LOCUS       NM_020440               6314 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens prostaglandin F2 receptor inhibitor (PTGFRN), mRNA.
ACCESSION   NM_020440 XM_040709
VERSION     NM_020440.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6314)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6314)
  AUTHORS   Marquez,J., Dong,J., Dong,C., Tian,C. and Serrero,G.
  TITLE     Identification of Prostaglandin F2 Receptor Negative Regulator
            (PTGFRN) as an internalizable target in cancer cells for
            antibody-drug conjugate development
  JOURNAL   PLoS One 16 (1), e0246197 (2021)
   PUBMED   33503070
  REMARK    GeneRIF: Identification of Prostaglandin F2 Receptor Negative
            Regulator (PTGFRN) as an internalizable target in cancer cells for
            antibody-drug conjugate development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6314)
  AUTHORS   Aguila,B., Morris,A.B., Spina,R., Bar,E., Schraner,J., Vinkler,R.,
            Sohn,J.W. and Welford,S.M.
  TITLE     The Ig superfamily protein PTGFRN coordinates survival signaling in
            glioblastoma multiforme
  JOURNAL   Cancer Lett 462, 33-42 (2019)
   PUBMED   31377205
  REMARK    GeneRIF: High PTGFRN expression is associated with glioblastoma
            multiforme.
REFERENCE   4  (bases 1 to 6314)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   5  (bases 1 to 6314)
  AUTHORS   Jouannet,S., Saint-Pol,J., Fernandez,L., Nguyen,V., Charrin,S.,
            Boucheix,C., Brou,C., Milhiet,P.E. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins differentially regulate the cleavage of ADAM10
            substrates, Notch activation and ADAM10 membrane
            compartmentalization
  JOURNAL   Cell Mol Life Sci 73 (9), 1895-1915 (2016)
   PUBMED   26686862
REFERENCE   6  (bases 1 to 6314)
  AUTHORS   Charrin,S., Le Naour,F., Oualid,M., Billard,M., Faure,G.,
            Hanash,S.M., Boucheix,C. and Rubinstein,E.
  TITLE     The major CD9 and CD81 molecular partner. Identification and
            characterization of the complexes
  JOURNAL   J Biol Chem 276 (17), 14329-14337 (2001)
   PUBMED   11278880
REFERENCE   7  (bases 1 to 6314)
  AUTHORS   Stipp,C.S., Orlicky,D. and Hemler,M.E.
  TITLE     FPRP, a major, highly stoichiometric, highly specific CD81- and
            CD9-associated protein
  JOURNAL   J Biol Chem 276 (7), 4853-4862 (2001)
   PUBMED   11087758
REFERENCE   8  (bases 1 to 6314)
  AUTHORS   Orlicky,D.J., Lieber,J.G., Morin,C.L. and Evans,R.M.
  TITLE     Synthesis and accumulation of a receptor regulatory protein
            associated with lipid droplet accumulation in 3T3-L1 cells
  JOURNAL   J Lipid Res 39 (6), 1152-1161 (1998)
   PUBMED   9643346
REFERENCE   9  (bases 1 to 6314)
  AUTHORS   Orlicky,D.J., Berry,R. and Sikela,J.M.
  TITLE     Human chromosome 1 localization of the gene for a prostaglandin
            F2alpha receptor negative regulatory protein
  JOURNAL   Hum Genet 97 (5), 655-658 (1996)
   PUBMED   8655148
REFERENCE   10 (bases 1 to 6314)
  AUTHORS   Orlicky,D.J.
