LOCUS       NM_002827               3979 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase non-receptor type 1
            (PTPN1), transcript variant 1, mRNA.
ACCESSION   NM_002827
VERSION     NM_002827.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3979)
  AUTHORS   Coronell-Tovar,A., Pardo,J.P., Rodriguez-Romero,A.,
            Sosa-Peinado,A., Vasquez-Bochm,L., Cano-Sanchez,P.,
            Alvarez-Anorve,L.I. and Gonzalez-Andrade,M.
  TITLE     Protein tyrosine phosphatase 1B (PTP1B) function, structure, and
            inhibition strategies to develop antidiabetic drugs
  JOURNAL   FEBS Lett 598 (15), 1811-1838 (2024)
   PUBMED   38724486
  REMARK    GeneRIF: Protein tyrosine phosphatase 1B (PTP1B) function,
            structure, and inhibition strategies to develop antidiabetic drugs.
            Review article
REFERENCE   2  (bases 1 to 3979)
  AUTHORS   Datta,R., Mukherjee,D., Podolsky,M.J., Yang,C.D., Alba,D.L.,
            Singh,S., Arnold,T.D., Koliwad,S., Lizama,C.O. and Atabai,K.
  TITLE     PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling
            through the beta5 integrin
  JOURNAL   J Biol Chem 300 (2), 105631 (2024)
   PUBMED   38199575
  REMARK    GeneRIF: PTP1B mediates the inhibitory effect of MFGE8 on insulin
            signaling through the beta5 integrin.
REFERENCE   3  (bases 1 to 3979)
  AUTHORS   Sharma,S., Skaist Mehlman,T., Sagabala,R.S., Boivin,B. and
            Keedy,D.A.
  TITLE     High-resolution double vision of the allosteric phosphatase PTP1B
  JOURNAL   Acta Crystallogr F Struct Biol Commun 80 (Pt 1), 1-12 (2024)
   PUBMED   38133579
  REMARK    GeneRIF: High-resolution double vision of the allosteric
            phosphatase PTP1B.
REFERENCE   4  (bases 1 to 3979)
  AUTHORS   Hsu,M.F., Ito,Y., Singh,J.P., Hsu,S.F., Wells,A., Jen,K.Y.,
            Meng,T.C. and Haj,F.G.
  TITLE     Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in
            the glomerular podocyte
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119590 (2024)
   PUBMED   37730132
  REMARK    GeneRIF: Protein tyrosine phosphatase 1B is a regulator of
            alpha-actinin4 in the glomerular podocyte.
REFERENCE   5  (bases 1 to 3979)
  AUTHORS   Yeh,C.Y., Izaguirre,J.A., Greisman,J.B., Willmore,L., Maragakis,P.
            and Shaw,D.E.
  TITLE     A Conserved Local Structural Motif Controls the Kinetics of PTP1B
            Catalysis
  JOURNAL   J Chem Inf Model 63 (13), 4115-4124 (2023)
   PUBMED   37378552
  REMARK    GeneRIF: A Conserved Local Structural Motif Controls the Kinetics
            of PTP1B Catalysis.
REFERENCE   6  (bases 1 to 3979)
  AUTHORS   Chen,J., Parsons,S. and Brautigan,D.L.
  TITLE     Tyrosine phosphorylation of protein phosphatase 2A in response to
            growth stimulation and v-src transformation of fibroblasts
  JOURNAL   J Biol Chem 269 (11), 7957-7962 (1994)
   PUBMED   7510677
REFERENCE   7  (bases 1 to 3979)
  AUTHORS   Frangioni,J.V., Beahm,P.H., Shifrin,V., Jost,C.A. and Neel,B.G.
