LOCUS       NM_032611               2849 bp    mRNA    linear   PRI 20-NOV-2022
DEFINITION  Homo sapiens protein tyrosine phosphatase 4A3 (PTP4A3), transcript
            variant 1, mRNA.
ACCESSION   NM_032611 XM_936815 XM_943014 XM_943024 XM_943031
VERSION     NM_032611.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2849)
  AUTHORS   Wang Y, Guo Y, Lu Y, Sun Y and Xu D.
  TITLE     The effects of endosulfan on cell migration and invasion in
            prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis
  JOURNAL   Sci Total Environ 845, 157252 (2022)
   PUBMED   35817112
  REMARK    GeneRIF: The effects of endosulfan on cell migration and invasion
            in prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis.
REFERENCE   2  (bases 1 to 2849)
  AUTHORS   Tao Y and You W.
  TITLE     The Deubiquitinating Enzyme USP4 Functions as an Oncoprotein in
            Gastric Cancer and Mediates NF-kappaB Signaling by Regulating PRL-3
            Expression
  JOURNAL   Front Biosci (Landmark Ed) 27 (10), 286 (2022)
   PUBMED   36336860
  REMARK    GeneRIF: The Deubiquitinating Enzyme USP4 Functions as an
            Oncoprotein in Gastric Cancer and Mediates NF-kappaB Signaling by
            Regulating PRL-3 Expression.
REFERENCE   3  (bases 1 to 2849)
  AUTHORS   Ge Z, Gu T, Zhang L, Fan Q, Ma L and Fang N.
  TITLE     The phosphatase of regenerating liver-3 protein (PRL-3) promotes
            glioma cell invasiveness by interacting with beta3 -tubulin
  JOURNAL   Bioengineered 13 (2), 4112-4121 (2022)
   PUBMED   35098869
  REMARK    GeneRIF: The phosphatase of regenerating liver-3 protein (PRL-3)
            promotes glioma cell invasiveness by interacting with beta3
            -tubulin.
REFERENCE   4  (bases 1 to 2849)
  AUTHORS   Shi Y, Xu S, Ngoi NYL, Hui Y and Ye Z.
  TITLE     Rag GTPases suppress PRL-3 degradation and predict poor clinical
            diagnosis of cancer patients with low PRL-3 mRNA expression
  JOURNAL   Biochem Biophys Res Commun 576, 108-116 (2021)
   PUBMED   34482023
  REMARK    GeneRIF: Rag GTPases suppress PRL-3 degradation and predict poor
            clinical diagnosis of cancer patients with low PRL-3 mRNA
            expression.
REFERENCE   5  (bases 1 to 2849)
  AUTHORS   Song Q, Zheng Y, Wu J, Wang S, Meng L, Yao Q, Li Z and Lian S.
  TITLE     PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates
            in Papillary Renal Cell Carcinoma
  JOURNAL   Front Immunol 12, 717688 (2021)
   PUBMED   34630392
  REMARK    GeneRIF: PTP4A3 Is a Prognostic Biomarker Correlated With Immune
            Infiltrates in Papillary Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2849)
  AUTHORS   Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix
            B, Romans KE, Choti MA, Lengauer C, Kinzler KW and Vogelstein B.
  TITLE     A phosphatase associated with metastasis of colorectal cancer
  JOURNAL   Science 294 (5545), 1343-1346 (2001)
   PUBMED   11598267
  REMARK    GeneRIF: Data suggest that the PRL-3 gene is important for
            colorectal cancer metastasis and provide a new therapeutic target
            for these intractable lesions.
REFERENCE   7  (bases 1 to 2849)
  AUTHORS   Matter WF, Estridge T, Zhang C, Belagaje R, Stancato L, Dixon J,
            Johnson B, Bloem L, Pickard T, Donaghue M, Acton S, Jeyaseelan R,
            Kadambi V and Vlahos CJ.
  TITLE     Role of PRL-3, a human muscle-specific tyrosine phosphatase, in
            angiotensin-II signaling
  JOURNAL   Biochem Biophys Res Commun 283 (5), 1061-1068 (2001)
   PUBMED   11355880
REFERENCE   8  (bases 1 to 2849)
  AUTHORS   Zeng Q, Si X, Horstmann H, Xu Y, Hong W and Pallen CJ.
