LOCUS       NM_001352702            5136 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens protein tyrosine kinase 2 (PTK2), transcript variant
            13, mRNA.
ACCESSION   NM_001352702 XM_006716608
VERSION     NM_001352702.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5136)
  AUTHORS   Tang,Z.Y., Wang,X.M., Xu,C.W., Sun,Q.Q., Hua,Y.X., Zhou,Q.Y.,
            Hu,H.Y., Liu,S.B., Guo,Y.J., Ao,L., Che,X., Zhang,X.C., Heger,M.,
            Zheng,X., Liu,A.J., Wang,Q., Zhan,Z.J., Cheng,S.Q. and Pan,W.W.
  TITLE     DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 421 (2024)
   PUBMED   39367995
  REMARK    GeneRIF: DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5136)
  AUTHORS   Chen,A., Zhang,J., Yan,Z., Lu,Y., Chen,W., Sun,Y., Gu,Q., Li,F.,
            Yang,Y., Qiu,S., Lin,X., Zhang,D., Teng,J., Fang,Y., Shen,B.,
            Song,N. and Ding,X.
  TITLE     Acidic preconditioning induced intracellular acid adaptation to
            protect renal injury via dynamic phosphorylation of focal adhesion
            kinase-dependent activation of sodium hydrogen exchanger 1
  JOURNAL   Cell Commun Signal 22 (1), 393 (2024)
   PUBMED   39118129
  REMARK    GeneRIF: Acidic preconditioning induced intracellular acid
            adaptation to protect renal injury via dynamic phosphorylation of
            focal adhesion kinase-dependent activation of sodium hydrogen
            exchanger 1.
            Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi:
            10.1186/s12964-024-01815-3.. PMID: 39261884]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5136)
  AUTHORS   Brown,N.D. and Vomhof-DeKrey,E.E.
  TITLE     Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal
            Homeostasis and Innate Immunity Crosstalk
  JOURNAL   Cells 13 (14), 1178 (2024)
   PUBMED   39056760
  REMARK    GeneRIF: Focal Adhesion Kinase and Colony Stimulating Factors:
            Intestinal Homeostasis and Innate Immunity Crosstalk.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5136)
  AUTHORS   Markowska,A., de Mezer,M., Kurzawa,P., Bednarek,W., Grybos,A.,
            Krzyzaniak,M., Markowska,J., Grybos,M. and Zurawski,J.
  TITLE     Analysis of Expression of the ANG1, CaSR and FAK Proteins in
            Uterine Fibroids
  JOURNAL   Int J Mol Sci 25 (13), 7164 (2024)
   PUBMED   39000274
  REMARK    GeneRIF: Analysis of Expression of the ANG1, CaSR and FAK Proteins
            in Uterine Fibroids.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5136)
  AUTHORS   Park,S.Y., Choi,H., Choi,S.M., Wang,S., Shim,S., Jun,W., Lee,J. and
            Chung,J.W.
  TITLE     T-plastin contributes to epithelial-mesenchymal transition in human
            lung cancer cells through FAK/AKT/Slug axis signaling pathway
  JOURNAL   BMB Rep 57 (6), 305-310 (2024)
   PUBMED   38835117
  REMARK    GeneRIF: T-plastin contributes to epithelial-mesenchymal transition
            in human lung cancer cells through FAK/AKT/Slug axis signaling
            pathway.
REFERENCE   6  (bases 1 to 5136)
  AUTHORS   Polte,T.R. and Hanks,S.K.
  TITLE     Interaction between focal adhesion kinase and Crk-associated
            tyrosine kinase substrate p130Cas
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10678-10682 (1995)
   PUBMED   7479864
REFERENCE   7  (bases 1 to 5136)
  AUTHORS   Guinebault,C., Payrastre,B., Racaud-Sultan,C., Mazarguil,H.,
            Breton,M., Mauco,G., Plantavid,M. and Chap,H.