  TITLE     The nontransmembrane tyrosine phosphatase PTP-1B localizes to the
            endoplasmic reticulum via its 35 amino acid C-terminal sequence
  JOURNAL   Cell 68 (3), 545-560 (1992)
   PUBMED   1739967
REFERENCE   8  (bases 1 to 3979)
  AUTHORS   Brown-Shimer,S., Johnson,K.A., Lawrence,J.B., Johnson,C.,
            Bruskin,A., Green,N.R. and Hill,D.E.
  TITLE     Molecular cloning and chromosome mapping of the human gene encoding
            protein phosphotyrosyl phosphatase 1B
  JOURNAL   Proc Natl Acad Sci U S A 87 (13), 5148-5152 (1990)
   PUBMED   2164224
REFERENCE   9  (bases 1 to 3979)
  AUTHORS   Chernoff,J., Schievella,A.R., Jost,C.A., Erikson,R.L. and Neel,B.G.
  TITLE     Cloning of a cDNA for a major human protein-tyrosine-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2735-2739 (1990)
   PUBMED   2157211
REFERENCE   10 (bases 1 to 3979)
  AUTHORS   Charbonneau,H., Tonks,N.K., Kumar,S., Diltz,C.D., Harrylock,M.,
            Cool,D.E., Krebs,E.G., Fischer,E.H. and Walsh,K.A.
  TITLE     Human placenta protein-tyrosine-phosphatase: amino acid sequence
            and relationship to a family of receptor-like proteins
  JOURNAL   Proc Natl Acad Sci U S A 86 (14), 5252-5256 (1989)
   PUBMED   2546149
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300354.1, BC015660.2,
            DB332370.1, AI474453.1 and AL133230.25.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_002827.3.
            
            Summary: The protein encoded by this gene is the founding member of
            the protein tyrosine phosphatase (PTP) family, which was isolated
            and identified based on its enzymatic activity and amino acid
            sequence. PTPs catalyze the hydrolysis of the phosphate monoesters
            specifically on tyrosine residues. Members of the PTP family share
            a highly conserved catalytic motif, which is essential for the
            catalytic activity. PTPs are known to be signaling molecules that
            regulate a variety of cellular processes including cell growth,
            differentiation, mitotic cycle, and oncogenic transformation. This
            PTP has been shown to act as a negative regulator of insulin
            signaling by dephosphorylating the phosphotryosine residues of
            insulin receptor kinase. This PTP was also reported to
            dephosphorylate epidermal growth factor receptor kinase, as well as
            JAK2 and TYK2 kinases, which implicated the role of this PTP in
            cell growth control, and cell response to interferon stimulation.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015660.2, SRR1803613.49220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371621.5/ ENSP00000360683.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DC300354.1         63-71
            10-3290             BC015660.2         1-3281
            3291-3492           DB332370.1         1-202               c
            3493-3500           AI474453.1         12-19               c
            3501-3979           AL133230.25        44352-44830
FEATURES             Location/Qualifiers
     source          1..3979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..3979
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /note="protein tyrosine phosphatase non-receptor type 1"
                     /db_xref="GeneID:5770"
                     /db_xref="HGNC:HGNC:9642"
                     /db_xref="MIM:176885"
     exon            1..208
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1453
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase, placental; protein-tyrosine
