LOCUS       NM_175907               7518 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens prostaglandin reductase 3 (PTGR3), transcript variant
            1, mRNA.
ACCESSION   NM_175907 NM_138478
VERSION     NM_175907.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7518)
  AUTHORS   He,J.Y., Zhou,X.Q. and Wang,W.T.
  TITLE     [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes
            to Promote Hepatocellular Carcinoma Cell Proliferation]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 53 (5), 744-751 (2022)
   PUBMED   36224673
  REMARK    GeneRIF: [Mechanism of miRNA-3679 Inhibiting Downstream
            ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell
            Proliferation].
REFERENCE   2  (bases 1 to 7518)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 7518)
  AUTHORS   Goroshchuk,O., Kolosenko,I., Kunold,E., Vidarsdottir,L.,
            Pirmoradian,M., Azimi,A., Jafari,R. and Palm-Apergi,C.
  TITLE     Thermal proteome profiling identifies PIP4K2A and ZADH2 as
            off-targets of Polo-like kinase 1 inhibitor volasertib
  JOURNAL   FASEB J 35 (7), e21741 (2021)
   PUBMED   34143546
  REMARK    GeneRIF: Thermal proteome profiling identifies PIP4K2A and ZADH2 as
            off-targets of Polo-like kinase 1 inhibitor volasertib.
REFERENCE   4  (bases 1 to 7518)
  AUTHORS   Madrid,A., Hogan,K.J., Papale,L.A., Clark,L.R., Asthana,S.,
            Johnson,S.C. and Alisch,R.S.
  TITLE     DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's
            Disease
  JOURNAL   J Alzheimers Dis 66 (3), 927-934 (2018)
   PUBMED   30372681
  REMARK    GeneRIF: In patients with late-onset Alzheimer disease, a number of
            differentially methylated postitions were hypomethylated in ZADH2
            compared with controls.
REFERENCE   5  (bases 1 to 7518)
  AUTHORS   Yu,Y.H., Chang,Y.C., Su,T.H., Nong,J.Y., Li,C.C. and Chuang,L.M.
  TITLE     Prostaglandin reductase-3 negatively modulates adipogenesis through
            regulation of PPARgamma activity
  JOURNAL   J Lipid Res 54 (9), 2391-2399 (2013)
   PUBMED   23821743
REFERENCE   6  (bases 1 to 7518)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7518)
  AUTHORS   McDonough,C.W., Bostrom,M.A., Lu,L., Hicks,P.J., Langefeld,C.D.,
            Divers,J., Mychaleckyj,J.C., Freedman,B.I. and Bowden,D.W.
  TITLE     Genetic analysis of diabetic nephropathy on chromosome 18 in
            African Americans: linkage analysis and dense SNP mapping
  JOURNAL   Hum Genet 126 (6), 805-817 (2009)
   PUBMED   19690890
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC018081.1, AC025105.10 and BU682476.1.