  TITLE     Integrin-dependent translocation of phosphoinositide 3-kinase to
            the cytoskeleton of thrombin-activated platelets involves specific
            interactions of p85 alpha with actin filaments and focal adhesion
            kinase
  JOURNAL   J Cell Biol 129 (3), 831-842 (1995)
   PUBMED   7537275
REFERENCE   8  (bases 1 to 5136)
  AUTHORS   Calalb,M.B., Polte,T.R. and Hanks,S.K.
  TITLE     Tyrosine phosphorylation of focal adhesion kinase at sites in the
            catalytic domain regulates kinase activity: a role for Src family
            kinases
  JOURNAL   Mol Cell Biol 15 (2), 954-963 (1995)
   PUBMED   7529876
REFERENCE   9  (bases 1 to 5136)
  AUTHORS   Bergman,M., Joukov,V., Virtanen,I. and Alitalo,K.
  TITLE     Overexpressed Csk tyrosine kinase is localized in focal adhesions,
            causes reorganization of alpha v beta 5 integrin, and interferes
            with HeLa cell spreading
  JOURNAL   Mol Cell Biol 15 (2), 711-722 (1995)
   PUBMED   7529872
REFERENCE   10 (bases 1 to 5136)
  AUTHORS   Schaller,M.D., Hildebrand,J.D., Shannon,J.D., Fox,J.W., Vines,R.R.
            and Parsons,J.T.
  TITLE     Autophosphorylation of the focal adhesion kinase, pp125FAK, directs
            SH2-dependent binding of pp60src
  JOURNAL   Mol Cell Biol 14 (3), 1680-1688 (1994)
   PUBMED   7509446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100860.2, AC105009.13,
            AC105235.7 and AC067931.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001352702.1.
            
            Summary: This gene encodes a cytoplasmic protein tyrosine kinase
            which is found concentrated in the focal adhesions that form
            between cells growing in the presence of extracellular matrix
            constituents. The encoded protein is a member of the FAK subfamily
            of protein tyrosine kinases but lacks significant sequence
            similarity to kinases from other subfamilies. Activation of this
            gene may be an important early step in cell growth and
            intracellular signal transduction pathways triggered in response to
            certain neural peptides or to cell interactions with the
            extracellular matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2017].
            
            Transcript Variant: This variant (13), as well as variants 10-12
            and 14, encodes isoform g.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696786.1/ ENSP00000512868.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC100860.2         64994-65151
            159-247             AC100860.2         140527-140615
            248-474             AC105009.13        32898-33124
            475-641             AC105009.13        44030-44196
            642-729             AC105009.13        59268-59355
            730-809             AC105009.13        76989-77068
            810-872             AC105009.13        77345-77407
            873-927             AC105235.7         116606-116660       c
            928-1068            AC105235.7         105014-105154       c
            1069-1146           AC105235.7         104411-104488       c
            1147-1254           AC105235.7         89677-89784         c
            1255-1372           AC105235.7         86593-86710         c
            1373-1403           AC105235.7         79488-79518         c
            1404-1456           AC105235.7         75608-75660         c
            1457-1540           AC105235.7         56850-56933         c
            1541-1558           AC105235.7         55709-55726         c
            1559-1615           AC105235.7         50368-50424         c
            1616-1636           AC105235.7         48502-48522         c
            1637-1734           AC105235.7         47299-47396         c
            1735-1819           AC105235.7         38366-38450         c
            1820-1920           AC105235.7         32894-32994         c
            1921-2036           AC105235.7         30786-30901         c
            2037-2137           AC105235.7         29364-29464         c
            2138-2227           AC105235.7         25152-25241         c