  TITLE     Prenylation-dependent association of protein-tyrosine phosphatases
            PRL-1, -2, and -3 with the plasma membrane and the early endosome
  JOURNAL   J Biol Chem 275 (28), 21444-21452 (2000)
   PUBMED   10747914
REFERENCE   9  (bases 1 to 2849)
  AUTHORS   Zeng Q, Hong W and Tan YH.
  TITLE     Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine
            phosphatases homologous to PRL-1
  JOURNAL   Biochem Biophys Res Commun 244 (2), 421-427 (1998)
   PUBMED   9514946
REFERENCE   10 (bases 1 to 2849)
  AUTHORS   Dayton MA and Knobloch TJ.
  TITLE     Multiple phosphotyrosine phosphatase mRNAs are expressed in the
            human lung fibroblast cell line WI-38
  JOURNAL   Recept Signal Transduct 7 (4), 241-256 (1997)
   PUBMED   9633825
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK311257.1, BC003105.1,
            BQ637038.1 and AC100803.11.
            
            On Jul 9, 2019 this sequence version replaced NM_032611.2.
            
            Summary: This gene encodes a member of the protein-tyrosine
            phosphatase family. Protein tyrosine phosphatases are cell
            signaling molecules that play regulatory roles in a variety of
            cellular processes. Studies of this class of protein tyrosine
            phosphatase in mice demonstrates that they are prenylated in vivo,
            suggesting their association with cell plasma membrane. The encoded
            protein may enhance cell proliferation, and overexpression of this
            gene has been implicated in tumor metastasis. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3038718.1,
                                           SRR11853564.26624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521578.6/ ENSP00000428976.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AK311257.1         1-64
            65-583              AK311257.1         65-583
            584-1246            BC003105.1         1-663
            1247-1622           BQ637038.1         151-526
            1623-2849           AC100803.11        122567-123793
FEATURES             Location/Qualifiers
     source          1..2849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2849
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /note="protein tyrosine phosphatase 4A3"
                     /db_xref="GeneID:11156"
                     /db_xref="HGNC:HGNC:9636"
                     /db_xref="MIM:606449"
     exon            1..64
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            65..1022
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             918..1439
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potentially prenylated protein tyrosine phosphatase;
                     protein-tyrosine phosphatase of regenerating liver 3;
                     protein tyrosine phosphatase type IVA, member 3"
                     /codon_start=1
                     /product="protein tyrosine phosphatase type IVA 3 isoform
                     1"
                     /protein_id="NP_116000.1"
                     /db_xref="CCDS:CCDS6383.1"
                     /db_xref="GeneID:11156"
                     /db_xref="HGNC:HGNC:9636"
                     /db_xref="MIM:606449"
                     /translation="MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATT
                     VVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAV
                     HCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRF
                     KDPHTHKTRCCVM"
     exon            1023..1115
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1246
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1321
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..2849
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1898..1903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /note="hexamer: AATAAA"
     polyA_site      1915