            
            On Nov 23, 2018 this sequence version replaced NM_175907.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.273178.1,
                                           SRR1803617.182256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322342.4/ ENSP00000323678.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               BC018081.1         188-492
            306-7360            AC025105.10        77606-84660         c
            7361-7518           BU682476.1         18-175              c
FEATURES             Location/Qualifiers
     source          1..7518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..7518
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="prostaglandin reductase 3"
                     /db_xref="GeneID:284273"
                     /db_xref="HGNC:HGNC:28697"
                     /db_xref="MIM:620604"
     exon            1..290
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1215
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /EC_number="1.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     zinc-binding alcohol dehydrogenase domain-containing
                     protein 2; zinc binding alcohol dehydrogenase domain
                     containing 2"
                     /codon_start=1
                     /product="prostaglandin reductase 3 isoform 1"
                     /protein_id="NP_787103.1"
                     /db_xref="CCDS:CCDS12008.1"
                     /db_xref="GeneID:284273"
                     /db_xref="HGNC:HGNC:28697"
                     /db_xref="MIM:620604"
                     /translation="MLRLVPTGARAIVDMSYARHFLDFQGSAIPQAMQKLVVTRLSPN
                     FREAVTLSRDCPVPLPGDGDLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIG
                     EVVALGLSASARYTVGQAVAYMAPGSFAEYTVVPASIATPVPSVKPEYLTLLVSGTTA
                     YISLKELGGLSEGKKVLVTAAAGGTGQFAMQLSKKAKCHVIGTCSSDEKSAFLKSLGC
                     DRPINYKTEPVGTVLKQEYPEGVDVVYESVGGAMFDLAVDALATKGRLIVIGFISGYQ
                     TPTGLSPVKAGTLPAKLLKKSASVQGFFLNHYLSKYQAAMSHLLEMCVSGDLVCEVDL
                     GDLSPEGRFTGLESIFRAVNYMYMGKNTGKIVVELPHSVNSKL"
     exon            291..7518
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2560..2565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="hexamer: ATTAAA"
     polyA_site      2579
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="major polyA site"
     regulatory      3487..3492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="hexamer: AATAAA"
     polyA_site      3506
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="major polyA site"
     regulatory      4999..5004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="hexamer: AATACA"
     polyA_site      5021
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="major polyA site"
     regulatory      5292..5297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="hexamer: AATAAG"
     polyA_site      5311
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
     regulatory      7499..7504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
                     /note="hexamer: AATAAA"
     polyA_site      7518
                     /gene="PTGR3"
