LOCUS       NM_000962               5020 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens prostaglandin-endoperoxide synthase 1 (PTGS1),
            transcript variant 1, mRNA.
ACCESSION   NM_000962
VERSION     NM_000962.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5020)
  AUTHORS   Zhang,L., Meng,Z., Wang,H. and Miao,Y.
  TITLE     Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of
            aspirin-treated patients with ischemic stroke in the Han population
            of China: A 4-year follow-up study
  JOURNAL   Medicine (Baltimore) 103 (19), e38031 (2024)
   PUBMED   38728491
  REMARK    GeneRIF: Effect of PEAR1, PTGS1 gene polymorphisms on the
            recurrence of aspirin-treated patients with ischemic stroke in the
            Han population of China: A 4-year follow-up study.
REFERENCE   2  (bases 1 to 5020)
  AUTHORS   Qin,N., Zhang,S.P., Reitz,T.L., Mei,J.M. and Flores,C.M.
  TITLE     Cloning, expression, and functional characterization of human
            cyclooxygenase-1 splicing variants: evidence for intron 1 retention
  JOURNAL   J Pharmacol Exp Ther 315 (3), 1298-1305 (2005)
   PUBMED   16141368
  REMARK    GeneRIF: Cloning, expression, and functional characterization of
            COX1 splicing variants were performed; there is evidence for intron
            retention.
REFERENCE   3  (bases 1 to 5020)
  AUTHORS   Dinchuk,J.E., Liu,R.Q. and Trzaskos,J.M.
  TITLE     COX-3: in the wrong frame in mind
  JOURNAL   Immunol Lett 86 (1), 121 (2003)
   PUBMED   12600754
REFERENCE   4  (bases 1 to 5020)
  AUTHORS   Chandrasekharan,N.V., Dai,H., Roos,K.L., Evanson,N.K., Tomsik,J.,
            Elton,T.S. and Simmons,D.L.
  TITLE     COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and
            other analgesic/antipyretic drugs: cloning, structure, and
            expression
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13926-13931 (2002)
   PUBMED   12242329
  REMARK    GeneRIF: cloning, structure and expression of the COX-3 isozyme
REFERENCE   5  (bases 1 to 5020)
  AUTHORS   Plant,M.H. and Laneuville,O.
  TITLE     Characterization of a novel transcript of prostaglandin
            endoperoxide H synthase 1 with a tissue-specific profile of
            expression
  JOURNAL   Biochem J 344 Pt 3 (Pt 3), 677-685 (1999)
   PUBMED   10585854
REFERENCE   6  (bases 1 to 5020)
  AUTHORS   Picot,D., Loll,P.J. and Garavito,R.M.
  TITLE     The X-ray crystal structure of the membrane protein prostaglandin
            H2 synthase-1
  JOURNAL   Nature 367 (6460), 243-249 (1994)
   PUBMED   8121489
  REMARK    GeneRIF: Prostaglandin G/H synthase is a moonlighting protein that
            functions both as a peroxidase as well as a cyclooxygenase.
REFERENCE   7  (bases 1 to 5020)
  AUTHORS   Diaz,A., Reginato,A.M. and Jimenez,S.A.
  TITLE     Alternative splicing of human prostaglandin G/H synthase mRNA and
            evidence of differential regulation of the resulting transcripts by
            transforming growth factor beta 1, interleukin 1 beta, and tumor
            necrosis factor alpha
  JOURNAL   J Biol Chem 267 (15), 10816-10822 (1992)
   PUBMED   1587858
REFERENCE   8  (bases 1 to 5020)
  AUTHORS   Takahashi,Y., Ueda,N., Yoshimoto,T., Yamamoto,S., Yokoyama,C.,
            Miyata,A., Tanabe,T., Fuse,I., Hattori,A. and Shibata,A.
  TITLE     Immunoaffinity purification and cDNA cloning of human platelet
            prostaglandin endoperoxide synthase (cyclooxygenase)
  JOURNAL   Biochem Biophys Res Commun 182 (2), 433-438 (1992)
   PUBMED   1734857
REFERENCE   9  (bases 1 to 5020)
  AUTHORS   Funk,C.D., Funk,L.B., Kennedy,M.E., Pong,A.S. and Fitzgerald,G.A.
