LOCUS       NM_001387584            4154 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens protein tyrosine kinase 2 (PTK2), transcript variant
            68, mRNA.
ACCESSION   NM_001387584
VERSION     NM_001387584.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4154)
  AUTHORS   Tang,Z.Y., Wang,X.M., Xu,C.W., Sun,Q.Q., Hua,Y.X., Zhou,Q.Y.,
            Hu,H.Y., Liu,S.B., Guo,Y.J., Ao,L., Che,X., Zhang,X.C., Heger,M.,
            Zheng,X., Liu,A.J., Wang,Q., Zhan,Z.J., Cheng,S.Q. and Pan,W.W.
  TITLE     DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 421 (2024)
   PUBMED   39367995
  REMARK    GeneRIF: DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4154)
  AUTHORS   Chen,A., Zhang,J., Yan,Z., Lu,Y., Chen,W., Sun,Y., Gu,Q., Li,F.,
            Yang,Y., Qiu,S., Lin,X., Zhang,D., Teng,J., Fang,Y., Shen,B.,
            Song,N. and Ding,X.
  TITLE     Acidic preconditioning induced intracellular acid adaptation to
            protect renal injury via dynamic phosphorylation of focal adhesion
            kinase-dependent activation of sodium hydrogen exchanger 1
  JOURNAL   Cell Commun Signal 22 (1), 393 (2024)
   PUBMED   39118129
  REMARK    GeneRIF: Acidic preconditioning induced intracellular acid
            adaptation to protect renal injury via dynamic phosphorylation of
            focal adhesion kinase-dependent activation of sodium hydrogen
            exchanger 1.
            Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi:
            10.1186/s12964-024-01815-3.. PMID: 39261884]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4154)
  AUTHORS   Brown,N.D. and Vomhof-DeKrey,E.E.
  TITLE     Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal
            Homeostasis and Innate Immunity Crosstalk
  JOURNAL   Cells 13 (14), 1178 (2024)
   PUBMED   39056760
  REMARK    GeneRIF: Focal Adhesion Kinase and Colony Stimulating Factors:
            Intestinal Homeostasis and Innate Immunity Crosstalk.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4154)
  AUTHORS   Markowska,A., de Mezer,M., Kurzawa,P., Bednarek,W., Grybos,A.,
            Krzyzaniak,M., Markowska,J., Grybos,M. and Zurawski,J.
  TITLE     Analysis of Expression of the ANG1, CaSR and FAK Proteins in
            Uterine Fibroids
  JOURNAL   Int J Mol Sci 25 (13), 7164 (2024)
   PUBMED   39000274
  REMARK    GeneRIF: Analysis of Expression of the ANG1, CaSR and FAK Proteins
            in Uterine Fibroids.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4154)
  AUTHORS   Park,S.Y., Choi,H., Choi,S.M., Wang,S., Shim,S., Jun,W., Lee,J. and
            Chung,J.W.
  TITLE     T-plastin contributes to epithelial-mesenchymal transition in human
            lung cancer cells through FAK/AKT/Slug axis signaling pathway
  JOURNAL   BMB Rep 57 (6), 305-310 (2024)
   PUBMED   38835117
  REMARK    GeneRIF: T-plastin contributes to epithelial-mesenchymal transition
            in human lung cancer cells through FAK/AKT/Slug axis signaling
            pathway.
REFERENCE   6  (bases 1 to 4154)
  AUTHORS   Polte,T.R. and Hanks,S.K.
  TITLE     Interaction between focal adhesion kinase and Crk-associated
            tyrosine kinase substrate p130Cas
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10678-10682 (1995)
   PUBMED   7479864
REFERENCE   7  (bases 1 to 4154)
  AUTHORS   Guinebault,C., Payrastre,B., Racaud-Sultan,C., Mazarguil,H.,
            Breton,M., Mauco,G., Plantavid,M. and Chap,H.
  TITLE     Integrin-dependent translocation of phosphoinositide 3-kinase to
            the cytoskeleton of thrombin-activated platelets involves specific
            interactions of p85 alpha with actin filaments and focal adhesion
            kinase
  JOURNAL   J Cell Biol 129 (3), 831-842 (1995)
   PUBMED   7537275
REFERENCE   8  (bases 1 to 4154)
  AUTHORS   Calalb,M.B., Polte,T.R. and Hanks,S.K.
