LOCUS       NM_002821               4222 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens protein tyrosine kinase 7 (inactive) (PTK7),
            transcript variant PTK7-1, mRNA.
ACCESSION   NM_002821
VERSION     NM_002821.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4222)
  AUTHORS   Qiu,L., Xu,H., Sui,B., Jiang,P., Wang,J., Xu,D., Liang,F., Ma,T.,
            Wang,H. and Chen,J.
  TITLE     Elucidating the Functional Mechanism of PTK7 in Cancer Development
            through Spatial Assembly Analysis Using Super Resolution Imaging
  JOURNAL   Anal Chem 96 (19), 7669-7678 (2024)
   PUBMED   38708542
  REMARK    GeneRIF: Elucidating the Functional Mechanism of PTK7 in Cancer
            Development through Spatial Assembly Analysis Using Super
            Resolution Imaging.
REFERENCE   2  (bases 1 to 4222)
  AUTHORS   Ji,J., Qian,Q., Cheng,W., Ye,X., Jing,A., Ma,S., Ding,Y., Ma,X.,
            Wang,Y., Sun,Q., Wang,X., Chen,Y., Zhu,L., Yuan,Q., Xu,M., Qin,J.,
            Ma,L., Yang,J., Zhang,M., Geng,T., Wang,S., Wang,D., Song,Y.,
            Zhang,B., Xu,Y., Xu,L., Liu,S., Liu,W. and Liu,B.
  TITLE     FOXP4-mediated induction of PTK7 activates the Wnt/beta-catenin
            pathway and promotes ovarian cancer development
  JOURNAL   Cell Death Dis 15 (5), 332 (2024)
   PUBMED   38740744
  REMARK    GeneRIF: FOXP4-mediated induction of PTK7 activates the
            Wnt/beta-catenin pathway and promotes ovarian cancer development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4222)
  AUTHORS   Shin,W.S., Oh,S.W., Park,H.N., Kim,J.H. and Lee,S.T.
  TITLE     Knockdown of PTK7 Reduces the Oncogenic Potential of Breast Cancer
            Cells by Impeding Receptor Tyrosine Kinase Signaling
  JOURNAL   Int J Mol Sci 24 (15), 12173 (2023)
   PUBMED   37569547
  REMARK    GeneRIF: Knockdown of PTK7 Reduces the Oncogenic Potential of
            Breast Cancer Cells by Impeding Receptor Tyrosine Kinase Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4222)
  AUTHORS   Peradziryi,H., Tolwinski,N.S. and Borchers,A.
  TITLE     The many roles of PTK7: a versatile regulator of cell-cell
            communication
  JOURNAL   Arch Biochem Biophys 524 (1), 71-76 (2012)
   PUBMED   22230326
  REMARK    Review article
REFERENCE   5  (bases 1 to 4222)
  AUTHORS   Jung,J.W., Ji,A.R., Lee,J., Kim,U.J. and Lee,S.T.
  TITLE     Organization of the human PTK7 gene encoding a receptor protein
            tyrosine kinase-like molecule and alternative splicing of its mRNA
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 153-163 (2002)
   PUBMED   12427550
  REMARK    GeneRIF: cloning, sequencing and expression of gene and its splice
            variants
REFERENCE   6  (bases 1 to 4222)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4222)
  AUTHORS   Banga,S.S., Ozer,H.L., Park,S.K. and Lee,S.T.
  TITLE     Assignment of PTK7 encoding a receptor protein tyrosine kinase-like
            molecule to human chromosome 6p21.1-->p12.2 by fluorescence in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 76 (1-2), 43-44 (1997)
   PUBMED   9154124
REFERENCE   8  (bases 1 to 4222)
  AUTHORS   Park,S.K., Lee,H.S. and Lee,S.T.
  TITLE     Characterization of the human full-length PTK7 cDNA encoding a
            receptor protein tyrosine kinase-like molecule closely related to
            chick KLG
  JOURNAL   J Biochem 119 (2), 235-239 (1996)
   PUBMED   8882711
REFERENCE   9  (bases 1 to 4222)
  AUTHORS   Mossie,K., Jallal,B., Alves,F., Sures,I., Plowman,G.D. and
            Ullrich,A.
  TITLE     Colon carcinoma kinase-4 defines a new subclass of the receptor
            tyrosine kinase family
  JOURNAL   Oncogene 11 (10), 2179-2184 (1995)
   PUBMED   7478540
REFERENCE   10 (bases 1 to 4222)
  AUTHORS   Lee,S.T., Strunk,K.M. and Spritz,R.A.
  TITLE     A survey of protein tyrosine kinase mRNAs expressed in normal human
            melanocytes
  JOURNAL   Oncogene 8 (12), 3403-3410 (1993)
   PUBMED   8247543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA389442.1, AF531868.1,
            AK291016.1 and AI140260.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002821.4.
