LOCUS       NM_001352736            4865 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens protein tyrosine kinase 2 (PTK2), transcript variant
            47, mRNA.
ACCESSION   NM_001352736
VERSION     NM_001352736.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4865)
  AUTHORS   Tang,Z.Y., Wang,X.M., Xu,C.W., Sun,Q.Q., Hua,Y.X., Zhou,Q.Y.,
            Hu,H.Y., Liu,S.B., Guo,Y.J., Ao,L., Che,X., Zhang,X.C., Heger,M.,
            Zheng,X., Liu,A.J., Wang,Q., Zhan,Z.J., Cheng,S.Q. and Pan,W.W.
  TITLE     DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 421 (2024)
   PUBMED   39367995
  REMARK    GeneRIF: DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4865)
  AUTHORS   Chen,A., Zhang,J., Yan,Z., Lu,Y., Chen,W., Sun,Y., Gu,Q., Li,F.,
            Yang,Y., Qiu,S., Lin,X., Zhang,D., Teng,J., Fang,Y., Shen,B.,
            Song,N. and Ding,X.
  TITLE     Acidic preconditioning induced intracellular acid adaptation to
            protect renal injury via dynamic phosphorylation of focal adhesion
            kinase-dependent activation of sodium hydrogen exchanger 1
  JOURNAL   Cell Commun Signal 22 (1), 393 (2024)
   PUBMED   39118129
  REMARK    GeneRIF: Acidic preconditioning induced intracellular acid
            adaptation to protect renal injury via dynamic phosphorylation of
            focal adhesion kinase-dependent activation of sodium hydrogen
            exchanger 1.
            Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi:
            10.1186/s12964-024-01815-3.. PMID: 39261884]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4865)
  AUTHORS   Brown,N.D. and Vomhof-DeKrey,E.E.
  TITLE     Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal
            Homeostasis and Innate Immunity Crosstalk
  JOURNAL   Cells 13 (14), 1178 (2024)
   PUBMED   39056760
  REMARK    GeneRIF: Focal Adhesion Kinase and Colony Stimulating Factors:
            Intestinal Homeostasis and Innate Immunity Crosstalk.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4865)
  AUTHORS   Markowska,A., de Mezer,M., Kurzawa,P., Bednarek,W., Grybos,A.,
            Krzyzaniak,M., Markowska,J., Grybos,M. and Zurawski,J.
  TITLE     Analysis of Expression of the ANG1, CaSR and FAK Proteins in
            Uterine Fibroids
  JOURNAL   Int J Mol Sci 25 (13), 7164 (2024)
   PUBMED   39000274
  REMARK    GeneRIF: Analysis of Expression of the ANG1, CaSR and FAK Proteins
            in Uterine Fibroids.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4865)
  AUTHORS   Park,S.Y., Choi,H., Choi,S.M., Wang,S., Shim,S., Jun,W., Lee,J. and
            Chung,J.W.
  TITLE     T-plastin contributes to epithelial-mesenchymal transition in human
            lung cancer cells through FAK/AKT/Slug axis signaling pathway
  JOURNAL   BMB Rep 57 (6), 305-310 (2024)
   PUBMED   38835117
  REMARK    GeneRIF: T-plastin contributes to epithelial-mesenchymal transition
            in human lung cancer cells through FAK/AKT/Slug axis signaling
            pathway.
REFERENCE   6  (bases 1 to 4865)
  AUTHORS   Polte,T.R. and Hanks,S.K.
  TITLE     Interaction between focal adhesion kinase and Crk-associated
            tyrosine kinase substrate p130Cas
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10678-10682 (1995)
   PUBMED   7479864
REFERENCE   7  (bases 1 to 4865)
  AUTHORS   Guinebault,C., Payrastre,B., Racaud-Sultan,C., Mazarguil,H.,
            Breton,M., Mauco,G., Plantavid,M. and Chap,H.
  TITLE     Integrin-dependent translocation of phosphoinositide 3-kinase to
            the cytoskeleton of thrombin-activated platelets involves specific
            interactions of p85 alpha with actin filaments and focal adhesion
            kinase
  JOURNAL   J Cell Biol 129 (3), 831-842 (1995)
   PUBMED   7537275
REFERENCE   8  (bases 1 to 4865)
  AUTHORS   Calalb,M.B., Polte,T.R. and Hanks,S.K.
  TITLE     Tyrosine phosphorylation of focal adhesion kinase at sites in the
            catalytic domain regulates kinase activity: a role for Src family
            kinases
  JOURNAL   Mol Cell Biol 15 (2), 954-963 (1995)
   PUBMED   7529876
REFERENCE   9  (bases 1 to 4865)
  AUTHORS   Bergman,M., Joukov,V., Virtanen,I. and Alitalo,K.