  TITLE     Tyrosine phosphorylation of focal adhesion kinase at sites in the
            catalytic domain regulates kinase activity: a role for Src family
            kinases
  JOURNAL   Mol Cell Biol 15 (2), 954-963 (1995)
   PUBMED   7529876
REFERENCE   9  (bases 1 to 4154)
  AUTHORS   Bergman,M., Joukov,V., Virtanen,I. and Alitalo,K.
  TITLE     Overexpressed Csk tyrosine kinase is localized in focal adhesions,
            causes reorganization of alpha v beta 5 integrin, and interferes
            with HeLa cell spreading
  JOURNAL   Mol Cell Biol 15 (2), 711-722 (1995)
   PUBMED   7529872
REFERENCE   10 (bases 1 to 4154)
  AUTHORS   Schaller,M.D., Hildebrand,J.D., Shannon,J.D., Fox,J.W., Vines,R.R.
            and Parsons,J.T.
  TITLE     Autophosphorylation of the focal adhesion kinase, pp125FAK, directs
            SH2-dependent binding of pp60src
  JOURNAL   Mol Cell Biol 14 (3), 1680-1688 (1994)
   PUBMED   7509446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100860.2, AC105009.13,
            AC105235.7 and AC067931.16.
            
            Summary: This gene encodes a cytoplasmic protein tyrosine kinase
            which is found concentrated in the focal adhesions that form
            between cells growing in the presence of extracellular matrix
            constituents. The encoded protein is a member of the FAK subfamily
            of protein tyrosine kinases but lacks significant sequence
            similarity to kinases from other subfamilies. Activation of this
            gene may be an important early step in cell growth and
            intracellular signal transduction pathways triggered in response to
            certain neural peptides or to cell interactions with the
            extracellular matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1996664.1,
                                           SRR14038194.4292213.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC100860.2         64197-64262
            67-293              AC105009.13        32898-33124
            294-381             AC105009.13        59268-59355
            382-461             AC105009.13        76989-77068
            462-524             AC105009.13        77345-77407
            525-579             AC105235.7         116606-116660       c
            580-720             AC105235.7         105014-105154       c
            721-798             AC105235.7         104411-104488       c
            799-906             AC105235.7         89677-89784         c
            907-1024            AC105235.7         86593-86710         c
            1025-1055           AC105235.7         79488-79518         c
            1056-1108           AC105235.7         75608-75660         c
            1109-1165           AC105235.7         50368-50424         c
            1166-1263           AC105235.7         47299-47396         c
            1264-1348           AC105235.7         38366-38450         c
            1349-1449           AC105235.7         32894-32994         c
            1450-1565           AC105235.7         30786-30901         c
            1566-1666           AC105235.7         29364-29464         c
            1667-1756           AC105235.7         25152-25241         c
            1757-1961           AC105235.7         21385-21589         c
            1962-2073           AC067931.16        194228-194339       c
            2074-2160           AC067931.16        182749-182835       c
            2161-2298           AC067931.16        179200-179337       c
            2299-2430           AC067931.16        177521-177652       c
            2431-2493           AC067931.16        163262-163324       c
            2494-2533           AC067931.16        152090-152129       c
            2534-2640           AC067931.16        150928-151034       c
            2641-2796           AC067931.16        144899-145054       c
            2797-2877           AC067931.16        141547-141627       c
            2878-4154           AC067931.16        135032-136308       c
FEATURES             Location/Qualifiers
     source          1..4154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..4154
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="protein tyrosine kinase 2"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
     exon            1..66
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            67..293
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..3090
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /EC_number="2.7.10.2"