                     phosphatase 1B"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type 1
                     isoform 1"
                     /protein_id="NP_002818.1"
                     /db_xref="CCDS:CCDS13430.1"
                     /db_xref="GeneID:5770"
                     /db_xref="HGNC:HGNC:9642"
                     /db_xref="MIM:176885"
                     /translation="MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRN
                     RYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQ
                     KSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLEL
                     ENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAG
                     IGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIE
                     GAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWV
                     KEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEP
                     SLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT"
     exon            209..299
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            300..400
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            401..499
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            500..637
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            638..847
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1009
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1233
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1429
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..3979
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3289..3294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /note="hexamer: AATAAA"
     polyA_site      3308
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
     regulatory      3473..3478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /note="hexamer: AATAAA"
     polyA_site      3500
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /note="major polyA site"
     regulatory      3954..3959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
                     /note="hexamer: ATTAAA"
     polyA_site      3979
                     /gene="PTPN1"
                     /gene_synonym="PTP1B"
ORIGIN      
        1 atgaagaagc agcagcggct agggcggcgg tagctgcagg ggtcggggat tgcagcgggc
       61 ctcggggcta agagcgcgac gcggcctaga gcggcagacg gcgcagtggg ccgagaagga
      121 ggcgcagcag ccgccctggc ccgtcatgga gatggaaaag gagttcgagc agatcgacaa
      181 gtccgggagc tgggcggcca tttaccagga tatccgacat gaagccagtg acttcccatg
      241 tagagtggcc aagcttccta agaacaaaaa ccgaaatagg tacagagacg tcagtccctt
      301 tgaccatagt cggattaaac tacatcaaga agataatgac tatatcaacg ctagtttgat
      361 aaaaatggaa gaagcccaaa ggagttacat tcttacccag ggccctttgc ctaacacatg
      421 cggtcacttt tgggagatgg tgtgggagca gaaaagcagg ggtgtcgtca tgctcaacag
      481 agtgatggag aaaggttcgt taaaatgcgc acaatactgg ccacaaaaag aagaaaaaga
      541 gatgatcttt gaagacacaa atttgaaatt aacattgatc tctgaagata tcaagtcata
      601 ttatacagtg cgacagctag aattggaaaa ccttacaacc caagaaactc gagagatctt
      661 acatttccac tataccacat ggcctgactt tggagtccct gaatcaccag cctcattctt
      721 gaactttctt ttcaaagtcc gagagtcagg gtcactcagc ccggagcacg ggcccgttgt
      781 ggtgcactgc agtgcaggca tcggcaggtc tggaaccttc tgtctggctg atacctgcct
      841 cttgctgatg gacaagagga aagacccttc ttccgttgat atcaagaaag tgctgttaga
      901 aatgaggaag tttcggatgg ggctgatcca gacagccgac cagctgcgct tctcctacct
      961 ggctgtgatc gaaggtgcca aattcatcat gggggactct tccgtgcagg atcagtggaa
     1021 ggagctttcc cacgaggacc tggagccccc acccgagcat atccccccac ctccccggcc
