LOCUS       NM_001394010            1884 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens PTOV1 extended AT-hook containing adaptor protein
            (PTOV1), transcript variant 10, mRNA.
ACCESSION   NM_001394010
VERSION     NM_001394010.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1884)
  AUTHORS   Garcia-Mayea,Y., Mir,C., Munoz,L., Benavente,S., Castellvi,J.,
            Temprana,J., Maggio,V., Lorente,J., Paciucci,R. and LLeonart,M.E.
  TITLE     Autophagy inhibition as a promising therapeutic target for
            laryngeal cancer
  JOURNAL   Carcinogenesis 40 (12), 1525-1534 (2019)
   PUBMED   31050705
  REMARK    GeneRIF: the acquisition of resistance in laryngeal cancer seems to
            be related to PTOV1
REFERENCE   2  (bases 1 to 1884)
  AUTHORS   Wu,Z., Liu,Z., Jiang,X., Mi,Z., Meng,M., Wang,H., Zhao,J., Zheng,B.
            and Yuan,Z.
  TITLE     Depleting PTOV1 sensitizes non-small cell lung cancer cells to
            chemotherapy through attenuating cancer stem cell traits
  JOURNAL   J Exp Clin Cancer Res 38 (1), 341 (2019)
   PUBMED   31387622
  REMARK    GeneRIF: this study revealed PTOV1 as a poor prognosis factor for
            NSCLC patients, and targeting PTOV1 can be a strategy to increase
            chemosensitivity in NSCLC.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1884)
  AUTHORS   Maggio,V., Canovas,V., Felix,A.J., Gomez,V., de Torres,I.,
            Semidey,M.E., Morote,J., Noe,V., Ciudad,C.J. and Paciucci,R.
  TITLE     A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1)
            required for the expression of ALDH1A1 and CCNG2 in cancer cells
  JOURNAL   Cancer Lett 452, 158-167 (2019)
   PUBMED   30922918
  REMARK    GeneRIF: PTOV1 interaction with translation complexes and its
            direct binding to ALDH1A1 and CCNG2 promoters found here reveal the
            PTOV1 capacity to modulate the expression of critical genes at
            multiple levels in aggressive cancers.
REFERENCE   4  (bases 1 to 1884)
  AUTHORS   Karna,S.K.L., Ahmad,F., Lone,B.A. and Pokharel,Y.R.
  TITLE     Knockdown of PTOV1 and PIN1 exhibit common phenotypic anti-cancer
            effects in MDA-MB-231 cells
  JOURNAL   PLoS One 14 (5), e0211658 (2019)
   PUBMED   31083670
  REMARK    GeneRIF: PTOV1 and PIN1 interact and exert oncogenic role in
            MDA-MB-231 cells by sharing the similar expression profile at
            transcriptional and translational level which can be a promising
            hub for therapeutic target.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1884)
  AUTHORS   Li,R., Leng,A.M., Liu,X.M., Hu,T.Z., Zhang,L.F., Li,M., Jiang,X.X.,
            Zhou,Y.W. and Xu,C.X.
  TITLE     Overexpressed PTOV1 associates with tumorigenesis and progression
            of esophageal squamous cell carcinoma
  JOURNAL   Tumour Biol 39 (6), 1010428317705013 (2017)
   PUBMED   28651486
  REMARK    GeneRIF: this study takes the lead to demonstrate that the
            overexpressed PTOV1 plays a vital role in the tumorigenesis and
            progression of esophageal squamous cell carcinoma, and it is
            potentially a valuable prognostic predicator and new
            chemotherapeutic target for esophageal squamous cell carcinoma
REFERENCE   6  (bases 1 to 1884)
  AUTHORS   Youn,H.S., Park,U.H., Kim,E.J. and Um,S.J.
  TITLE     PTOV1 antagonizes MED25 in RAR transcriptional activation
  JOURNAL   Biochem Biophys Res Commun 404 (1), 239-244 (2011)
   PUBMED   21110951
  REMARK    GeneRIF: MED25 and PTOV1 differentially modulate retinoic acid
            sensitivity in cancer cells depending on their expression levels.
REFERENCE   7  (bases 1 to 1884)
  AUTHORS   Morote,J., Fernandez,S., Alana,L., Iglesias,C., Planas,J.,
            Reventos,J., Ramon Y Cajal,S., Paciucci,R. and de Torres,I.M.