                     /note="isoform 56 is encoded by transcript variant 68;
                     focal adhesion kinase 1; FAK-related non-kinase
                     polypeptide; focal adhesion kinase-related nonkinase;
                     protein phosphatase 1 regulatory subunit 71; PTK2 protein
                     tyrosine kinase 2"
                     /codon_start=1
                     /product="focal adhesion kinase 1 isoform 56"
                     /protein_id="NP_001374513.1"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
                     /translation="MEMLLMSGYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYML
                     EIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSV
                     KAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELA
                     IGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTA
                     PSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAV
                     SVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENP
                     ALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLG
                     ELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLG
                     DFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVK
                     PFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTI
                     LEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMV
                     QTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLD
                     LRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQG
                     PIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISP
                     PPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD
                     ETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHAL
                     AVDAKNLLDVIDQARLKMLGQTRPH"
     exon            294..381
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            382..461
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            462..524
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            525..579
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            580..720
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            721..798
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            799..906
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1024
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1055
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1108
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1165
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1263
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1348
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1449
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1565
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1666
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1756
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1961
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2073
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2160
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2298
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2430
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2493
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2533
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2640
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2796
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2877
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..4154
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4132..4137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: ATTAAA"
     polyA_site      4154
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="major polyA site"
ORIGIN      
        1 cacaccgcgg aagcccgggt cggtgtcggg gcgagccttc cctccttttc ctggagcccg
       61 tctcagaata tgacagatac ctagcatcta gcaaaataat ggcagctgct taccttgacc
      121 ccaacttgaa tcacacacca aattcgagta ctaagactca cctgggtact ggtatggaac
      181 gttctcctgg tgcaatggag cgagtattaa aggtctttca ttattttgaa agcaatagtg
      241 agccaaccac ctgggccagt attatcaggc atggagatgc tactgatgtc aggatatgaa
      301 ttgagaattc gttatttgcc aaaaggattt ctaaaccagt ttactgaaga taagccaact
      361 ttgaatttct tctatcaaca ggtgaagagc gattatatgt tagagatagc tgatcaagtg
      421 gaccaggaaa ttgctttgaa gttgggttgt ctagaaatac ggcgatcata ctgggagatg
      481 cggggcaatg cactagaaaa gaagtctaac tatgaagtat tagaaaaaga tgttggttta
      541 aagcgatttt ttcctaagag tttactggat tctgtcaagg ccaaaacact aagaaaactg
