LOCUS       NM_001352694            4915 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens protein tyrosine kinase 2 (PTK2), transcript variant
            5, mRNA.
ACCESSION   NM_001352694 XM_017013673
VERSION     NM_001352694.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4915)
  AUTHORS   Tang,Z.Y., Wang,X.M., Xu,C.W., Sun,Q.Q., Hua,Y.X., Zhou,Q.Y.,
            Hu,H.Y., Liu,S.B., Guo,Y.J., Ao,L., Che,X., Zhang,X.C., Heger,M.,
            Zheng,X., Liu,A.J., Wang,Q., Zhan,Z.J., Cheng,S.Q. and Pan,W.W.
  TITLE     DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 421 (2024)
   PUBMED   39367995
  REMARK    GeneRIF: DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4915)
  AUTHORS   Chen,A., Zhang,J., Yan,Z., Lu,Y., Chen,W., Sun,Y., Gu,Q., Li,F.,
            Yang,Y., Qiu,S., Lin,X., Zhang,D., Teng,J., Fang,Y., Shen,B.,
            Song,N. and Ding,X.
  TITLE     Acidic preconditioning induced intracellular acid adaptation to
            protect renal injury via dynamic phosphorylation of focal adhesion
            kinase-dependent activation of sodium hydrogen exchanger 1
  JOURNAL   Cell Commun Signal 22 (1), 393 (2024)
   PUBMED   39118129
  REMARK    GeneRIF: Acidic preconditioning induced intracellular acid
            adaptation to protect renal injury via dynamic phosphorylation of
            focal adhesion kinase-dependent activation of sodium hydrogen
            exchanger 1.
            Erratum:[Cell Commun Signal. 2024 Sep 11;22(1):439. doi:
            10.1186/s12964-024-01815-3.. PMID: 39261884]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4915)
  AUTHORS   Brown,N.D. and Vomhof-DeKrey,E.E.
  TITLE     Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal
            Homeostasis and Innate Immunity Crosstalk
  JOURNAL   Cells 13 (14), 1178 (2024)
   PUBMED   39056760
  REMARK    GeneRIF: Focal Adhesion Kinase and Colony Stimulating Factors:
            Intestinal Homeostasis and Innate Immunity Crosstalk.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4915)
  AUTHORS   Markowska,A., de Mezer,M., Kurzawa,P., Bednarek,W., Grybos,A.,
            Krzyzaniak,M., Markowska,J., Grybos,M. and Zurawski,J.
  TITLE     Analysis of Expression of the ANG1, CaSR and FAK Proteins in
            Uterine Fibroids
  JOURNAL   Int J Mol Sci 25 (13), 7164 (2024)
   PUBMED   39000274
  REMARK    GeneRIF: Analysis of Expression of the ANG1, CaSR and FAK Proteins
            in Uterine Fibroids.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4915)
  AUTHORS   Park,S.Y., Choi,H., Choi,S.M., Wang,S., Shim,S., Jun,W., Lee,J. and
            Chung,J.W.
  TITLE     T-plastin contributes to epithelial-mesenchymal transition in human
            lung cancer cells through FAK/AKT/Slug axis signaling pathway
  JOURNAL   BMB Rep 57 (6), 305-310 (2024)
   PUBMED   38835117
  REMARK    GeneRIF: T-plastin contributes to epithelial-mesenchymal transition
            in human lung cancer cells through FAK/AKT/Slug axis signaling
            pathway.
REFERENCE   6  (bases 1 to 4915)
  AUTHORS   Polte,T.R. and Hanks,S.K.
  TITLE     Interaction between focal adhesion kinase and Crk-associated
            tyrosine kinase substrate p130Cas
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10678-10682 (1995)
   PUBMED   7479864
REFERENCE   7  (bases 1 to 4915)
  AUTHORS   Guinebault,C., Payrastre,B., Racaud-Sultan,C., Mazarguil,H.,
            Breton,M., Mauco,G., Plantavid,M. and Chap,H.