  TITLE     Negative regulatory activity of a prostaglandin F2 alpha receptor
            associated protein (FPRP)
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 54 (4), 247-259 (1996)
   PUBMED   8804121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157904.24, DA572787.1, AB037857.1, AK074637.1 and AA045111.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020440.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152454.1, AB037857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393203.3/ ENSP00000376899.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL157904.24        88956-88962
            8-151               DA572787.1         1-144
            152-797             AB037857.1         1-646
            798-798             AK074637.1         657-657
            799-6311            AB037857.1         648-6160
            6312-6314           AA045111.1         13-15               c
FEATURES             Location/Qualifiers
     source          1..6314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1"
     gene            1..6314
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /note="prostaglandin F2 receptor inhibitor"
                     /db_xref="GeneID:5738"
                     /db_xref="HGNC:HGNC:9601"
                     /db_xref="MIM:601204"
     exon            1..337
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2928
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /note="CD9 partner 1; glu-Trp-Ile EWI motif-containing
                     protein F; prostaglandin F2-alpha receptor regulatory
                     protein; prostaglandin F2-alpha receptor-associated
                     protein; prostaglandin F2 receptor negative regulator"
                     /codon_start=1
                     /product="prostaglandin F2 receptor negative regulator
                     precursor"
                     /protein_id="NP_065173.2"
                     /db_xref="CCDS:CCDS890.1"
                     /db_xref="GeneID:5738"
                     /db_xref="HGNC:HGNC:9601"
                     /db_xref="MIM:601204"
                     /translation="MGRLASRPLLLALLSLALCRGRVVRVPTATLVRVVGTELVIPCN
                     VSDYDGPSEQNFDWSFSSLGSSFVELASTWEVGFPAQLYQERLQRGEILLRRTANDAV
                     ELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTVQVKVLADSLHVGPSARPPPSLSLR
                     EGEPFELRCTAASASPLHTHLALLWEVHRGPARRSVLALTHEGRFHPGLGYEQRYHSG
                     DVRLDTVGSDAYRLSVSRALSADQGSYRCIVSEWIAEQGNWQEIQEKAVEVATVVIQP
                     SVLRAAVPKNVSVAEGKELDLTCNITTDRADDVRPEVTWSFSRMPDSTLPGSRVLARL
                     DRDSLVHSSPHVALSHVDARSYHLLVRDVSKENSGYYYCHVSLWAPGHNRSWHKVAEA
                     VSSPAGVGVTWLEPDYQVYLNASKVPGFADDPTELACRVVDTKSGEANVRFTVSWYYR
                     MNRRSDNVVTSELLAVMDGDWTLKYGERSKQRAQDGDFIFSKEHTDTFNFRIQRTTEE
                     DRGNYYCVVSAWTKQRNNSWVKSKDVFSKPVNIFWALEDSVLVVKARQPKPFFAAGNT
                     FEMTCKVSSKNIKSPRYSVLIMAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASR
                     VDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPVRGSLWREAATSLSNPIEID
                     FQTSGPIFNASVHSDTPSVIRGDLIKLFCIITVEGAALDPDDMAFDVSWFAVHSFGLD
                     KAPVLLSSLDRKGIVTTSRRDWKSDLSLERVSVLEFLLQVHGSEDQDFGNYYCSVTPW
                     VKSPTGSWQKEAEIHSKPVFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSH
                     WCCKKEVQETRRERRRLMSMEMD"
     exon            338..706
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1120
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1501
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1927
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2347
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2455
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2761
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..6314
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6293..6298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /note="hexamer: ATTAAA"
     polyA_site      6314
                     /gene="PTGFRN"
                     /gene_synonym="CD315; CD9P-1; EWI-F; FPRP; SMAP-6"
                     /note="major polyA site"
ORIGIN      
        1 cccttctgct ttcgggaagc ggtcggggct gcacactcgg atcggcgggg ccggctcccg
       61 ggcccggccg gctggaggag ggagggaagg aggcgggagg gagcgagcgg agccaggggc
      121 gcacgtacgc cccagcgctg ggatttatcg gctcgcgagg agagcggagc aggcgcgcgg
      181 cccaggcgga ggagcgccga ctctggagca gccggagctg gaagaggagg aggaggagag
      241 gcggcgggga aggaggagga gggggagagt cgctcccgcc gggcgagcat ggggcgcctg
      301 gcctcgaggc cgctgctgct ggcgctcctg tcgttggctc tttgccgagg gcgtgtggtg
      361 agagtcccca cagcgaccct ggttcgagtg gtgggcactg agctggtcat cccctgcaac
      421 gtcagtgact atgatggccc cagcgagcaa aactttgact ggagcttctc atctttgggg
      481 agcagctttg tggagcttgc aagcacctgg gaggtggggt tcccagccca gctgtaccag
      541 gagcggctgc agaggggcga gatcctgtta aggcggactg ccaacgacgc cgtggagctc
      601 cacataaaga acgtccagcc ttcagaccaa ggccactaca aatgttcaac ccccagcaca
      661 gatgccactg tccagggaaa ctatgaggac acagtgcagg ttaaagtgct ggccgactcc
      721 ctgcacgtgg gccccagcgc gcggcccccg ccgagcctga gcctgcggga gggggagccc
      781 ttcgagctgc gctgcaccgc cgcctccgcc tcgccgctgc acacgcacct ggcgctgctg
      841 tgggaggtgc accgcggccc ggccaggcgg agcgtcctcg ccctgaccca cgagggcagg
      901 ttccacccgg gcctggggta cgagcagcgc taccacagtg gggacgtgcg cctcgacacc
      961 gtgggcagcg acgcctaccg cctctcagtg tcccgggctc tgtctgccga ccagggctcc
     1021 tacaggtgta tcgtcagcga gtggatcgcc gagcagggca actggcagga aatccaagaa
     1081 aaggccgtgg aagttgccac cgtggtgatc cagccatcag ttctgcgagc agctgtgccc
     1141 aagaatgtgt ctgtggctga aggaaaggaa ctggacctga cctgtaacat cacaacagac
     1201 cgagccgatg acgtccggcc cgaggtgacg tggtccttca gcaggatgcc tgacagcacc
     1261 ctacctggct cccgcgtgtt ggcgcggctt gaccgtgatt ccctggtgca cagctcgcct
     1321 catgttgctt tgagtcatgt ggatgcacgc tcctaccatt tactggttcg ggatgttagc
     1381 aaagaaaact ctggctacta ttactgccac gtgtccctgt gggcacccgg acacaacagg
     1441 agctggcaca aagtggcaga ggccgtgtct tccccagctg gtgtgggtgt gacctggcta
