LOCUS       NM_002824               1162 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens parathymosin (PTMS), transcript variant 2, mRNA.
ACCESSION   NM_002824
VERSION     NM_002824.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 1162)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1162)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1162)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 1162)
  AUTHORS   Martic,G., Karetsou,Z., Kefala,K., Politou,A.S., Clapier,C.R.,
            Straub,T. and Papamarcaki,T.
  TITLE     Parathymosin affects the binding of linker histone H1 to
            nucleosomes and remodels chromatin structure
  JOURNAL   J Biol Chem 280 (16), 16143-16150 (2005)
   PUBMED   15716277
REFERENCE   6  (bases 1 to 1162)
  AUTHORS   Kondili,K., Tsolas,O. and Papamarcaki,T.
  TITLE     Selective interaction between parathymosin and histone H1
  JOURNAL   Eur J Biochem 242 (1), 67-74 (1996)
   PUBMED   8954154
REFERENCE   7  (bases 1 to 1162)
  AUTHORS   Clinton,M., Graeve,L., el-Dorry,H., Rodriguez-Boulan,E. and
            Horecker,B.L.
  TITLE     Evidence for nuclear targeting of prothymosin and parathymosin
            synthesized in situ
  JOURNAL   Proc Natl Acad Sci U S A 88 (15), 6608-6612 (1991)
   PUBMED   1862085
REFERENCE   8  (bases 1 to 1162)
  AUTHORS   Clinton,M., Frangou-Lazaridis,M., Panneerselvam,C. and
            Horecker,B.L.
  TITLE     The sequence of human parathymosin deduced from a cloned human
            kidney cDNA
  JOURNAL   Biochem Biophys Res Commun 158 (3), 855-862 (1989)
   PUBMED   2537638
REFERENCE   9  (bases 1 to 1162)
  AUTHORS   Szabo,P., Clinton,M., Macera,M. and Horecker,B.L.
  TITLE     Localization of the gene coding for parathymosin to chromosome 17
            in humans
  JOURNAL   Cytogenet Cell Genet 50 (2-3), 91-92 (1989)
   PUBMED   2776490
REFERENCE   10 (bases 1 to 1162)
  AUTHORS   Panneerselvam,C., Caldarella,J. and Horecker,B.L.
  TITLE     A radioimmunoassay for parathymosin
  JOURNAL   J Immunol Methods 104 (1-2), 131-136 (1987)
   PUBMED   2445824
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY157657.1, BC017025.1 and
            BQ023417.1.
            
            On Jun 2, 2019 this sequence version replaced NM_002824.5.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the central coding region, which results in a frameshift,
            compared to variant 1. The encoded isoform (2) has a shorter and
            distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279827.1020.1, ERR279826.10039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309083.8/ ENSP00000310088.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               HY157657.1         47-339
            294-1153            BC017025.1         1-860
            1154-1162           BQ023417.1         17-25               c
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1162
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /note="parathymosin"
                     /db_xref="GeneID:5763"
                     /db_xref="HGNC:HGNC:9629"
                     /db_xref="MIM:168440"
     exon            1..388
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..652
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="parathymosin isoform 2"
                     /protein_id="NP_002815.3"
                     /db_xref="CCDS:CCDS8560.1"
                     /db_xref="GeneID:5763"
                     /db_xref="HGNC:HGNC:9629"
                     /db_xref="MIM:168440"
                     /translation="MSEKSVEAAAELSAKDLKEKKEKVEEKASRKERKKEVVEEEENG
                     AEEEEEETAEDGEEEDEGEEEDEEEEEEDDEGPALKRAAEEEDEADPKRQKTENGASA
                     "
     exon            389..460
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /inference="alignment:Splign:2.1.0"
     exon            461..539
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /inference="alignment:Splign:2.1.0"
     exon            540..601
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1162
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1136..1141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /note="hexamer: AAGAAA"
     polyA_site      1162
                     /gene="PTMS"
                     /gene_synonym="ParaT"
                     /note="major polyA site"
ORIGIN      
        1 agcggctggt cggcggcagc tctgctggtg cgggggcggc gagcccggga tcgagctacc
       61 gcggccgagc gcgccggcca ccgcctgcac cgcccttccg cccgccctcc ggacggccgc
      121 agccctgcgg gtctccgctc cagacccacc cccgccccac cccgcgcgcc tctgccgcct
      181 cttccagaga cccagcttgc cgagcggccg ccgctgccgc tgtcgccgcc gccgccgcca
      241 ccgcgccagg ttccggccgc ggccaccctc cgccgtccag ggcccctccg tctcggcccc
      301 gggaccccgg ctccccgcca gccccggccc cggccccggc accatgtcgg agaaaagcgt
      361 ggaggcagcg gccgagttga gcgccaagga cctgaaggag aagaaggaga aggtggagga
      421 gaaggcaagc cggaaagagc gaaagaaaga agtggtggag gaggaggaga acggggctga
      481 ggaggaagaa gaagaaactg ccgaggatgg agaggaggaa gatgaagggg aagaagaaga
      541 tgaggaagaa gaagaagagg atgatgaagg gcccgcgctg aagagagctg ccgaagagga
      601 ggatgaagcg gatcccaaac ggcagaagac agaaaatggg gcatcggcgt gagcccctgc
      661 caacaggctg gggttgggag gcctctctgg gcctggaggt gggggtgggg gcagccaagt
      721 ccagccactc ttcacctggc tccctgctct gggccctgca ccagagctgc caccctcttc
      781 tttctcccca gccttctcat ttccgcctct ccagacactg cgccctccac cctcactctg
      841 ccattgttcc acctcctgac ctgctccatc tgagctctcc agctggcccc caattgctcc
      901 tctctctctt tgctctcttt ctccctcccc taccagcctc attcttcctc cggtagcctc
      961 tcccacctaa cctctgcatc ccccagcctc atgtcctgcc ccatccctat cctgcctgat
     1021 ccctggatct ccctcagatc ccctcttctc agacagcgcc aggccggggt ggggccgggg
     1081 ttggggccga gccccacagc tgcccccctc ccctcccttt ttgtataatt taataaagaa
     1141 atggtcgcgc ttctgttttt aa
//
