LOCUS       XM_047422026            5097 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens protein tyrosine kinase 2 (PTK2),
            transcript variant X11, mRNA.
ACCESSION   XM_047422026
VERSION     XM_047422026.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..5097
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="protein tyrosine kinase 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 111 ESTs, 1661 long SRA reads, 3 Proteins, and 97%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 14 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
     CDS             181..3531
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /codon_start=1
                     /product="focal adhesion kinase 1 isoform X9"
                     /protein_id="XP_047277982.1"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
                     /translation="MWNPLTWMADCIAELGLPCIFQLQIQCLLQFPQSSSRITEEYDR
                     YLASSKIMAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTT
                     WASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVRE
                     KYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEI
                     ALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQ
                     QTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYL
                     TDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMA
                     DLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSDEISGDE
                     TDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIELGRCIGEGQFGDVHQGIYMSP
                     ENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELC
                     TLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCV
                     KLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMH
                     GVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL
                     STILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQ
                     HMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDST
                     VLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGS
                     LQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQE
                     ISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLA
                     TVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAA
                     HALAVDAKNLLDVIDQARLKMLGQTRPH"
ORIGIN      
        1 acggcctcga gggcgcgagc ccgcgccgcc gccgccgccg ccggtcccgg accactgtga
       61 gcccgcggcg tgaggcgtgg gaggaagcgc ggctgctgtc gcccagcgcc gccccgtcgt
      121 cgtctgcctt cgcttcacgg cgccgagccg cggtccgaat ccatggttgg ttgaatctgg
      181 atgtggaacc cgctgacgtg gatggctgac tgtattgcag aactggggct cccttgcatc
      241 ttccagttac aaattcagtg ccttctgcag tttccccaga gctcctcaag aataacggaa
      301 gaatatgaca gatacctagc atctagcaaa ataatggcag ctgcttacct tgaccccaac
      361 ttgaatcaca caccaaattc gagtactaag actcacctgg gtactggtat ggaacgttct
      421 cctggtgcaa tggagcgagt attaaaggtc tttcattatt ttgaaagcaa tagtgagcca
      481 accacctggg ccagtattat caggcatgga gatgctactg atgtcagggg catcattcag
      541 aagatagtgg acagtcacaa agtaaagcat gtggcctgct atggattccg cctcagtcac
      601 ctgcggtcag aggaggttca ctggcttcac gtggatatgg gcgtctccag tgtgagggag
      661 aagtatgagc ttgctcaccc accagaggag tggaaatatg aattgagaat tcgttatttg
      721 ccaaaaggat ttctaaacca gtttactgaa gataagccaa ctttgaattt cttctatcaa
      781 caggtgaaga gcgattatat gttagagata gctgatcaag tggaccagga aattgctttg
      841 aagttgggtt gtctagaaat acggcgatca tactgggaga tgcggggcaa tgcactagaa
      901 aagaagtcta actatgaagt attagaaaaa gatgttggtt taaagcgatt ttttcctaag
      961 agtttactgg attctgtcaa ggccaaaaca ctaagaaaac tgatccaaca aacatttaga
     1021 caatttgcca accttaatag agaagaaagt attctgaaat tctttgagat cctgtctcca
     1081 gtctacagat ttgataagga atgcttcaag tgtgctcttg gttcaagctg gattatttca
     1141 gtggaactgg caatcggccc agaagaagga atcagttacc taacggacaa gggctgcaat
     1201 cccacacatc ttgctgactt cactcaagtg caaaccattc agtattcaaa cagtgaagac
     1261 aaggacagaa aaggaatgct acaactaaaa atagcaggtg cacccgagcc tctgacagtg
     1321 acggcaccat ccctaaccat tgcggagaat atggctgacc taatagatgg gtactgccgg
     1381 ctggtgaatg gaacctcgca gtcatttatc atcagacctc agaaagaagg tgaacgggct
     1441 ttgccatcaa taccaaagtt ggccaacagc gaaaagcaag gcatgcggac acacgccgtc
     1501 tctgtgtcag atgaaattag tggggacgaa acagatgatt atgctgagat tatagatgaa