  TITLE     Integrin-dependent translocation of phosphoinositide 3-kinase to
            the cytoskeleton of thrombin-activated platelets involves specific
            interactions of p85 alpha with actin filaments and focal adhesion
            kinase
  JOURNAL   J Cell Biol 129 (3), 831-842 (1995)
   PUBMED   7537275
REFERENCE   8  (bases 1 to 4915)
  AUTHORS   Calalb,M.B., Polte,T.R. and Hanks,S.K.
  TITLE     Tyrosine phosphorylation of focal adhesion kinase at sites in the
            catalytic domain regulates kinase activity: a role for Src family
            kinases
  JOURNAL   Mol Cell Biol 15 (2), 954-963 (1995)
   PUBMED   7529876
REFERENCE   9  (bases 1 to 4915)
  AUTHORS   Bergman,M., Joukov,V., Virtanen,I. and Alitalo,K.
  TITLE     Overexpressed Csk tyrosine kinase is localized in focal adhesions,
            causes reorganization of alpha v beta 5 integrin, and interferes
            with HeLa cell spreading
  JOURNAL   Mol Cell Biol 15 (2), 711-722 (1995)
   PUBMED   7529872
REFERENCE   10 (bases 1 to 4915)
  AUTHORS   Schaller,M.D., Hildebrand,J.D., Shannon,J.D., Fox,J.W., Vines,R.R.
            and Parsons,J.T.
  TITLE     Autophosphorylation of the focal adhesion kinase, pp125FAK, directs
            SH2-dependent binding of pp60src
  JOURNAL   Mol Cell Biol 14 (3), 1680-1688 (1994)
   PUBMED   7509446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100860.2, AC105009.13,
            AC105235.7 and AC067931.16.
            
            On Jun 2, 2019 this sequence version replaced NM_001352694.1.
            
            Summary: This gene encodes a cytoplasmic protein tyrosine kinase
            which is found concentrated in the focal adhesions that form
            between cells growing in the presence of extracellular matrix
            constituents. The encoded protein is a member of the FAK subfamily
            of protein tyrosine kinases but lacks significant sequence
            similarity to kinases from other subfamilies. Activation of this
            gene may be an important early step in cell growth and
            intracellular signal transduction pathways triggered in response to
            certain neural peptides or to cell interactions with the
            extracellular matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2017].
            
            Transcript Variant: This variant (5), as well as variant 1, encodes
            isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.31286.1,
                                           SRR11853558.23554.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC100860.2         64994-65151
            159-385             AC105009.13        32898-33124
            386-552             AC105009.13        44030-44196
            553-640             AC105009.13        59268-59355
            641-720             AC105009.13        76989-77068
            721-783             AC105009.13        77345-77407
            784-838             AC105235.7         116606-116660       c
            839-979             AC105235.7         105014-105154       c
            980-1057            AC105235.7         104411-104488       c
            1058-1165           AC105235.7         89677-89784         c
            1166-1283           AC105235.7         86593-86710         c
            1284-1314           AC105235.7         79488-79518         c
            1315-1367           AC105235.7         75608-75660         c
            1368-1424           AC105235.7         50368-50424         c
            1425-1522           AC105235.7         47299-47396         c
            1523-1607           AC105235.7         38366-38450         c
            1608-1708           AC105235.7         32894-32994         c
            1709-1824           AC105235.7         30786-30901         c
            1825-1925           AC105235.7         29364-29464         c
            1926-2015           AC105235.7         25152-25241         c
            2016-2220           AC105235.7         21385-21589         c
