LOCUS       NM_005048               2752 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens parathyroid hormone 2 receptor (PTH2R), transcript
            variant 1, mRNA.
ACCESSION   NM_005048
VERSION     NM_005048.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2752)
  AUTHORS   Wang,X., Cheng,X., Zhao,L., Wang,Y., Ye,C., Zou,X., Dai,A.,
            Cong,Z., Chen,J., Zhou,Q., Xia,T., Jiang,H., Xu,H.E., Yang,D. and
            Wang,M.W.
  TITLE     Molecular insights into differentiated ligand recognition of the
            human parathyroid hormone receptor 2
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34353904
  REMARK    GeneRIF: Molecular insights into differentiated ligand recognition
            of the human parathyroid hormone receptor 2.
REFERENCE   2  (bases 1 to 2752)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2752)
  AUTHORS   Sato,E., Williams,M.R., Sanford,J.A., Sen,G.L., Nakama,T.,
            Imafuku,S. and Gallo,R.L.
  TITLE     The parathyroid hormone family member TIP39 interacts with
            sarco/endoplasmic reticulum Ca2+ - ATPase activity by influencing
            calcium homoeostasis
  JOURNAL   Exp Dermatol 26 (9), 792-797 (2017)
   PUBMED   28094886
  REMARK    GeneRIF: expressed in the epidermis in Darier disease
REFERENCE   4  (bases 1 to 2752)
  AUTHORS   Sato,E., Muto,J., Zhang,L.J., Adase,C.A., Sanford,J.A.,
            Takahashi,T., Nakatsuji,T., Usdin,T.B. and Gallo,R.L.
  TITLE     The Parathyroid Hormone Second Receptor PTH2R and its Ligand
            Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate
            Intracellular Calcium and Influence Keratinocyte Differentiation
  JOURNAL   J Invest Dermatol 136 (7), 1449-1459 (2016)
   PUBMED   27000502
  REMARK    GeneRIF: PTH2R and its ligand TIP39 regulate intracellular calcium
            and influence keratinocyte differentiation
REFERENCE   5  (bases 1 to 2752)
  AUTHORS   Kim,J., Won,H.H., Kim,Y., Choi,J.R., Yu,N. and Lee,K.A.
  TITLE     Breakpoint mapping by whole genome sequencing identifies PTH2R gene
            disruption in a patient with midline craniosynostosis and a de novo
            balanced chromosomal rearrangement
  JOURNAL   J Med Genet 52 (10), 706-709 (2015)
   PUBMED   26044810
  REMARK    GeneRIF: Authors report PTH2R as a gene that is disrupted in NSC.
            The disruption of the PTH2R gene may cause uncontrolled
            proliferation and differentiation of chondrocytes.
REFERENCE   6  (bases 1 to 2752)
  AUTHORS   John,M.R., Arai,M., Rubin,D.A., Jonsson,K.B. and Juppner,H.
  TITLE     Identification and characterization of the murine and human gene
            encoding the tuberoinfundibular peptide of 39 residues
  JOURNAL   Endocrinology 143 (3), 1047-1057 (2002)
   PUBMED   11861531
REFERENCE   7  (bases 1 to 2752)
  AUTHORS   Hoare,S.R., Clark,J.A. and Usdin,T.B.
  TITLE     Molecular determinants of tuberoinfundibular peptide of 39 residues
            (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor.
            N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor
            binding selectivity
  JOURNAL   J Biol Chem 275 (35), 27274-27283 (2000)
   PUBMED   10854439
REFERENCE   8  (bases 1 to 2752)
  AUTHORS   Clark,J.A., Bonner,T.I., Kim,A.S. and Usdin,T.B.
  TITLE     Multiple regions of ligand discrimination revealed by analysis of
            chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide
            (PTHrP) receptors
  JOURNAL   Mol Endocrinol 12 (2), 193-206 (1998)
   PUBMED   9482662
REFERENCE   9  (bases 1 to 2752)
  AUTHORS   Usdin,T.B., Modi,W. and Bonner,T.I.
  TITLE     Assignment of the human PTH2 receptor gene (PTHR2) to chromosome
            2q33 by fluorescence in situ hybridization
  JOURNAL   Genomics 37 (1), 140-141 (1996)
   PUBMED   8921382
REFERENCE   10 (bases 1 to 2752)
  AUTHORS   Usdin,T.B., Gruber,C. and Bonner,T.I.