     1561 gaagatactt acaccatgcc ctcaaaaagc tatggaatag atgaagccag ggattatgag
     1621 attcaaagag aaagaataga acttggacga tgtattggag aaggccaatt tggagatgta
     1681 catcaaggca tttatatgag tccagagaat ccagctttgg cggttgcaat taaaacatgt
     1741 aaaaactgta cttcggacag cgtgagagag aaatttcttc aagaagcctt aacaatgcgt
     1801 cagtttgacc atcctcatat tgtgaagctg attggagtca tcacagagaa tcctgtctgg
     1861 ataatcatgg agctgtgcac acttggagag ctgaggtcat ttttgcaagt aaggaaatac
     1921 agtttggatc tagcatcttt gatcctgtat gcctatcagc ttagtacagc tcttgcatat
     1981 ctagagagca aaagatttgt acacagggac attgctgctc ggaatgttct ggtgtcctca
     2041 aatgattgtg taaaattagg agactttgga ttatcccgat atatggaaga tagtacttac
     2101 tacaaagctt ccaaaggaaa attgcctatt aaatggatgg ctccagagtc aatcaatttt
     2161 cgacgtttta cctcagctag tgacgtatgg atgtttggtg tgtgtatgtg ggagatactg
     2221 atgcatggtg tgaagccttt tcaaggagtg aagaacaatg atgtaatcgg tcgaattgaa
     2281 aatggggaaa gattaccaat gcctccaaat tgtcctccta ccctctacag ccttatgacg
     2341 aaatgctggg cctatgaccc cagcaggcgg cccaggttta ctgaacttaa agctcagctc
     2401 agcacaatcc tggaggaaga gaaggctcag caagaagagc gcatgaggat ggagtccaga
     2461 agacaggcca cagtgtcctg ggactccgga gggtctgatg aagcaccgcc caagcccagc
     2521 agaccgggtt atcccagtcc gaggtccagc gaaggatttt atcccagccc acagcacatg
     2581 gtacaaacca atcattacca ggtttctggc taccctggtt cacatggaat cacagccatg
     2641 gctggcagca tctatccagg tcaggcatct cttttggacc aaacagattc atggaatcat
     2701 agacctcagg agatagcaat gtggcagccc aatgtggagg actctacagt attggacctg
     2761 cgagggattg ggcaagtgtt gccaacccat ctgatggaag agcgtctaat ccgacagcaa
     2821 caggaaatgg aagaagatca gcgctggctg gaaaaagagg aaagatttct gaaacctgat
     2881 gtgagactct ctcgaggcag tattgacagg gaggatggaa gtcttcaggg tccgattgga
     2941 aaccaacata tatatcagcc tgtgggtaaa ccagatcctg cagctccacc aaagaaaccg
     3001 cctcgccctg gagctcccgg tcatctggga agccttgcca gcctcagcag ccctgctgac
     3061 agctacaacg agggtgtcaa gcttcagccc caggaaatca gcccccctcc tactgccaac
     3121 ctggaccggt cgaatgataa ggtgtacgag aatgtgacgg gcctggtgaa agctgtcatc
     3181 gagatgtcca gtaaaatcca gccagcccca ccagaggagt atgtccctat ggtgaaggaa
     3241 gtcggcttgg ccctgaggac attattggcc actgtggatg agaccattcc cctcctacca
     3301 gccagcaccc accgagagat tgagatggca cagaagctat tgaactctga cctgggtgag
     3361 ctcatcaaca agatgaaact ggcccagcag tatgtcatga ccagcctcca gcaagagtac
     3421 aaaaagcaaa tgctgactgc tgctcacgcc ctggctgtgg atgccaaaaa cttactcgat
     3481 gtcattgacc aagcaagact gaaaatgctt gggcagacga gaccacactg agcctcccct
     3541 aggagcacgt cttgctaccc tcttttgaag atgttctcta gccttccacc agcagcgagg
     3601 aattaaccct gtgtcctcag tcgccagcac ttacagctcc aacttttttg aatgaccatc
     3661 tggttgaaaa atctttctca tataagttta accacacttt gatttgggtt cattttttgt
     3721 tttgtttttt tcaatcatga tattcagaaa aatccaggat ccaaaatgtg gcgtttttct
     3781 aagaatgaaa attatatgta agcttttaag catcatgaag aacaatttat gttcacatta
     3841 agatacgttc taaaggggga tggccaaggg gtgacatctt aattcctaaa ctaccttagc
     3901 tgcatagtgg aagaggagag catgaagcaa agaattccag gaaacccaag aggctgagaa
     3961 ttcttttgtc taccatagaa ttattatcca gactggaatt tttgtttgtt agaacaccct
     4021 tcagttgcaa tatgctaatc ccactttaca aagaatataa aagctatatt ttgaagactt
     4081 gagttatttc agaaaaaact acagcccttt ttgtcttacc tgccttttac tttcgtgtgg
     4141 atatgtgaag cattgggtcg ggaactagct gtagaacaca actaaaaact catgtctttt
     4201 ttcacagaat aatgtgccag ttttttgtag caatgttatt tctcttggaa gcagaaatgc
     4261 tttgtaccag agcacctcca aactgcattg aggagaagtt ccagaaccat cccctttttc
     4321 catttttata taatttataa agaaagatta aagccatgtt gactatttta cagccactgg
     4381 agttaactaa cccttccttg tatctgtctt cccaggagag aatgaagcaa aacaggaatt
     4441 tggttttctt ttgatgtcca gttacaccat ccattctgtt aattttgaaa aaatataccc
     4501 tccctttagt ttgttggggg atataaatta ttctcaggaa gaatataatg aactgtacag
     4561 ttactttgac ctattaaaaa ggtgttacca gtaaagttct tgttgtaata tcctttcttt
     4621 tggttctgtt tcttcagatg gcttttcagg tgacttgtca gataagataa catacaagag
     4681 agttcccaat aattatcagg aagcctctca ctaattagtt tctttttttt tatttaatct
     4741 tctaaacaag tcaaggatgt taccacagaa gggtagcgtg gcgtaagtta accttttcat
     4801 tccatcgtca cctattaaat gcagagctca ggatggaagt agcaatggtc ttcaatgaaa
     4861 gaaccttccc ctgcgcaggg tctcactatt ccgctaactc ggactcaaag cataattcac
     4921 ttgtcaagga aattgttagc atttcccagg cccaccctag tcttgctaga atctctgtga
     4981 gccacagagc agggagcaaa tagaactgag atctccagca ctagggactc agactccaaa
     5041 gggagggatt tgagtgaatt ttttccaggt aaatacatgc tcttatgtgc aaaagca
//
