LOCUS       NM_080391               3910 bp    mRNA    linear   PRI 26-JAN-2025
DEFINITION  Homo sapiens protein tyrosine phosphatase 4A2 (PTP4A2), transcript
            variant 1, mRNA.
ACCESSION   NM_080391 XM_941000 XM_944909 XM_944911 XM_944912 XM_944916
            XM_944928 XM_944931 XM_944938
VERSION     NM_080391.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Hardy,S., Zolotarov,Y., Coleman,J., Roitman,S., Khursheed,H.,
            Aubry,I., Uetani,N. and Tremblay,M.L.
  TITLE     PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to
            regulate cellular bioenergetics
  JOURNAL   Proc Natl Acad Sci U S A 120 (14), e2221083120 (2023)
   PUBMED   36972446
  REMARK    GeneRIF: This study established the existence of a magnesium
            transporter protein complex (PTP4A2/CNNM3/TRPM7) governing the
            cellular uptake of this divalent cation. Moreover, PTP4A2 acts as a
            magnesium biosensor, controlling the activity of this complex to
            reprogram cellular metabolism.
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Li,Q., Bai,Y., Lyle,L.T., Yu,G., Amarasinghe,O., Nguele Meke,F.,
            Carlock,C. and Zhang,Z.Y.
  TITLE     Mechanism of PRL2 phosphatase-mediated PTEN degradation and
            tumorigenesis
  JOURNAL   Proc Natl Acad Sci U S A 117 (34), 20538-20548 (2020)
   PUBMED   32788364
  REMARK    GeneRIF: Mechanism of PRL2 phosphatase-mediated PTEN degradation
            and tumorigenesis.
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Cai,F., Huang,Y., Wang,M., Sun,M., Zhao,Y. and Hattori,M.
  TITLE     A FRET-based screening method to detect potential inhibitors of the
            binding of CNNM3 to PRL2
  JOURNAL   Sci Rep 10 (1), 12879 (2020)
   PUBMED   32733084
  REMARK    GeneRIF: A FRET-based screening method to detect potential
            inhibitors of the binding of CNNM3 to PRL2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3910)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3910)
  AUTHORS   Si,X., Zeng,Q., Ng,C.H., Hong,W. and Pallen,C.J.
  TITLE     Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase,
            with the beta-subunit of geranylgeranyltransferase II
  JOURNAL   J Biol Chem 276 (35), 32875-32882 (2001)
   PUBMED   11447212
REFERENCE   7  (bases 1 to 3910)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   8  (bases 1 to 3910)
  AUTHORS   Zeng,Q., Hong,W. and Tan,Y.H.
  TITLE     Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine
            phosphatases homologous to PRL-1
  JOURNAL   Biochem Biophys Res Commun 244 (2), 421-427 (1998)
   PUBMED   9514946
REFERENCE   9  (bases 1 to 3910)
  AUTHORS   Cates,C.A., Michael,R.L., Stayrook,K.R., Harvey,K.A., Burke,Y.D.,
            Randall,S.K., Crowell,P.L. and Crowell,D.N.
  TITLE     Prenylation of oncogenic human PTP(CAAX) protein tyrosine
            phosphatases
  JOURNAL   Cancer Lett 110 (1-2), 49-55 (1996)
   PUBMED   9018080
REFERENCE   10 (bases 1 to 3910)
  AUTHORS   Zhao,Z., Lee,C.C., Monckton,D.G., Yazdani,A., Coolbaugh,M.I.,
            Li,X., Bailey,J., Shen,Y. and Caskey,C.T.
  TITLE     Characterization and genomic mapping of genes and pseudogenes of a
            new human protein tyrosine phosphatase
  JOURNAL   Genomics 35 (1), 172-181 (1996)
   PUBMED   8661118
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136115.21, BC018662.1,
            BC070182.1 and BM996809.1.
            
            On Nov 22, 2018 this sequence version replaced NM_080391.3.
