LOCUS       NM_003463               4621 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens protein tyrosine phosphatase 4A1 (PTP4A1), transcript
            variant 1, mRNA.
ACCESSION   NM_003463
VERSION     NM_003463.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4621)
  AUTHORS   Cho,M.J., Lee,D.G., Lee,J.W., Hwang,B., Yoon,S.J., Lee,S.J.,
            Park,Y.J., Park,S.H., Lee,H.G., Kim,Y.H., Lee,C.H., Lee,J.,
            Lee,N.K., Han,T.S., Cho,H.S., Moon,J.H., Lee,G.S., Bae,K.H.,
            Hwang,G.S., Lee,S.H., Chung,S.J., Shim,S., Cho,J., Oh,G.T.,
            Kwon,Y.G., Park,J.G. and Min,J.K.
  TITLE     Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20
            axis-mediated NF-kappaB inactivation
  JOURNAL   Cardiovasc Res 119 (5), 1265-1278 (2023)
   PUBMED   36534975
  REMARK    GeneRIF: Endothelial PTP4A1 mitigates vascular inflammation via
            USF1/A20 axis-mediated NF-kappaB inactivation.
REFERENCE   2  (bases 1 to 4621)
  AUTHORS   Hu,H., Ye,L. and Liu,Z.
  TITLE     GINS2 regulates the proliferation and apoptosis of colon cancer
            cells through PTP4A1
  JOURNAL   Mol Med Rep 25 (4) (2022)
   PUBMED   35137928
  REMARK    GeneRIF: GINS2 regulates the proliferation and apoptosis of colon
            cancer cells through PTP4A1.
REFERENCE   3  (bases 1 to 4621)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4621)
  AUTHORS   Li,O., Jiang,B., Yi,W.M., Zhang,Y., Yang,P.Z., Guo,C., Sun,Z.P. and
            Peng,C.
  TITLE     LncRNA NEAT1 promotes cell proliferation, migration, and invasion
            via the miR-186-5p/PTP4A1 axis in cholangiocarcinoma
  JOURNAL   Kaohsiung J Med Sci 37 (5), 379-391 (2021)
   PUBMED   33502823
  REMARK    GeneRIF: LncRNA NEAT1 promotes cell proliferation, migration, and
            invasion via the miR-186-5p/PTP4A1 axis in cholangiocarcinoma.
REFERENCE   5  (bases 1 to 4621)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4621)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Fahey,C., Kenny,E.M., Terenin,I.M.,
            Dmitriev,S.E., Cormican,P., Morris,D.W., Shatsky,I.N. and
            Baranov,P.V.
  TITLE     Translation of 5' leaders is pervasive in genes resistant to eIF2
            repression
  JOURNAL   Elife 4, e03971 (2015)
   PUBMED   25621764
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4621)
  AUTHORS   Tsujimoto,H., Nishizuka,S., Redpath,J.L. and Stanbridge,E.J.
  TITLE     Differential gene expression in tumorigenic and nontumorigenic HeLa
            x normal human fibroblast hybrid cells
  JOURNAL   Mol Carcinog 26 (4), 298-304 (1999)
   PUBMED   10569806
REFERENCE   8  (bases 1 to 4621)
  AUTHORS   Peng,Y., Genin,A., Spinner,N.B., Diamond,R.H. and Taub,R.
  TITLE     The gene encoding human nuclear protein tyrosine phosphatase,
            PRL-1. Cloning, chromosomal localization, and identification of an
            intron enhancer
  JOURNAL   J Biol Chem 273 (27), 17286-17295 (1998)
   PUBMED   9642300
REFERENCE   9  (bases 1 to 4621)
  AUTHORS   Dayton,M.A. and Knobloch,T.J.
  TITLE     Multiple phosphotyrosine phosphatase mRNAs are expressed in the
            human lung fibroblast cell line WI-38
  JOURNAL   Recept Signal Transduct 7 (4), 241-256 (1997)
   PUBMED   9633825
REFERENCE   10 (bases 1 to 4621)
  AUTHORS   Cates,C.A., Michael,R.L., Stayrook,K.R., Harvey,K.A., Burke,Y.D.,
            Randall,S.K., Crowell,P.L. and Crowell,D.N.
