LOCUS       NM_000959               5429 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens prostaglandin F receptor (PTGFR), transcript variant
            1, mRNA.
ACCESSION   NM_000959
VERSION     NM_000959.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5429)
  AUTHORS   Wu,C., Xu,Y., He,Q., Li,D., Duan,J., Li,C., You,C., Chen,H.,
            Fan,W., Jiang,Y. and Eric Xu,H.
  TITLE     Ligand-induced activation and G protein coupling of prostaglandin
            F2alpha receptor
  JOURNAL   Nat Commun 14 (1), 2668 (2023)
   PUBMED   37160891
  REMARK    GeneRIF: Ligand-induced activation and G protein coupling of
            prostaglandin F2alpha receptor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5429)
  AUTHORS   Xu,X., Wang,B., Chen,Y., Zhou,W. and Li,L.
  TITLE     Replicative verification of susceptibility genes previously
            identified from families with segregating developmental dysplasia
            of the hip
  JOURNAL   Ital J Pediatr 47 (1), 140 (2021)
   PUBMED   34174923
  REMARK    GeneRIF: Replicative verification of susceptibility genes
            previously identified from families with segregating developmental
            dysplasia of the hip.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5429)
  AUTHORS   Wang,Y., Yan,S., Xiao,B., Zuo,S., Zhang,Q., Chen,G., Yu,Y.,
            Chen,D., Liu,Q., Liu,Y., Shen,Y. and Yu,Y.
  TITLE     Prostaglandin F2alpha Facilitates Hepatic Glucose Production
            Through CaMKIIgamma/p38/FOXO1 Signaling Pathway in Fasting and
            Obesity
  JOURNAL   Diabetes 67 (9), 1748-1760 (2018)
   PUBMED   29773555
  REMARK    GeneRIF: Data, including data from studies using transgenic mice,
            suggest that signaling via prostaglandin-F2alpha/PTGFR and
            Camk2g/p38/Foxo1 MAP kinase/calcium pathways are involved in
            regulation of hepatic gluconeogenesis in both obesity and fasting.
            (PTGFR = prostaglandin F2alpha receptor; Camk2g =
            calcium-calmodulin-dependent protein kinase type 2 gamma; p38 = p38
            MAP kinase; Foxo1 = forkhead box transcription factor O1)
REFERENCE   4  (bases 1 to 5429)
  AUTHORS   Sleno,R., Devost,D., Petrin,D., Zhang,A., Bourque,K., Shinjo,Y.,
            Aoki,J., Inoue,A. and Hebert,T.E.
  TITLE     Conformational biosensors reveal allosteric interactions between
            heterodimeric AT1 angiotensin and prostaglandin F2alpha receptors
  JOURNAL   J Biol Chem 292 (29), 12139-12152 (2017)
   PUBMED   28584054
  REMARK    GeneRIF: Data suggest that allosteric communication between
            heterodimeric AT1R and PTGFR is mediated through GNAQ and may also
            involve proximal phospholipase C but not distal protein kinase C
            signaling partners; PTGFR activation has negligible effects on
            AT1R-based conformational biosensors. (AT1R = angiotensin II
            receptor, type 1; PTGFR = prostaglandin F2alpha receptor; GNAQ =
            GTP-binding protein G[q] subunit alpha)
REFERENCE   5  (bases 1 to 5429)
  AUTHORS   Cui,X.J., Zhao,A.G. and Wang,X.L.
  TITLE     Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with
            intra-ocular pressure response to latanoprost in patients with
            primary open-angle glaucoma
  JOURNAL   J Clin Pharm Ther 42 (1), 87-92 (2017)
   PUBMED   27862086
  REMARK    GeneRIF: The genotype frequencies of six SNPs in AFAP1, GMDS and
            PTGFR genes were conformed to Hardy-Weinberg equilibrium (HWE).
REFERENCE   6  (bases 1 to 5429)
  AUTHORS   Duncan,A.M., Anderson,L.L., Funk,C.D., Abramovitz,M. and Adam,M.
  TITLE     Chromosomal localization of the human prostanoid receptor gene
            family
  JOURNAL   Genomics 25 (3), 740-742 (1995)
   PUBMED   7759114
REFERENCE   7  (bases 1 to 5429)
  AUTHORS   Lake,S., Gullberg,H., Wahlqvist,J., Sjogren,A.M., Kinhult,A.,
            Lind,P., Hellstrom-Lindahl,E. and Stjernschantz,J.
  TITLE     Cloning of the rat and human prostaglandin F2 alpha receptors and
            the expression of the rat prostaglandin F2 alpha receptor
  JOURNAL   FEBS Lett 355 (3), 317-325 (1994)
   PUBMED   7988697
REFERENCE   8  (bases 1 to 5429)
  AUTHORS   Bastien,L., Sawyer,N., Grygorczyk,R., Metters,K.M. and Adam,M.
  TITLE     Cloning, functional expression, and characterization of the human
            prostaglandin E2 receptor EP2 subtype
  JOURNAL   J Biol Chem 269 (16), 11873-11877 (1994)
   PUBMED   8163486
REFERENCE   9  (bases 1 to 5429)
  AUTHORS   Abramovitz,M., Boie,Y., Nguyen,T., Rushmore,T.H., Bayne,M.A.,
            Metters,K.M., Slipetz,D.M. and Grygorczyk,R.
