LOCUS       NM_002825               1482 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens pleiotrophin (PTN), transcript variant 1, mRNA.
ACCESSION   NM_002825
VERSION     NM_002825.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Ma,Y., Liu,Y. and Meng,H.
  TITLE     Prognostic evaluation of oral squamous cell carcinoma based on
            pleiotrophin, urokinase plasminogen activator, and glycoprotein
            nonmetastatic melanoma protein B expression
  JOURNAL   Medicine (Baltimore) 102 (45), e35634 (2023)
   PUBMED   37960806
  REMARK    GeneRIF: Prognostic evaluation of oral squamous cell carcinoma
            based on pleiotrophin, urokinase plasminogen activator, and
            glycoprotein nonmetastatic melanoma protein B expression.
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Qiu,X., Guo,Y., Liu,M.F., Zhang,B., Li,J., Wei,J.F. and Li,M.
  TITLE     Single-cell RNA-sequencing analysis reveals enhanced non-canonical
            neurotrophic factor signaling in the subacute phase of traumatic
            brain injury
  JOURNAL   CNS Neurosci Ther 29 (11), 3446-3459 (2023)
   PUBMED   37269057
  REMARK    GeneRIF: Single-cell RNA-sequencing analysis reveals enhanced
            non-canonical neurotrophic factor signaling in the subacute phase
            of traumatic brain injury.
REFERENCE   3  (bases 1 to 1482)
  AUTHORS   Said,E.A., Al-Dughaishi,S., Al-Hatmi,W., Al-Reesi,I.,
            Al-Balushi,M.S., Al-Bimani,A., Al-Busaidi,J.Z., Al-Riyami,M.,
            Al-Khabori,M., Al-Kindi,S., Procopio,F.A., Al-Sinawi,S.,
            Al-Ansari,A., Koh,C.Y., Al-Naamani,K. and Al-Jabri,A.A.
  TITLE     Differential Production of Midkine and Pleiotrophin by Innate APCs
            upon Stimulation through Nucleic Acid-Sensing TLRs
  JOURNAL   J Immunol Res 2023, 7944102 (2023)
   PUBMED   37850119
  REMARK    GeneRIF: Differential Production of Midkine and Pleiotrophin by
            Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1482)
  AUTHORS   Ganguly,D., Schmidt,M.O., Coleman,M., Ngo,T.C., Sorrelle,N.,
            Dominguez,A.T.A., Murimwa,G.Z., Toombs,J.E., Lewis,C., Fang,Y.V.,
            Valdes-Mora,F., Gallego-Ortega,D., Wellstein,A. and Brekken,R.A.
  TITLE     Pleiotrophin drives a prometastatic immune niche in breast cancer
  JOURNAL   J Exp Med 220 (5) (2023)
   PUBMED   36828390
  REMARK    GeneRIF: Pleiotrophin drives a prometastatic immune niche in breast
            cancer.
REFERENCE   5  (bases 1 to 1482)
  AUTHORS   Peng,B.H., Ji,Y.F. and Qiu,X.J.
  TITLE     LncRNA PITPNA-AS1/miR-223-3p/PTN axis regulates malignant
            progression and stemness in lung squamous cell carcinoma
  JOURNAL   J Clin Lab Anal 36 (7), e24506 (2022)
   PUBMED   35588441
  REMARK    GeneRIF: LncRNA PITPNA-AS1/miR-223-3p/PTN axis regulates malignant
            progression and stemness in lung squamous cell carcinoma.
REFERENCE   6  (bases 1 to 1482)
  AUTHORS   Schulte,A.M., Lai,S., Kurtz,A., Czubayko,F., Riegel,A.T. and
            Wellstein,A.
  TITLE     Human trophoblast and choriocarcinoma expression of the growth
            factor pleiotrophin attributable to germ-line insertion of an
            endogenous retrovirus
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14759-14764 (1996)
   PUBMED   8962128
REFERENCE   7  (bases 1 to 1482)
  AUTHORS   Li,Y.S., Hoffman,R.M., Le Beau,M.M., Espinosa,R. 3rd, Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G. and Deuel,T.F.
  TITLE     Characterization of the human pleiotrophin gene. Promoter region
            and chromosomal localization
  JOURNAL   J Biol Chem 267 (36), 26011-26016 (1992)
   PUBMED   1464612
REFERENCE   8  (bases 1 to 1482)
  AUTHORS   Milner,P.G., Shah,D., Veile,R., Donis-Keller,H. and Kumar,B.V.
  TITLE     Cloning, nucleotide sequence, and chromosome localization of the
            human pleiotrophin gene
  JOURNAL   Biochemistry 31 (48), 12023-12028 (1992)
   PUBMED   1457401
REFERENCE   9  (bases 1 to 1482)
  AUTHORS   Wellstein,A., Fang,W.J., Khatri,A., Lu,Y., Swain,S.S.,
            Dickson,R.B., Sasse,J., Riegel,A.T. and Lippman,M.E.
  TITLE     A heparin-binding growth factor secreted from breast cancer cells
            homologous to a developmentally regulated cytokine
  JOURNAL   J Biol Chem 267 (4), 2582-2587 (1992)
   PUBMED   1733956
REFERENCE   10 (bases 1 to 1482)
  AUTHORS   Tezuka,K., Takeshita,S., Hakeda,Y., Kumegawa,M., Kikuno,R. and
            Hashimoto-Gotoh,T.
