LOCUS       NM_000960               2078 bp    mRNA    linear   PRI 09-JAN-2022
DEFINITION  Homo sapiens prostaglandin I2 receptor (PTGIR), mRNA.
ACCESSION   NM_000960
VERSION     NM_000960.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2078)
  AUTHORS   Georges A, Albuisson J, Berrandou T, Dupre D, Lorthioir A,
            D'Escamard V, Di Narzo AF, Kadian-Dodov D, Olin JW,
            Warchol-Celinska E, Prejbisz A, Januszewicz A, Bruneval P,
            Baranowska AA, Webb TR, Hamby SE, Samani NJ, Adlam D,
            Fendrikova-Mahlay N, Hazen S, Wang Y, Yang ML, Hunker K, Combaret
            N, Motreff P, Chedid A, Fiquet B, Plouin PF, Mousseaux E, Azarine
            A, Amar L, Azizi M, Gornik HL, Ganesh SK, Kovacic JC, Jeunemaitre X
            and Bouatia-Naji N.
  TITLE     Rare loss-of-function mutations of PTGIR are enriched in
            fibromuscular dysplasia
  JOURNAL   Cardiovasc Res 117 (4), 1154-1165 (2021)
   PUBMED   32531060
  REMARK    GeneRIF: Rare loss-of-function mutations of PTGIR are enriched in
            fibromuscular dysplasia.
REFERENCE   2  (bases 1 to 2078)
  AUTHORS   Mulvaney EP, O'Meara F, Khan AR, O'Connell DJ and Kinsella BT.
  TITLE     Identification of alpha-helix 4 (alpha4) of Rab11a as a novel
            Rab11-binding domain (RBD): Interaction of Rab11a with the
            Prostacyclin Receptor
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (10), 1819-1832 (2017)
   PUBMED   28739266
  REMARK    GeneRIF: these studies are not only the first to identify alpha4
            helix of Rab11a as a protein binding domain on the GTPase but also
            reveal novel mechanistic insights into the intracellular
            trafficking of the human prostacyclin receptor (hIP), and
            potentially of other members of the GPCR superfamily, involving
            Rab11-dependent mechanisms.
REFERENCE   3  (bases 1 to 2078)
  AUTHORS   Eivers SB and Kinsella BT.
  TITLE     Regulated expression of the prostacyclin receptor (IP) gene by
            androgens within the vasculature: Combined role for androgens and
            serum cholesterol
  JOURNAL   Biochim Biophys Acta 1859 (10), 1333-1351 (2016)
   PUBMED   27365208
  REMARK    GeneRIF: The human prostacyclin receptor gene is under the
            transcriptional regulation of dihydrotestosterone, where this
            regulation is further influenced by serum-cholesterol levels.
REFERENCE   4  (bases 1 to 2078)
  AUTHORS   Batchu SN, Majumder S, Bowskill BB, White KE, Advani SL, Brijmohan
            AS, Liu Y, Thai K, Azizi PM, Lee WL and Advani A.
  TITLE     Prostaglandin I2 Receptor Agonism Preserves beta-Cell Function and
            Attenuates Albuminuria Through Nephrin-Dependent Mechanisms
  JOURNAL   Diabetes 65 (5), 1398-1409 (2016)
   PUBMED   26868296
  REMARK    GeneRIF: Data (including data from studies using transgenic mice,
            an murine experimental model of diabetes, and mouse/human cell
            lines) suggest prostaglandin I2 receptor (PTGIR) is involved in
            insulin secretion in pancreatic beta-cells and in permselectivity
            in glomerular podocytes; the mechanism appears to involve
            regulation of post-translational phosphorylation of nephrin.
REFERENCE   5  (bases 1 to 2078)
  AUTHORS   Ghandour RA, Giroud M, Vegiopoulos A, Herzig S, Ailhaud G, Amri EZ
            and Pisani DF.
  TITLE     IP-receptor and PPARs trigger the conversion of human white to
            brite adipocyte induced by carbaprostacyclin
  JOURNAL   Biochim Biophys Acta 1861 (4), 285-293 (2016)
   PUBMED   26775637
  REMARK    GeneRIF: cPGI2 generates via its cognate cell-surface receptor
            IP-R, converting white adipocytes to brite adipocytes.
