LOCUS       NM_001387651            2119 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens protein tyrosine kinase 2 (PTK2), transcript variant
            125, mRNA.
ACCESSION   NM_001387651
VERSION     NM_001387651.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Tang,Z.Y., Wang,X.M., Xu,C.W., Sun,Q.Q., Hua,Y.X., Zhou,Q.Y.,
            Hu,H.Y., Liu,S.B., Guo,Y.J., Ao,L., Che,X., Zhang,X.C., Heger,M.,
            Zheng,X., Liu,A.J., Wang,Q., Zhan,Z.J., Cheng,S.Q. and Pan,W.W.
  TITLE     DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 421 (2024)
   PUBMED   39367995
  REMARK    GeneRIF: DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Chen,A., Zhang,J., Yan,Z., Lu,Y., Chen,W., Sun,Y., Gu,Q., Li,F.,
            Yang,Y., Qiu,S., Lin,X., Zhang,D., Teng,J., Fang,Y., Shen,B.,
            Song,N. and Ding,X.
  TITLE     Acidic preconditioning induced intracellular acid adaptation to
            protect renal injury via dynamic phosphorylation of focal adhesion
            kinase-dependent activation of sodium hydrogen exchanger 1
  JOURNAL   Cell Commun Signal 22 (1), 393 (2024)
   PUBMED   39118129
  REMARK    GeneRIF: Acidic preconditioning induced intracellular acid
            adaptation to protect renal injury via dynamic phosphorylation of
            focal adhesion kinase-dependent activation of sodium hydrogen
            exchanger 1.
            Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi:
            10.1186/s12964-024-01815-3.. PMID: 39261884]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Brown,N.D. and Vomhof-DeKrey,E.E.
  TITLE     Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal
            Homeostasis and Innate Immunity Crosstalk
  JOURNAL   Cells 13 (14), 1178 (2024)
   PUBMED   39056760
  REMARK    GeneRIF: Focal Adhesion Kinase and Colony Stimulating Factors:
            Intestinal Homeostasis and Innate Immunity Crosstalk.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Markowska,A., de Mezer,M., Kurzawa,P., Bednarek,W., Grybos,A.,
            Krzyzaniak,M., Markowska,J., Grybos,M. and Zurawski,J.
  TITLE     Analysis of Expression of the ANG1, CaSR and FAK Proteins in
            Uterine Fibroids
  JOURNAL   Int J Mol Sci 25 (13), 7164 (2024)
   PUBMED   39000274
  REMARK    GeneRIF: Analysis of Expression of the ANG1, CaSR and FAK Proteins
            in Uterine Fibroids.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Park,S.Y., Choi,H., Choi,S.M., Wang,S., Shim,S., Jun,W., Lee,J. and
            Chung,J.W.
  TITLE     T-plastin contributes to epithelial-mesenchymal transition in human
            lung cancer cells through FAK/AKT/Slug axis signaling pathway
  JOURNAL   BMB Rep 57 (6), 305-310 (2024)
   PUBMED   38835117
  REMARK    GeneRIF: T-plastin contributes to epithelial-mesenchymal transition
            in human lung cancer cells through FAK/AKT/Slug axis signaling
            pathway.
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Polte,T.R. and Hanks,S.K.
  TITLE     Interaction between focal adhesion kinase and Crk-associated
            tyrosine kinase substrate p130Cas
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10678-10682 (1995)
   PUBMED   7479864
REFERENCE   7  (bases 1 to 2119)
  AUTHORS   Guinebault,C., Payrastre,B., Racaud-Sultan,C., Mazarguil,H.,
            Breton,M., Mauco,G., Plantavid,M. and Chap,H.
  TITLE     Integrin-dependent translocation of phosphoinositide 3-kinase to
            the cytoskeleton of thrombin-activated platelets involves specific
            interactions of p85 alpha with actin filaments and focal adhesion
            kinase
  JOURNAL   J Cell Biol 129 (3), 831-842 (1995)
   PUBMED   7537275
REFERENCE   8  (bases 1 to 2119)
  AUTHORS   Calalb,M.B., Polte,T.R. and Hanks,S.K.
  TITLE     Tyrosine phosphorylation of focal adhesion kinase at sites in the
            catalytic domain regulates kinase activity: a role for Src family
            kinases
  JOURNAL   Mol Cell Biol 15 (2), 954-963 (1995)
   PUBMED   7529876
REFERENCE   9  (bases 1 to 2119)
  AUTHORS   Bergman,M., Joukov,V., Virtanen,I. and Alitalo,K.
  TITLE     Overexpressed Csk tyrosine kinase is localized in focal adhesions,
            causes reorganization of alpha v beta 5 integrin, and interferes
            with HeLa cell spreading
  JOURNAL   Mol Cell Biol 15 (2), 711-722 (1995)
   PUBMED   7529872
REFERENCE   10 (bases 1 to 2119)
  AUTHORS   Schaller,M.D., Hildebrand,J.D., Shannon,J.D., Fox,J.W., Vines,R.R.
            and Parsons,J.T.
  TITLE     Autophosphorylation of the focal adhesion kinase, pp125FAK, directs
            SH2-dependent binding of pp60src
  JOURNAL   Mol Cell Biol 14 (3), 1680-1688 (1994)
   PUBMED   7509446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100860.2 and AC105009.13.