            2221-2332           AC067931.16        194228-194339       c
            2333-2419           AC067931.16        182749-182835       c
            2420-2557           AC067931.16        179200-179337       c
            2558-2689           AC067931.16        177521-177652       c
            2690-2752           AC067931.16        163262-163324       c
            2753-2792           AC067931.16        152090-152129       c
            2793-2899           AC067931.16        150928-151034       c
            2900-3055           AC067931.16        144899-145054       c
            3056-3136           AC067931.16        141547-141627       c
            3137-4915           AC067931.16        134530-136308       c
FEATURES             Location/Qualifiers
     source          1..4915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..4915
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="protein tyrosine kinase 2"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
     exon            1..158
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            159..385
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..3349
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 5; focal
                     adhesion kinase 1; FAK-related non-kinase polypeptide;
                     focal adhesion kinase-related nonkinase; protein
                     phosphatase 1 regulatory subunit 71; PTK2 protein tyrosine
                     kinase 2"
                     /codon_start=1
                     /product="focal adhesion kinase 1 isoform 1"
                     /protein_id="NP_001339623.1"
                     /db_xref="CCDS:CCDS6381.1"
                     /db_xref="GeneID:5747"
                     /db_xref="HGNC:HGNC:9611"
                     /db_xref="MIM:600758"
                     /translation="MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFE
                     SNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDM
                     GVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIA
                     DQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAK
                     TLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGP
                     EEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSL
                     TIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVS
                     ETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALA
                     VAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELR
                     SFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFG
                     LSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQ
                     GVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEE
                     EKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTN
                     HYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRG
                     IGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIG
                     NQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPT
                     ANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI
                     PLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVD
                     AKNLLDVIDQARLKMLGQTRPH"
     exon            386..552
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            553..640
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            641..720
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            721..783
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            784..838
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            839..979
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1057
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1165
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1283
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1314
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1367
