LOCUS       NM_173176               4074 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript
            variant 3, mRNA.
ACCESSION   NM_173176
VERSION     NM_173176.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4074)
  AUTHORS   Wu,Z., Jiao,M., Shu,C., Zhang,S., Wang,J., Pu,J., Zhu,J., Zeng,Y.,
            Zhu,Y. and Liu,Z.
  TITLE     Integrin alphaVbeta1-activated PYK2 promotes the progression of
            non-small-cell lung cancer via the STAT3-VGF axis
  JOURNAL   Cell Commun Signal 22 (1), 313 (2024)
   PUBMED   38844957
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4074)
  AUTHORS   Porter,T., Del Valle,M.M. and Kucheryavykh,L.
  TITLE     Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in
            Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic
            Population
  JOURNAL   Int J Mol Sci 25 (9), 4947 (2024)
   PUBMED   38732165
  REMARK    GeneRIF: Ethnicity-Based Variations in Focal Adhesion Kinase
            Signaling in Glioblastoma Gene Expression: A Study of the Puerto
            Rican Hispanic Population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4074)
  AUTHORS   Gil-Henn,H., Girault,J.A. and Lev,S.
  TITLE     PYK2, a hub of signaling networks in breast cancer progression
  JOURNAL   Trends Cell Biol 34 (4), 312-326 (2024)
   PUBMED   37586982
  REMARK    GeneRIF: PYK2, a hub of signaling networks in breast cancer
            progression.
            Review article
REFERENCE   4  (bases 1 to 4074)
  AUTHORS   Yang,C.C., Lee,I.T., Lin,Y.J., Wu,W.B., Hsiao,L.D. and Yang,C.M.
  TITLE     Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human
            Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent AP-1
            Pathway Modulation
  JOURNAL   Int J Mol Sci 24 (20), 15130 (2023)
   PUBMED   37894811
  REMARK    GeneRIF: Thrombin-Induced COX-2 Expression and PGE2 Synthesis in
            Human Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent
            AP-1 Pathway Modulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4074)
  AUTHORS   Guo,Y., Sun,C.K., Tang,L. and Tan,M.S.
  TITLE     Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's Disease
  JOURNAL   Curr Alzheimer Res 20 (10), 692-704 (2023)
   PUBMED   38321895
  REMARK    GeneRIF: Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's
            Disease.
            Review article
REFERENCE   6  (bases 1 to 4074)
  AUTHORS   Avraham,S., London,R., Fu,Y., Ota,S., Hiregowdara,D., Li,J.,
            Jiang,S., Pasztor,L.M., White,R.A., Groopman,J.E. et al.
  TITLE     Identification and characterization of a novel related adhesion
            focal tyrosine kinase (RAFTK) from megakaryocytes and brain
  JOURNAL   J Biol Chem 270 (46), 27742-27751 (1995)
   PUBMED   7499242
REFERENCE   7  (bases 1 to 4074)
  AUTHORS   Sasaki,H., Nagura,K., Ishino,M., Tobioka,H., Kotani,K. and
            Sasaki,T.
  TITLE     Cloning and characterization of cell adhesion kinase beta, a novel
            protein-tyrosine kinase of the focal adhesion kinase subfamily
  JOURNAL   J Biol Chem 270 (36), 21206-21219 (1995)
   PUBMED   7673154
REFERENCE   8  (bases 1 to 4074)
  AUTHORS   Lev,S., Moreno,H., Martinez,R., Canoll,P., Peles,E.,
            Musacchio,J.M., Plowman,G.D., Rudy,B. and Schlessinger,J.
  TITLE     Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation
            of ion channel and MAP kinase functions
  JOURNAL   Nature 376 (6543), 737-745 (1995)
   PUBMED   7544443
REFERENCE   9  (bases 1 to 4074)
  AUTHORS   Calalb,M.B., Polte,T.R. and Hanks,S.K.
