LOCUS       NM_001387621            4416 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens protein tyrosine kinase 2 (PTK2), transcript variant
            95, mRNA.
ACCESSION   NM_001387621
VERSION     NM_001387621.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4416)
  AUTHORS   Tang,Z.Y., Wang,X.M., Xu,C.W., Sun,Q.Q., Hua,Y.X., Zhou,Q.Y.,
            Hu,H.Y., Liu,S.B., Guo,Y.J., Ao,L., Che,X., Zhang,X.C., Heger,M.,
            Zheng,X., Liu,A.J., Wang,Q., Zhan,Z.J., Cheng,S.Q. and Pan,W.W.
  TITLE     DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 421 (2024)
   PUBMED   39367995
  REMARK    GeneRIF: DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4416)
  AUTHORS   Chen,A., Zhang,J., Yan,Z., Lu,Y., Chen,W., Sun,Y., Gu,Q., Li,F.,
            Yang,Y., Qiu,S., Lin,X., Zhang,D., Teng,J., Fang,Y., Shen,B.,
            Song,N. and Ding,X.
  TITLE     Acidic preconditioning induced intracellular acid adaptation to
            protect renal injury via dynamic phosphorylation of focal adhesion
            kinase-dependent activation of sodium hydrogen exchanger 1
  JOURNAL   Cell Commun Signal 22 (1), 393 (2024)
   PUBMED   39118129
  REMARK    GeneRIF: Acidic preconditioning induced intracellular acid
            adaptation to protect renal injury via dynamic phosphorylation of
            focal adhesion kinase-dependent activation of sodium hydrogen
            exchanger 1.
            Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi:
            10.1186/s12964-024-01815-3.. PMID: 39261884]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4416)
  AUTHORS   Brown,N.D. and Vomhof-DeKrey,E.E.
  TITLE     Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal
            Homeostasis and Innate Immunity Crosstalk
  JOURNAL   Cells 13 (14), 1178 (2024)
   PUBMED   39056760
  REMARK    GeneRIF: Focal Adhesion Kinase and Colony Stimulating Factors:
            Intestinal Homeostasis and Innate Immunity Crosstalk.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4416)
  AUTHORS   Markowska,A., de Mezer,M., Kurzawa,P., Bednarek,W., Grybos,A.,
            Krzyzaniak,M., Markowska,J., Grybos,M. and Zurawski,J.
  TITLE     Analysis of Expression of the ANG1, CaSR and FAK Proteins in
            Uterine Fibroids
  JOURNAL   Int J Mol Sci 25 (13), 7164 (2024)
   PUBMED   39000274
  REMARK    GeneRIF: Analysis of Expression of the ANG1, CaSR and FAK Proteins
            in Uterine Fibroids.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4416)
  AUTHORS   Park,S.Y., Choi,H., Choi,S.M., Wang,S., Shim,S., Jun,W., Lee,J. and
            Chung,J.W.
  TITLE     T-plastin contributes to epithelial-mesenchymal transition in human
            lung cancer cells through FAK/AKT/Slug axis signaling pathway
  JOURNAL   BMB Rep 57 (6), 305-310 (2024)
   PUBMED   38835117
  REMARK    GeneRIF: T-plastin contributes to epithelial-mesenchymal transition
            in human lung cancer cells through FAK/AKT/Slug axis signaling
            pathway.
REFERENCE   6  (bases 1 to 4416)
  AUTHORS   Polte,T.R. and Hanks,S.K.
  TITLE     Interaction between focal adhesion kinase and Crk-associated
            tyrosine kinase substrate p130Cas
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10678-10682 (1995)
   PUBMED   7479864
REFERENCE   7  (bases 1 to 4416)
  AUTHORS   Guinebault,C., Payrastre,B., Racaud-Sultan,C., Mazarguil,H.,
            Breton,M., Mauco,G., Plantavid,M. and Chap,H.
  TITLE     Integrin-dependent translocation of phosphoinositide 3-kinase to
            the cytoskeleton of thrombin-activated platelets involves specific
            interactions of p85 alpha with actin filaments and focal adhesion
            kinase
  JOURNAL   J Cell Biol 129 (3), 831-842 (1995)
   PUBMED   7537275
REFERENCE   8  (bases 1 to 4416)
  AUTHORS   Calalb,M.B., Polte,T.R. and Hanks,S.K.
