LOCUS       NM_178449                454 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens parathyroid hormone 2 (PTH2), mRNA.
ACCESSION   NM_178449
VERSION     NM_178449.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Sato,E., Williams,M.R., Sanford,J.A., Sen,G.L., Nakama,T.,
            Imafuku,S. and Gallo,R.L.
  TITLE     The parathyroid hormone family member TIP39 interacts with
            sarco/endoplasmic reticulum Ca2+ - ATPase activity by influencing
            calcium homoeostasis
  JOURNAL   Exp Dermatol 26 (9), 792-797 (2017)
   PUBMED   28094886
  REMARK    GeneRIF: modulator of endoplasmic reticulum calcium signalling
REFERENCE   3  (bases 1 to 454)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 454)
  AUTHORS   Wu,X., Ruan,J., Ma,B. and Luo,M.
  TITLE     Bit1-a potential positive regulator of epithelial-mesenchymal
            transition in lens epithelial cells
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 254 (7), 1311-1318 (2016)
   PUBMED   27122244
  REMARK    GeneRIF: Bit1 promotes TGF-beta2 induced alpha-SMA expression and
            acts as an positive regulator of EMT.
REFERENCE   5  (bases 1 to 454)
  AUTHORS   Bago,A.G., Dimitrov,E., Saunders,R., Seress,L., Palkovits,M.,
            Usdin,T.B. and Dobolyi,A.
  TITLE     Parathyroid hormone 2 receptor and its endogenous ligand
            tuberoinfundibular peptide of 39 residues are concentrated in
            endocrine, viscerosensory and auditory brain regions in macaque and
            human
  JOURNAL   Neuroscience 162 (1), 128-147 (2009)
   PUBMED   19401215
  REMARK    GeneRIF: The results demonstrate that TIP39 and the PTH2R are
            expressed in the brain of primates in locations that suggest
            involvement in regulation of fear, anxiety, reproductive behaviors,
            release of pituitary hormones, and nociception.
REFERENCE   6  (bases 1 to 454)
  AUTHORS   Hansen,I.A., Jakob,O., Wortmann,S., Arzberger,T., Allolio,B. and
            Blind,E.
  TITLE     Characterization of the human and mouse genes encoding the
            tuberoinfundibular peptide of 39 residues, a ligand of the
            parathyroid hormone receptor family
  JOURNAL   J Endocrinol 174 (1), 95-102 (2002)
   PUBMED   12098667
REFERENCE   7  (bases 1 to 454)
  AUTHORS   John,M.R., Arai,M., Rubin,D.A., Jonsson,K.B. and Juppner,H.
  TITLE     Identification and characterization of the murine and human gene
            encoding the tuberoinfundibular peptide of 39 residues
  JOURNAL   Endocrinology 143 (3), 1047-1057 (2002)
   PUBMED   11861531
REFERENCE   8  (bases 1 to 454)
  AUTHORS   Dobolyi,A., Ueda,H., Uchida,H., Palkovits,M. and Usdin,T.B.
  TITLE     Anatomical and physiological evidence for involvement of
            tuberoinfundibular peptide of 39 residues in nociception
  JOURNAL   Proc Natl Acad Sci U S A 99 (3), 1651-1656 (2002)
   PUBMED   11818570
REFERENCE   9  (bases 1 to 454)
  AUTHORS   Hoare,S.R., Clark,J.A. and Usdin,T.B.
  TITLE     Molecular determinants of tuberoinfundibular peptide of 39 residues
            (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor.
            N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor
            binding selectivity
  JOURNAL   J Biol Chem 275 (35), 27274-27283 (2000)
   PUBMED   10854439
REFERENCE   10 (bases 1 to 454)
  AUTHORS   Usdin,T.B., Hoare,S.R., Wang,T., Mezey,E. and Kowalak,J.A.
  TITLE     TIP39: a new neuropeptide and PTH2-receptor agonist from
            hypothalamus
  JOURNAL   Nat Neurosci 2 (11), 941-943 (1999)
   PUBMED   10526330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY037555.1 and BC093997.1.
            
            On May 17, 2019 this sequence version replaced NM_178449.3.
            
            Summary: This gene encodes the precursor of a peptide hormone that
            shares sequence similarity with the parathyroid hormone. This gene
            is expressed in various regions of the brain where it plays a role
            in the release of pituitary hormones, anxiety and nociception. The
            encoded precursor protein is proteolytically processed to generate
            the biologically active neuropeptide. [provided by RefSeq, Jul
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY037555.1, BC093997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02400289 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal (PMID:12098667)
            MANE Ensembl match               :: ENST00000270631.2/
                                                ENSP00000270631.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AY037555.1         1-320
            321-450             BC093997.1         264-393
            451-454             AY037555.1         451-454
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..454
                     /gene="PTH2"
                     /gene_synonym="TIP39"
                     /note="parathyroid hormone 2"
                     /db_xref="GeneID:113091"
                     /db_xref="HGNC:HGNC:30828"
                     /db_xref="MIM:608386"
     exon            1..230
                     /gene="PTH2"
                     /gene_synonym="TIP39"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..405
                     /gene="PTH2"
                     /gene_synonym="TIP39"
                     /note="tuberoinfundibular peptide of 39 residues;
                     tuberoinfundibular 39 residue protein"
                     /codon_start=1
                     /product="tuberoinfundibular peptide of 39 residues
                     preproprotein"
                     /protein_id="NP_848544.1"
                     /db_xref="CCDS:CCDS12763.1"
                     /db_xref="GeneID:113091"
                     /db_xref="HGNC:HGNC:30828"
                     /db_xref="MIM:608386"
                     /translation="METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSL
                     RPPGRAWADPATPRPRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP"
     exon            231..454
                     /gene="PTH2"
                     /gene_synonym="TIP39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      428..433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTH2"
                     /gene_synonym="TIP39"
                     /note="hexamer: AATAAA"
     polyA_site      454
                     /gene="PTH2"
                     /gene_synonym="TIP39"
                     /note="major polyA site"
ORIGIN      
        1 gtaggggact gtgcgggaag ctgggggtgg atgcatggtg gggcccgggg ttctgggccg
       61 ggatgcagcc ctactgagcc cctttctggt tctccacagg tgatggagac ccgccaggtg
      121 tccaggagcc ctcgggttcg gctgctgctg ctgctgctgc tgctgctggt ggtgccctgg
      181 ggcgtccgca ctgcctcggg agtcgccctg cccccggtcg gggtcctcag cctccgcccc
      241 ccaggacggg cctgggcgga tcccgccacc cccaggccgc ggaggagcct ggcgctggcg
      301 gacgacgcgg ccttccggga gcgcgcgcgg ttgctggccg ccctcgagcg ccgccactgg
      361 ctgaactcgt acatgcacaa gctgctggtg ttggatgcgc cctgagcgcg ctgcccgtcc
      421 ccatcttaat aaagaccatg ccctgcgctc cgga
//