  TITLE     Identification and functional expression of a receptor selectively
            recognizing parathyroid hormone, the PTH2 receptor
  JOURNAL   J Biol Chem 270 (26), 15455-15458 (1995)
   PUBMED   7797535
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012362.7 and AC019185.8.
            
            On Jul 26, 2019 this sequence version replaced NM_005048.3.
            
            Summary: The protein encoded by this gene is a member of the
            G-protein coupled receptor 2 family. This protein is a receptor for
            parathyroid hormone (PTH). This receptor is more selective in
            ligand recognition and has a more specific tissue distribution
            compared to parathyroid hormone receptor 1 (PTHR1). It is activated
            only by PTH and not by parathyroid hormone-like hormone (PTHLH) and
            is particularly abundant in brain and pancreas. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036811.1, U25128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2162568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272847.7/ ENSP00000272847.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AC012362.7         103237-103563
            328-430             AC012362.7         124646-124748
            431-541             AC012362.7         133982-134092
            542-663             AC012362.7         134205-134326
            664-761             AC012362.7         138809-138906
            762-951             AC012362.7         139793-139982
            952-1105            AC012362.7         141179-141332
            1106-1166           AC012362.7         147194-147254
            1167-1233           AC012362.7         156340-156406
            1234-1328           AC019185.8         22894-22988
            1329-1467           AC019185.8         30836-30974
            1468-1509           AC019185.8         32463-32504
            1510-2752           AC019185.8         35088-36330
FEATURES             Location/Qualifiers
     source          1..2752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2752
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /note="parathyroid hormone 2 receptor"
                     /db_xref="GeneID:5746"
                     /db_xref="HGNC:HGNC:9609"
                     /db_xref="MIM:601469"
     exon            1..327
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1905
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; parathyroid hormone receptor 2; PTH2 receptor"
                     /codon_start=1
                     /product="parathyroid hormone 2 receptor isoform 1
                     precursor"
                     /protein_id="NP_005039.1"
                     /db_xref="CCDS:CCDS2383.1"
                     /db_xref="GeneID:5746"
                     /db_xref="HGNC:HGNC:9609"
                     /db_xref="MIM:601469"
                     /translation="MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKA
                     KVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKISAVPCPPYIYDFNHKGVAFRH
                     CNPNGTWDFMHSLNKTWANYSDCLRFLQPDISIGKQEFFERLYVMYTVGYSISFGSLA
                     VAILIIGYFRRLHCTRNYIHMHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDD
                     PQNSIEATSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYL
                     WGFILIGWGFPAAFVAAWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFL
                     NTVRVLATKIWETNAVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWE
                     IRMHCELFFNSFQGFFVSIIYCYCNGEVQAEVKKMWSRWNLSVDWKRTPPCGSRRCGS
                     VLTTVTHSTSSQSQVAASTRMVLISGKAAKIASRQPDSHITLPGYVWSNSEQDCLPHS
                     FHEETKEDSGRQGDDILMEKPSRPMESNPDTEGCQGETEDVL"
     exon            328..430
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..541
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..663
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..761
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..951
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1105
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1166