  TITLE     Tyrosine phosphorylation of focal adhesion kinase at sites in the
            catalytic domain regulates kinase activity: a role for Src family
            kinases
  JOURNAL   Mol Cell Biol 15 (2), 954-963 (1995)
   PUBMED   7529876
REFERENCE   9  (bases 1 to 4416)
  AUTHORS   Bergman,M., Joukov,V., Virtanen,I. and Alitalo,K.
  TITLE     Overexpressed Csk tyrosine kinase is localized in focal adhesions,
            causes reorganization of alpha v beta 5 integrin, and interferes
            with HeLa cell spreading
  JOURNAL   Mol Cell Biol 15 (2), 711-722 (1995)
   PUBMED   7529872
REFERENCE   10 (bases 1 to 4416)
  AUTHORS   Schaller,M.D., Hildebrand,J.D., Shannon,J.D., Fox,J.W., Vines,R.R.
            and Parsons,J.T.
  TITLE     Autophosphorylation of the focal adhesion kinase, pp125FAK, directs
            SH2-dependent binding of pp60src
  JOURNAL   Mol Cell Biol 14 (3), 1680-1688 (1994)
   PUBMED   7509446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100860.2, AC105009.13,
            AC105235.7 and AC067931.16.
            
            Summary: This gene encodes a cytoplasmic protein tyrosine kinase
            which is found concentrated in the focal adhesions that form
            between cells growing in the presence of extracellular matrix
            constituents. The encoded protein is a member of the FAK subfamily
            of protein tyrosine kinases but lacks significant sequence
            similarity to kinases from other subfamilies. Activation of this
            gene may be an important early step in cell growth and
            intracellular signal transduction pathways triggered in response to
            certain neural peptides or to cell interactions with the
            extracellular matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1924092.1,
                                           SRR18074967.2807362.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC100860.2         64994-65151
            159-216             AC100860.2         117553-117610
            217-443             AC105009.13        32898-33124
            444-610             AC105009.13        44030-44196
            611-698             AC105009.13        59268-59355
            699-778             AC105009.13        76989-77068
            779-841             AC105009.13        77345-77407
            842-982             AC105235.7         105014-105154       c
            983-1060            AC105235.7         104411-104488       c
            1061-1168           AC105235.7         89677-89784         c
            1169-1286           AC105235.7         86593-86710         c
            1287-1317           AC105235.7         79488-79518         c
            1318-1370           AC105235.7         75608-75660         c
            1371-1427           AC105235.7         50368-50424         c
            1428-1525           AC105235.7         47299-47396         c
            1526-1610           AC105235.7         38366-38450         c
            1611-1711           AC105235.7         32894-32994         c
            1712-1827           AC105235.7         30786-30901         c
            1828-1928           AC105235.7         29364-29464         c
            1929-2018           AC105235.7         25152-25241         c
            2019-2223           AC105235.7         21385-21589         c
            2224-2335           AC067931.16        194228-194339       c
            2336-2422           AC067931.16        182749-182835       c
            2423-2560           AC067931.16        179200-179337       c
            2561-2692           AC067931.16        177521-177652       c
            2693-2755           AC067931.16        163262-163324       c
            2756-2795           AC067931.16        152090-152129       c
            2796-2902           AC067931.16        150928-151034       c
            2903-3058           AC067931.16        144899-145054       c
            3059-3139           AC067931.16        141547-141627       c
            3140-4416           AC067931.16        135032-136308       c
FEATURES             Location/Qualifiers
     source          1..4416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..4416
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="protein tyrosine kinase 2"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
     exon            1..158
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            159..216
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            217..443
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            444..610