     1501 gaaccagact accaggtgta cctgaatgct tccaaggtcc ccgggtttgc ggatgacccc
     1561 acagagctgg catgccgggt ggtggacacg aagagtgggg aggcgaatgt ccgattcacg
     1621 gtttcgtggt actacaggat gaaccggcgc agcgacaatg tggtgaccag cgagctgctt
     1681 gcagtcatgg acggggactg gacgctaaaa tatggagaga ggagcaagca gcgggcccag
     1741 gatggagact ttattttttc taaggaacat acagacacgt tcaatttccg gatccaaagg
     1801 actacagagg aagacagagg caattattac tgtgttgtgt ctgcctggac caaacagcgg
     1861 aacaacagct gggtgaaaag caaggatgtc ttctccaagc ctgttaacat attttgggca
     1921 ttagaagatt ccgtgcttgt ggtgaaggcg aggcagccaa agcctttctt tgctgccgga
     1981 aatacatttg agatgacttg caaagtatct tccaagaata ttaagtcgcc acgctactct
     2041 gttctcatca tggctgagaa gcctgtcggc gacctctcca gtcccaatga aacgaagtac
     2101 atcatctctc tggaccagga ttctgtggtg aagctggaga attggacaga tgcatcacgg
     2161 gtggatggcg ttgttttaga aaaagtgcag gaggatgagt tccgctatcg aatgtaccag
     2221 actcaggtct cagacgcagg gctgtaccgc tgcatggtga cagcctggtc tcctgtcagg
     2281 ggcagccttt ggcgagaagc agcaaccagt ctctccaatc ctattgagat agacttccaa
     2341 acctcaggtc ctatatttaa tgcttctgtg cattcagaca caccatcagt aattcgggga
     2401 gatctgatca aattgttctg tatcatcact gtcgagggag cagcactgga tccagatgac
     2461 atggcctttg atgtgtcctg gtttgcggtg cactcttttg gcctggacaa ggctcctgtg
     2521 ctcctgtctt ccctggatcg gaagggcatc gtgaccacct cccggaggga ctggaagagc
     2581 gacctcagcc tggagcgcgt gagtgtgctg gaattcttgc tgcaagtgca tggctccgag
     2641 gaccaggact ttggcaacta ctactgttcc gtgactccat gggtgaagtc accaacaggt
     2701 tcctggcaga aggaggcaga gatccactcc aagcccgttt ttataactgt gaagatggat
     2761 gtgctgaacg ccttcaagta tcccttgctg atcggcgtcg gtctgtccac ggtcatcggg
     2821 ctcctgtcct gtctcatcgg gtactgcagc tcccactggt gttgtaagaa ggaggttcag
     2881 gagacacggc gcgagcgccg caggctcatg tcgatggaga tggactaggc tggcccggga
     2941 ggggagtgac agagggacgt tctaggagca attggggcaa gaagaggaca gtgatatttt
     3001 aaaacaaagt gtgttacact aaaaaccagt cctctctaat ctcaggtggg acttggcgct
     3061 ctctcttttc tgcatgtcaa gttctgagcg cggacatgtt taccagcaca cggctcttct
     3121 tcccacggca ctttctgatg taacaatcga gtgtgtgttt tcccaactgc agctttttaa
     3181 tggttaacct tcatctaatt ttttttctcc cactggttta tagatcctct gacttgtgtg
     3241 tgtttatagc ttttgtttcg cggggttgtg gtgaggaagg ggtgatggca tgcggagttc
     3301 tttatcttca gtgagaatgt gcctgcccgc ctgagagcca gcttccgcgt tggaggcacg
     3361 tgttcagaga gctgctgagc gccaccctct acccggctga cagacaacac agacctgtgc
     3421 cgaaggctaa tttgtggctt ttacgaccct accccacccc ctgttttcag gggtttagac
     3481 tacatttgaa atccaaactt ggagtatata acttcttatt gagcccaact gctttttttt
     3541 tttttttttt tgcttctctg ccccttttcc atttcttttg tatttgtttt ctgtgagagc
     3601 actgaaatgg cagccctgga atctacaatt tggctctcca ctgagcacct tatcttgcca
     3661 ccttagcctt aagaatgaat atgaagaaaa atacacagcc acctctgtcc agggcagtaa
     3721 gaagggctgc aaggaagggg aggatgggga caaggaaagg atcagatacc tgctccagta
     3781 gttgtgaggc cactgtgtct caggggactc caggaggagc agaagaggga tcccacgaag
     3841 ttattcttac gcagctgggg ccaggagggt cagagtggtg ccaggtgcaa gttaggctaa