  TITLE     Prenylation of oncogenic human PTP(CAAX) protein tyrosine
            phosphatases
  JOURNAL   Cancer Lett 110 (1-2), 49-55 (1996)
   PUBMED   9018080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135905.6.
            
            On Jul 14, 2020 this sequence version replaced NM_003463.4.
            
            Summary: This gene encodes a member of a small class of prenylated
            protein tyrosine phosphatases (PTPs), which contain a PTP domain
            and a characteristic C-terminal prenylation motif. The encoded
            protein is a cell signaling molecule that plays regulatory roles in
            a variety of cellular processes, including cell proliferation and
            migration. The protein may also be involved in cancer development
            and metastasis. This tyrosine phosphatase is a nuclear protein, but
            may associate with plasma membrane by means of its prenylation
            motif. Pseudogenes related to this gene are located on chromosomes
            1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023975.2, SRR11853560.24902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000626021.3/ ENSP00000485687.1
            RefSeq Select criteria :: based on conservation, expression
            regulatory uORF        :: PMID: 25621764
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AL135905.6         90212-90451
            241-790             AL135905.6         94168-94717
            791-883             AL135905.6         96169-96261
            884-1014            AL135905.6         96630-96760
            1015-1089           AL135905.6         96989-97063
            1090-4621           AL135905.6         97789-101320
FEATURES             Location/Qualifiers
     source          1..4621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q12"
     gene            1..4621
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /note="protein tyrosine phosphatase 4A1"
                     /db_xref="GeneID:7803"
                     /db_xref="HGNC:HGNC:9634"
                     /db_xref="MIM:601585"
     exon            1..240
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      202..336
                     /regulatory_class="uORF"
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:25621764]"
                     /note="this uORF is predicted to encode a 44 aa peptide
                     (PMID:25621764)"
     exon            241..790
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             686..1207
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein tyrosine phosphatase type IVA protein 1;
                     protein-tyrosine phosphatase of regenerating liver 1;
                     PVT1/PTP4A1 fusion; protein tyrosine phosphatase type IVA,
                     member 1"
                     /codon_start=1
                     /product="protein tyrosine phosphatase type IVA 1 isoform
                     1"
                     /protein_id="NP_003454.1"
                     /db_xref="CCDS:CCDS4965.1"
                     /db_xref="GeneID:7803"
                     /db_xref="HGNC:HGNC:9634"
                     /db_xref="MIM:601585"
                     /translation="MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTT
                     IVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAV
                     HCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRF
                     KDSNGHRNNCCIQ"
