LOCUS       NM_001253829            4403 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase domain containing 1
            (PTPDC1), transcript variant 3, mRNA.
ACCESSION   NM_001253829
VERSION     NM_001253829.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4403)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4403)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4403)
  AUTHORS   Levine,D.M., Ek,W.E., Zhang,R., Liu,X., Onstad,L., Sather,C.,
            Lao-Sirieix,P., Gammon,M.D., Corley,D.A., Shaheen,N.J., Bird,N.C.,
            Hardie,L.J., Murray,L.J., Reid,B.J., Chow,W.H., Risch,H.A.,
            Nyren,O., Ye,W., Liu,G., Romero,Y., Bernstein,L., Wu,A.H.,
            Casson,A.G., Chanock,S.J., Harrington,P., Caldas,I.,
            Debiram-Beecham,I., Caldas,C., Hayward,N.K., Pharoah,P.D.,
            Fitzgerald,R.C., Macgregor,S., Whiteman,D.C. and Vaughan,T.L.
  TITLE     A genome-wide association study identifies new susceptibility loci
            for esophageal adenocarcinoma and Barrett's esophagus
  JOURNAL   Nat Genet 45 (12), 1487-1493 (2013)
   PUBMED   24121790
REFERENCE   4  (bases 1 to 4403)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA218576.1, AK289692.1,
            DA312531.1, BC067120.1 and AW052114.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001253829.1.
            
            Summary: The protein encoded by this gene contains a characteristic
            motif of protein tyrosine phosphatases (PTPs). PTPs regulate
            activities of phosphoproteins through dephosphorylation. They are
            signaling molecules involved in the regulation of a wide variety of
            biological processes. The specific function of this protein has not
            yet been determined. Alternatively spliced transcript variants
            encoding distinct isoforms have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 5' coding region, but maintains the reading frame, compared
            to variant 1. The encoded isoform (3) is longer than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.138523.1,
                                           SRR1803611.220843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620992.5/ ENSP00000477817.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA218576.1         36-49
            15-502              AK289692.1         1-488
            503-810             DA312531.1         114-421
            811-2802            AK289692.1         797-2788
            2803-4381           BC067120.1         2899-4477
            4382-4403           AW052114.1         14-35               c
FEATURES             Location/Qualifiers
     source          1..4403
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..4403
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /note="protein tyrosine phosphatase domain containing 1"
                     /db_xref="GeneID:138639"
                     /db_xref="HGNC:HGNC:30184"
     exon            1..311
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2494
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /EC_number="3.1.3.48"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein tyrosine phosphatase PTP9Q22; protein tyrosine
                     phosphatase domain-containing protein 1"
                     /codon_start=1
                     /product="protein tyrosine phosphatase domain-containing
                     protein 1 isoform 3"
                     /protein_id="NP_001240758.1"
                     /db_xref="CCDS:CCDS75860.1"
                     /db_xref="GeneID:138639"
                     /db_xref="HGNC:HGNC:30184"
                     /translation="MQVQDATRRPSAVRFLSSFLQGRRHSTSDPVLRLQQARRGSGLG