                     /gene_synonym="PRG-3; PTGR-3; ZADH2"
ORIGIN      
        1 agagcacagc cgagccgagc ggcccgggcg ggggccgacc ccggccagcg tcggcgcaga
       61 gagcgggcgg aggcgcaggc catgctgcgg ctggtgccca ccggggcccg ggccatcgtg
      121 gacatgtcgt acgcccgcca cttcctggac ttccagggct ccgccattcc ccaagccatg
      181 cagaagctgg tggtgacccg gctgagcccc aacttccgcg aggccgtcac cctgagccgg
      241 gactgcccgg tgccgctccc cggggacgga gacctcctcg tccggaaccg atttgttggt
      301 gttaacgcat ctgacatcaa ctattcagca ggccgctatg acccctcagt taagcctccc
      361 tttgacatag gtttcgaagg cattggggag gtggtggccc taggcctctc tgctagtgcc
      421 agatacacag ttggccaagc tgtggcttac atggcacctg gttcttttgc tgagtacaca
      481 gttgtgcctg ccagcattgc aactccagtg ccctcagtga aacccgagta tcttaccctg
      541 ctggtaagtg gcaccaccgc atacatcagc ctgaaagagc tcggaggact gtcggaaggg
      601 aaaaaagttt tggtgacagc agcagctggg ggaacgggcc agtttgccat gcagctttca
      661 aagaaggcaa agtgccatgt aattggaacc tgctcttctg atgaaaagtc tgcttttctg
      721 aaatctcttg gctgtgatcg tcctatcaac tataaaactg aacccgtagg taccgtcctt
      781 aagcaggagt accctgaagg tgtcgatgtg gtctatgaat ctgttggggg agccatgttt
      841 gacttggctg tagacgccct ggctacgaaa gggcgcttga tagtaatagg gtttatctct
      901 ggctaccaaa ctcctactgg cctttcgcct gtgaaagcag gaacattgcc agccaaactg
      961 ctcaagaaat ctgccagcgt acagggcttc ttcctgaacc attacctttc taagtatcaa
     1021 gcagccatga gccacttgct cgagatgtgt gtgagcggag acctggtttg tgaggtggac
     1081 cttggagatc tgtctccaga gggcaggttt actggcctgg agtccatatt ccgtgctgtc
     1141 aattatatgt acatgggaaa aaacactgga aaaattgtag ttgaattacc tcactctgtc
     1201 aacagtaagc tgtaaaaaca gaacaatgac ataaatcaag ggagaaagaa aatgggcact
     1261 ttatgtctca gaattactca aatcaattta tttttagttg gtaatggata taatatttct
     1321 taaaacaaaa gtaaggtgtt aatgaatagg tctctccttc tcctcctcct cctcctcttc
     1381 ccttggggga aaaaaaaaaa tgtgctaata aaacttccct ccatggctaa gagggaaaac
     1441 gcttacattc aattctttag tcatggatgg tctcgttcca gatgttattg ttccagggaa
     1501 ctaaattcat tcctgatgcc agatctgatc gagtcagtat gtcttcagct tgatcagatt
     1561 ttaaaatcag ttttgaaagt ggttcccgac ttctttgctt tgggagaatt tggtcttatg
     1621 ctcataagca gttcatgagt gacaagtgta gcaaaagcca gccatatatt ttcagaatct
     1681 atatcctcag gaaatggtcc tttttttttc tataaatcac caaccaacta tctaaatgga
     1741 catttggggg aattccctcc caaatttgat tttgttatta gaaaaatgat tccgtgaaca
     1801 cagatgtgtt ttgaagaagt agcacgtaat ggcttttatc taccatcaac ctgataaggc
     1861 acatgtgaaa tggaaatgtt ctctttcctc tgaagcagca aattaatgtt gaaaacttac
     1921 atagacagaa agtaggtttt ggaaagggaa accacagaga ttagggggac ttaaaattaa
     1981 tataggcaca ggaaagagaa aagtgtgcgc tccattctca gtgggggttc accacaaaac
     2041 acgggcccca ggagggaagc gctgtctagg cacacggcaa ggccttagta acagcatgct
     2101 acactgctcg aggtacggta tgtcccatcg ccctgtgcac cgtagagacc tcagtcatct
     2161 caaggaagaa tacatttgct tctccttaga ggcgttcgaa ctagaagcta tgcgttacct
     2221 ctgattctgg aaacagaata gcagccactc attctgcatt cccatttttc tctccacgtg
     2281 ttctggtgga atgagatgct ccttggcact atagcctgat gtcccacatt gacccactga
     2341 ccacacagga aaagcagcga aacctgcacc ctctcttctg agtcacgcct gtggctcatc
     2401 ggcttccctc ttaaccttta gtgccctgaa gactgctgcc gctgtcaccg ttgcgctgaa
