LOCUS       NM_001146108            1599 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens prostaglandin reductase 1 (PTGR1), transcript variant
            1, mRNA.
ACCESSION   NM_001146108
VERSION     NM_001146108.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Lee,D.H., Bae,W.H., Ha,H., Kim,W.R., Park,E.G., Lee,Y.J., Kim,J.M.,
            Shin,H.J. and Kim,H.S.
  TITLE     The human PTGR1 gene expression is controlled by TE-derived Z-DNA
            forming sequence cooperating with miR-6867-5p
  JOURNAL   Sci Rep 14 (1), 4723 (2024)
   PUBMED   38413664
  REMARK    GeneRIF: The human PTGR1 gene expression is controlled by
            TE-derived Z-DNA forming sequence cooperating with miR-6867-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Liu,K., Shu,L., Huang,A.Y., Chang,Y., Chen,Z. and Zhang,C.
  TITLE     PTGR1 is involved in cell proliferation in thoracic ossification of
            the ligamentum flavum
  JOURNAL   PLoS One 18 (11), e0292821 (2023)
   PUBMED   37910537
  REMARK    GeneRIF: PTGR1 is involved in cell proliferation in thoracic
            ossification of the ligamentum flavum.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Tanaka,K., Kanesaka,Y., Takami,M., Suzuki,A., Hosokawa,H.,
            Onodera,A., Kamata,T., Nagato,K., Nakayama,T., Yoshino,I. and
            Motohashi,S.
  TITLE     Role of leukotriene B4 12-hydroxydehydrogenase in
            alpha-galactosylceramide-pulsed dendritic cell therapy for
            non-small cell lung cancer
  JOURNAL   Biochem Biophys Res Commun 506 (1), 27-32 (2018)
   PUBMED   30336981
  REMARK    GeneRIF: LTB4DH plays a pivotal role in
            alpha-galactosylceramide-pulsed dendritic cell immunotherapy for
            non-small cell lung cancer.
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Kang,G.J., Lee,H.J., Byun,H.J., Kim,E.J., Kim,H.J., Park,M.K. and
            Lee,C.H.
  TITLE     Novel involvement of miR-522-3p in high-mobility group box
            1-induced prostaglandin reductase 1 expression and reduction of
            phagocytosis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (4), 625-633 (2017)
   PUBMED   28088550
  REMARK    GeneRIF: The data indicate that HMGB1-miR-522-3p-PTGR1 axis may be
            involved in the abnormal resolution of inflammation and suggest
            that this mechanism might be a target for modulation of chronic
            inflammatory disorder.
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Zhao,Y., Weng,C.C., Tong,M., Wei,J. and Tai,H.H.
  TITLE     Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15-
            oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung
            cancer growth in vitro and in vivo
  JOURNAL   Lung Cancer 68 (2), 161-169 (2010)
   PUBMED   19595472
  REMARK    GeneRIF: restoration of expression in enzyme-negative lung cancer
            cell lines induces apoptosis and growth inhibition
REFERENCE   7  (bases 1 to 1599)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1599)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 1599)
  AUTHORS   Tai,H.H., Ensor,C.M., Tong,M., Zhou,H. and Yan,F.
  TITLE     Prostaglandin catabolizing enzymes
  JOURNAL   Prostaglandins Other Lipid Mediat 68-69, 483-493 (2002)
   PUBMED   12432938
  REMARK    Review article
REFERENCE   10 (bases 1 to 1599)
  AUTHORS   Yokomizo,T., Ogawa,Y., Uozumi,N., Kume,K., Izumi,T. and Shimizu,T.
  TITLE     cDNA cloning, expression, and mutagenesis study of leukotriene B4
            12-hydroxydehydrogenase
  JOURNAL   J Biol Chem 271 (5), 2844-2850 (1996)
   PUBMED   8576264
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289597.1, AL135787.13 and
            AA876375.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001146108.1.