  TITLE     PTOV1 expression predicts prostate cancer in men with isolated
            high-grade prostatic intraepithelial neoplasia in needle biopsy
  JOURNAL   Clin Cancer Res 14 (9), 2617-2622 (2008)
   PUBMED   18451224
  REMARK    GeneRIF: PTOV1 is overexpressed in high-grade prostatic
            intraepithelial neoplasia associated with cancer and is a potential
            marker for studying the carcinogenesis and progression of prostate
            cancer.
REFERENCE   8  (bases 1 to 1884)
  AUTHORS   Santamaria,A., Castellanos,E., Gomez,V., Benedit,P.,
            Renau-Piqueras,J., Morote,J., Reventos,J., Thomson,T.M. and
            Paciucci,R.
  TITLE     PTOV1 enables the nuclear translocation and mitogenic activity of
            flotillin-1, a major protein of lipid rafts
  JOURNAL   Mol Cell Biol 25 (5), 1900-1911 (2005)
   PUBMED   15713644
  REMARK    GeneRIF: PTOV1 assists flotillin-1 in its translocation to the
            nucleus and both proteins are required for cell proliferation.
REFERENCE   9  (bases 1 to 1884)
  AUTHORS   Santamaria,A., Fernandez,P.L., Farre,X., Benedit,P., Reventos,J.,
            Morote,J., Paciucci,R. and Thomson,T.M.
  TITLE     PTOV-1, a novel protein overexpressed in prostate cancer, shuttles
            between the cytoplasm and the nucleus and promotes entry into the S
            phase of the cell division cycle
  JOURNAL   Am J Pathol 162 (3), 897-905 (2003)
   PUBMED   12598323
  REMARK    GeneRIF: This protein, overexpressed in prostate cancer, shuttles
            between the cytoplasm and the nucleus and promotes entry into the S
            phase of the cell division cycle.
REFERENCE   10 (bases 1 to 1884)
  AUTHORS   Benedit,P., Paciucci,R., Thomson,T.M., Valeri,M., Nadal,M.,
            Caceres,C., de Torres,I., Estivill,X., Lozano,J.J., Morote,J. and
            Reventos,J.
  TITLE     PTOV1, a novel protein overexpressed in prostate cancer containing
            a new class of protein homology blocks
  JOURNAL   Oncogene 20 (12), 1455-1464 (2001)
   PUBMED   11313889
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018766.2.
            
            Summary: This gene encodes a protein that was found to be
            overexpressed in prostate adenocarcinomas. The encoded protein was
            found to interact with the lipid raft protein flotillin-1 and
            shuttle it from the cytoplasm to the nucleus in a cell cycle
            dependent manner. Alternative splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Feb 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2912836.1,
                                           SRR14038194.2505836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391842.6/ ENSP00000375717.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AC018766.2         26664-27004
            342-479             AC018766.2         29911-30048
            480-562             AC018766.2         30157-30239
            563-620             AC018766.2         30336-30393
            621-728             AC018766.2         30475-30582
            729-884             AC018766.2         32480-32635
            885-974             AC018766.2         33198-33287
            975-1048            AC018766.2         33409-33482
            1049-1106           AC018766.2         33562-33619
            1107-1211           AC018766.2         34054-34158
            1212-1409           AC018766.2         35491-35688
            1410-1884           AC018766.2         35773-36247
FEATURES             Location/Qualifiers
     source          1..1884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1884
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /note="PTOV1 extended AT-hook containing adaptor protein"
                     /db_xref="GeneID:53635"
                     /db_xref="HGNC:HGNC:9632"
                     /db_xref="MIM:610195"
     exon            1..341
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1421
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /note="isoform 1 is encoded by transcript variant 10;
                     activator interaction domain-containing protein 2;
                     prostate tumor-overexpressed gene 1 protein; prostate
                     tumor overexpressed 1"
                     /codon_start=1