                     SGSATKLLSSSSLQVMVAVSSVSHAEGNPTFPERKSKGNLERPTPKYTKVGERLRHVI
                     PGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHI
                     IDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGV
                     ASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRA
                     KRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEAR
                     LLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLR
                     HDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDS
                     DLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLS
                     FWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVH
                     KDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKD
                     LSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWE
                     RICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTIL
                     CVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRK
                     MTKDGPKPGL"
     exon            312..483
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     exon            484..564
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     exon            565..683
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     exon            684..821
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     exon            822..2080
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2266
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2377
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..4403
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4380..4385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /note="hexamer: AATAAA"
     polyA_site      4403
                     /gene="PTPDC1"
                     /gene_synonym="PTP9Q22"
                     /note="major polyA site"
ORIGIN      
        1 agtgaaagtt cctcactgag tgagtggggc tgactcttcc tgcctccggc tcttgcctcc
       61 cagtgccatg caggtgcagg atgcaaccag gcggccctca gccgtgcgct tcctcagctc
      121 ctttctccag ggccgccggc actccacctc agacccagta ctgcggctgc agcaggcccg
      181 gcggggctct ggcttgggct ccggctctgc cacgaagctg ctgtcctcgt cctctctcca
      241 ggtgatggtg gctgtttcct cagtcagcca tgcagaggga aacccaactt tccccgaaag
      301 aaaaagtaaa ggaaatttag aacgtccaac accaaagtac acaaaagtag gggagcgttt
      361 acggcatgtc attcctggac acatggcatg ttccatggcg tgtggcggta gagcttgcaa
      421 gtatgagaac ccagcccgct ggagtgagca ggagcaagcc attaaggggg tttactcatc
      481 ctgggtcact gataatatac tggccatggc ccgcccatcc tctgagctcc tggagaagta
      541 ccacatcatt gatcagttcc tcagccatgg cataaaaaca ataatcaacc tccagcgccc
      601 tggtgagcat gctagctgtg ggaaccctct ggaacaagaa agtggcttca cataccttcc
      661 tgaggctttc atggaggctg gcatttactt ctacaatttc ggatggaagg attatggtgt
      721 agcgtctctt actactatcc tagatatggt gaaggtgatg acatttgcct tacaggaagg
      781 aaaagtagct atccattgtc atgcagggct tggtcgaaca ggtgttttaa tagcctgtta
      841 cttagttttt gcaacgagaa tgactgctga ccaagcaatt atatttgtgc gggcaaagcg
      901 acccaattcc atacaaacca gaggacagct cctctgtgta agggaattta ctcagtttct
      961 aactcctctc cgcaatatat tctcttgctg tgatcccaaa gcacatgctg tcaccttacc
     1021 tcaatatcta attcgccagc gtcatctgct tcatggttat gaggcacgac ttctgaaaca
     1081 cgtgccaaaa attatccacc tagtttgcaa attgctgctg gacttagcgg agaacaggcc
     1141 agtgatgatg aaggatgtgt ccgaaggacc tggtctctct gctgaaatag aaaagacaat
     1201 gtctgagatg gtcaccatgc agctggataa agagttactg aggcatgaca gtgatgtgtc
     1261 caacccgcct aaccccactg cagtggcagc agattttgac aatcgaggca tgattttctc
     1321 caatgagcaa cagtttgacc ctctttggaa aaggcggaat gttgagtgcc ttcaacccct
     1381 gactcatctg aaaaggcggc tcagctacag tgactcagat ttaaagaggg ccgagaacct