            
            Summary: The protein encoded by this gene belongs to a small class
            of the protein tyrosine phosphatase (PTP) family. PTPs are cell
            signaling molecules that play regulatory roles in a variety of
            cellular processes. PTPs in this class contain a protein tyrosine
            phosphatase catalytic domain and a characteristic C-terminal
            prenylation motif. This PTP has been shown to primarily associate
            with plasmic and endosomal membrane through its C-terminal
            prenylation. This PTP was found to interact with the beta-subunit
            of Rab geranylgeranyltransferase II (beta GGT II), and thus may
            function as a regulator of GGT II activity. Overexpression of this
            gene in mammalian cells conferred a transformed phenotype, which
            suggested its role in tumorigenesis. Alternatively spliced
            transcript variants have been described. Related pseudogenes exist
            on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1, 6 and 7
            encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.119124.1,
                                           SRR1163658.491480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000647444.2/ ENSP00000493688.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL136115.21        68373-68386         c
            15-570              BC018662.1         5-560
            571-924             BC018662.1         562-915
            925-925             AL136115.21        49134-49134         c
            926-1672            BC018662.1         916-1662
            1673-2077           BC070182.1         1026-1430
            2078-3575           AL136115.21        36774-38271         c
            3576-3910           BM996809.1         19-353              c
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..3910
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /note="protein tyrosine phosphatase 4A2"
                     /db_xref="GeneID:8073"
                     /db_xref="HGNC:HGNC:9635"
                     /db_xref="MIM:601584"
     exon            1..382
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..1071
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             976..1479
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase IVA; phosphatase of
                     regenerating liver 2; protein tyrosine phosphatase IVA2;
                     protein tyrosine phosphatase type IVA 2; PTP(CAAXII);
                     protein-tyrosine phosphatase of regenerating liver 2;
                     protein tyrosine phosphatase type IVA, member 2"
                     /codon_start=1
                     /product="protein tyrosine phosphatase type IVA 2 isoform
                     1"
                     /protein_id="NP_536316.1"
                     /db_xref="CCDS:CCDS348.1"
                     /db_xref="GeneID:8073"
                     /db_xref="HGNC:HGNC:9635"
                     /db_xref="MIM:601584"
                     /translation="MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVR
                     VCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCV
                     AGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDT
                     NGHCCVQ"
     exon            1072..1164
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1295
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1370
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..3910
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3888..3893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /note="hexamer: AATAAA"
     polyA_site      3910
                     /gene="PTP4A2"
                     /gene_synonym="HH13; HH7-2; HU-PP-1; OV-1; PRL-2; PRL2;
                     ptp-IV1a; ptp-IV1b; PTP4A; PTPCAAX2"
                     /note="major polyA site"
ORIGIN      
        1 ccggctgcgc gcgcagcggt ggtggtggcg gcgcgatcgg ccgggctgta accgtcgtct
       61 gtccgggagc ggctggagcg gcagcggcgg ccgggcacgg cgcgaggtga cgccacaggg
      121 cagcggcggc agcggaggca gcggcggcag caggagacgc agcggcggcc gcagcagcag
      181 cagcaagacg gactcgtgga gacgcgccgc cgccgccgcc gccgggccgg gccgggtgtc
      241 gcgcgccgag gctggggggg agtcgtcgcc gccgccgcca ccgctaccgc cgccgccgcc
      301 gccgccgagg tgactgagga gagaggcgcc tcctcgctcc cgccaccgcc ggacttcaat
      361 gcccagtccc cagctcgcca gcgtttttcg ttggaatata cgttgcacat ttatggcgat