  TITLE     Tyrosine phosphorylation of focal adhesion kinase at sites in the
            catalytic domain regulates kinase activity: a role for Src family
            kinases
  JOURNAL   Mol Cell Biol 15 (2), 954-963 (1995)
   PUBMED   7529876
REFERENCE   10 (bases 1 to 4074)
  AUTHORS   Coffer,P.J. and Woodgett,J.R.
  TITLE     Molecular cloning and characterisation of a novel putative
            protein-serine kinase related to the cAMP-dependent and protein
            kinase C families
  JOURNAL   Eur J Biochem 201 (2), 475-481 (1991)
   PUBMED   1718748
  REMARK    Erratum:[Eur J Biochem. 1992 May 1;205(3):1217.. PMID: 1533586]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC042599.2, U33284.1,
            AL120380.1, AF311103.5 and AW130888.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_173176.2.
            
            Summary: This gene encodes a cytoplasmic protein tyrosine kinase
            which is involved in calcium-induced regulation of ion channels and
            activation of the map kinase signaling pathway. The encoded protein
            may represent an important signaling intermediate between
            neuropeptide-activated receptors or neurotransmitters that increase
            calcium flux and the downstream signals that regulate neuronal
            activity. The encoded protein undergoes rapid tyrosine
            phosphorylation and activation in response to increases in the
            intracellular calcium concentration, nicotinic acetylcholine
            receptor activation, membrane depolarization, or protein kinase C
            activation. This protein has been shown to bind CRK-associated
            substrate, nephrocystin, GTPase regulator associated with FAK, and
            the SH2 domain of GRB2. The encoded protein is a member of the FAK
            subfamily of protein tyrosine kinases but lacks significant
            sequence similarity to kinases from other subfamilies. Four
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.244956.1,
                                           SRR1803617.276465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000346049.10/ ENSP00000332816.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               BC042599.2         19-514
            497-2794            U33284.1           437-2734
            2795-3188           AL120380.1         113-506
            3189-4048           AF311103.5         68384-69243
            4049-4074           AW130888.1         34-59               c
FEATURES             Location/Qualifiers
     source          1..4074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..4074
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /note="protein tyrosine kinase 2 beta"
                     /db_xref="GeneID:2185"
                     /db_xref="HGNC:HGNC:9612"
                     /db_xref="MIM:601212"
     exon            1..130
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            131..371
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..3197
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /EC_number="2.7.10.2"
                     /note="isoform a is encoded by transcript variant 3;
                     protein kinase B; cell adhesion kinase beta; related
                     adhesion focal tyrosine kinase; calcium-dependent tyrosine
                     kinase; proline-rich tyrosine kinase 2; focal adhesion
                     kinase 2; FADK 2; CAK-beta; calcium-regulated non-receptor
                     proline-rich tyrosine kinase; PTK2B protein tyrosine
                     kinase 2 beta"
                     /codon_start=1
                     /product="protein-tyrosine kinase 2-beta isoform a"
                     /protein_id="NP_775268.1"
                     /db_xref="CCDS:CCDS6057.1"
                     /db_xref="GeneID:2185"
                     /db_xref="HGNC:HGNC:9612"
                     /db_xref="MIM:601212"
                     /translation="MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVC
                     FYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEI
                     HWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRN
                     DYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQM
                     QENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNIT
                     VDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIK
                     TSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLS
                     ESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGE
                     KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYG
                     ELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLG
                     DFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQ
                     PFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDV
                     YQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVP
                     EGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWE
                     AEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPP
                     QKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVG
                     LTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEEC
                     KRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE"
     exon            372..550
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            551..638
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            639..718
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            719..781
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            782..836
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            837..977
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1052
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1154
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1272
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1312
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1359
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1410
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1508
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1593
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1694
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1810
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1911
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2001
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2206
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2315
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2381
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2507
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2654
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2690
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2715
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2762
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2900
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..2981
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..4074
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4055..4060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /note="hexamer: ATTAAA"
     polyA_site      4074
                     /gene="PTK2B"
                     /gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
                     RAFTK"
                     /note="major polyA site"
ORIGIN      
        1 ccttttactc agccacagcc tccggagccg ttgcacacct acctgcccgg ccgacttacc
       61 tgtacttgcc gccgtcccgg ctcacctggc ggtgcccgag gagtagtcgc tggagtccgc
      121 gcctccctgg gactgcaatg tgccgatctt agctgctgcc tgagaggatg tctggggtgt
      181 ccgagcccct gagtcgagta aagttgggca cgttacgccg gcctgaaggc cctgcagagc
      241 ccatggtggt ggtaccagta gatgtggaaa aggaggacgt gcgtatcctc aaggtctgct
      301 tctatagcaa cagcttcaat cctgggaaaa acttcaaact ggtcaaatgc actgtccaga
      361 cggagatccg ggagatcatc acctccatcc tgctgagcgg gcggatcggg cccaacatcc
      421 ggttggctga gtgctatggg ctgaggctga agcacatgaa gtccgatgag atccactggc
      481 tgcacccaca gatgacggtg ggtgaggtgc aggacaagta tgagtgtctg cacgtggaag
      541 ccgagtggag gtatgacctt caaatccgct acttgccaga agacttcatg gagagcctga
      601 aggaggacag gaccacgctg ctctattttt accaacagct ccggaacgac tacatgcagc
      661 gctacgccag caaggtcagc gagggcatgg ccctgcagct gggctgcctg gagctcaggc