     1081 acccaaacga atcctggagc cacacaatgg gaaatgcagg gagttcttcc caaatcacca
     1141 gtgggtgaag gaagagaccc aggaggataa agactgcccc atcaaggaag aaaaaggaag
     1201 ccccttaaat gccgcaccct acggcatcga aagcatgagt caagacactg aagttagaag
     1261 tcgggtcgtg gggggaagtc ttcgaggtgc ccaggctgcc tccccagcca aaggggagcc
     1321 gtcactgccc gagaaggacg aggaccatgc actgagttac tggaagccct tcctggtcaa
     1381 catgtgcgtg gctacggtcc tcacggccgg cgcttacctc tgctacaggt tcctgttcaa
     1441 cagcaacaca tagcctgacc ctcctccact ccacctccac ccactgtccg cctctgcccg
     1501 cagagcccac gcccgactag caggcatgcc gcggtaggta agggccgccg gaccgcgtag
     1561 agagccgggc cccggacgga cgttggttct gcactaaaac ccatcttccc cggatgtgtg
     1621 tctcacccct catcctttta ctttttgccc cttccacttt gagtaccaaa tccacaagcc
     1681 attttttgag gagagtgaaa gagagtacca tgctggcggc gcagagggaa ggggcctaca
     1741 cccgtcttgg ggctcgcccc acccagggct ccctcctgga gcatcccagg cgggcggcac
     1801 gccaacagcc ccccccttga atctgcaggg agcaactctc cactccatat ttatttaaac
     1861 aattttttcc ccaaaggcat ccatagtgca ctagcatttt cttgaaccaa taatgtatta
     1921 aaattttttg atgtcagcct tgcatcaagg gctttatcaa aaagtacaat aataaatcct
     1981 caggtagtac tgggaatgga aggctttgcc atgggcctgc tgcgtcagac cagtactggg
     2041 aaggaggacg gttgtaagca gttgttattt agtgatattg tgggtaacgt gagaagatag
     2101 aacaatgcta taatatataa tgaacacgtg ggtatttaat aagaaacatg atgtgagatt
     2161 actttgtccc gcttattctc ctccctgtta tctgctagat ctagttctca atcactgctc
     2221 ccccgtgtgt attagaatgc atgtaaggtc ttcttgtgtc ctgatgaaaa atatgtgctt
     2281 gaaatgagaa actttgatct ctgcttacta atgtgcccca tgtccaagtc caacctgcct
     2341 gtgcatgacc tgatcattac atggctgtgg ttcctaagcc tgttgctgaa gtcattgtcg
     2401 ctcagcaata gggtgcagtt ttccaggaat aggcatttgc ctaattcctg gcatgacact
     2461 ctagtgactt cctggtgagg cccagcctgt cctggtacag cagggtcttg ctgtaactca
     2521 gacattccaa gggtatggga agccatattc acacctcacg ctctggacat gatttaggga
     2581 agcagggaca ccccccgccc cccacctttg ggatcagcct ccgccattcc aagtcaacac
     2641 tcttcttgag cagaccgtga tttggaagag aggcacctgc tggaaaccac acttcttgaa
     2701 acagcctggg tgacggtcct ttaggcagcc tgccgccgtc tctgtcccgg ttcaccttgc
     2761 cgagagaggc gcgtctgccc caccctcaaa ccctgtgggg cctgatggtg ctcacgactc
     2821 ttcctgcaaa gggaactgaa gacctccaca ttaagtggct ttttaacatg aaaaacacgg
     2881 cagctgtagc tcccgagcta ctctcttgcc agcattttca cattttgcct ttctcgtggt
     2941 agaagccagt acagagaaat tctgtggtgg gaacattcga ggtgtcaccc tgcagagcta
     3001 tggtgaggtg tggataaggc ttaggtgcca ggctgtaagc attctgagct gggcttgttg
     3061 tttttaagtc ctgtatatgt atgtagtagt ttgggtgtgt atatatagta gcatttcaaa
     3121 atggacgtac tggtttaacc tcctatcctt ggagagcagc tggctctcca ccttgttaca
     3181 cattatgtta gagaggtagc gagctgctct gctatatgcc ttaagccaat atttactcat
     3241 caggtcatta ttttttacaa tggccatgga ataaaccatt tttacaaaaa taaaaacaaa
     3301 aaaagcaagg tgttttggta taataccttt tcaggtgtgt gtggatacgt ggctgcatga
     3361 ccgggtgggt gggggggagt gtctcagggt cttctgtgac ctcacagaac tgtcagactg
     3421 tacagttttc caacttgcca tattcatgat gggtttgcat tttagctgca acaataaaat
     3481 ttttttctaa agaacatgaa tttggggtgc ttcccatttt tttctttgct taatagagct
     3541 aaaccaggat gagtaactcc tgtttctttc tatccctgct gatgtgaaac agatgttgtc
     3601 aatcagctgg ggttagagtt ttccacttct aagaattaac ctcagcatcc ctgcattgcc
     3661 agcaccctca ggctggagcg ctttccttga ctgtgagctt gttgaacacc ttaggcctca
     3721 gcccatttcc ttcccaaatt gacgctttgc ctgtgtaggg ccctcagata acttaacaaa
     3781 cttaccagtg ttgtttgaag aacagtgttt tgagttgtaa tctcaaaacc atatccctta
     3841 cccaattacc tgtaagacac aatggttacc acatctcagt acgtaaagtc cacttgatat
     3901 agaattgact tagaaataag acagattagt atagtttttc atttgtgtac aaaattaaac
     3961 aatgtaaatt ccccccaaa
//