            
            Summary: This gene encodes a member of the receptor protein
            tyrosine kinase family of proteins that transduce extracellular
            signals across the cell membrane. The encoded protein lacks
            detectable catalytic tyrosine kinase activity, is involved in the
            Wnt signaling pathway and plays a role in multiple cellular
            processes including polarity and adhesion. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (PTK7-1) represents the longest
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071557.1, U33635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230419.9/ ENSP00000230419.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CA389442.1         47-74
            29-3620             AF531868.1         1-3592
            3621-3802           AK291016.1         3379-3560
            3803-4222           AI140260.1         6-425               c
FEATURES             Location/Qualifiers
     source          1..4222
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..4222
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /note="protein tyrosine kinase 7 (inactive)"
                     /db_xref="GeneID:5754"
                     /db_xref="HGNC:HGNC:9618"
                     /db_xref="MIM:601890"
     exon            1..254
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..3388
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant PTK7-1; tyrosine-protein kinase-like 7; inactive
                     tyrosine-protein kinase 7; colon carcinoma kinase 4;
                     pseudo tyrosine kinase receptor 7; PTK7 protein tyrosine
                     kinase 7"
                     /codon_start=1
                     /product="inactive tyrosine-protein kinase 7 isoform a
                     precursor"
                     /protein_id="NP_002812.2"
                     /db_xref="CCDS:CCDS4884.1"
                     /db_xref="GeneID:5754"
                     /db_xref="HGNC:HGNC:9618"
                     /db_xref="MIM:601890"
                     /translation="MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDAL
                     QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCV
                     ARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTY
                     QWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLS
                     IADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLR
                     RATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT
                     AGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCH
                     AANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQM
                     LISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPP
                     QPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAG
                     NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ
                     WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV
                     DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE
                     GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQP
                     ITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHA
                     NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQV
                     ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRW
                     MSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE
                     GCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP"
     exon            255..542
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..645
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            646..836
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            837..987
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1136
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1403
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1537
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1673
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1793
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1943
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2094
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2222
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2426
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2582
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2815
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2896
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3048
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3227
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..4222
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4205..4210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /note="hexamer: AATAAG"
     polyA_site      4222
                     /gene="PTK7"
                     /gene_synonym="CCK-4; CCK4"
                     /note="major polyA site"
ORIGIN      
        1 actgggcgcg cgcggctccg gctcgggacg cctcgggacg cctcggggtc gggctccggc
       61 tgcggctgct gctgcggcgc ccgcgctccg gtgcgctccg cctcctgtgc ccgccgcgga
      121 gcgcagtctg cgcgcccgcc gtgcgccctc agctcctttt cctgagcccg ccgcgatggg