                     /product="prostate tumor-overexpressed gene 1 protein
                     isoform 1"
                     /protein_id="NP_001380939.1"
                     /db_xref="CCDS:CCDS12782.1"
                     /db_xref="GeneID:53635"
                     /db_xref="HGNC:HGNC:9632"
                     /db_xref="MIM:610195"
                     /translation="MVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGP
                     QPPRIRARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQ
                     EKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNS
                     QLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLI
                     PYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSR
                     SKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLE
                     TLKSLCRIMDNGFAGCVHFSYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRR
                     VIANQQQVLQRNLEQEQQQRGMGG"
     exon            342..479
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..562
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..620
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..728
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..884
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..974
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1048
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1106
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1211
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1409
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1884
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1863..1868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /note="hexamer: AATAAA"
     polyA_site      1884
                     /gene="PTOV1"
                     /gene_synonym="ACID2; PTOV-1"
                     /note="major polyA site"
ORIGIN      
        1 agtggttcgg ccgcggcgac cccactccgg cggcgcgtcc cccgagcttg gtacggctca
       61 gcccgtctcc cccgaagccg cgcgcccgcg cccgcgcccc tcagtcggtg gagcccgcag
      121 ccccccttgt ggcccgcggc agctccccgc ccgctcggcc cgcgcccgcc atggtccgtc
      181 cgcgccgtgc cccgtaccgc tccggcgccg ggggccccct cgggggtcgc ggccgccctc
      241 cgcggcccct cgtggtgcgc gccgtccgct cgcgctcctg gcctgccagc ccccgaggcc
      301 cgcagcctcc gcggatccgg gcccgctcgg cccctcccat ggaaggtgct cgggtcttcg
      361 gggcactggg tcccatcggt ccctcctcac ctgggctcac cctcgggggt ctggccgtga
      421 gcgagcaccg gctcagcaac aagctgctgg cttggagcgg cgtcctcgag tggcaggaga
      481 agcgcagacc ctactctgac tccactgcaa agctgaagcg gaccctgccc tgccaagcct
      541 acgtgaacca aggcgagaac ctggagaccg accagtggcc gcagaagctg atcatgcagc
      601 tgatccctca gcagctgctg accaccctgg gccccctgtt ccggaactcc cagttggcac
      661 agttccactt caccaacaga gactgcgact cgctcaaggg gctctgccgc atcatgggca
      721 acggcttcgc gggctgcatg ctgttccccc acatctcccc ctgtgaggtg cgcgtgctca
      781 tgctcctgta ctcgtccaag aagaagatct tcatgggcct catcccctac gaccagagcg
      841 gcttcgtcag tgccatccgg caggtcatca ccacccgcaa gcaggcagtg ggacctggtg
      901 gtgtcaactc aggcccagtc cagatcgtca acaacaagtt tctggcatgg agtggtgtca
      961 tggagtggca ggagcccagg cctgagccca acagtcggtc caagaggtgg ctgccatccc
     1021 acgtctacgt gaaccagggg gagatcctga ggaccgagca gtggccaagg aagctgtaca
     1081 tgcagctcat cccgcagcag ctgctgacca ccctagtgcc gctgttccgg aactcgcgcc
     1141 tggtccagtt ccacttcacc aaggacctgg agacactgaa gagcctgtgc cggatcatgg
     1201 acaatggctt cgccggctgc gtgcactttt cctacaaagc atcgtgtgag atccgcgtgc
     1261 ttatgctcct gtactcttca gagaagaaaa tcttcattgg cctcatcccc catgaccagg
     1321 gcaactttgt caacggcatc cggcgtgtca ttgccaacca gcagcaggtc ctgcagcgga
     1381 acctggagca ggagcaacag caacgaggga tgggggggta gtggttaccc cgggctgggc
     1441 ccctccagga gtcacagatg aggcccccgc agagactggt gagtggtgac cctgtcatgt
     1501 acaggaggga ccctggggca tgtggggggg gtggggttgg gaaagaagca gggcgacctt
     1561 ggccttgggg agagcagagc agagggagag gcagcagtcc cagcggtcct aggctgtcgg
     1621 gaaactgcag cccagcctca gggccatggg aggtggtatc caggcctggg tggggccagg
     1681 cctctgctca cagggatgtg gggtcagtgc ttgggagcct gtggccagca gcccccactg
     1741 cacccctgcc cccaggtgac acgcttctga gcaggggccc ctggggactt caactgccca
     1801 gcaacatgga ggatggtgtc ctgaggcctc caaggacggt ccccacccct ctacgtttcc
     1861 ccaataaagc cttttaaaaa cctg
//