  TITLE     Overexpressed Csk tyrosine kinase is localized in focal adhesions,
            causes reorganization of alpha v beta 5 integrin, and interferes
            with HeLa cell spreading
  JOURNAL   Mol Cell Biol 15 (2), 711-722 (1995)
   PUBMED   7529872
REFERENCE   10 (bases 1 to 4865)
  AUTHORS   Schaller,M.D., Hildebrand,J.D., Shannon,J.D., Fox,J.W., Vines,R.R.
            and Parsons,J.T.
  TITLE     Autophosphorylation of the focal adhesion kinase, pp125FAK, directs
            SH2-dependent binding of pp60src
  JOURNAL   Mol Cell Biol 14 (3), 1680-1688 (1994)
   PUBMED   7509446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100860.2, AC105009.13,
            AC105235.7 and AC067931.16.
            
            On Jun 2, 2019 this sequence version replaced NM_001352736.1.
            
            Summary: This gene encodes a cytoplasmic protein tyrosine kinase
            which is found concentrated in the focal adhesions that form
            between cells growing in the presence of extracellular matrix
            constituents. The encoded protein is a member of the FAK subfamily
            of protein tyrosine kinases but lacks significant sequence
            similarity to kinases from other subfamilies. Activation of this
            gene may be an important early step in cell growth and
            intracellular signal transduction pathways triggered in response to
            certain neural peptides or to cell interactions with the
            extracellular matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC100860.2         64994-65151
            159-247             AC100860.2         140527-140615
            248-308             AC105009.13        33064-33124
            309-475             AC105009.13        44030-44196
            476-563             AC105009.13        59268-59355
            564-643             AC105009.13        76989-77068
            644-706             AC105009.13        77345-77407
            707-761             AC105235.7         116606-116660       c
            762-902             AC105235.7         105014-105154       c
            903-980             AC105235.7         104411-104488       c
            981-1088            AC105235.7         89677-89784         c
            1089-1206           AC105235.7         86593-86710         c
            1207-1237           AC105235.7         79488-79518         c
            1238-1290           AC105235.7         75608-75660         c
            1291-1308           AC105235.7         55709-55726         c
            1309-1365           AC105235.7         50368-50424         c
            1366-1463           AC105235.7         47299-47396         c
            1464-1548           AC105235.7         38366-38450         c
            1549-1649           AC105235.7         32894-32994         c
            1650-1765           AC105235.7         30786-30901         c
            1766-1866           AC105235.7         29364-29464         c
            1867-1956           AC105235.7         25152-25241         c
            1957-2161           AC105235.7         21385-21589         c
            2162-2273           AC067931.16        194228-194339       c
            2274-2360           AC067931.16        182749-182835       c
            2361-2498           AC067931.16        179200-179337       c
            2499-2630           AC067931.16        177521-177652       c
            2631-2693           AC067931.16        163262-163324       c
            2694-2733           AC067931.16        152090-152129       c
            2734-2840           AC067931.16        150928-151034       c
            2841-2849           AC067931.16        146357-146365       c
            2850-3005           AC067931.16        144899-145054       c
            3006-3086           AC067931.16        141547-141627       c
            3087-4865           AC067931.16        134530-136308       c
FEATURES             Location/Qualifiers
     source          1..4865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..4865
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="protein tyrosine kinase 2"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
     exon            1..158
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            159..247
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            248..308
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            309..475
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..3299
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /EC_number="2.7.10.2"
                     /note="isoform 30 is encoded by transcript variant 47;
                     focal adhesion kinase 1; FAK-related non-kinase
                     polypeptide; focal adhesion kinase-related nonkinase;
                     protein phosphatase 1 regulatory subunit 71; PTK2 protein
                     tyrosine kinase 2"
                     /codon_start=1
                     /product="focal adhesion kinase 1 isoform 30"