      601 atccaacaaa catttagaca atttgccaac cttaatagag aagaaagtat tctgaaattc
      661 tttgagatcc tgtctccagt ctacagattt gataaggaat gcttcaagtg tgctcttggt
      721 tcaagctgga ttatttcagt ggaactggca atcggcccag aagaaggaat cagttaccta
      781 acggacaagg gctgcaatcc cacacatctt gctgacttca ctcaagtgca aaccattcag
      841 tattcaaaca gtgaagacaa ggacagaaaa ggaatgctac aactaaaaat agcaggtgca
      901 cccgagcctc tgacagtgac ggcaccatcc ctaaccattg cggagaatat ggctgaccta
      961 atagatgggt actgccggct ggtgaatgga acctcgcagt catttatcat cagacctcag
     1021 aaagaaggtg aacgggcttt gccatcaata ccaaagttgg ccaacagcga aaagcaaggc
     1081 atgcggacac acgccgtctc tgtgtcagaa acagatgatt atgctgagat tatagatgaa
     1141 gaagatactt acaccatgcc ctcaaccagg gattatgaga ttcaaagaga aagaatagaa
     1201 cttggacgat gtattggaga aggccaattt ggagatgtac atcaaggcat ttatatgagt
     1261 ccagagaatc cagctttggc ggttgcaatt aaaacatgta aaaactgtac ttcggacagc
     1321 gtgagagaga aatttcttca agaagcctta acaatgcgtc agtttgacca tcctcatatt
     1381 gtgaagctga ttggagtcat cacagagaat cctgtctgga taatcatgga gctgtgcaca
     1441 cttggagagc tgaggtcatt tttgcaagta aggaaataca gtttggatct agcatctttg
     1501 atcctgtatg cctatcagct tagtacagct cttgcatatc tagagagcaa aagatttgta
     1561 cacagggaca ttgctgctcg gaatgttctg gtgtcctcaa atgattgtgt aaaattagga
     1621 gactttggat tatcccgata tatggaagat agtacttact acaaagcttc caaaggaaaa
     1681 ttgcctatta aatggatggc tccagagtca atcaattttc gacgttttac ctcagctagt
     1741 gacgtatgga tgtttggtgt gtgtatgtgg gagatactga tgcatggtgt gaagcctttt
     1801 caaggagtga agaacaatga tgtaatcggt cgaattgaaa atggggaaag attaccaatg
     1861 cctccaaatt gtcctcctac cctctacagc cttatgacga aatgctgggc ctatgacccc
     1921 agcaggcggc ccaggtttac tgaacttaaa gctcagctca gcacaatcct ggaggaagag
     1981 aaggctcagc aagaagagcg catgaggatg gagtccagaa gacaggccac agtgtcctgg
     2041 gactccggag ggtctgatga agcaccgccc aagcccagca gaccgggtta tcccagtccg
     2101 aggtccagcg aaggatttta tcccagccca cagcacatgg tacaaaccaa tcattaccag
     2161 gtttctggct accctggttc acatggaatc acagccatgg ctggcagcat ctatccaggt
     2221 caggcatctc ttttggacca aacagattca tggaatcata gacctcagga gatagcaatg
     2281 tggcagccca atgtggagga ctctacagta ttggacctgc gagggattgg gcaagtgttg
     2341 ccaacccatc tgatggaaga gcgtctaatc cgacagcaac aggaaatgga agaagatcag
     2401 cgctggctgg aaaaagagga aagatttctg aaacctgatg tgagactctc tcgaggcagt
     2461 attgacaggg aggatggaag tcttcagggt ccgattggaa accaacatat atatcagcct
     2521 gtgggtaaac cagatcctgc agctccacca aagaaaccgc ctcgccctgg agctcccggt
     2581 catctgggaa gccttgccag cctcagcagc cctgctgaca gctacaacga gggtgtcaag
     2641 cttcagcccc aggaaatcag cccccctcct actgccaacc tggaccggtc gaatgataag
     2701 gtgtacgaga atgtgacggg cctggtgaaa gctgtcatcg agatgtccag taaaatccag
     2761 ccagccccac cagaggagta tgtccctatg gtgaaggaag tcggcttggc cctgaggaca
     2821 ttattggcca ctgtggatga gaccattccc ctcctaccag ccagcaccca ccgagagatt
     2881 gagatggcac agaagctatt gaactctgac ctgggtgagc tcatcaacaa gatgaaactg
     2941 gcccagcagt atgtcatgac cagcctccag caagagtaca aaaagcaaat gctgactgct
     3001 gctcacgccc tggctgtgga tgccaaaaac ttactcgatg tcattgacca agcaagactg
     3061 aaaatgcttg ggcagacgag accacactga gcctccccta ggagcacgtc ttgctaccct
     3121 cttttgaaga tgttctctag ccttccacca gcagcgagga attaaccctg tgtcctcagt
     3181 cgccagcact tacagctcca acttttttga atgaccatct ggttgaaaaa tctttctcat
     3241 ataagtttaa ccacactttg atttgggttc attttttgtt ttgttttttt caatcatgat
     3301 attcagaaaa atccaggatc caaaatgtgg cgtttttcta agaatgaaaa ttatatgtaa
     3361 gcttttaagc atcatgaaga acaatttatg ttcacattaa gatacgttct aaagggggat
     3421 ggccaagggg tgacatctta attcctaaac taccttagct gcatagtgga agaggagagc
     3481 atgaagcaaa gaattccagg aaacccaaga ggctgagaat tcttttgtct accatagaat
     3541 tattatccag actggaattt ttgtttgtta gaacaccctt cagttgcaat atgctaatcc
     3601 cactttacaa agaatataaa agctatattt tgaagacttg agttatttca gaaaaaacta
     3661 cagccctttt tgtcttacct gccttttact ttcgtgtgga tatgtgaagc attgggtcgg
     3721 gaactagctg tagaacacaa ctaaaaactc atgtcttttt tcacagaata atgtgccagt
     3781 tttttgtagc aatgttattt ctcttggaag cagaaatgct ttgtaccaga gcacctccaa
     3841 actgcattga ggagaagttc cagaaccatc ccctttttcc atttttatat aatttataaa
     3901 gaaagattaa agccatgttg actattttac agccactgga gttaactaac ccttccttgt
     3961 atctgtcttc ccaggagaga atgaagcaaa acaggaattt ggttttcttt tgatgtccag
     4021 ttacaccatc cattctgtta attttgaaaa aatataccct ccctttagtt tgttggggga
     4081 tataaattat tctcaggaag aatataatga actgtacagt tactttgacc tattaaaaag
     4141 gtgttaccag taaa
//