     3901 agaagccacc actattcctc tctcttgccc attgtggggg gcaaaggcat tggtcaccaa
     3961 gagtcttgca gggggaccca cagatatgcc atgtccttca cacgtgcttg ggctccttaa
     4021 cctgaaggca aattgctact tgcaagactg actgacttca aggaatcaga aattacctag
     4081 aagcaccatg ttttttctat gaccttttca gtccttcagg tcattttaag gtccactgca
     4141 gggggttagt gagaaagggt atactttgtg gtatgttttg ctttcctaat agggacatga
     4201 aggaaaccca gcaatttgct gttatgtgaa tggcctgtag agcagagtca agagcggtgt
     4261 gctttgcccg actgctccca tcaggaatag gagagtagac agagatcttc cacatcccag
     4321 gcttctgctg ctgctttaaa agctctgtcc ttggagcctc ccgctccctg aagtgtctcg
     4381 ccccctgcac agcactggcc tttcggaagc atcccagtag ggttttctga ggctcgctgg
     4441 tgactcatgc cctaattgca atcctctgct tttatcttga ctttgaagga tctaacactg
     4501 ctctctcttc caaaggggaa aaaaagattc atttgttttg agcaataaac taatacaaaa
     4561 tgatggccat tcatgtgcag ctctttgtca ccatgggccg gatgagttgt gctcctcctg
     4621 gctcaccatt tccccctgct cccccacagc cggttctgca cttatcaccg agtcgcccct
     4681 ggaagcagat tcccattgag ttttccccac caaggggacc atgcacatgg tagaaacatt
     4741 agattctgca ttgacagtag cctttccttg gcccgggcct gtggtgggaa gacgggcaac
     4801 aagtataccc caccagggcc tgagtgacta gaggaagagg acgaggcctt gttggcacta
     4861 gatttgggta ttttctgcat gtcataacat atcctaactg ctatttcaga agaggcagct
     4921 tgtaggtgat tgtacaagtg agaattaaag agagaacaga tatttaaaca ggtgctgtat
     4981 tagtaacagc cagtgccctt tcagcccttg catctattaa aaggagattc aggattttat
     5041 tggcacaggc ccttcttagt aggaagaaag ggtgcttagc tttggacctg accgggtgtg
     5101 tgtaaaacca tggactgagt cacagcagac actcgatggt ggtaaatgtg atgggtgctt
     5161 acacactgta ccttttcctt tcatactgat gctgcagttc agggctggag ttgttaaggc
     5221 attgacctcc acccacctgc cccatgtcca ctgggctgcc caagctgcat gtcacctgag
     5281 ggctggcagg aaggggcgag aaatcccagg gcattgtacc aaggacctag ttccttctag
     5341 ggatataaat ttccaggaat gtgtattttt aatgtggtga gatgcactct tttgttgtac
     5401 caaatagggc tccccacccc acccctgcga caagtgctct tctagaacag gttcctacca
     5461 gcagcactgg tgtgaatgaa agagagaccc agccgcgtct cacacaggtg gaattgcact
     5521 tcttaacaaa aaggaacttt ataaaagttt gggatttttt ttcctaatca taaaaatagc
     5581 cccagaaaga gcctaagcta tgttcagata gaagcctcga aattcctgta aattgtttac
     5641 tttatgatgt ttacatacac gtttcacttt gaaaaaaaat gcaaatcgac tttttaacaa
     5701 ctgttgagat gtttcatggg acagtagaac tctgactcac caactgggct aaattttaat
     5761 ttaaaaatgt atttatttga gtgtctttcc ccccctcacc ctcaccatct gaggggctcc
     5821 ctgagatctt ggtagaggag gcccctcctg cccagacctt cgtttgtttc cccggtggcc
     5881 cttgcttctt gctttgcaga ctgcctgcag ccatgatttt gtcactgaca tctgtgagcc
     5941 aaagactgag cctttttggc aggaataata agcaatacta cacaacttgc tactttcaga
     6001 aaactttttt ttagcttcac cgatgacaac agaggaagaa gggaactggg atttgggtaa
     6061 gttctcctcc actgtttgac caaattctca gtgataaata tgtgtgcaga tccctagaag
     6121 agaaaacgct gactttcttt ttaagtgtgg cacataagga tctgcagaat tttccgtaga
     6181 caaagaaagg atcttgtgta tttttgtcca tatccaatgt tatatgaact aattgtattg
     6241 ttttatactg tgaccacaaa tattatgcaa tgcaccattt gttttttatt tcattaaagg
     6301 aagtttaatt taaa
//