            2228-2432           AC105235.7         21385-21589         c
            2433-2544           AC067931.16        194228-194339       c
            2545-2631           AC067931.16        182749-182835       c
            2632-2769           AC067931.16        179200-179337       c
            2770-2901           AC067931.16        177521-177652       c
            2902-2964           AC067931.16        163262-163324       c
            2965-3004           AC067931.16        152090-152129       c
            3005-3111           AC067931.16        150928-151034       c
            3112-3120           AC067931.16        146357-146365       c
            3121-3276           AC067931.16        144899-145054       c
            3277-3357           AC067931.16        141547-141627       c
            3358-5136           AC067931.16        134530-136308       c
FEATURES             Location/Qualifiers
     source          1..5136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..5136
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="protein tyrosine kinase 2"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
     exon            1..158
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            159..247
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            248..474
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..3570
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /EC_number="2.7.10.2"
                     /note="isoform 7 is encoded by transcript variant 13;
                     focal adhesion kinase 1; FAK-related non-kinase
                     polypeptide; focal adhesion kinase-related nonkinase;
                     protein phosphatase 1 regulatory subunit 71; PTK2 protein
                     tyrosine kinase 2"
                     /codon_start=1
                     /product="focal adhesion kinase 1 isoform 7"
                     /protein_id="NP_001339631.1"
                     /db_xref="CCDS:CCDS94346.1"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
                     /translation="MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFE
                     SNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDM
                     GVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIA
                     DQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAK
                     TLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGP
                     EEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSL
                     TIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVS
                     GVSHCQHKVKKARRFLPLVFCSHDPPSTDEISGDETDDYAEIIDEEDTYTMPSKSYGI
                     DEARDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREK
                     FLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLIL
                     YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGK
                     LPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERL
                     PMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQA
                     TVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMA
                     GSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQ
                     QQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPP
                     KKPPRPGAPGHLGSLASLSSPADSYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENV
                     TGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMA
                     QKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLK
                     MLGQTRPH"
     exon            475..641
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            642..729
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            730..809
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            810..872
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            873..927
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1068
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1146
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1254
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1372
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1403