                     /protein_id="NP_001339665.1"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
                     /translation="MGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLN
                     FFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGL
                     KRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCA
                     LGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLK
                     IAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLA
                     NSEKQGMRTHAVSVSDEISGDETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIG
                     EGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI
                     GVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHR
                     DIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSAS
                     DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAY
                     DPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPG
                     YPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHR
                     PQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKP
                     DVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSS
                     PADSYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPE
                     EYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQ
                     YVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH"
     exon            476..563
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            564..643
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            644..706
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            707..761
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            762..902
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            903..980
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1088
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1206
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1237
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1290
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1308
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1365
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1463
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1548
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1649
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1765
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1866
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1956
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2161
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2273
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2360
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2498
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2630
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2693
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2733
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2840
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2849
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..3005
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3086
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..4865
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4341..4346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: ATTAAA"
     regulatory      4358..4363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: AGTAAA"
     polyA_site      4363
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="major polyA site"
     polyA_site      4380
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
     regulatory      4582..4587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: ATTAAA"
     polyA_site      4601
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
ORIGIN      
        1 acggcctcga gggcgcgagc ccgcgccgcc gccgccgccg ccggtcccgg accactgtga
       61 gcccgcggcg tgaggcgtgg gaggaagcgc ggctgctgtc gcccagcgcc gccccgtcgt
      121 cgtctgcctt cgcttcacgg cgccgagccg cggtccgagc agaactgggg ctcccttgca
      181 tcttccagtt acaaattcag tgccttctgc agtttcccca gagctcctca agaataacgg
      241 aagggagcaa tagtgagcca accacctggg ccagtattat caggcatgga gatgctactg
      301 atgtcagggg catcattcag aagatagtgg acagtcacaa agtaaagcat gtggcctgct
      361 atggattccg cctcagtcac ctgcggtcag aggaggttca ctggcttcac gtggatatgg
      421 gcgtctccag tgtgagggag aagtatgagc ttgctcaccc accagaggag tggaaatatg
      481 aattgagaat tcgttatttg ccaaaaggat ttctaaacca gtttactgaa gataagccaa
      541 ctttgaattt cttctatcaa caggtgaaga gcgattatat gttagagata gctgatcaag
      601 tggaccagga aattgctttg aagttgggtt gtctagaaat acggcgatca tactgggaga
      661 tgcggggcaa tgcactagaa aagaagtcta actatgaagt attagaaaaa gatgttggtt
      721 taaagcgatt ttttcctaag agtttactgg attctgtcaa ggccaaaaca ctaagaaaac
      781 tgatccaaca aacatttaga caatttgcca accttaatag agaagaaagt attctgaaat
      841 tctttgagat cctgtctcca gtctacagat ttgataagga atgcttcaag tgtgctcttg