     2461 accccatggg cccgttctga ttgaaggtga agcccaccag attatttttc aaagtcttag
     2521 gtttcggtgt atctaacctg ctcagtaaat atggacgcaa ttaaagatgc tctaggaaat
     2581 ttggggactg tatttaattt ttctttcctt ccatctgagg agcaaggaaa tcctactgct
     2641 gaatagctgt tagtatctat tttacaagat ttactcattt tcaggtacct aatgtagctg
     2701 ctagcatgca tgcacaacaa tacaatttat atggtaaatg gaaccaaata atggcttcac
     2761 tgaatgttat ggctgcactg aagggaaatg tcacggtaaa tagctgccaa attatggatc
     2821 atgccgaagt gtcacaactg cactaaagac aaatagcact agaggctatt gccactgtga
     2881 cgcttttgag ttatgaagaa gggtagcggc ctgatgcgag gctctttgtg tcctcattat
     2941 agcaaagggt tactggtgca ggggactagg aaaaacccgt ccagtgtggt gcttagttat
     3001 tcatccatcc ctttcagacc taacagccac agccacacgg aaagagactt tgcctcactt
     3061 ttacattcac aaacaaacaa aggagggggg agcaggtttt atgaatgtaa ctgtgcacag
     3121 gaaatgactg gtaatggaaa aaatgttgta ataaaataat ctaatcaaag aatattatta
     3181 aatttaacat agtctatgtc caaaaggctt agttgcttct tatgcagata gatgtgtgaa
     3241 atctaagcag taatgtactt tctccctttg taaagacttg gggagtaagg acattaccaa
     3301 ctaaattgct tcttcgaaac tgaagtgagt cccggtttgt ttcattttaa tgggagggta
     3361 ataaagatga aagaccaaca ttttaactga tggatccctt aagctacaga atagaaattt
     3421 attgtgtttt gagggaatat actaaatgca gctatgtaaa aataaaattc aaacgcccag
     3481 gattaaaata aaatataatc tgaaaacctc atgttctctc tttccccaaa ctaagaaagt
     3541 gcactgcatg ctgttttcac ttattcttag aaaacaagca tgaaagattc cgcccattca
     3601 gataatgcca aaaatatgtt taaacttttt tttattcttt tgaaaaatga tttgtaaatt
     3661 gagggtcata gttcagcatc agtttcatct tctgggatta ttgttcaaga ccagcctcta
     3721 atgggaggtg aaacggtacg atggtctcaa cacctttctt ctgaactgta atacatatca
     3781 caaaaagtac atccataatt cagggcaatt gtcagtcttt ttagagaagg ggccagggtg
     3841 gaacaatccc agtgagtaaa ttatttctca gcgtggactt ctctgcatgt cgggcttaag
     3901 gtcaccagcc gggcagggtg gaaggagctt gcctctttga gaaaccaagg agtcccagtg
     3961 atctgttacc atttggttat gacttctaaa gagccaaatg ctattccttc aagcctgttt
     4021 tgcaggcaga aaataccagc agtgtcattt aggggttcct ttgatgatga ctactgctgt
     4081 taactgacct cagcattaaa aaaaaaaaaa ttcagggaat agtttgcaaa gaaatgaagg
     4141 aagttttgca tgatatattc tataacttgt cattatatga tttcatctgg atgaagttcc
     4201 tcaggagtag gatagagcct ctgtaaatgg tcattagtat tacattctgt gtttatctaa
     4261 tgaaagtgca gtgacaagta gctgcttctt attaaaatga aaatcctgca ttatgtactt
     4321 gaggaacatt ccagctaatg aggatgtaat gtcctcagta caacgcagac cttctttttg
     4381 tgttcaccac cacaagatgc tggaagcttg acaaatgata tcatttaaga cacatgcctg
     4441 ccttagggac ctggtttttg gcttcctgtt tctggctttt atttgggtaa cgtttataat
     4501 ggccacccga cttgtacctg ggtaatgttt taaccccttc cccagagttc tcaattagca
     4561 tgaatttact acagtcagag tttcctttaa attggggtgg gggtgctaag cactgaaaat
     4621 atctttcttg attactttac catgtggaca tatgggataa atactgtatt tcagatttac
     4681 ataaaagtag attagtaatg cacagctttc agaataaaaa ctgataaaaa agaccaagca
     4741 ctatcaactt tggacagtaa tttcctaggt gttaaacaag ttttctgaat acaatctgga
     4801 tgcaaaacgg cctgatttga tgaattcata attttcttct gtatactttc attttattaa
     4861 atattttatt acttggttaa acacaagaat tatctatgta aacttcatgg gcttttttgt
     4921 tgaaagttag atgttcagta actaatttcc cagttatggc ccagaattaa acatttatga