     exon            791..883
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1014
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1089
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..4621
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /note="hexamer: AATAAA"
     polyA_site      2489
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /note="major polyA site"
     regulatory      4389..4394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /note="hexamer: ATTAAA"
     polyA_site      4410
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /note="major polyA site"
     regulatory      4515..4520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /note="hexamer: ATTAAA"
     polyA_site      4545
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
     regulatory      4599..4604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
                     /note="hexamer: AATAAA"
     polyA_site      4621
                     /gene="PTP4A1"
                     /gene_synonym="HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1"
ORIGIN      
        1 gcctcggcgc gtgtattggc tccttcggct gcgggccggc tcggctacgc gctctgctcc
       61 gagccgctca ctgcatggta gagtctggtg cccccgccgc cgcctgcatc gccgccaccg
      121 ccgctccgcc acgaccaccg ccgcctcctg ccctgcagcc accgccaccg cctgtgtcgc
      181 cgccgcctcg ggaccggctg tatgattagg ccacaatctt caatgagtaa acatattcct
      241 caattctgtg gtgttcttgg tcacacattt atggagtttc tgaagggcag tggagattac
      301 tgccaggcac agcacgacct ctatgcagac aagtgaactg tagaaactga ttactgctcc
      361 accaagaagc ccccataaga gtggttatcc tggacacaga agtgttgaat tgaaatccac
      421 agagcatttt acaagagttc tgacctggat ggggtaaacc tcagtgcact tcttttctgt
      481 tggcctcagt attactggat tgaagaattg ctgcttcttg ttaggaggtt catttcactt
      541 atcattactt acaacttcat actcaaagca ctgagaattt caagtggagt atattgaagt
      601 agacttcagt ttctttgcat catttctgta ttcaattttt ttaattattt cataacccta
      661 ttgagtgttt tttaactaaa ttaacatggc tcgaatgaac cgcccagctc ctgtggaagt
      721 cacatacaag aacatgagat ttcttattac acacaatcca accaatgcga ccttaaacaa
      781 atttatagag gaacttaaga agtatggagt taccacaata gtaagagtat gtgaagcaac
      841 ttatgacact actcttgtgg agaaagaagg tatccatgtt cttgattggc cttttgatga
      901 tggtgcacca ccatccaacc agattgttga tgactggtta agtcttgtga aaattaagtt
      961 tcgtgaagaa cctggttgtt gtattgctgt tcattgcgtt gcaggccttg ggagagctcc
     1021 agtacttgtt gccctagcat taattgaagg tggaatgaaa tacgaagatg cagtacaatt
     1081 cataagacaa aagcggcgtg gagcttttaa cagcaagcaa cttctgtatt tggagaagta
     1141 tcgtcctaaa atgcggctgc gtttcaaaga ttccaacggt catagaaaca actgttgcat
     1201 tcaataaaat tggggtgcct aatgctactg gaagtggaac ttgagatagg gcctaatttg
     1261 ttatacatat tagccaacat gttggcttag taagtctaat gaagcttcca taggagtatt
     1321 gaaaggcagt tttaccaggc ctcaagctag acagatttgg caacctctgt atttgggtta
     1381 cagtcaacct atttggatac ttggcaaaag attcttgctg tcagcatata aaatgtgctt
     1441 gtcatttgta tcaattgacc tttccccaaa tcatgcagta ttgagttatg acttgttaaa
     1501 tctattccca tgccagaatc ttatcaatac ataagaaatt taggaagatt aggtgccaaa
     1561 atacccagca caatacttgt atatttttag taccatacag aagtaaaatc ccaggaacta
     1621 tgaacactag accttatgtg gtttattcct tcaatcattt caaacattga aagtagggcc
     1681 tacatggtta tttgcctgct cactttatgt ttacatctcc cacattcata ccaatatacg
     1741 tcaggtttgc ttaaccattg attttttttt ttttttacca agtcttacag tgattatttt
     1801 acgtgtttcc atgtatctca ctttgtgctg tattaaaaaa acctccattt tgaaaatcta