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1456
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1540
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1558
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1615
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1636
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1734
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1819
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1920
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2036
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2137
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2227
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2432
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2544
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2631
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2769
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2901
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..2964
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3004
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3111
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3120
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3276
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3357
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..5136
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4612..4617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: ATTAAA"
     regulatory      4629..4634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: AGTAAA"
     polyA_site      4634
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="major polyA site"
     polyA_site      4651
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
     regulatory      4853..4858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: ATTAAA"
     polyA_site      4872
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
ORIGIN      
        1 acggcctcga gggcgcgagc ccgcgccgcc gccgccgccg ccggtcccgg accactgtga
       61 gcccgcggcg tgaggcgtgg gaggaagcgc ggctgctgtc gcccagcgcc gccccgtcgt
      121 cgtctgcctt cgcttcacgg cgccgagccg cggtccgagc agaactgggg ctcccttgca
      181 tcttccagtt acaaattcag tgccttctgc agtttcccca gagctcctca agaataacgg
      241 aagggagaat atgacagata cctagcatct agcaaaataa tggcagctgc ttaccttgac
      301 cccaacttga atcacacacc aaattcgagt actaagactc acctgggtac tggtatggaa
      361 cgttctcctg gtgcaatgga gcgagtatta aaggtctttc attattttga aagcaatagt
      421 gagccaacca cctgggccag tattatcagg catggagatg ctactgatgt caggggcatc
      481 attcagaaga tagtggacag tcacaaagta aagcatgtgg cctgctatgg attccgcctc
      541 agtcacctgc ggtcagagga ggttcactgg cttcacgtgg atatgggcgt ctccagtgtg
      601 agggagaagt atgagcttgc tcacccacca gaggagtgga aatatgaatt gagaattcgt
      661 tatttgccaa aaggatttct aaaccagttt actgaagata agccaacttt gaatttcttc
      721 tatcaacagg tgaagagcga ttatatgtta gagatagctg atcaagtgga ccaggaaatt
      781 gctttgaagt tgggttgtct agaaatacgg cgatcatact gggagatgcg gggcaatgca
      841 ctagaaaaga agtctaacta tgaagtatta gaaaaagatg ttggtttaaa gcgatttttt
      901 cctaagagtt tactggattc tgtcaaggcc aaaacactaa gaaaactgat ccaacaaaca
      961 tttagacaat ttgccaacct taatagagaa gaaagtattc tgaaattctt tgagatcctg
     1021 tctccagtct acagatttga taaggaatgc ttcaagtgtg ctcttggttc aagctggatt
     1081 atttcagtgg aactggcaat cggcccagaa gaaggaatca gttacctaac ggacaagggc
     1141 tgcaatccca cacatcttgc tgacttcact caagtgcaaa ccattcagta ttcaaacagt
     1201 gaagacaagg acagaaaagg aatgctacaa ctaaaaatag caggtgcacc cgagcctctg
     1261 acagtgacgg caccatccct aaccattgcg gagaatatgg ctgacctaat agatgggtac
     1321 tgccggctgg tgaatggaac ctcgcagtca tttatcatca gacctcagaa agaaggtgaa
     1381 cgggctttgc catcaatacc aaagttggcc aacagcgaaa agcaaggcat gcggacacac
     1441 gccgtctctg tgtcaggagt cagtcactgc caacataaag ttaagaaagc taggcgcttt
     1501 ctccctttgg tcttctgttc ccatgatcct ccttctacgg atgaaattag tggggacgaa
     1561 acagatgatt atgctgagat tatagatgaa gaagatactt acaccatgcc ctcaaaaagc
     1621 tatggaatag atgaagccag ggattatgag attcaaagag aaagaataga acttggacga
     1681 tgtattggag aaggccaatt tggagatgta catcaaggca tttatatgag tccagagaat
     1741 ccagctttgg cggttgcaat taaaacatgt aaaaactgta cttcggacag cgtgagagag