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1233
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1328
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1467
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1509
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2752
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2730..2735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /note="hexamer: ATTAAA"
     polyA_site      2752
                     /gene="PTH2R"
                     /gene_synonym="PTHR2"
                     /note="major polyA site"
ORIGIN      
        1 aggactcggg ccagtctctc cggaagacaa gaccaacctc gcgccgcggc gcagcagcac
       61 gcgggttctg agaagcgcgt ggctccggcg acaagacccc aagcaccctc ggccggtggc
      121 ccgggcccga ccaccccagc tgcgcgtcgt tactggccac aagtttgctc tgggccagcc
      181 aagttggcaa cttggaagct tctcccgggc tctggaggag ggtccctgct tcttcctaca
      241 gccgttccgg gcatggccgg gctgggggcg tcgctccacg tctggggttg gctaatgctc
      301 ggcagctgcc tcctggccag agcccagctg gattctgatg gcaccattac tatagaggag
      361 cagattgtcc ttgtgctgaa agcgaaagta caatgtgaac tcaacatcac agctcaactc
      421 caggagggag aaggtaattg tttccctgaa tgggatggac tcatttgttg gcccagagga
      481 acagtgggga aaatatcggc tgttccatgc cctccttata tttatgactt caaccataaa
      541 ggagttgctt tccgacactg taaccccaat ggaacatggg attttatgca cagcttaaat
      601 aaaacatggg ccaattattc agactgcctt cgctttctgc agccagatat cagcatagga
      661 aagcaagaat tctttgaacg cctctatgta atgtataccg ttggctactc catctctttt
      721 ggttccttgg ctgtggctat tctcatcatt ggttacttca gacgattgca ttgcactagg
      781 aactatatcc acatgcactt atttgtgtct ttcatgctga gagctacaag catctttgtc
      841 aaagacagag tagtccatgc tcacatagga gtaaaggagc tggagtccct aataatgcag
      901 gatgacccac aaaattccat tgaggcaact tctgtggaca aatcacaata tatcgggtgc
      961 aagattgctg ttgtgatgtt tatttacttc ctggctacaa attattattg gatcctggtg
     1021 gaaggtctct acctgcataa tctcatcttt gtggctttct tttcggacac caaatacctg
     1081 tggggcttca tcttgatagg ctgggggttt ccagcagcat ttgttgcagc atgggctgtg
     1141 gcacgagcaa ctctggctga tgcgaggtgc tgggaactta gtgctggaga catcaagtgg
     1201 atttatcaag caccgatctt agcagctatt gggctgaatt ttattctgtt tctgaatacg
     1261 gttagagttc tagctaccaa aatctgggag accaatgcag ttgggcatga cacaaggaag
     1321 caatacagga aactggccaa atcgacactg gtcctggtcc tagtctttgg agtgcattac
     1381 atcgtgttcg tatgcctgcc tcactccttc actgggctcg ggtgggagat ccgcatgcac
     1441 tgtgagctct tcttcaactc ctttcagggt ttctttgtgt ctatcatcta ctgctactgc
     1501 aatggagagg ttcaggcaga ggtgaagaag atgtggagtc ggtggaacct ctccgtggac
     1561 tggaaaagga caccgccatg tggcagccgc agatgcggct cagtgctcac caccgtgacg
     1621 cacagcacca gcagccagtc acaggtggcg gccagcacac gcatggtgct tatctctggc
     1681 aaagctgcca agatcgccag cagacagcct gacagccaca tcactttacc tggctatgtc
     1741 tggagtaact cagagcagga ctgcctgcca cactctttcc acgaggagac caaggaagat
     1801 agtgggaggc agggagatga tattctaatg gagaagcctt ccaggcctat ggaatctaac
     1861 ccagacactg aaggatgcca aggagaaact gaggatgttc tctgaatgga catttgtggc
     1921 tgactttcat gggctggtcc aatggctggt tgtgtgagag ggcttggctg atactcctat
     1981 gcttgagttc aaaggctgaa aattcagtta aggtgttact taataatagt ttttaggctc
     2041 catgaattgg ctcctgtaaa tactaacgac atgaaaatgc aagtgtcaat ggagtagttt
     2101 attaccttct attggcatca agttttcctc taaattaatg tatggtattt gctctgtgat
     2161 tgttcatttt tttctgctac ttttgggtag aaaaaagatt caattgcttg gctgtagctt
     2221 tctctcatat atatcaccct aaatataatg aagatctttt agtgtgtatc attttccttt
     2281 tagaaactag tattctctta tttcttactt taatgtactt ctatcactgc atttattttg
     2341 cctgtgcata ggagcaatta ggatctaaaa aaatatatgg gaagataaaa gatctaagaa
     2401 caagtacttg ctggaaaatt agttggctgg acattgataa aataatgcat ttataacaat
     2461 tacatgtgtt tctgggaaca aggaaaattt ctcaaaaaag aatatttcac acatcccttc
     2521 ttttgaatgg cctctttgtg accagccaga cctcaggtct tcactctttc ttctttgtaa
     2581 actatgtcat gtggaaagat ttcctcagtt agtgagcttg tgtctgcaaa ttgattttgt
     2641 ttgtaatgta ttttgatagc aaatcatgct gcatctatat ctttttcttg tttgagctgt
     2701 tactacattg tacatggcat gtgggatcaa ttaaaaattt gttttaaaaa ta
//