      181 agctgcgcgg ggatccccgg ccagaccccg ccggttgcct ctgctcagcg tcctgctgct
      241 gccgctgctg ggcggtaccc agacagccat tgtcttcatc aagcagccgt cctcccagga
      301 tgcactgcag gggcgccggg cgctgcttcg ctgtgaggtt gaggctccgg gcccggtaca
      361 tgtgtactgg ctgctcgatg gggcccctgt ccaggacacg gagcggcgtt tcgcccaggg
      421 cagcagcctg agctttgcag ctgtggaccg gctgcaggac tctggcacct tccagtgtgt
      481 ggctcgggat gatgtcactg gagaagaagc ccgcagtgcc aacgcctcct tcaacatcaa
      541 atggattgag gcaggtcctg tggtcctgaa gcatccagcc tcggaagctg agatccagcc
      601 acagacccag gtcacacttc gttgccacat tgatgggcac cctcggccca cctaccaatg
      661 gttccgagat gggacccccc tttctgatgg tcagagcaac cacacagtca gcagcaagga
      721 gcggaacctg acgctccggc cagctggtcc tgagcatagt gggctgtatt cctgctgcgc
      781 ccacagtgct tttggccagg cttgcagcag ccagaacttc accttgagca ttgctgatga
      841 aagctttgcc agggtggtgc tggcacccca ggacgtggta gtagcgaggt atgaggaggc
      901 catgttccat tgccagttct cagcccagcc acccccgagc ctgcagtggc tctttgagga
      961 tgagactccc atcactaacc gcagtcgccc cccacacctc cgcagagcca cagtgtttgc
     1021 caacgggtct ctgctgctga cccaggtccg gccacgcaat gcagggatct accgctgcat
     1081 tggccagggg cagaggggcc cacccatcat cctggaagcc acacttcacc tagcagagat
     1141 tgaagacatg ccgctatttg agccacgggt gtttacagct ggcagcgagg agcgtgtgac
     1201 ctgccttccc cccaagggtc tgccagagcc cagcgtgtgg tgggagcacg cgggagtccg
     1261 gctgcccacc catggcaggg tctaccagaa gggccacgag ctggtgttgg ccaatattgc
     1321 tgaaagtgat gctggtgtct acacctgcca cgcggccaac ctggctggtc agcggagaca
     1381 ggatgtcaac atcactgtgg ccactgtgcc ctcctggctg aagaagcccc aagacagcca
     1441 gctggaggag ggcaaacccg gctacttgga ttgcctgacc caggccacac caaaacctac
     1501 agttgtctgg tacagaaacc agatgctcat ctcagaggac tcacggttcg aggtcttcaa
     1561 gaatgggacc ttgcgcatca acagcgtgga ggtgtatgat gggacatggt accgttgtat
     1621 gagcagcacc ccagccggca gcatcgaggc gcaagcccgt gtccaagtgc tggaaaagct
     1681 caagttcaca ccaccacccc agccacagca gtgcatggag tttgacaagg aggccacggt
     1741 gccctgttca gccacaggcc gagagaagcc cactattaag tgggaacggg cagatgggag
     1801 cagcctccca gagtgggtga cagacaacgc tgggaccctg cattttgccc gggtgactcg
     1861 agatgacgct ggcaactaca cttgcattgc ctccaacggg ccgcagggcc agattcgtgc
     1921 ccatgtccag ctcactgtgg cagtttttat caccttcaaa gtggaaccag agcgtacgac
     1981 tgtgtaccag ggccacacag ccctactgca gtgcgaggcc cagggggacc ccaagccgct
     2041 gattcagtgg aaaggcaagg accgcatcct ggaccccacc aagctgggac ccaggatgca
     2101 catcttccag aatggctccc tggtgatcca tgacgtggcc cctgaggact caggccgcta
     2161 cacctgcatt gcaggcaaca gctgcaacat caagcacacg gaggcccccc tctatgtcgt
     2221 ggacaagcct gtgccggagg agtcggaggg ccctggcagc cctcccccct acaagatgat
     2281 ccagaccatt gggttgtcgg tgggtgccgc tgtggcctac atcattgccg tgctgggcct
     2341 catgttctac tgcaagaagc gctgcaaagc caagcggctg cagaagcagc ccgagggcga
     2401 ggagccagag atggaatgcc tcaacggtgg gcctttgcag aacgggcagc cctcagcaga
     2461 gatccaagaa gaagtggcct tgaccagctt gggctccggc cccgcggcca ccaacaaacg
     2521 ccacagcaca agtgataaga tgcacttccc acggtctagc ctgcagccca tcaccacgct
     2581 ggggaagagt gagtttgggg aggtgttcct ggcaaaggct cagggcttgg aggagggagt
     2641 ggcagagacc ctggtacttg tgaagagcct gcagagcaag gatgagcagc agcagctgga
     2701 cttccggagg gagttggaga tgtttgggaa gctgaaccac gccaacgtgg tgcggctcct
     2761 ggggctgtgc cgggaggctg agccccacta catggtgctg gaatatgtgg atctgggaga
     2821 cctcaagcag ttcctgagga tttccaagag caaggatgaa aaattgaagt cacagcccct
     2881 cagcaccaag cagaaggtgg ccctatgcac ccaggtagcc ctgggcatgg agcacctgtc
     2941 caacaaccgc tttgtgcata aggacttggc tgcgcgtaac tgcctggtca gtgcccagag
     3001 acaagtgaag gtgtctgccc tgggcctcag caaggatgtg tacaacagtg agtactacca
     3061 cttccgccag gcctgggtgc cgctgcgctg gatgtccccc gaggccatcc tggagggtga
     3121 cttctctacc aagtctgatg tctgggcctt cggtgtgctg atgtgggaag tgtttacaca
     3181 tggagagatg ccccatggtg ggcaggcaga tgatgaagta ctggcagatt tgcaggctgg
     3241 gaaggctaga cttcctcagc ccgagggctg cccttccaaa ctctatcggc tgatgcagcg
     3301 ctgctgggcc ctcagcccca aggaccggcc ctccttcagt gagattgcca gcgccctggg
     3361 agacagcacc gtggacagca agccgtgagg agggagcccg ctcaggatgg cctgggcagg
     3421 ggaggacatc tctagaggga agctcacagc atgatgggca agatccctgt cctcctgggc
     3481 cctgaggccc ctgccctagt gcaacaggca ttgctgaggt ctgagcaggg cctggccttt
     3541 cctcctcttc ctcaccctca tcctttggga ggctgacttg gacccaaact gggcgactag
     3601 ggctttgagc tgggcagttt tccctgccac ctcttcctct atcagggaca gtgtgggtgc
     3661 cacaggtaac cccaatttct ggccttcaac ttctcccctt gaccgggtcc aactctgcca
     3721 ctcatctgcc aactttgcct ggggagggct aggcttggga tgagctgggt ttgtggggag
     3781 ttccttaata ttctcaagtt ctgggcacac agggttaatg agtctcttgg cccactggtc
     3841 ccacttgggg gtctagacca ggattataga ggacacagca agtgagtcct ccccactctg
     3901 ggcttgtgca cactgaccca gacccacgtc ttccccaccc ttctctcctt tcctcatcct
     3961 aagtgcctgg cagatgaagg agttttcagg agcttttgac actatataaa ccgccctttt
     4021 tgtatgcacc acgggcggct tttatatgta attgcagcgt ggggtgggtg ggcatgggag
     4081 gtaggggtgg gccctggaga tgaggagggt gggccatcct taccccacac ttttattgtt
     4141 gtcgtttttt gtttgttttg tttttttgtt tttgtttttg tttttacact cgctgctctc
     4201 aataaataag ccttttttac aa
//