  TITLE     Human platelet/erythroleukemia cell prostaglandin G/H synthase:
            cDNA cloning, expression, and gene chromosomal assignment
  JOURNAL   FASEB J 5 (9), 2304-2312 (1991)
   PUBMED   1907252
REFERENCE   10 (bases 1 to 5020)
  AUTHORS   Yokoyama,C. and Tanabe,T.
  TITLE     Cloning of human gene encoding prostaglandin endoperoxide synthase
            and primary structure of the enzyme
  JOURNAL   Biochem Biophys Res Commun 165 (2), 888-894 (1989)
   PUBMED   2512924
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA392280.1, AL162424.20,
            M59979.1, AL359636.17 and AI813317.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000962.3.
            
            Summary: This is one of two genes encoding similar enzymes that
            catalyze the conversion of arachidonate to prostaglandin. The
            encoded protein regulates angiogenesis in endothelial cells, and is
            inhibited by nonsteroidal anti-inflammatory drugs such as aspirin.
            Based on its ability to function as both a cyclooxygenase and as a
            peroxidase, the encoded protein has been identified as a
            moonlighting protein. The protein may promote cell proliferation
            during tumor progression. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2021].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.139547.1,
                                           SRR1803611.220452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000362012.7/
                                               ENSP00000354612.2
            multifunctional gene product(s) :: PMID: 8121489
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                DA392280.1         20-101
            83-83               AL162424.20        206436-206436
            84-2275             M59979.1           28-2219
            2276-4506           AL359636.17        5275-7505
            4507-5020           AI813317.1         7-520               c
FEATURES             Location/Qualifiers
     source          1..5020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..5020
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /note="prostaglandin-endoperoxide synthase 1"
                     /db_xref="GeneID:5742"
                     /db_xref="HGNC:HGNC:9604"
                     /db_xref="MIM:176805"
     exon            1..68
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1861
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /EC_number="1.14.99.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PGH synthase 1; cyclooxygenase-1; prostaglandin
                     H2 synthase 1; prostaglandin-endoperoxide synthase 1
                     (prostaglandin G/H synthase and cyclooxygenase)"
                     /codon_start=1
                     /product="prostaglandin G/H synthase 1 isoform 1
                     precursor"
                     /protein_id="NP_000953.2"
                     /db_xref="CCDS:CCDS6842.1"
                     /db_xref="GeneID:5742"
                     /db_xref="HGNC:HGNC:9604"
                     /db_xref="MIM:176805"
                     /translation="MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQG
                     ICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFV
                     NATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPT
                     PMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPG
                     FTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPR
                     GIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLI
                     LIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPD
                     SFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDV
                     IRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLL
                     EKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKL
                     VCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL"
     exon            69..155
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            156..272
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            273..413
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            414..557
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            558..739
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            740..823
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1070
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1357
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1505
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..5020
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2596..2601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /note="hexamer: AATAAA"
     polyA_site      2619
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /note="major polyA site"
     regulatory      5001..5006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /note="hexamer: AATAAA"
     polyA_site      5020
                     /gene="PTGS1"
                     /gene_synonym="COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1;
                     PGHS1; PHS1; PTGHS"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcgag gcgcacgcac aggagcctgc actctgcgtc ccgcacccca gcagccgcgc
       61 catgagccgg agtctcttgc tctggttctt gctgttcctg ctcctgctcc cgccgctccc
      121 cgtcctgctc gcggacccag gggcgcccac gccagtgaat ccctgttgtt actatccatg
      181 ccagcaccag ggcatctgtg tccgcttcgg ccttgaccgc taccagtgtg actgcacccg
      241 cacgggctat tccggcccca actgcaccat ccctggcctg tggacctggc tccggaattc
      301 actgcggccc agcccctctt tcacccactt cctgctcact cacgggcgct ggttctggga
      361 gtttgtcaat gccaccttca tccgagagat gctcatgcgc ctggtactca cagtgcgctc
      421 caaccttatc cccagtcccc ccacctacaa ctcagcacat gactacatca gctgggagtc
      481 tttctccaac gtgagctatt acactcgtat tctgccctct gtgcctaaag attgccccac
      541 acccatggga accaaaggga agaagcagtt gccagatgcc cagctcctgg cccgccgctt
      601 cctgctcagg aggaagttca tacctgaccc ccaaggcacc aacctcatgt ttgccttctt
      661 tgcacaacac ttcacccacc agttcttcaa aacttctggc aagatgggtc ctggcttcac
      721 caaggccttg ggccatgggg tagacctcgg ccacatttat ggagacaatc tggagcgtca
      781 gtatcaactg cggctcttta aggatgggaa actcaagtac caggtgctgg atggagaaat
      841 gtacccgccc tcggtagaag aggcgcctgt gttgatgcac tacccccgag gcatcccgcc
      901 ccagagccag atggctgtgg gccaggaggt gtttgggctg cttcctgggc tcatgctgta
      961 tgccacgctc tggctacgtg agcacaaccg tgtgtgtgac ctgctgaagg ctgagcaccc
     1021 cacctggggc gatgagcagc ttttccagac gacccgcctc atcctcatag gggagaccat
     1081 caagattgtc atcgaggagt acgtgcagca gctgagtggc tatttcctgc agctgaaatt
     1141 tgacccagag ctgctgttcg gtgtccagtt ccaataccgc aaccgcattg ccatggagtt
     1201 caaccatctc taccactggc accccctcat gcctgactcc ttcaaggtgg gctcccagga
     1261 gtacagctac gagcagttct tgttcaacac ctccatgttg gtggactatg gggttgaggc
     1321 cctggtggat gccttctctc gccagattgc tggccggatc ggtgggggca ggaacatgga
     1381 ccaccacatc ctgcatgtgg ctgtggatgt catcagggag tctcgggaga tgcggctgca
     1441 gcccttcaat gagtaccgca agaggtttgg catgaaaccc tacacctcct tccaggagct
     1501 cgtaggagag aaggagatgg cagcagagtt ggaggaattg tatggagaca ttgatgcgtt
     1561 ggagttctac cctggactgc ttcttgaaaa gtgccatcca aactctatct ttggggagag
     1621 tatgatagag attggggctc ccttttccct caagggtctc ctagggaatc ccatctgttc
     1681 tccggagtac tggaagccga gcacatttgg cggcgaggtg ggctttaaca ttgtcaagac
     1741 ggccacactg aagaagctgg tctgcctcaa caccaagacc tgtccctacg tttccttccg
     1801 tgtgccggat gccagtcagg atgatgggcc tgctgtggag cgaccatcca cagagctctg
     1861 aggggcagga aagcagcatt ctggagggga gagctttgtg cttgtcattc cagagtgctg
     1921 aggccagggc tgatggtctt aaatgctcat tttctggttt ggcatggtga gtgttggggt