     1801 aaatttcttc aagaagcctt aacaatgcgt cagtttgacc atcctcatat tgtgaagctg
     1861 attggagtca tcacagagaa tcctgtctgg ataatcatgg agctgtgcac acttggagag
     1921 ctgaggtcat ttttgcaagt aaggaaatac agtttggatc tagcatcttt gatcctgtat
     1981 gcctatcagc ttagtacagc tcttgcatat ctagagagca aaagatttgt acacagggac
     2041 attgctgctc ggaatgttct ggtgtcctca aatgattgtg taaaattagg agactttgga
     2101 ttatcccgat atatggaaga tagtacttac tacaaagctt ccaaaggaaa attgcctatt
     2161 aaatggatgg ctccagagtc aatcaatttt cgacgtttta cctcagctag tgacgtatgg
     2221 atgtttggtg tgtgtatgtg ggagatactg atgcatggtg tgaagccttt tcaaggagtg
     2281 aagaacaatg atgtaatcgg tcgaattgaa aatggggaaa gattaccaat gcctccaaat
     2341 tgtcctccta ccctctacag ccttatgacg aaatgctggg cctatgaccc cagcaggcgg
     2401 cccaggttta ctgaacttaa agctcagctc agcacaatcc tggaggaaga gaaggctcag
     2461 caagaagagc gcatgaggat ggagtccaga agacaggcca cagtgtcctg ggactccgga
     2521 gggtctgatg aagcaccgcc caagcccagc agaccgggtt atcccagtcc gaggtccagc
     2581 gaaggatttt atcccagccc acagcacatg gtacaaacca atcattacca ggtttctggc
     2641 taccctggtt cacatggaat cacagccatg gctggcagca tctatccagg tcaggcatct
     2701 cttttggacc aaacagattc atggaatcat agacctcagg agatagcaat gtggcagccc
     2761 aatgtggagg actctacagt attggacctg cgagggattg ggcaagtgtt gccaacccat
     2821 ctgatggaag agcgtctaat ccgacagcaa caggaaatgg aagaagatca gcgctggctg
     2881 gaaaaagagg aaagatttct gaaacctgat gtgagactct ctcgaggcag tattgacagg
     2941 gaggatggaa gtcttcaggg tccgattgga aaccaacata tatatcagcc tgtgggtaaa
     3001 ccagatcctg cagctccacc aaagaaaccg cctcgccctg gagctcccgg tcatctggga
     3061 agccttgcca gcctcagcag ccctgctgac agctacaacg agggtgtcaa gccatggagg
     3121 cttcagcccc aggaaatcag cccccctcct actgccaacc tggaccggtc gaatgataag
     3181 gtgtacgaga atgtgacggg cctggtgaaa gctgtcatcg agatgtccag taaaatccag
     3241 ccagccccac cagaggagta tgtccctatg gtgaaggaag tcggcttggc cctgaggaca
     3301 ttattggcca ctgtggatga gaccattccc ctcctaccag ccagcaccca ccgagagatt
     3361 gagatggcac agaagctatt gaactctgac ctgggtgagc tcatcaacaa gatgaaactg
     3421 gcccagcagt atgtcatgac cagcctccag caagagtaca aaaagcaaat gctgactgct
     3481 gctcacgccc tggctgtgga tgccaaaaac ttactcgatg tcattgacca agcaagactg
     3541 aaaatgcttg ggcagacgag accacactga gcctccccta ggagcacgtc ttgctaccct
     3601 cttttgaaga tgttctctag ccttccacca gcagcgagga attaaccctg tgtcctcagt
     3661 cgccagcact tacagctcca acttttttga atgaccatct ggttgaaaaa tctttctcat
     3721 ataagtttaa ccacactttg atttgggttc attttttgtt ttgttttttt caatcatgat
     3781 attcagaaaa atccaggatc caaaatgtgg cgtttttcta agaatgaaaa ttatatgtaa
     3841 gcttttaagc atcatgaaga acaatttatg ttcacattaa gatacgttct aaagggggat
     3901 ggccaagggg tgacatctta attcctaaac taccttagct gcatagtgga agaggagagc
     3961 atgaagcaaa gaattccagg aaacccaaga ggctgagaat tcttttgtct accatagaat
     4021 tattatccag actggaattt ttgtttgtta gaacaccctt cagttgcaat atgctaatcc
     4081 cactttacaa agaatataaa agctatattt tgaagacttg agttatttca gaaaaaacta
     4141 cagccctttt tgtcttacct gccttttact ttcgtgtgga tatgtgaagc attgggtcgg
     4201 gaactagctg tagaacacaa ctaaaaactc atgtcttttt tcacagaata atgtgccagt
     4261 tttttgtagc aatgttattt ctcttggaag cagaaatgct ttgtaccaga gcacctccaa
     4321 actgcattga ggagaagttc cagaaccatc ccctttttcc atttttatat aatttataaa
     4381 gaaagattaa agccatgttg actattttac agccactgga gttaactaac ccttccttgt
     4441 atctgtcttc ccaggagaga atgaagcaaa acaggaattt ggttttcttt tgatgtccag
     4501 ttacaccatc cattctgtta attttgaaaa aatataccct ccctttagtt tgttggggga
     4561 tataaattat tctcaggaag aatataatga actgtacagt tactttgacc tattaaaaag
     4621 gtgttaccag taaagttctt gttgtaatat cctttctttt ggttctgttt cttcagatgg
     4681 cttttcaggt gacttgtcag ataagataac atacaagaga gttcccaata attatcagga
     4741 agcctctcac taattagttt cttttttttt atttaatctt ctaaacaagt caaggatgtt
     4801 accacagaag ggtagcgtgg cgtaagttaa ccttttcatt ccatcgtcac ctattaaatg
     4861 cagagctcag gatggaagta gcaatggtct tcaatgaaag aaccttcccc tgcgcagggt
     4921 ctcactattc cgctaactcg gactcaaagc ataattcact tgtcaaggaa attgttagca
     4981 tttcccaggc ccaccctagt cttgctagaa tctctgtgag ccacagagca gggagcaaat
     5041 agaactgaga tctccagcac tagggactca gactccaaag ggagggattt gagtgaattt
     5101 tttccaggta aatacatgct cttatgtgca aaagca
//