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            611..698
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            699..778
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            779..841
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            842..982
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1060
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1168
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     CDS             1136..3352
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /EC_number="2.7.10.2"
                     /note="isoform 71 is encoded by transcript variant 95;
                     focal adhesion kinase 1; FAK-related non-kinase
                     polypeptide; focal adhesion kinase-related nonkinase;
                     protein phosphatase 1 regulatory subunit 71; PTK2 protein
                     tyrosine kinase 2"
                     /codon_start=1
                     /product="focal adhesion kinase 1 isoform 71"
                     /protein_id="NP_001374550.1"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
                     /translation="MLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSF
                     IIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYE
                     IQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALT
                     MRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLST
                     ALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMA
                     PESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP
                     PTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSG
                     GSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQ
                     ASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEED
                     QRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPG
                     APGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEM
                     SSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGE
                     LINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH"
     exon            1169..1286
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1317
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1370
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1427
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1525
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1610
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1711
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1827
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1928
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2018
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2223
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2335
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2422
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2560
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2692
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2755
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2795
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2902
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3058
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3139
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..4416
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4394..4399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: ATTAAA"
     polyA_site      4416
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="major polyA site"
ORIGIN      
        1 acggcctcga gggcgcgagc ccgcgccgcc gccgccgccg ccggtcccgg accactgtga
       61 gcccgcggcg tgaggcgtgg gaggaagcgc ggctgctgtc gcccagcgcc gccccgtcgt
      121 cgtctgcctt cgcttcacgg cgccgagccg cggtccgaat ccatggttgg ttgaatctgg
      181 atgtggaacc cgctgacgtg gatggctgac tgtattaata tgacagatac ctagcatcta
      241 gcaaaataat ggcagctgct taccttgacc ccaacttgaa tcacacacca aattcgagta
      301 ctaagactca cctgggtact ggtatggaac gttctcctgg tgcaatggag cgagtattaa
      361 aggtctttca ttattttgaa agcaatagtg agccaaccac ctgggccagt attatcaggc
      421 atggagatgc tactgatgtc aggggcatca ttcagaagat agtggacagt cacaaagtaa
      481 agcatgtggc ctgctatgga ttccgcctca gtcacctgcg gtcagaggag gttcactggc
      541 ttcacgtgga tatgggcgtc tccagtgtga gggagaagta tgagcttgct cacccaccag
      601 aggagtggaa atatgaattg agaattcgtt atttgccaaa aggatttcta aaccagttta
      661 ctgaagataa gccaactttg aatttcttct atcaacaggt gaagagcgat tatatgttag
      721 agatagctga tcaagtggac caggaaattg ctttgaagtt gggttgtcta gaaatacggc