            
            Summary: This gene encodes an enzyme that is involved in the
            inactivation of the chemotactic factor, leukotriene B4. The encoded
            protein specifically catalyzes the NADP+ dependent conversion of
            leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene
            is found on chromosome 1. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.173122.1,
                                           SRR1803612.237078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407693.7/ ENSP00000385763.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AK289597.1         209-341
            134-134             AL135787.13        40208-40208         c
            135-1193            AK289597.1         343-1401
            1194-1199           AA876375.1         3-8                 c
            1200-1599           AL135787.13        5431-5830           c
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..1599
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /note="prostaglandin reductase 1"
                     /db_xref="GeneID:22949"
                     /db_xref="HGNC:HGNC:18429"
                     /db_xref="MIM:601274"
     exon            1..45
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            46..161
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1045
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /EC_number="1.3.1.48"
                     /EC_number="1.3.1.74"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leukotriene B4 12-hydroxydehydrogenase; zinc binding
                     alcohol dehydrogenase domain containing 3;
                     15-oxoprostaglandin 13-reductase; NADP-dependent
                     leukotriene B4 12-hydroxydehydrogenase; PRG-1;
                     D3T-inducible gene 1 protein; dithiolethione-inducible
                     gene 1 protein; NAD(P)H-dependent alkenal/one
                     oxidoreductase"
                     /codon_start=1
                     /product="prostaglandin reductase 1 isoform 1"
                     /protein_id="NP_001139580.1"
                     /db_xref="CCDS:CCDS6779.1"
                     /db_xref="GeneID:22949"
                     /db_xref="HGNC:HGNC:18429"
                     /db_xref="MIM:601274"
                     /translation="MVRTKTWTLKKHFVGYPTNSDFELKTAELPPLKNGEVLLEALFL
                     TVDPYMRVAAKRLKEGDTMMGQQVAKVVESKNVALPKGTIVLASPGWTTHSISDGKDL
                     EKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQ
                     IAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNV
                     GGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQ
                     GDARQKALKDLLKWVLEGKIQYKEYIIEGFENMPAAFMGMLKGDNLGKTIVKA"
     exon            162..207
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            208..264
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            265..432
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            433..550
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..706
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..815
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..934
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1599
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1173..1178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /note="hexamer: AATAAA"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /note="hexamer: AATACA"
     polyA_site      1194
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /note="major polyA site"
     polyA_site      1199
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /note="hexamer: AATAAT"
     polyA_site      1308
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
     polyA_site      1572
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
     regulatory      1577..1582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
                     /note="hexamer: ATTAAA"
     polyA_site      1599
                     /gene="PTGR1"
                     /gene_synonym="DIG-1; LTB4DH; PGR1; ZADH3"
ORIGIN      
        1 gcagtcccag ccgccttccc caggcagtgg aaccttcggg ctcctgagct tcaggatggt
       61 tcgtactaag acatggaccc tgaagaagca ctttgttggc tatcctacta atagtgactt
      121 tgagttgaag acagctgagc tcccaccctt aaaaaatgga gaggtcctgc ttgaagcttt
      181 gttcctcacc gtggatccct acatgagagt ggcagccaaa agattgaagg aaggtgatac
      241 aatgatgggg cagcaagtgg ccaaagttgt ggaaagtaaa aatgtagccc taccaaaagg
      301 aactattgta ctggcttctc caggctggac aacgcactcc atttctgatg ggaaagatct
      361 ggaaaagctg ctgacagagt ggccagacac aataccactg tctttggctc tggggacagt
      421 tggcatgcca ggcctgactg cctactttgg cctacttgaa atctgtggtg tgaagggtgg
      481 agaaacagtg atggttaatg cagcagctgg agctgtgggc tcagtcgtgg ggcagattgc
      541 aaagctcaag ggctgcaaag ttgttggagc agtagggtct gatgaaaagg ttgcctacct
      601 tcaaaagctt ggatttgatg tcgtctttaa ctacaagacg gtagagtctt tggaagaaac
      661 cttgaagaaa gcgtctcctg atggttatga ttgttatttt gataatgtag gtggagagtt
      721 ttcaaacact gttatcggcc agatgaagaa atttggaagg attgccatat gtggagccat
      781 ctctacatat aacagaaccg gcccacttcc cccaggccca cccccagaga ttgttatcta
      841 tcaggagctt cgcatggaag cttttgtcgt ctaccgctgg caaggagatg cccgccaaaa
      901 agctctgaag gacttgctga aatgggtctt agagggtaaa atccagtaca aggaatatat
      961 cattgaagga tttgaaaaca tgccagctgc atttatggga atgctgaaag gagataattt
     1021 ggggaagaca atagtgaaag catgaaaaag aggacacatg gaatctggag gccatttaga
     1081 tgattagtta atttgttttt caccatttag caaaaatgta tactacctta aatgtcttaa
     1141 gaaatagtac tcataatgag tttgagctac ttaataaaat acatttaagt ggtatgtaat
     1201 tagtgatgga ggatggaagt ttcaaagtca acaacaacca gtcacctcac tgttcactac
     1261 agcttcttct gagttgtggt agaaaataat ggctttgaag tgtgaaaatt ttccaaacac
     1321 tgtatgtttt cattcataag tgggagctga acaatgagaa cacatggaca tagggagggg
     1381 aacaacacac gctggggcct gtggaagccg gggtgaggga gggagagcat caggataaat
     1441 agctaatgcc ttcgggggct aatacctagg tgatgggttg acaggtgaag caaaccatca
     1501 tggcacacgt ttacctatgt aacaaacctg cacattccac acaattatcc cggaactgaa
     1561 aataaaataa aattaaatta aaaaaaaaag ttagccggg
//