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1424
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1522
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1607
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1708
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1824
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1925
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2015
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2220
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2332
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2419
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2557
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2689
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2752
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2792
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2899
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3055
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3136
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..4915
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4391..4396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: ATTAAA"
     regulatory      4408..4413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: AGTAAA"
     polyA_site      4413
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="major polyA site"
     polyA_site      4430
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
     regulatory      4632..4637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
                     /note="hexamer: ATTAAA"
     polyA_site      4651
                     /gene="PTK2"
                     /gene_synonym="FADK; FADK 1; FAK; FAK1; FRNK; p125FAK;
                     pp125FAK; PPP1R71"
ORIGIN      
        1 acggcctcga gggcgcgagc ccgcgccgcc gccgccgccg ccggtcccgg accactgtga
       61 gcccgcggcg tgaggcgtgg gaggaagcgc ggctgctgtc gcccagcgcc gccccgtcgt
      121 cgtctgcctt cgcttcacgg cgccgagccg cggtccgaaa tatgacagat acctagcatc
      181 tagcaaaata atggcagctg cttaccttga ccccaacttg aatcacacac caaattcgag
      241 tactaagact cacctgggta ctggtatgga acgttctcct ggtgcaatgg agcgagtatt
      301 aaaggtcttt cattattttg aaagcaatag tgagccaacc acctgggcca gtattatcag
      361 gcatggagat gctactgatg tcaggggcat cattcagaag atagtggaca gtcacaaagt
      421 aaagcatgtg gcctgctatg gattccgcct cagtcacctg cggtcagagg aggttcactg
      481 gcttcacgtg gatatgggcg tctccagtgt gagggagaag tatgagcttg ctcacccacc
      541 agaggagtgg aaatatgaat tgagaattcg ttatttgcca aaaggatttc taaaccagtt
      601 tactgaagat aagccaactt tgaatttctt ctatcaacag gtgaagagcg attatatgtt
      661 agagatagct gatcaagtgg accaggaaat tgctttgaag ttgggttgtc tagaaatacg
      721 gcgatcatac tgggagatgc ggggcaatgc actagaaaag aagtctaact atgaagtatt
      781 agaaaaagat gttggtttaa agcgattttt tcctaagagt ttactggatt ctgtcaaggc
      841 caaaacacta agaaaactga tccaacaaac atttagacaa tttgccaacc ttaatagaga
      901 agaaagtatt ctgaaattct ttgagatcct gtctccagtc tacagatttg ataaggaatg
      961 cttcaagtgt gctcttggtt caagctggat tatttcagtg gaactggcaa tcggcccaga
     1021 agaaggaatc agttacctaa cggacaaggg ctgcaatccc acacatcttg ctgacttcac
     1081 tcaagtgcaa accattcagt attcaaacag tgaagacaag gacagaaaag gaatgctaca
     1141 actaaaaata gcaggtgcac ccgagcctct gacagtgacg gcaccatccc taaccattgc
     1201 ggagaatatg gctgacctaa tagatgggta ctgccggctg gtgaatggaa cctcgcagtc
     1261 atttatcatc agacctcaga aagaaggtga acgggctttg ccatcaatac caaagttggc
     1321 caacagcgaa aagcaaggca tgcggacaca cgccgtctct gtgtcagaaa cagatgatta
     1381 tgctgagatt atagatgaag aagatactta caccatgccc tcaaccaggg attatgagat
     1441 tcaaagagaa agaatagaac ttggacgatg tattggagaa ggccaatttg gagatgtaca
     1501 tcaaggcatt tatatgagtc cagagaatcc agctttggcg gttgcaatta aaacatgtaa
     1561 aaactgtact tcggacagcg tgagagagaa atttcttcaa gaagccttaa caatgcgtca
     1621 gtttgaccat cctcatattg tgaagctgat tggagtcatc acagagaatc ctgtctggat
     1681 aatcatggag ctgtgcacac ttggagagct gaggtcattt ttgcaagtaa ggaaatacag
