgg tagttccttt
     3901 ctgaggtctc tcagtccctt gagactttgg ggtagtttgg ctgccattct cactgacaaa
     3961 atgtatatca gcccccacct ccacccccca atattccttg aactttgaat tgcttcagaa
     4021 cacaggtgtg gcctgaaggt attcccttat tagggaagtg tcactgctgt cttctagtca
     4081 aacttgtaaa gaaaaagatt ccagttcagt atttgcagca agaagcttga atgctgttct
     4141 ttttatcgca ttgttacatc gactcattct ccattttgct ttggttttgt cttgacttga
     4201 cttgactttg ggggtaaagt ctttcaccag cacacaagag tttgattgta caaatatatc
     4261 ttctgcatta acatctctgc ctgttgctta agatcagttg cttttatact cagaatggaa
     4321 atacctgatc ttggctagtt ttgttataag atattgattt catttagatt tccctccacg
     4381 aggtcagcaa actatcatgt tcttatgtaa acttaggcca aggccagagt tatcatagtc
     4441 cctaggttgc tacggcttat catgtgcttg gtaaaaggtg atcgcaggtt ctcagacgag
     4501 tttactttac atgagatgga atcaggcaga gaggctggga tgatggagaa agctcgaggt
     4561 gaagttttaa aaaaaaagtt gtggaaagga aagttccaaa gaggtggttt ctgaggaagt
     4621 cagagcgccc agggccagag cagtcagtaa tgggtgaatg aggttgtttg gaaagtcggt
     4681 gtgacagaca catggatgcc atctacttct aggttgctgg tgggtattaa atatgcacaa
     4741 tattccatag ctcactgagg attttaaaat tataagcata ggattttata ttttggggtg
     4801 aaagaattat ctggcacatt aggtattgga gtttaaaaaa aaagccaaat ttcacagtct
     4861 taataacttt ttttaaaaaa aactaaaagg cgcttcatgt ccagtgtgtg gcccttctga
     4921 aacttatggt catctctccc actgaaacca aggtcttttc aaatgtggct aaatggggat
     4981 gaggagacac gggtaggact ttcttggtgt gtgtgcattc tttaaagagc caagttgctt
     5041 cggggaaaca gccaggaaaa tggtcaagat tatttttaga ggttatttta ttggggattt
     5101 taagaactaa taacatcttg agttattttt aattcagggg gatgtggaaa ggtttgcaat
     5161 tgtcaagtgt tttgttgtag cttagtatcc ataagggaaa cttagactat agacataact
     5221 acaaagccag tgcagctttt gttttctgta tgttgttggg ggatcaactt tcacacatag
     5281 caagcacatg gcctccctga tgtcaggatg cctttgttag gatctgtatt tgcccttaat
     5341 tttgttgaaa tcttttttcc ttcttcctct tgaaaagttc caaaatatag tttattgtat
     5401 ctttcatcac taaaaatttg ttcctttttc actatgggca gttcacacaa ggcaaaaact
     5461 attgaacagt tggttttagt gtgttgtata actttgctgt atatcaaact aattttgaca
     5521 agttttcatc ctaagcctca aatcatgtaa ttaataattt gcctgtttat ttatgaccta
     5581 attgtgattc ttttattaat aaaagctaat gggaaaagga tccctgatta agctgatgac
     5641 tagacctaca attaattttc ctgcagtata tgaagtattg taccagagta ttaaaagata
     5701 tgtaatattt tattgataaa tctatccttt aaaaggaata cgttttagga tgtcatcatt
     5761 ttgatgtgaa tcatgtaaat gttgataata tgctgtttat tatacattta gtgtttcaag
     5821 agattcactt aattgccttt ttgcccacgt atattatgta gtctatttgc aactgttctt
     5881 aaaaaaatga cattaaaaga atagtttatg tagagaaaca ttagtggatg ttaattgtct
     5941 ccccacctat atttatgggt gttagcgcaa ctgctttgct agttgcaaag ctgtattatc
     6001 agagtaaaag tgtatttgta aactgtatgg gaactaaaaa ttaggaataa aaccattttc
     6061 ttatatgatg gca
//