     1861 cgttgtacag aagcacatgt ctttaatgtc ttcagacaaa aaagccttac attaatttaa
     1921 tgtttgcact ctgaggtgca acttaacagg gagggcctga gaaaagaatg ggagggggct
     1981 attaattatt tttagcaaaa tgttgccttt gtcttgtgca aacatgtaga atatgctctt
     2041 taatttagta aaatattttt ttaaaaggta gagatgcttt gttattgtaa tcataaactt
     2101 cctgaaattc ttgtaatttt tttcccatac ttatcagaag tgtgtttacc aacttatttt
     2161 tgtttgaaag tgtgattttt tttttccttc ccaacctctc ttgcaaaaaa agaaatgggt
     2221 ttctgctaat gaattgagca gacatctaat attttatatg ccttttgagc tgtgtaactt
     2281 aatatttgga tacttgacaa tttgttttat tatgtaattg ataaaatggt gatgtgtatt
     2341 aatgttagtt caaccatata tttatactgt ctggggatgt gtggttatag ttctgtggga
     2401 gaaataattt tgtcagtgtt caccagcttg taaaaactta gtgcgagagc tgaaacatct
     2461 aaataaataa tgacatgcat ttatcatcat tgagattggt ttgcttaaaa ttaacttatt
     2521 ttgtagaaga caaaatgaat tgcacttcac ttaatgtgtg tcctcatctt tttacaaata
     2581 aatgaaggat tataaatgat gtcagcattt tagtaaactt ttagacaaaa tttgttaggg
     2641 tcattcatga aaactttaat actaaaagca ctttccatta tatacttttt aaaggtctag
     2701 ataattttga accaatttat tattgtgtac tgaggagaaa taatgtatag tagaggacag
     2761 ccttggtttg taaagctcag ttccactagt tcatggtttt gtgcaacttc tgagcctcag
     2821 ttttctcctt tgcaaattaa taattacata cctttataga ttttgaaatt aatttaaata
     2881 ttagtatttg gtacatgaag gcttaatgtt aagtttcctt taatgatcca caataatccc
     2941 tttgatcacg ttaatctaaa tctagatgtc tttgtctaat tttttttgaa tagcagttat
     3001 aaatgtaaag gactcaaagt ttaagtaaaa agtgatactc caccttgtgt ttcaaagaat
     3061 ttagttccac ctcttcatac cagtttaaca cttaatatat ttcattggat tttagacagg
     3121 gcaaaaggaa gaacaggggc ctctggaggc ccttggttat ttaaatcttg gattatttgt
     3181 gatagtaatc acaaattttt ggctaatttt taacctgagg ttttgttttt tttttaaagg
     3241 aaatgcagcc tagtcttgag aacataattt tatataatca attactaaat gttaaactat
     3301 taccacacag cccataaaac agcatttgcg tttattgaga gagaggatgt gccatcatga
     3361 ttaatgaaaa ctatcttttg agtttgaaaa gaaattaatt tgcagtgttt ggattgtata
     3421 tatggtgcta aaaataaatt aatttacttt ataaacctta tctgtacatt atacgatgtg
     3481 atgaaatttg ctttttatcc aaatattttg tatcttgtaa atatggctaa ttataggaat
     3541 gcctataata catcttagat tccttatatc taataagagt tcaaagagtt atgagttgaa
     3601 gtcttgaatg caggaaacta tctgatagtg ttctaaaatt tggttacttg ggtttggata
     3661 cccttagtgg gatgatgtaa atagaggcta gctacctagg cttgtctata gcaaccataa
     3721 tgttgatgta agtaatgcgg ttactgaatc ataagaaaat gccatctctt tttagttgaa
     3781 ggaaaactct ggaagtaggt gccattggtc attctgcagt gcactgcaac cattgtttcc
     3841 cctagtgccc tcttttccct agggcattgc tctcctattc ccacgcctta acacagctct
     3901 atacctagaa gcagccagcc caggcatgca gtcacattta atcacatccc ccttctagag
     3961 tgcttcaaaa tgatgtagtc cctcaacttg gctaaagaat ctcaatctct tgaaatttat
     4021 ttttttaatg tcatattcat ctggtaaata tctactgttt gccaggcatt taagaatatg
     4081 gcaaagaaca taaaagatgg tgtcaccaga ttttggtcac caatgagtac ccgacccgtt
     4141 gccatgatta agagagaatg ctttctattg gagtttcagg aaatataatt tgagaatact
     4201 ttaaagggaa gtggaagtat aagtgaatga tatttttctt ttacatgtaa acaatgaagt
     4261 tatttcaaag ttaagtttta aacaaaatac atgaagtagt gtctgccata catgttaata
     4321 ttctacattc ttgcttcctt aaattaatat gtttgtgtgt atatatgtgc ctcacacctg
     4381 aattgaaaat taaagactgg tttaaaagtg gtttaaaagt gacatttaat gtttctccat
     4441 tacgtttggg gtaaccagcc taagtggaat cttggaagga aagtaaggga aaaacttgta
     4501 tttgccttca atgaattaaa ccagtgatat gtgttaacgt atgaatgaaa ggattgatgg
     4561 tgattttata attatatata ttgccgcagt aaccagttaa taaattgata gctaccattt
     4621 a
//