     4981 tcatatttca gaagtcaaaa tacaaaactg gattatcaaa acggttggtg tggtcacttt
     5041 aaactggact atcagtatgg ttgccgtggt cactttaagc gggattatca gtacggttgg
     5101 tgtggtcact ttggtttatc atcaatacag ttggtgtggt cactttaaac tggattacca
     5161 atatggttgg tgtggtcgct ttaaagtttg ttttcatttt ttttctattt ttaattctta
     5221 cgggtatata gaaggtgtat atatttatgg ggtacatgag atgtcttgaa acaggcatgc
     5281 aatgtgaaat aaataagcac atcatggaga atggggtgtc tacctcctca agcatttatc
     5341 cattgagttg caaacaatcc agctacactc agttatttaa aaatgtacag ttattattgc
     5401 ttatagtcac cctgtttgct atcaaatagt aggtcttact ctattttttt cattttaaac
     5461 tttgaatttt atttttccta ggcttatagc atcatgctat cccccttgta aaaggaggaa
     5521 tgcttggcat gagaacctta ctgctgttac catgaacaaa ctatggaatg ttggcaaaag
     5581 aaaaaaaaaa gttacacaaa acacacaaat aacattttaa taatatgtat cagatcaagt
     5641 gattcttagt agtagttgat attcacagga agtcaaaaaa ggacctattt caattatgtc
     5701 tgcttgaatc ctgtttaatt gtttccctgg ctgagtagct agtgtgacac agcagcaaga
     5761 ctaaaggggc tctgtggtcc acattgtcct cgagtctatt cttgcccatt atagacctgc
     5821 ccattggtgc tcactcactg catcccagga ggcttgactg tcctcaggaa gcatgttggg
     5881 gtgcccttaa gggtaagtat cccggggagc acagtttgga gaaaaccaat acgtcttcat
     5941 gtatgttgag aagcgctggg ccaaagtaca gacttttttt tttttttttt ttttttttgg
     6001 gacaagacct cggctctgtc acccaggctg gagtgcagtg gtgcaatcat ggttgattgc
     6061 aacctcaacc tccctggttc aagccatcct cccacctcag tctcctgagt agctgggact
     6121 acaggtgcac atcaccatgc ccggctaatt tttttgtatt tttttactag agatgaggtt
     6181 ctactatgta gcccaggctg ctctggaact cctgggctca agcaatcctc ccacctcggc
     6241 ctcccaaagt gctgggattg caggcatgag ccaccatact ggcctaagtg cagaaatttg
     6301 aacatgtgcc tccaccccaa gccaaaattt cccttgagga gcactatcta tctgatgatg
     6361 tctttgaaac ggtatgaaat taaaataatt aaaacatcct gcacataggt ggtagcatct
     6421 aatatgaaag atggatttat gcttagagct cagaaaaatc ctcataaaat tattgtgtct
     6481 tatcctcggc acctaaagaa ctgaacaggg tcttagaatg atcaaatgga tggtttgttt
     6541 ggttggtggg agatgttgaa acgtgggtaa ggaatggtgt ccttagaaga gaggttgccc
     6601 tagatgccga aaccctggag gtccatggtt gccagcagaa acttacagct gggaggagcc
     6661 tgcacccatc tctggctctt gtgaatgaga agactcaatt tgtgtttttg tttttttgag
     6721 aaagggtctt gctctgtcac ccagactgaa gtacagtagc gtgatctcag ttcactgcag
     6781 ccttgacctc ctgggcccaa gcgatcctcc cacctcagcc tcctgagtag ttaagacttc
     6841 aggtatgcat taccatgcct ggctaatgtt tttttatttt ttgtagagac aaggtctccc
     6901 tcgttgccca ggctggtctc aaactcttgg gctcaagtga ctttcctgcc tcggccatcc
     6961 aaagtgctgg gattacaggc ataagccacc gcaacatgcc ccagttgctt ttaaactgtt
     7021 aaatgtggga tttaaagaat aatctagttc tacccatttt atgaatgaag aaaagaaact
     7081 gggacccaga gagaaaaggt gcccggtcca aggttacaga gcccgttgga ctcagaagtg
     7141 aagctggaac actggccaat gccctcccat ccgccaggtg acttctctgc agtccccttt
     7201 accatctgcc cgggtccttt gggatacggc tgactagggg tttgaagaac agcaattggc
     7261 ctttgttatg aatctttttg tggagataaa cccagtagaa gtatcacggt tctgaccatg
     7321 aaagtgtgtt caactctaat ccagcacaat taggattcca gatcatttga ttctgtgtcg
     7381 tctaaatatc acagaaagtt aaaaacaaat tagcctcaat ggaattaatg gcttaatatc
     7441 cataatttag ttttaatgct aggaggaagg gctcctgtga atgtgttctt acaaatcaaa
     7501 taaagaaaat caaataga
//