      721 ggttcttcaa ggatatgccc cacaatgcac ttgacaagaa gtccaacttc gagctcctag
      781 aaaaggaagt ggggctggac ttgtttttcc caaagcagat gcaggagaac ttaaagccca
      841 aacagttccg gaagatgatc cagcagacct tccagcagta cgcctcgctc agggaggagg
      901 agtgcgtcat gaagttcttc aacactctcg ccggcttcgc caacatcgac caggagacct
      961 accgctgtga actcattcaa ggatggaaca ttactgtgga cctggtcatt ggccctaaag
     1021 ggatccgcca gctgactagt caggacgcaa agcccacctg cctggccgag ttcaagcaga
     1081 tcaggtccat caggtgcctc ccgctggagg agggccaggc agtacttcag ctgggcattg
     1141 aaggtgcccc ccaggccttg tccatcaaaa cctcatccct agcagaggct gagaacatgg
     1201 ctgacctcat agacggctac tgccggctgc agggtgagca ccaaggctct ctcatcatcc
     1261 atcctaggaa agatggtgag aagcggaaca gcctgcccca gatccccatg ctaaacctgg
     1321 aggcccggcg gtcccacctc tcagagagct gcagcataga gtcagacatc tacgcagaga
     1381 ttcccgacga aaccctgcga aggcccggag gtccacagta tggcattgcc cgtgaagatg
     1441 tggtcctgaa tcgtattctt ggggaaggct tttttgggga ggtctatgaa ggtgtctaca
     1501 caaatcacaa aggggagaaa atcaatgtag ctgtcaagac ctgcaagaaa gactgcactc
     1561 tggacaacaa ggagaagttc atgagcgagg cagtgatcat gaagaacctc gaccacccgc
     1621 acatcgtgaa gctgatcggc atcattgaag aggagcccac ctggatcatc atggaattgt
     1681 atccctatgg ggagctgggc cactacctgg agcggaacaa gaactccctg aaggtgctca
     1741 ccctcgtgct gtactcactg cagatatgca aagccatggc ctacctggag agcatcaact
     1801 gcgtgcacag ggacattgct gtccggaaca tcctggtggc ctcccctgag tgtgtgaagc
     1861 tgggggactt tggtctttcc cggtacattg aggacgagga ctattacaaa gcctctgtga
     1921 ctcgtctccc catcaaatgg atgtccccag agtccattaa cttccgacgc ttcacgacag
     1981 ccagtgacgt ctggatgttc gccgtgtgca tgtgggagat cctgagcttt gggaagcagc
     2041 ccttcttctg gctggagaac aaggatgtca tcggggtgct ggagaaagga gaccggctgc
     2101 ccaagcctga tctctgtcca ccggtccttt ataccctcat gacccgctgc tgggactacg
     2161 accccagtga ccggccccgc ttcaccgagc tggtgtgcag cctcagtgac gtttatcaga
     2221 tggagaagga cattgccatg gagcaagaga ggaatgctcg ctaccgaacc cccaaaatct
     2281 tggagcccac agccttccag gaacccccac ccaagcccag ccgacctaag tacagacccc
     2341 ctccgcaaac caacctcctg gctccaaagc tgcagttcca ggttcctgag ggtctgtgtg
     2401 ccagctctcc tacgctcacc agccctatgg agtatccatc tcccgttaac tcactgcaca
     2461 ccccacctct ccaccggcac aatgtcttca aacgccacag catgcgggag gaggacttca
     2521 tccaacccag cagccgagaa gaggcccagc agctgtggga ggctgaaaag gtcaaaatgc
     2581 ggcaaatcct ggacaaacag cagaagcaga tggtggagga ctaccagtgg ctcaggcagg
     2641 aggagaagtc cctggacccc atggtttata tgaatgataa gtccccattg acgccagaga
     2701 aggaggtcgg ctacctggag ttcacagggc ccccacagaa gcccccgagg ctgggcgcac
     2761 agtccatcca gcccacagct aacctggacc ggactgatga cctggtgtac ctcaatgtca
     2821 tggagctggt gcgggccgtg ctggagctca agaatgagct ctgtcagctg ccccccgagg
     2881 gctacgtggt ggtggtgaag aatgtggggc tgaccctgcg gaagctcatc gggagcgtgg
     2941 atgatctcct gccttccttg ccgtcatctt cacggacaga gatcgagggc acccagaaac
     3001 tgctcaacaa agacctggca gagctcatca acaagatgcg gctggcacag cagaacgccg
     3061 tgacctccct aagtgaggag tgcaagaggc agatgctgac ggcttcacac accctggctg
     3121 tggacgccaa gaacctgctc gacgctgtgg accaggccaa ggttctggcc aatctggccc
     3181 acccacctgc agagtgacgg agggtggggg ccacctgcct gcgtcttccg cccctgcctg
     3241 ccatgtacct cccctgcctt gctgttggtc atgtgggtct tccaggggga aggccaaggg
     3301 gagtcacctt cccttgccac tttgcacgac gccctctccc cacccctacc cctggctgta
     3361 ctgctcaggc tgcagctgga cagaggggac tctgggctat ggacacaggg tgacggtgac
     3421 aaagatggct cagaggggga ctgctgctgc ctggccactg ctccctaagc cagcctggtc
     3481 catgcagggg gctcctgggg gtggggaggt gtcacatggt gcccctagct ttatatatgg
     3541 acatggcagg ccgatttggg aaccaagcta ttcctttccc ttcctcttcg gccctcagat
     3601 gtcccttgat gcacagagaa gctggggagg agctttgttt tgggggtcag gcagccagtg
     3661 agatgaggga tgggcctggc attcttgtac agtgtatatt gaaatttatt taatgtgagt
     3721 ttggtctgga ctgacagcat gtgccctcct gagggaggac ctggggcaca gtccaggaac
     3781 aagctaattg ggagtccagg cacaggatgc tgtgttgtca acaaaccaag catcaggggg
     3841 aagaagcaga gagatgcggc caagatagga ccttgggcca aatccgctct cttcctgccc
     3901 ctctttctct ttcttccttt actttccctt gcttttccct cttttcttac tcctcctctt
     3961 tctctcccca acccccattc tcatctgcac ccttcttttc tcatgtgttt gcataaacat
     4021 tcttttaact tctttctatt tgacttgtgg ttgaattaaa attgtcccat ttgc
//