      781 gatcatactg ggagatgcgg ggcaatgcac tagaaaagaa gtctaactat gaagtattag
      841 agccaaaaca ctaagaaaac tgatccaaca aacatttaga caatttgcca accttaatag
      901 agaagaaagt attctgaaat tctttgagat cctgtctcca gtctacagat ttgataagga
      961 atgcttcaag tgtgctcttg gttcaagctg gattatttca gtggaactgg caatcggccc
     1021 agaagaagga atcagttacc taacggacaa gggctgcaat cccacacatc ttgctgactt
     1081 cactcaagtg caaaccattc agtattcaaa cagtgaagac aaggacagaa aaggaatgct
     1141 acaactaaaa atagcaggtg cacccgagcc tctgacagtg acggcaccat ccctaaccat
     1201 tgcggagaat atggctgacc taatagatgg gtactgccgg ctggtgaatg gaacctcgca
     1261 gtcatttatc atcagacctc agaaagaagg tgaacgggct ttgccatcaa taccaaagtt
     1321 ggccaacagc gaaaagcaag gcatgcggac acacgccgtc tctgtgtcag aaacagatga
     1381 ttatgctgag attatagatg aagaagatac ttacaccatg ccctcaacca gggattatga
     1441 gattcaaaga gaaagaatag aacttggacg atgtattgga gaaggccaat ttggagatgt
     1501 acatcaaggc atttatatga gtccagagaa tccagctttg gcggttgcaa ttaaaacatg
     1561 taaaaactgt acttcggaca gcgtgagaga gaaatttctt caagaagcct taacaatgcg
     1621 tcagtttgac catcctcata ttgtgaagct gattggagtc atcacagaga atcctgtctg
     1681 gataatcatg gagctgtgca cacttggaga gctgaggtca tttttgcaag taaggaaata
     1741 cagtttggat ctagcatctt tgatcctgta tgcctatcag cttagtacag ctcttgcata
     1801 tctagagagc aaaagatttg tacacaggga cattgctgct cggaatgttc tggtgtcctc
     1861 aaatgattgt gtaaaattag gagactttgg attatcccga tatatggaag atagtactta
     1921 ctacaaagct tccaaaggaa aattgcctat taaatggatg gctccagagt caatcaattt
     1981 tcgacgtttt acctcagcta gtgacgtatg gatgtttggt gtgtgtatgt gggagatact
     2041 gatgcatggt gtgaagcctt ttcaaggagt gaagaacaat gatgtaatcg gtcgaattga
     2101 aaatggggaa agattaccaa tgcctccaaa ttgtcctcct accctctaca gccttatgac
     2161 gaaatgctgg gcctatgacc ccagcaggcg gcccaggttt actgaactta aagctcagct
     2221 cagcacaatc ctggaggaag agaaggctca gcaagaagag cgcatgagga tggagtccag
     2281 aagacaggcc acagtgtcct gggactccgg agggtctgat gaagcaccgc ccaagcccag
     2341 cagaccgggt tatcccagtc cgaggtccag cgaaggattt tatcccagcc cacagcacat
     2401 ggtacaaacc aatcattacc aggtttctgg ctaccctggt tcacatggaa tcacagccat
     2461 ggctggcagc atctatccag gtcaggcatc tcttttggac caaacagatt catggaatca
     2521 tagacctcag gagatagcaa tgtggcagcc caatgtggag gactctacag tattggacct
     2581 gcgagggatt gggcaagtgt tgccaaccca tctgatggaa gagcgtctaa tccgacagca
     2641 acaggaaatg gaagaagatc agcgctggct ggaaaaagag gaaagatttc tgaaacctga
     2701 tgtgagactc tctcgaggca gtattgacag ggaggatgga agtcttcagg gtccgattgg
     2761 aaaccaacat atatatcagc ctgtgggtaa accagatcct gcagctccac caaagaaacc
     2821 gcctcgccct ggagctcccg gtcatctggg aagccttgcc agcctcagca gccctgctga
     2881 cagctacaac gagggtgtca agcttcagcc ccaggaaatc agcccccctc ctactgccaa
     2941 cctggaccgg tcgaatgata aggtgtacga gaatgtgacg ggcctggtga aagctgtcat
     3001 cgagatgtcc agtaaaatcc agccagcccc accagaggag tatgtcccta tggtgaagga
     3061 agtcggcttg gccctgagga cattattggc cactgtggat gagaccattc ccctcctacc
     3121 agccagcacc caccgagaga ttgagatggc acagaagcta ttgaactctg acctgggtga
     3181 gctcatcaac aagatgaaac tggcccagca gtatgtcatg accagcctcc agcaagagta
     3241 caaaaagcaa atgctgactg ctgctcacgc cctggctgtg gatgccaaaa acttactcga
     3301 tgtcattgac caagcaagac tgaaaatgct tgggcagacg agaccacact gagcctcccc
     3361 taggagcacg tcttgctacc ctcttttgaa gatgttctct agccttccac cagcagcgag
     3421 gaattaaccc tgtgtcctca gtcgccagca cttacagctc caactttttt gaatgaccat
     3481 ctggttgaaa aatctttctc atataagttt aaccacactt tgatttgggt tcattttttg
     3541 ttttgttttt ttcaatcatg atattcagaa aaatccagga tccaaaatgt ggcgtttttc
     3601 taagaatgaa aattatatgt aagcttttaa gcatcatgaa gaacaattta tgttcacatt
     3661 aagatacgtt ctaaaggggg atggccaagg ggtgacatct taattcctaa actaccttag
     3721 ctgcatagtg gaagaggaga gcatgaagca aagaattcca ggaaacccaa gaggctgaga
     3781 attcttttgt ctaccataga attattatcc agactggaat ttttgtttgt tagaacaccc
     3841 ttcagttgca atatgctaat cccactttac aaagaatata aaagctatat tttgaagact
     3901 tgagttattt cagaaaaaac tacagccctt tttgtcttac ctgcctttta ctttcgtgtg
     3961 gatatgtgaa gcattgggtc gggaactagc tgtagaacac aactaaaaac tcatgtcttt
     4021 tttcacagaa taatgtgcca gttttttgta gcaatgttat ttctcttgga agcagaaatg
     4081 ctttgtacca gagcacctcc aaactgcatt gaggagaagt tccagaacca tccccttttt
     4141 ccatttttat ataatttata aagaaagatt aaagccatgt tgactatttt acagccactg
     4201 gagttaacta acccttcctt gtatctgtct tcccaggaga gaatgaagca aaacaggaat
     4261 ttggttttct tttgatgtcc agttacacca tccattctgt taattttgaa aaaatatacc
     4321 ctccctttag tttgttgggg gatataaatt attctcagga agaatataat gaactgtaca
     4381 gttactttga cctattaaaa aggtgttacc agtaaa
//