  TITLE     Isolation of mouse and human cDNA clones encoding a protein
            expressed specifically in osteoblasts and brain tissues
  JOURNAL   Biochem Biophys Res Commun 173 (1), 246-251 (1990)
   PUBMED   1701634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M57399.1, BC005916.1 and
            AW020400.1.
            
            On May 17, 2019 this sequence version replaced NM_002825.6.
            
            Summary: The protein encoded by this gene is a secreted
            heparin-binding growth factor. The protein has significant roles in
            cell growth and survival, cell migration, angiogenesis and
            tumorigenesis. Alternative splicing and the use of alternative
            promoters results in multiple transcript variants. [provided by
            RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform. Variants 1 and 2 encode
            the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.624419.1,
                                           SRR3476690.748364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03568911 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348225.7/ ENSP00000341170.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-930               M57399.1           100-1029
            931-1220            BC005916.1         986-1275
            1221-1482           AW020400.1         185-446
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1482
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /note="pleiotrophin"
                     /db_xref="GeneID:5764"
                     /db_xref="HGNC:HGNC:9630"
                     /db_xref="MIM:162095"
     exon            1..295
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..411
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..803
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; heparin affin regulatory protein;
                     heparin-binding growth-associated molecule; pleiotrophin
                     (heparin binding growth factor 8, neurite growth-promoting
                     factor 1); osteoblast-specific factor 1; heparin-binding
                     brain mitogen; heparin-binding growth factor 8;
                     heparin-binding neurite outgrowth-promoting factor 1;
                     heparin-binding neurite outgrowth promoting factor"
                     /codon_start=1
                     /product="pleiotrophin isoform 1 precursor"
                     /protein_id="NP_002816.1"
                     /db_xref="CCDS:CCDS5844.1"
                     /db_xref="GeneID:5764"
                     /db_xref="HGNC:HGNC:9630"
                     /db_xref="MIM:162095"
                     /translation="MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKK
                     SDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQ
                     FQAWGECDLNTALKTRTGSLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEG
                     KKQEKMLD"
     exon            412..585
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..747
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1482
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1191
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /note="major polyA site"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /note="hexamer: AATAAA"
     polyA_site      1255
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /note="major polyA site"
     regulatory      1373..1378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
                     /note="hexamer: CATAAA"
     polyA_site      1398
                     /gene="PTN"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF;
                     HBNF-1; NEGF1; OSF-1"
ORIGIN      
        1 attctccatt tcccttccgt tccctccctg tcagggcgta attgagtcaa aggcaggatc
       61 aggttccccg ccttccagtc caaaaatccc gccaagagag ccccagagca gaggaaaatc
      121 caaagtggag agaggggaag aaagagacca gtgagtcatc cgtccagaag gcggggagag
      181 cagcagcggc ccaagcagga gctgcagcga gccgggtacc tggactcagc ggtagcaacc
      241 tcgccccttg caacaaaggc agactgagcg ccagagagga cgtttccaac tcaaaaatgc
      301 aggctcaaca gtaccagcag cagcgtcgaa aatttgcagc tgccttcttg gcattcattt
      361 tcatactggc agctgtggat actgctgaag cagggaagaa agagaaacca gaaaaaaaag
      421 tgaagaagtc tgactgtgga gaatggcagt ggagtgtgtg tgtgcccacc agtggagact
      481 gtgggctggg cacacgggag ggcactcgga ctggagctga gtgcaagcaa accatgaaga
      541 cccagagatg taagatcccc tgcaactgga agaagcaatt tggcgcggag tgcaaatacc
      601 agttccaggc ctggggagaa tgtgacctga acacagccct gaagaccaga actggaagtc
      661 tgaagcgagc cctgcacaat gccgaatgcc agaagactgt caccatctcc aagccctgtg
      721 gcaaactgac caagcccaaa cctcaagcag aatctaagaa gaagaaaaag gaaggcaaga
      781 aacaggagaa gatgctggat taaaagatgt cacctgtgga acataaaaag gacatcagca
      841 aacaggatca gttaactatt gcatttatat gtaccgtagg ctttgtattc aaaaattatc
      901 tatagctaag tacacaataa gcaaaaacaa aaagaaaaga aaatttttgt agtagcgttt
      961 tttaaatgta tactatagta ccagtagggg cttataataa aggactgtaa tcttatttag
     1021 gaagttgact tatagtacat gataaatgat agacaattga ggtaagtttt ttgaaattat
     1081 gtgacatttt acattaaatt ttttttacat tttttgggca gcaatttaaa tgttatgact
     1141 atgtaaacta cttctcttgt taggtaattt ttttcaccta gatttttttc ccaattgaga
     1201 aaaatatata ctaaacaaaa tagcaataaa acataatcac tctatttgaa gaaaatatct
     1261 tgttttctgc caatagattt tttaaaatgt agtcagcaaa atgggggtgg ggaagcagag
     1321 catgtcctag ttcaatgttg actttttttt tttttaaaga aaagcattaa gacataaaat
     1381 tctttcactt tggcagaagc atttgttttc ttgatgaaat tatttttcca tctgaggaaa
     1441 aaaatactag gaaaataaat caaggtgatg ctgaaaaaaa aa
//