      421 tctgagtgtg agggcagact tctgccaggc tcagcacagc attttcgctg acaagtgagc
      481 ttggaggttc tatgtgccat aattaacatt gccttgaaga ctcctggaca ccgagactgg
      541 cctcagaaat agttggcttt tttttttttt aattgcaagc atatttcttt taatgactcc
      601 agtaaaatta agcatcaagt aaacaagtgg aaagtgacct acacttttaa cttgtctcac
      661 tagtgcctaa atgtagtaaa ggctgcttaa gttttgtatg tagttggatt ttttggagtc
      721 cgaaggtatc catctgcaga aattgaggcc caaattgaat ttggattcaa gtggattcta
      781 aatactttgc ttatcttgaa gagagaagct tcataaggaa taaacaagtt gaatagagaa
      841 aacactgatt gataataggc attttagtgg tctttttaat gttttctgct gtgaaacatt
      901 tcaagattta ttgatttttt tttttcactt tccccatcac actcacacgc acgctcacac
      961 tttttatttg ccataatgaa ccgtccagcc cctgtggaga tctcctatga gaacatgcgt
     1021 tttctgataa ctcacaaccc taccaatgct actctcaaca agttcacaga ggaacttaag
     1081 aagtatggag tgacgacttt ggttcgagtt tgtgatgcta catatgataa agctccagtt
     1141 gaaaaagaag gaatccacgt tctagattgg ccatttgatg atggagctcc accccctaat
     1201 cagatagtag atgattggtt aaacctgtta aaaaccaaat ttcgtgaaga gccaggttgc
     1261 tgtgttgcag tgcattgtgt tgcaggattg ggaagggcac ctgtgctggt tgcacttgct
     1321 ttgattgaat gtggaatgaa gtacgaagat gcagttcagt ttataagaca aaaaagaagg
     1381 ggagcgttca attccaaaca gctgctttat ttggagaaat accgacctaa gatgcgatta
     1441 cgcttcagag ataccaatgg gcattgctgt gttcagtaga aggaaatgta aacgaaggct
     1501 gacttgattg tgccatttag agggaactct tggtacctgg aaatgtgaat ctggaatatt
     1561 acctgtgtca tcaaagtagt gatggattca gtactcctca accactctcc taatgattgg
     1621 aacaaaagca aacaaaaaag aaatctctct ataaaatgaa taaaatgttt aagaaaagag
     1681 aaagagaaaa ggaattaatt cagtgaagga tgattttgct cctagttttg gagtttgaat
     1741 ttctgccagg attgaattat tttgaaatct cctgtctttt taaacttttt caaaataggt
     1801 ctctaaggaa aaccagcaga acattagcct gtgcaaaacc atctgtttgg ggagcacact
     1861 cttccattat gcttggcaca tagatctccc tgtggtggga tttttttttt cccttttttt
     1921 gtgggggagg gttggtggta tatttttccc ctcttttttc cttcctctcc tacatctccc
     1981 ttttcccccg atccaagttg tagatggaat agaagccctt gttgctgtag atgtgcgtgc
     2041 agtctggcag ccttaagccc acctgggcac ttttagataa aaaaaaaaaa aaaacaaaaa
     2101 acaacaccaa aaaaacagca gtgatatata tatatatata tatatatata tatatatata
     2161 tatatatata tatatatata tatatatata atataatata tatatatata tatatatttt
     2221 ccaggtggtt tttagtcttt actgatgaaa gggtgttcat gttagtttct tcaaaaccct
     2281 atctaatact aggcaaagta gccaagagcc ttttgttttg tttttatttt gataaattag
     2341 tggagaaatg gcattttaag aggagtctct tctcaactta cctgagagtc gaattcttct
     2401 cttccctaac caatgaagct aagtggttat cccagaaact tgtcttctaa aagggaggac
     2461 tccaggccat caataaagat gtccaggcag tgagcgtact ttttacaccc tgtagaattg
     2521 tgggctgtag cgttactctg attttctgtc tagtatcaga gaatgctggt agcttaaaat
     2581 ttttatttta ggacttgtac tctgaatttt caggaaccgt caaaggagca gcagcaaatt
     2641 cacatatttt cgacttgaga aatgcttgtg gtatgtgttt tccaaactgc cccctatatg
     2701 taaagttcag tttaaccact gattgccttg ttattactag gttttttgag attaaaaaaa
     2761 aaaaatccct ggtttaaaac caacaatgat gcctagtgag tatgtgtcca caggccataa
     2821 cagggtagaa gagagacatc gtgcaaccca atgagtagtg aagggactgt gttgcttgtg
     2881 aagcggtgta gtagcatttt tgcagattct tggctgggtt tagtgtactg atctagaaaa
     2941 gctgtttttc tgctcctttg tggaaggcag ttatgatcag gctgcatgga caaagcaggt
     3001 agaggggcac catcaggggc tcttgcacta ttttcacctc taaatattac gtactcagta
     3061 gtgccctgct tctagggctc tgaatacggg cttaaagtca tcttgtcctg ctggaatttg
     3121 ctgtgcagag ccataagcct cccattttgt tagcgtcagc taggccaata ggaacagacc
     3181 gggaccttgt ctcacactga tgatacctca catgttgacc ggctatgtga actgcctatt
     3241 tcctatgctg gagttttgat ttttaactaa acgcaaatct gtagattctc tcctctccca
     3301 tcccagaaaa caaaacaaaa taatgctttt cgaaattgtt tctaggactt taaaacataa
     3361 tggtatatcc aaaattcttt atttcagaat gcaacaatag attccattaa tatagactca
     3421 agatcaaaac agcatacctg ctaagctaag atagatggtg ttgattccac tgggttttga
     3481 tcaatacaat aacaaacctt tttcctttga catactctga attttgttgt ttggggggag
     3541 ggggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatgtg tgtgtgtgtg tgtgcacgcg
     3601 cagtgtccat cagtatcagt gcctgcctga gttaggaaaa ttacattcct ggttctgtat
     3661 tgaggagaag gatgtataaa gcaacatgaa acattagccc tccttttatt ttaaagacta
     3721 atgttaattg ttcttaaaac tggatttttt ttccttaaag caattttttt cttttcgatt
     3781 taatgaagta ttgctagctg aagccagttt gacatagaga gatgtcagat tgatttgaaa
     3841 ggtgtgcagc ctgatttaaa accaaaccct gaaccctttt aaagaacaat aaaacatatt
     3901 ttacacgctc
//