REFERENCE   6  (bases 1 to 2078)
  AUTHORS   Ogawa Y, Tanaka I, Inoue M, Yoshitake Y, Isse N, Nakagawa O, Usui
            T, Itoh H, Yoshimasa T, Narumiya S et al.
  TITLE     Structural organization and chromosomal assignment of the human
            prostacyclin receptor gene
  JOURNAL   Genomics 27 (1), 142-148 (1995)
   PUBMED   7665161
REFERENCE   7  (bases 1 to 2078)
  AUTHORS   Duncan AM, Anderson LL, Funk CD, Abramovitz M and Adam M.
  TITLE     Chromosomal localization of the human prostanoid receptor gene
            family
  JOURNAL   Genomics 25 (3), 740-742 (1995)
   PUBMED   7759114
REFERENCE   8  (bases 1 to 2078)
  AUTHORS   Nakagawa O, Tanaka I, Usui T, Harada M, Sasaki Y, Itoh H, Yoshimasa
            T, Namba T, Narumiya S and Nakao K.
  TITLE     Molecular cloning of human prostacyclin receptor cDNA and its gene
            expression in the cardiovascular system
  JOURNAL   Circulation 90 (4), 1643-1647 (1994)
   PUBMED   7923647
REFERENCE   9  (bases 1 to 2078)
  AUTHORS   Katsuyama M, Sugimoto Y, Namba T, Irie A, Negishi M, Narumiya S and
            Ichikawa A.
  TITLE     Cloning and expression of a cDNA for the human prostacyclin
            receptor
  JOURNAL   FEBS Lett 344 (1), 74-78 (1994)
   PUBMED   7514139
REFERENCE   10 (bases 1 to 2078)
  AUTHORS   Boie Y, Rushmore TH, Darmon-Goodwin A, Grygorczyk R, Slipetz DM,
            Metters KM and Abramovitz M.
  TITLE     Cloning and expression of a cDNA for the human prostanoid IP
            receptor
  JOURNAL   J Biol Chem 269 (16), 12173-12178 (1994)
   PUBMED   7512962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA652875.1, D25418.1 and
            BQ185457.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000960.3.
            
            Summary: The protein encoded by this gene is a member of the
            G-protein coupled receptor family 1 and has been shown to be a
            receptor for prostacyclin. Prostacyclin, the major product of
            cyclooxygenase in macrovascular endothelium, elicits a potent
            vasodilation and inhibition of platelet aggregation through binding
            to this receptor. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110342.1, BC075814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291294.7/ ENSP00000291294.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DA652875.1         9-22
            15-1993             D25418.1           1-1979
            1994-2078           BQ185457.1         18-102              c
FEATURES             Location/Qualifiers
     source          1..2078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2078
                     /gene="PTGIR"
                     /gene_synonym="IP; PRIPR"
                     /note="prostaglandin I2 receptor"
                     /db_xref="GeneID:5739"
                     /db_xref="HGNC:HGNC:9602"
                     /db_xref="MIM:600022"
     exon            1..93
                     /gene="PTGIR"
                     /gene_synonym="IP; PRIPR"
                     /inference="alignment:Splign:2.1.0"
     exon            94..873
                     /gene="PTGIR"
                     /gene_synonym="IP; PRIPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1266
                     /gene="PTGIR"
                     /gene_synonym="IP; PRIPR"
                     /note="prostanoid IP receptor; PGI receptor; PGI2
                     receptor; prostaglandin I2 (prostacyclin) receptor (IP)"
                     /codon_start=1
                     /product="prostacyclin receptor"
                     /protein_id="NP_000951.1"
                     /db_xref="CCDS:CCDS12686.1"
                     /db_xref="GeneID:5739"
                     /db_xref="HGNC:HGNC:9602"