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /note="major polyA site"
     regulatory      2824..2829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
                     /note="hexamer: AGTAAA"
     polyA_site      2849
                     /gene="PTP4A3"
                     /gene_synonym="PRL-3; PRL-R; PRL3"
ORIGIN      
        1 gtgcgcgagg gcgcgcgcgt cccgagccct ccacccgtcg tgccggcgcc gcccggaccg
       61 ccagatgctg tgtgctgtgg acccacctgg ggttcatgga gtgggccacg gggcccagcc
      121 ctaagcactg ctgcgcccag ggtcgccgcg cctcctgctg aggggtcccc gtgccactgg
      181 ctctcaccat tgccctcgcc tgccgatggc ctctgctgcc cagcctgggg ccagctctac
      241 cgcctgagcc ccctgcccca ctccaggact caccgtaccc cgatggggta acgtgacaca
      301 ggccccacac gtcagaggcc gctgtcccca cggccactgc ccgtgacccc tggcccaagg
      361 cagctggagt tggttcagtt caagttcatt cttcctctgg cccttggggg cttggggccc
      421 acctctgagt gaagggggct gtctgcccat ccaccaatgt ggagagggcg cccccggtgt
      481 ggggtccagc tctggacact gcttggcggc cgggttcact ttgagttttt aagttttctt
      541 tgctgagctt ttttggttgt tctttttatt ttttgcctct ttatgactat ccagctctga
      601 gagacgggag tttggagttg cccgctttac tttggttggg ttgggggggg cggcgggctg
      661 ttttgttcct tttctttttt aagagttggg ttttcttttt taattatcca aacagtgggc
      721 agcttcctcc cccacaccca agtatttgca caatatttgt gcggggtatg ggggtgggtt
      781 tttaaatctc gtttctcttg gacaagcaca gggatctcgt tctcctcatt ttttgggggt
      841 gtgtggggac ttctcaggtc gtgtccccag ccttctctgc agtcccttct gccctgccgg
      901 gcccgtcggg aggcgccatg gctcggatga accgcccggc cccggtggag gtgagctaca
      961 aacacatgcg cttcctcatc acccacaacc ccaccaacgc cacgctcagc accttcattg
     1021 aggacctgaa gaagtacggg gctaccactg tggtgcgtgt gtgtgaagtg acctatgaca
     1081 aaacgccgct ggagaaggat ggcatcaccg ttgtggactg gccgtttgac gatggggcgc
     1141 ccccgcccgg caaggtagtg gaagactggc tgagcctggt gaaggccaag ttctgtgagg
     1201 cccccggcag ctgcgtggct gtgcactgcg tggcgggcct gggccgggct ccagtccttg
     1261 tggcgctggc ccttattgag agcgggatga agtacgagga cgccatccag ttcatccgcc
     1321 agaagcgccg cggagccatc aacagcaagc agctcaccta cctggagaaa taccggccca
     1381 aacagaggct gcggttcaaa gacccacaca cgcacaagac ccggtgctgc gttatgtagc
     1441 tcaggacctt ggctgggcct ggtcgtcatg taggtcagga ccttggctgg acctggaggc
     1501 cctgcccagc cctgctctgc ccagcccagc aggggctcca ggccttggct ggccccacat
     1561 cgccttttcc tccccgacac ctccgtgcac ttgtgtccga ggagcgagga gcccctcggg
     1621 ccctgggtgg cctctgggcc ctttctcctg tctccgccac tccctctggc ggcgctggcc
     1681 gtggctctgt ctctctgagg tgggtcgggc gccctctgcc cgccccctcc cacaccagcc
     1741 aggctggtct cctctagcct gtttgttgtg gggtgggggt atattttgta accactgggc
     1801 ccccagcccc tcttttgcga ccccttgtcc tgacctgttc tcggcacctt aaattattag
     1861 accccggggc agtcaggtgc tccggacacc cgaaggcaat aaaacaggag ccgtggccgt
     1921 gtgtgtggag tgggctacag cgtcaggcgg ggcgggctgg tggcctgggg gccccagagg
     1981 ctgctgtctg gatcctgggc tggtgcccag gatggggctc ccgcgtgctc ttgcgctgcc
     2041 ctctggtggc cgctctgggt ccttgcaccc cgacccaggg gccagcctgc cctgtcctgt
     2101 cctgataccg aggtgggagc cctgccttgg ccagggtggc cgtgttgacg gttcttggga
     2161 ctgtgacatt ggaaggcgag gcaggtcacc agcactgtcc tctgcaggat gggctgggat
     2221 tcatttggca gcttctcagg gcctgtgtcc ggctggttgg tccctgtgct gcccaaacca
     2281 ggtgtccaca tttccggctc cgaggcgcag agaagggggc aggtggtggc ttgggtggag
     2341 gaagtcacca tccatcagcc cagggaggga gggtgccacc tgggcacctg gggctggatg
     2401 tgagaggcct ggaccagggc ccgccggagg gcgtggacca gatgctcatg tgttcctggg
     2461 tgcagtgtct gtgttggggg ctggccccac cctgggccgg ggtgcatgga gggcatggcc
     2521 ccagcgggga ggaaggtggg cctagggctg gctccagggt gtggagagcc tgggagtggt
     2581 ctccgtcctg gggccccagg aggttcccgc aaggagcgac tggggcaggt gctggaggag
     2641 gtcagtggac aagatgggga gatgtggaaa ccccaaaagc cccttctcag gcagccctgc
     2701 ccccaagacc gacagatggc taagggggcc gcagacctgg ctcccccagc tcctgtgtgg
     2761 agaaagggca acagctgtcc cggatggtta ttctctcctt tcctcaaaca catttggaac
     2821 tcaagtaaat ccaatgcatg ttgggtgaa
//