     1981 tgacatttag aactttaagt ctcacccatt atctggaata ttgtgattct gtttattctt
     2041 ccagaatgct gaactccttg ttagcccttc agattgttag gagtggttct catttggtct
     2101 gccagaatac tgggttctta gttgacaacc tagaatgtca gatttctggt tgatttgtaa
     2161 cacagtcatt ctaggatgtg gagctactga tgaaatctgc tagaaagtta gggggttctt
     2221 attttgcatt ccagaatctt gactttctga ttggtgattc aaagtgttgt gttcctggct
     2281 gatgatccag aacagtggct cgtatcccaa atctgtcagc atctggctgt ctagaatgtg
     2341 gatttgattc attttcctgt tcagtgagat atcatagaga cggagatcct aaggtccaac
     2401 aagaatgcat tccctgaatc tgtgcctgca ctgagagggc aaggaagtgg ggtgttcttc
     2461 ttgggacccc cactaagacc ctggtctgag gatgtagaga gaacaggtgg gctgtattca
     2521 cgccattggt tggaagctac cagagctcta tccccatcca ggtcttgact catggcagct
     2581 gtttctcatg aagctaataa aattcgcttt ctaaagttac ctgttatata tctcttttgg
     2641 tcccatcctc taaagcagag gcaacactgg aacatggcta gcctttcttg tagccatggc
     2701 tgggcgtgct agaggttgca gcatgagact ttctgctggg atccttgggc ccatcactgt
     2761 atagacatgc taccactggt acttcctttc tccctgcggg ccaggcactg cccttttcag
     2821 gaagctctct taaaataccc attgccccag acctggaaga tataacattc agttcccacc
     2881 atctgattaa aacaacttcc tcccttacag agcatacaac agagggggca cccggggagg
     2941 agagcacata ctgtgttcca atttcacgct tttaattctc atttgttctc acaccaacag
     3001 tgtgaagtgc gtggtataat ctccatttca aaaccaagga agcagcctca gagtggtcga
     3061 gtgacacacc tcacgcaggc tgagtccaga gcttgtgctc ctcttgattc ctggtttgac
     3121 tcagttccag gcctgatctt gcctgtctgg ctcagggtca aagacagaat ggtggagtgt
     3181 agcctccacc tgatattcag gctactcatt cagtcccaaa tatgtatttt cctaagtgtt
     3241 tactatgtgc cagttcctgt aacaggtgtg gggacacagc agtgagtaat caatacagac
     3301 aaggttctgc ccttatggag ctcacactcc agtggcagac aaacagacca taaataagga
     3361 aacgatgaaa taagatatat acaaggtgag tgtgacttcc cttctaaccc cctctgctct
     3421 gtcctcccct attgcgctct caagaccaga gacccaacag cagtgatctc agggcagaca
     3481 gccctccact ccagctctga gacccttttc tcaggacctc tgtaggcagc agagagagag
     3541 gacagagggg taagatgagg ggttgaggga aggttcttca tgatccacac tttgggctta
     3601 gtatttctca ggaagagcta tggcccagaa acaacagggg aaactagagt tcggtctgac
     3661 agtccttggg gttaagtctc ctgtcttatg gtccagaaac tcctgtttct ccttagttgg
     3721 ctggaaactg ctcccatcat tccttctggc ctctgctgaa tgcagggaat gcaatccttc
     3781 cctgctcttg cagttgctct gacgtagaaa gatccttcgg gtgctggaag tctccatgaa
     3841 gagcttgtgt cctgtccttt cttgcagatt ctatttcccc tcttctgcta atacctctta
     3901 ctttgcttga gaatcctctc ctttcttatt aatttcagtc ttggtggttc tatcaggggt
     3961 gcattctggc caaggggtgg gcctgtgaat caatcctggg caatcagaca ccctctcctt
     4021 aaaaactggc ccgtggagac tgagatcact gactctgact catccccaca gctggctctg
     4081 acaagatggt ccatttgttc ctgcttccga gatccccagg gcagcctgga tccctgccct
     4141 tctcaagact ttagcttttc cttccatccg gtggcctatt ccaggaattc ctcttttgct
     4201 taaatcagtt ggagtttgtg tctgttgctt gtaatcaagc ctttatggct gctgggctga
     4261 gtgacacaag cactttaatg gcctggaggg acttttaatc agtgaagatg caatcagaca
     4321 agtgttttgg aaagagcacc ctcgagaagg gtggatgaca gggcagagca ggaaggacag
     4381 gaagctggca gaacggagga ggctgcagcc gtggtccaac caggagctga tggcagctgg
     4441 ggctagggga agggctttga gggtggaagg atgggatggg ttccagaggt attcctctct
     4501 taaatgcaag tgcctagatt aggtagactt tgcttagtat tgacaactgc acatgaaagt
     4561 tttgcaaagg gaaacaggct aaatgcacca agaaagcttc ttcagagtga agaatcttaa
     4621 tgcttgtaat ttaaacattt gttcctggag ttttgatttg gtggatgtga tggttggttt
     4681 tatttgtcag tttggttggg ctatagcaca cagttattta atcaaacagt aatctaggtg
     4741 tggctgtgaa ggtattttgt agatgtgatt aacatctaca atcagttgac tttaagtgaa
     4801 agagattact taaataattt gggtgagctg cacctgatta gttgaaaggc ctcaagaaca
     4861 aacactgcag tttcctggaa aagaagaaac tttgcctcaa gactatagcc atcgactcct
     4921 gcctgagttt ccagcctgct agtctgccct atggatttga agtttgccaa ccccaacaat
     4981 tgtgtgaatt aatttctaaa aataaagcta tatacagcca
//