     1741 tttggatcta gcatctttga tcctgtatgc ctatcagctt agtacagctc ttgcatatct
     1801 agagagcaaa agatttgtac acagggacat tgctgctcgg aatgttctgg tgtcctcaaa
     1861 tgattgtgta aaattaggag actttggatt atcccgatat atggaagata gtacttacta
     1921 caaagcttcc aaaggaaaat tgcctattaa atggatggct ccagagtcaa tcaattttcg
     1981 acgttttacc tcagctagtg acgtatggat gtttggtgtg tgtatgtggg agatactgat
     2041 gcatggtgtg aagccttttc aaggagtgaa gaacaatgat gtaatcggtc gaattgaaaa
     2101 tggggaaaga ttaccaatgc ctccaaattg tcctcctacc ctctacagcc ttatgacgaa
     2161 atgctgggcc tatgacccca gcaggcggcc caggtttact gaacttaaag ctcagctcag
     2221 cacaatcctg gaggaagaga aggctcagca agaagagcgc atgaggatgg agtccagaag
     2281 acaggccaca gtgtcctggg actccggagg gtctgatgaa gcaccgccca agcccagcag
     2341 accgggttat cccagtccga ggtccagcga aggattttat cccagcccac agcacatggt
     2401 acaaaccaat cattaccagg tttctggcta ccctggttca catggaatca cagccatggc
     2461 tggcagcatc tatccaggtc aggcatctct tttggaccaa acagattcat ggaatcatag
     2521 acctcaggag atagcaatgt ggcagcccaa tgtggaggac tctacagtat tggacctgcg
     2581 agggattggg caagtgttgc caacccatct gatggaagag cgtctaatcc gacagcaaca
     2641 ggaaatggaa gaagatcagc gctggctgga aaaagaggaa agatttctga aacctgatgt
     2701 gagactctct cgaggcagta ttgacaggga ggatggaagt cttcagggtc cgattggaaa
     2761 ccaacatata tatcagcctg tgggtaaacc agatcctgca gctccaccaa agaaaccgcc
     2821 tcgccctgga gctcccggtc atctgggaag ccttgccagc ctcagcagcc ctgctgacag
     2881 ctacaacgag ggtgtcaagc ttcagcccca ggaaatcagc ccccctccta ctgccaacct
     2941 ggaccggtcg aatgataagg tgtacgagaa tgtgacgggc ctggtgaaag ctgtcatcga
     3001 gatgtccagt aaaatccagc cagccccacc agaggagtat gtccctatgg tgaaggaagt
     3061 cggcttggcc ctgaggacat tattggccac tgtggatgag accattcccc tcctaccagc
     3121 cagcacccac cgagagattg agatggcaca gaagctattg aactctgacc tgggtgagct
     3181 catcaacaag atgaaactgg cccagcagta tgtcatgacc agcctccagc aagagtacaa
     3241 aaagcaaatg ctgactgctg ctcacgccct ggctgtggat gccaaaaact tactcgatgt
     3301 cattgaccaa gcaagactga aaatgcttgg gcagacgaga ccacactgag cctcccctag
     3361 gagcacgtct tgctaccctc ttttgaagat gttctctagc cttccaccag cagcgaggaa
     3421 ttaaccctgt gtcctcagtc gccagcactt acagctccaa cttttttgaa tgaccatctg
     3481 gttgaaaaat ctttctcata taagtttaac cacactttga tttgggttca ttttttgttt
     3541 tgtttttttc aatcatgata ttcagaaaaa tccaggatcc aaaatgtggc gtttttctaa
     3601 gaatgaaaat tatatgtaag cttttaagca tcatgaagaa caatttatgt tcacattaag
     3661 atacgttcta aagggggatg gccaaggggt gacatcttaa ttcctaaact accttagctg
     3721 catagtggaa gaggagagca tgaagcaaag aattccagga aacccaagag gctgagaatt
     3781 cttttgtcta ccatagaatt attatccaga ctggaatttt tgtttgttag aacacccttc
     3841 agttgcaata tgctaatccc actttacaaa gaatataaaa gctatatttt gaagacttga
     3901 gttatttcag aaaaaactac agcccttttt gtcttacctg ccttttactt tcgtgtggat
     3961 atgtgaagca ttgggtcggg aactagctgt agaacacaac taaaaactca tgtctttttt
     4021 cacagaataa tgtgccagtt ttttgtagca atgttatttc tcttggaagc agaaatgctt
     4081 tgtaccagag cacctccaaa ctgcattgag gagaagttcc agaaccatcc cctttttcca
     4141 tttttatata atttataaag aaagattaaa gccatgttga ctattttaca gccactggag
     4201 ttaactaacc cttccttgta tctgtcttcc caggagagaa tgaagcaaaa caggaatttg
     4261 gttttctttt gatgtccagt tacaccatcc attctgttaa ttttgaaaaa atataccctc
     4321 cctttagttt gttgggggat ataaattatt ctcaggaaga atataatgaa ctgtacagtt
     4381 actttgacct attaaaaagg tgttaccagt aaagttcttg ttgtaatatc ctttcttttg
     4441 gttctgtttc ttcagatggc ttttcaggtg acttgtcaga taagataaca tacaagagag
     4501 ttcccaataa ttatcaggaa gcctctcact aattagtttc ttttttttta tttaatcttc
     4561 taaacaagtc aaggatgtta ccacagaagg gtagcgtggc gtaagttaac cttttcattc
     4621 catcgtcacc tattaaatgc agagctcagg atggaagtag caatggtctt caatgaaaga
     4681 accttcccct gcgcagggtc tcactattcc gctaactcgg actcaaagca taattcactt
     4741 gtcaaggaaa ttgttagcat ttcccaggcc caccctagtc ttgctagaat ctctgtgagc
     4801 cacagagcag ggagcaaata gaactgagat ctccagcact agggactcag actccaaagg
     4861 gagggatttg agtgaatttt ttccaggtaa atacatgctc ttatgtgcaa aagca
//