                     /db_xref="MIM:600022"
                     /translation="MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPA
                     RPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFF
                     GLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQ
                     HQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQK
                     RHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLL
                     AFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPR
                     APSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC"
     exon            874..2078
                     /gene="PTGIR"
                     /gene_synonym="IP; PRIPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2053..2058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGIR"
                     /gene_synonym="IP; PRIPR"
                     /note="hexamer: AATAAA"
     polyA_site      2078
                     /gene="PTGIR"
                     /gene_synonym="IP; PRIPR"
                     /note="major polyA site"
ORIGIN      
        1 acacagaccg acacaggcag cgagagacac gaggagcaaa gcaagtgaag gcacagacgc
       61 acgggacagg agagcctggg caagactgga gagcccagac ctgggatggc ggattcgtgc
      121 aggaacctca cctacgtgcg gggctcggtg gggccggcca ccagcaccct gatgttcgtg
      181 gccggtgtgg tgggcaacgg gctggccctg ggcatcctga gcgcacggcg accggcgcgc
      241 ccctcggcct tcgcggtgct ggtgaccgga ctggcggcca ccgacctgct gggcaccagc
      301 ttcctgagcc cggccgtgtt cgtggcctat gcgcgcaaca gctccctgct gggcctggcc
      361 cgaggcggcc ccgccctgtg cgatgccttc gccttcgcca tgaccttctt cggcctggcg
      421 tccatgctca tcctctttgc catggccgtg gagcgctgcc tggcgctgag ccacccctac
      481 ctctacgcgc agctggacgg gccccgctgc gcccgcctgg cgctgccagc catctacgcc
      541 ttctgcgtcc tcttctgcgc gctgcccctg ctgggcctgg gccaacacca gcagtactgc
      601 cccggcagct ggtgcttcct ccgcatgcgc tgggcccagc cgggcggcgc cgccttctcg
      661 ctggcctacg ccggcctggt ggccctgctg gtggctgcca tcttcctctg caacggctcg
      721 gtcaccctca gcctctgccg catgtaccgc cagcagaagc gccaccaggg ctctctgggt
      781 ccacggccgc gcaccggaga ggacgaggtg gaccacctga tcctgctggc cctcatgaca
      841 gtggtcatgg ccgtgtgctc cctgcctctc acgatccgct gcttcaccca ggctgtcgcc
      901 cctgacagca gcagtgagat gggggacctc cttgccttcc gcttctacgc cttcaacccc
      961 atcctggacc cctgggtctt catccttttc cgcaaggctg tcttccagcg actcaagctc
     1021 tgggtctgct gcctgtgcct cgggcctgcc cacggagact cgcagacacc cctttcccag
     1081 ctcgcctcag ggaggaggga cccaagggcc ccctctgctc ctgtgggaaa ggaggggagc
     1141 tgcgtgcctt tgtcggcttg gggcgagggg caggtggagc ccttgcctcc cacacagcag
     1201 tccagcggca gcgccgtggg aacgtcgtcc aaagcagaag ccagcgtcgc ctgctccctc
     1261 tgctgacatt tcaagctgac cctgtgatct ctgccctgtc ttcgggcgac aggagccaga
     1321 aaatcaggga catggctgat ggctgcggat gctggaacct tggcccccaa actctggggc
     1381 cgatcagctg ctgtttctcc tgcggcaggg cagtcgctgc tggctctggg aagagagtga
     1441 gggacagagg aaacgtttat cctggagtgc agaaagaatg gttctctcaa aataaccagt
     1501 ggcctggccg acctgctctg gccctggatt ccccatccat ctcattgtct aaatatttag
     1561 aaggcggaga agttcccaga ggcttctgta cagtcaggtc tgctctggtc tgggtgctgg
     1621 ctccaatctg cgtccactta ggaggcccaa ctgcccaccc caagtcccca ggggatggcc
     1681 ctccccctct accaagccac tccaagagcc agcccctttc tgctccacaa aaaccacagt
     1741 tattggaaaa gctccctgcc ttcccttgcc gctggtcccc caccaggctt gggagccctg
     1801 gcatcccaaa ggggcaacgg gaggaagggg aggctgctgc attgtgggtg atgacgtagg
     1861 acatgtgctt ggtacaaaaa gggcctgaga cattccacct agcttgactg gctgcaagat
     1921 gagaactggg ggggtgcagg tggtggggag acagatggag aagctggcag atgaagggtg
     1981 ggggctgcgg atcccaggga ctgccccaga acacaaacct aagtcctgtg cctgtcccca
     2041 gggtcctgaa taaataaaag cctccttgca gagcctga
//