      901 gttcaagctg gattatttca gtggaactgg caatcggccc agaagaagga atcagttacc
      961 taacggacaa gggctgcaat cccacacatc ttgctgactt cactcaagtg caaaccattc
     1021 agtattcaaa cagtgaagac aaggacagaa aaggaatgct acaactaaaa atagcaggtg
     1081 cacccgagcc tctgacagtg acggcaccat ccctaaccat tgcggagaat atggctgacc
     1141 taatagatgg gtactgccgg ctggtgaatg gaacctcgca gtcatttatc atcagacctc
     1201 agaaagaagg tgaacgggct ttgccatcaa taccaaagtt ggccaacagc gaaaagcaag
     1261 gcatgcggac acacgccgtc tctgtgtcag atgaaattag tggggacgaa acagatgatt
     1321 atgctgagat tatagatgaa gaagatactt acaccatgcc ctcaaccagg gattatgaga
     1381 ttcaaagaga aagaatagaa cttggacgat gtattggaga aggccaattt ggagatgtac
     1441 atcaaggcat ttatatgagt ccagagaatc cagctttggc ggttgcaatt aaaacatgta
     1501 aaaactgtac ttcggacagc gtgagagaga aatttcttca agaagcctta acaatgcgtc
     1561 agtttgacca tcctcatatt gtgaagctga ttggagtcat cacagagaat cctgtctgga
     1621 taatcatgga gctgtgcaca cttggagagc tgaggtcatt tttgcaagta aggaaataca
     1681 gtttggatct agcatctttg atcctgtatg cctatcagct tagtacagct cttgcatatc
     1741 tagagagcaa aagatttgta cacagggaca ttgctgctcg gaatgttctg gtgtcctcaa
     1801 atgattgtgt aaaattagga gactttggat tatcccgata tatggaagat agtacttact
     1861 acaaagcttc caaaggaaaa ttgcctatta aatggatggc tccagagtca atcaattttc
     1921 gacgttttac ctcagctagt gacgtatgga tgtttggtgt gtgtatgtgg gagatactga
     1981 tgcatggtgt gaagcctttt caaggagtga agaacaatga tgtaatcggt cgaattgaaa
     2041 atggggaaag attaccaatg cctccaaatt gtcctcctac cctctacagc cttatgacga
     2101 aatgctgggc ctatgacccc agcaggcggc ccaggtttac tgaacttaaa gctcagctca
     2161 gcacaatcct ggaggaagag aaggctcagc aagaagagcg catgaggatg gagtccagaa
     2221 gacaggccac agtgtcctgg gactccggag ggtctgatga agcaccgccc aagcccagca
     2281 gaccgggtta tcccagtccg aggtccagcg aaggatttta tcccagccca cagcacatgg
     2341 tacaaaccaa tcattaccag gtttctggct accctggttc acatggaatc acagccatgg
     2401 ctggcagcat ctatccaggt caggcatctc ttttggacca aacagattca tggaatcata
     2461 gacctcagga gatagcaatg tggcagccca atgtggagga ctctacagta ttggacctgc
     2521 gagggattgg gcaagtgttg ccaacccatc tgatggaaga gcgtctaatc cgacagcaac
     2581 aggaaatgga agaagatcag cgctggctgg aaaaagagga aagatttctg aaacctgatg
     2641 tgagactctc tcgaggcagt attgacaggg aggatggaag tcttcagggt ccgattggaa
     2701 accaacatat atatcagcct gtgggtaaac cagatcctgc agctccacca aagaaaccgc
     2761 ctcgccctgg agctcccggt catctgggaa gccttgccag cctcagcagc cctgctgaca
     2821 gctacaacga gggtgtcaag ccatggaggc ttcagcccca ggaaatcagc ccccctccta
     2881 ctgccaacct ggaccggtcg aatgataagg tgtacgagaa tgtgacgggc ctggtgaaag
     2941 ctgtcatcga gatgtccagt aaaatccagc cagccccacc agaggagtat gtccctatgg
     3001 tgaaggaagt cggcttggcc ctgaggacat tattggccac tgtggatgag accattcccc
     3061 tcctaccagc cagcacccac cgagagattg agatggcaca gaagctattg aactctgacc
     3121 tgggtgagct catcaacaag atgaaactgg cccagcagta tgtcatgacc agcctccagc
     3181 aagagtacaa aaagcaaatg ctgactgctg ctcacgccct ggctgtggat gccaaaaact
     3241 tactcgatgt cattgaccaa gcaagactga aaatgcttgg gcagacgaga ccacactgag
     3301 cctcccctag gagcacgtct tgctaccctc ttttgaagat gttctctagc cttccaccag
     3361 cagcgaggaa ttaaccctgt gtcctcagtc gccagcactt acagctccaa cttttttgaa
     3421 tgaccatctg gttgaaaaat ctttctcata taagtttaac cacactttga tttgggttca
     3481 ttttttgttt tgtttttttc aatcatgata ttcagaaaaa tccaggatcc aaaatgtggc
     3541 gtttttctaa gaatgaaaat tatatgtaag cttttaagca tcatgaagaa caatttatgt
     3601 tcacattaag atacgttcta aagggggatg gccaaggggt gacatcttaa ttcctaaact
     3661 accttagctg catagtggaa gaggagagca tgaagcaaag aattccagga aacccaagag
     3721 gctgagaatt cttttgtcta ccatagaatt attatccaga ctggaatttt tgtttgttag
     3781 aacacccttc agttgcaata tgctaatccc actttacaaa gaatataaaa gctatatttt
     3841 gaagacttga gttatttcag aaaaaactac agcccttttt gtcttacctg ccttttactt
     3901 tcgtgtggat atgtgaagca ttgggtcggg aactagctgt agaacacaac taaaaactca
     3961 tgtctttttt cacagaataa tgtgccagtt ttttgtagca atgttatttc tcttggaagc
     4021 agaaatgctt tgtaccagag cacctccaaa ctgcattgag gagaagttcc agaaccatcc
     4081 cctttttcca tttttatata atttataaag aaagattaaa gccatgttga ctattttaca
     4141 gccactggag ttaactaacc cttccttgta tctgtcttcc caggagagaa tgaagcaaaa
     4201 caggaatttg gttttctttt gatgtccagt tacaccatcc attctgttaa ttttgaaaaa
     4261 atataccctc cctttagttt gttgggggat ataaattatt ctcaggaaga atataatgaa
     4321 ctgtacagtt actttgacct attaaaaagg tgttaccagt aaagttcttg ttgtaatatc
     4381 ctttcttttg gttctgtttc ttcagatggc ttttcaggtg acttgtcaga taagataaca
     4441 tacaagagag ttcccaataa ttatcaggaa gcctctcact aattagtttc ttttttttta
     4501 tttaatcttc taaacaagtc aaggatgtta ccacagaagg gtagcgtggc gtaagttaac
     4561 cttttcattc catcgtcacc tattaaatgc agagctcagg atggaagtag caatggtctt
     4621 caatgaaaga accttcccct gcgcagggtc tcactattcc gctaactcgg actcaaagca
     4681 taattcactt gtcaaggaaa ttgttagcat ttcccaggcc caccctagtc ttgctagaat
     4741 ctctgtgagc cacagagcag ggagcaaata gaactgagat ctccagcact agggactcag
     4801 actccaaagg gagggatttg agtgaatttt ttccaggtaa atacatgctc ttatgtgcaa
     4861 aagca
//