            
            Summary: This gene encodes a cytoplasmic protein tyrosine kinase
            which is found concentrated in the focal adhesions that form
            between cells growing in the presence of extracellular matrix
            constituents. The encoded protein is a member of the FAK subfamily
            of protein tyrosine kinases but lacks significant sequence
            similarity to kinases from other subfamilies. Activation of this
            gene may be an important early step in cell growth and
            intracellular signal transduction pathways triggered in response to
            certain neural peptides or to cell interactions with the
            extracellular matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA858598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC100860.2         65272-65396
            126-352             AC105009.13        32898-33124
            353-2119            AC105009.13        44030-45796
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2119
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="protein tyrosine kinase 2"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
     exon            1..125
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            126..352
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..523
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /EC_number="2.7.10.2"
                     /note="isoform 69 is encoded by transcript variant 125;
                     focal adhesion kinase 1; FAK-related non-kinase
                     polypeptide; focal adhesion kinase-related nonkinase;
                     protein phosphatase 1 regulatory subunit 71; PTK2 protein
                     tyrosine kinase 2"
                     /codon_start=1
                     /product="focal adhesion kinase 1 isoform 69"
                     /protein_id="NP_001374580.1"
                     /db_xref="CCDS:CCDS94345.1"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
                     /translation="MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFE
                     SNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDM
                     GVSSVREKYELAHPPEEWK"
     exon            353..2119
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      807..812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: AATAAA"
     polyA_site      828
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="major polyA site"
     regulatory      2096..2101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgggg cggatgcggc ggagaccggc ccctcccgcg cccccggccc gggttctggg
       61 aggaggggag gccggtggcc gtgaggaggt tgggggccct cgcggaggcc gagaggctta
      121 aggagaatat gacagatacc tagcatctag caaaataatg gcagctgctt accttgaccc
      181 caacttgaat cacacaccaa attcgagtac taagactcac ctgggtactg gtatggaacg
      241 ttctcctggt gcaatggagc gagtattaaa ggtctttcat tattttgaaa gcaatagtga
      301 gccaaccacc tgggccagta ttatcaggca tggagatgct actgatgtca ggggcatcat
      361 tcagaagata gtggacagtc acaaagtaaa gcatgtggcc tgctatggat tccgcctcag
      421 tcacctgcgg tcagaggagg ttcactggct tcacgtggat atgggcgtct ccagtgtgag
      481 ggagaagtat gagcttgctc acccaccaga ggagtggaag taagatacaa acctgctttg
      541 gtgtgatgca cacttgattt cttttgcttt ttaaaaacat gcacaagata acaaatgtat
      601 atgtttaatt ttcacactgc ttgtcattac aactctggta taaataaaat tcgttagtaa
      661 ttattaacga atgatctctt ctagacctct agtctagctt ttgggtatta ttaattatac
      721 tttgagccat ctgatttccg ttttctgtga tggtcttttg ctagctaatt tctcatcagt
      781 gctactttgt ttcaaccttt gctcccaata aaactcaaat catatatata tgtgtgtgtg
      841 tatgtatata tatataatgt tttcatccct tgtcatcctt ttatgtagca ggagttgctg
      901 tcactcctaa ataccttatt aatgggctac atagcttgtt ttattatgcc ctgtaatcta
      961 gagcgcacct acaaagagtg agtgtatatt tgatattcac atgcaacgtt aaaattagga
     1021 cgtaatctct taatgactcc tgttgaaatg ttaaggaaaa taaaattatt tcagggcaaa
     1081 ttaaaagaat tccctataat tgttcttttt ctggtctccc ctactaattt tttttttttt
     1141 tttttactac taagcaactc aagatgttac taggaaattg tacatctaaa atacatttgt
     1201 gagaggtata acttgtaaaa atgggcttct ttcactaggg ttctaatttt tataggcaat
     1261 gctacagaaa taaagataat tgtaggctga agagtgcatt caaagggtca gtaactttga
     1321 aggatctaga ttgattaggg tagacatttt aaaagacaaa catgttaagg tgaataattt
     1381 tttttttttc ttttttgaga cagagtctcg ccctgtcacc caggctgcag tacggtggca
     1441 tgaacatggc tcactgcagc ctcttgggct caagcgattc tcccacttca gcttcttgag
     1501 tagctgggac tgtaggcaca gaccgccacg cccagctaat ttttgtattg tttacagagc
     1561 tggggtttca gcatgttgcc cagacagatc tcaaactcct gggctcaaac agtctgccca
     1621 ccttggcctc ccaaagtgtt gggattacag gtgtgagcca ccatgcccag cctgaataaa
     1681 tcttatgttg aataaaaccc tacgccagtt acagagttca tcaaagaaat atagctgtat
     1741 tttcaaattt gtcaggtagc tggtaccaag ctaacaaaat actccttgag aatatagttt
     1801 cattggttca catcaatggc tagagaagat ttgacttcca actatttagt caattaagca
     1861 agtgagcatt ccaaaacaaa ggatatgtaa aagttagata aaaatacctg cagggttttt
     1921 gtgttgtttt gttttttgag atggtcatct tgctgtgttg cttgggctgg tcttgaactc
     1981 ccctactcag gtgatcctcc tgtgtcaagg tacttttatt taacacaagt ctattatctt
     2041 ggtttatatg gacatgtcag atgcagactt tgttataatg aaatccttag tgctcaataa
     2101 aatggtcatt gaatctaaa
//