     1441 cctggagcaa ggggagactc cacagacagt gcctgcccag atcttggttg gccacaagcc
     1501 caggcagcag aagctcataa gccattgtta catcccacag tctccagaac cagacttaca
     1561 caaggaagcc ttggttcgca gcacactttc tttctggagt cagtcaaagt ttggaggcct
     1621 ggaaggactc aaagataatg ggtcaccaat tttccatgga aggatcattc caaaggaagc
     1681 acagcagagt ggagctttct ctgcagatgt ttcaggctca cacagccctg gggagccagt
     1741 ttcacccagc tttgcaaatg tccataagga tccaaaccct gctcaccagc aagtgtctca
     1801 ctgtcagtgt aaaactcatg gtgttgggag ccctggctct gtcaggcaga acagcaggac
     1861 accccgaagc cctctggact gtggctccag tcccaaagca cagttcttgg ttgaacatga
     1921 aacccaggac agtaaagatc tgtctgaagc agcttcacac tctgcattac agtctgaatt
     1981 gagtgctgag gcaagaagaa tactggcggc caaagcccta gcaaatttaa atgaatctgt
     2041 agaaaaggag gaactaaaaa ggaaggtaga aatgtggcag aaagagctta attcccgaga
     2101 tggagcttgg gaaagaatat gtggcgagag ggaccctttc atcctatgca gcttgatgtg
     2161 gtcttgggtg gagcaactga aggagcctgt aatcaccaaa gaggatgtgg acatgttggt
     2221 tgacaggcga gcagatgccg cagaagcact ttttttatta gagaagggac agcaccagac
     2281 tattctctgc gtgttgcact gcatagtgaa cctgcagaca attcccgtgg atgtggagga
     2341 agctttcctt gcccatgcca ttaaggcatt cactaaggtt aattttgatt ctgaaaatgg
     2401 accaacagtt tacaacaccc tgaagaaaat atttaagcac acgctggaag aaaaaagaaa
     2461 aatgacaaaa gatggcccta agcctggcct ctagctttca ctcgtggtga atatttcaga
     2521 cctaaagatc cagatagtat ctctgttcat atgtgaataa gttgaagatt gtggggctac
     2581 tttttctcat agcactttat tttgaatgtt gttagtttgt gctgagaatg gtcgtccgta
     2641 tttgaaccaa ttatttattt taaaatatat ttaagctaca tttttgtttt gaaaaattgc
     2701 cataaatttg gtgccacttt cttttattta tttgactgag ttaatattat tgtattaaca
     2761 ttttaagtat atggtgttta cattcttatt tcttttgaca ttttggaaat aatcataact
     2821 tgtctttcca aaataaccat tttcttgatg gaactcttcc tagagttttt accaaatagc
     2881 taactttagt agtaaaacct cattgtgtat ccattccccc acagatgaac taagaaagtc
     2941 accaagtgtc ttaagctgtt ttatatttgt tacgaagaag gctattgcta caatattttt
     3001 aaaggtttct tttttaactt tgaaattttt tgtttttcct tttcttttta taaatgtaac
     3061 agagggtttc aaagcatatt atttttcaga gagatttagt tttactttaa tggagtgact
     3121 gtgaagtggt tgggattttt tgcttgtaga aagtagactt gctctttgtc agatttccaa
     3181 acaaccttgc cagccttggc tgtcaaaagg aggcaggagc agttctcaac acaccaagcc
     3241 ttattcccac tcccttgggt tgctgctgag ccaaatagca tctttacaga ggaagtggga
     3301 tcagaggcag gaagtgtgga aagttgctaa gaagcagggc ttgcctctgt cctcccgggg
     3361 actccacagg gatattcgtg cagggcaggg gctctgtgcc agccctgctc tctcagatgc
     3421 cacagccact ctgcagaggt gactcttgga gctggaggaa gtcaaaactg ggccactgtt
     3481 tgtactgatg gtgtattagc atgagcagcg tggccctggc cccacactcc caaatctgcc
     3541 actccataga cccacttgcc tcaaggcttt atatttggct gctttcttac aatgagaatt
     3601 aagattttta aactgaagtt gaccatacag gttgcattag ccctaactgg cttcatgtaa
     3661 gaagggtgac tgcctaaact agttccttgt aagctgaacc atcaattatc agttgaagcc
     3721 atacttttat ttaaattaat atacgtagat accagaggcc aagccacaga gaggataata
     3781 gttcttccca ataaaggtga tattaatcag actaatttcg aactaaagaa gttactgctt
     3841 aaagacggaa tttcagggga agcaagactc atttagaaca aatgaaattt ctccagtcct
     3901 acatttctga attgacttct agcacatcaa aaatatttca gtcattatca gtctcattaa
     3961 ctgaaatgcc aaatgctaaa tgcagtgttc tttcacactg ttttaatttt cttgggaaat
     4021 tgagtccagt ggatgttaat ggagtgggtt gcccatccct gaaatgtctt attttcaagt
     4081 gcctggcctg ggaaagaagg ggaagaaaca attgcattat atccaaagat acactataaa
     4141 aatagagttt ttaccaaaaa aagatgtttg ttctcatctc agtaggcctc atttgggcaa
     4201 gtgacccaca ggtcttttgg cgagtttgct atttgcctgt tgaaatactt gtttcaactt
     4261 agagaacagt tatgatgtga ccatagcatg gcacaactaa aaatctaagc ctgaaacctg
     4321 aaaaaagaga tatgacaagg gaaattaatc aggctataca taagtattgt atttatttga
     4381 ataaaaataa aaagagcaac cca
//