  TITLE     Cloning and expression of a cDNA for the human prostanoid FP
            receptor
  JOURNAL   J Biol Chem 269 (4), 2632-2636 (1994)
   PUBMED   8300593
REFERENCE   10 (bases 1 to 5429)
  AUTHORS   Funk,C.D., Furci,L., FitzGerald,G.A., Grygorczyk,R., Rochette,C.,
            Bayne,M.A., Abramovitz,M., Adam,M. and Metters,K.M.
  TITLE     Cloning and expression of a cDNA for the human prostaglandin E
            receptor EP1 subtype
  JOURNAL   J Biol Chem 268 (35), 26767-26772 (1993)
   PUBMED   8253813
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136324.6 and BC112965.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000959.3.
            
            Summary: The protein encoded by this gene is member of the
            G-protein coupled receptor family. This protein is a receptor for
            prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent
            luteolytic agent, and may also be involved in modulating
            intraocular pressure and smooth muscle contraction in uterus.
            Knockout studies in mice suggest that the interaction of PGF2-alpha
            with this receptor may initiate parturition in ovarian luteal cells
            and thus induce luteolysis. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.38271.1,
                                           SRR1803614.169721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370757.8/ ENSP00000359793.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL136324.6         57966-58034
            70-263              AL136324.6         58035-58228
            264-1569            BC112965.2         106-1411
            1570-5429           AL136324.6         103834-107693
FEATURES             Location/Qualifiers
     source          1..5429
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..5429
                     /gene="PTGFR"
                     /gene_synonym="FP"
                     /note="prostaglandin F receptor"
                     /db_xref="GeneID:5737"
                     /db_xref="HGNC:HGNC:9600"
                     /db_xref="MIM:600563"
     exon            1..263
                     /gene="PTGFR"
                     /gene_synonym="FP"
                     /inference="alignment:Splign:2.1.0"
     exon            264..1133
                     /gene="PTGFR"
                     /gene_synonym="FP"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..1415
                     /gene="PTGFR"
                     /gene_synonym="FP"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; prostanoid FP receptor; prostaglandin receptor
                     (2-alpha); PGF receptor; PGF2 alpha receptor;
                     prostaglandin F2-alpha receptor; FP prostanoid receptor"
                     /codon_start=1
                     /product="prostaglandin F2-alpha receptor isoform a
                     precursor"
                     /protein_id="NP_000950.1"
                     /db_xref="CCDS:CCDS686.1"
                     /db_xref="GeneID:5737"
                     /db_xref="HGNC:HGNC:9600"
                     /db_xref="MIM:600563"
                     /translation="MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSN
                     SLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFD
                     QSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVC
                     LFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLL
                     CNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGING
                     NHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWE
                     LSSIKNSLKVAAISESPVAEKSAST"
     exon            1134..5429
                     /gene="PTGFR"
                     /gene_synonym="FP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4458..4463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGFR"
                     /gene_synonym="FP"
                     /note="hexamer: AATAAA"
     polyA_site      4477
                     /gene="PTGFR"
                     /gene_synonym="FP"
                     /note="major polyA site"
     regulatory      5409..5414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGFR"
                     /gene_synonym="FP"
                     /note="hexamer: AATGAA"
     polyA_site      5429
                     /gene="PTGFR"
                     /gene_synonym="FP"
ORIGIN      
        1 actcgcgcgc cccatccctc ccaggctgcc agcgcagcta ggtgcagagg gatcccagga
       61 gccgcgcgcg ccccgcagtt tccgcgctaa gggaacgagt gcgcggaggg gacgagcggc
      121 tggaccacag ccggcgcccg atcaggatct ccgcgctggg atcggtggaa cttgaggcag
      181 cggcggcgcg gggcgccatg gcacaccgag cggctccgtc ttctgctcct cagagagccc
      241 ggctggcggc ctgggatgac aagatgtctg gactgcaatc ctgcacagtt ttgagaggga
      301 gatgacttga gtggttggct tttatctcca caacaatgtc catgaacaat tccaaacagc
      361 tagtgtctcc tgcagctgcg cttctttcaa acacaacctg ccagacggaa aaccggcttt
      421 ccgtattttt ttcagtaatc ttcatgacag tgggaatctt gtcaaacagc cttgccatcg
      481 ccattctcat gaaggcatat cagagattta gacagaagtc caaggcatcg tttctgcttt
      541 tggccagtgg cctggtaatc actgatttct ttggccatct catcaatgga gccatagcag
      601 tatttgtata tgcttctgat aaagaatgga tccgctttga ccaatcaaat gtcctttgca
      661 gtatttttgg tatctgcatg gtgttttctg gtctgtgccc acttcttcta ggcagtgtga
      721 tggccattga gcggtgtatt ggagtcacaa aaccaatatt tcattctacg aaaattacat
      781 ccaaacatgt gaaaatgatg ttaagtggtg tgtgcttgtt tgctgttttc atagctttgc
      841 tgcccatcct tggacatcga gactataaaa ttcaggcgtc gaggacctgg tgtttctaca
      901 acacagaaga catcaaagac tgggaagata gattttatct tctacttttt tcttttctgg
      961 ggctcttagc ccttggtgtt tcattgttgt gcaatgcaat cacaggaatt acacttttaa
     1021 gagttaaatt taaaagtcag cagcacagac aaggcagatc tcatcatttg gaaatggtaa
     1081 tccagctcct ggcgataatg tgtgtctcct gtatttgttg gagcccattt ctggttacaa
     1141 tggccaacat tggaataaat ggaaatcatt ctctggaaac ctgtgaaaca acactttttg
     1201 ctctccgaat ggcaacatgg aatcaaatct tagatccttg ggtatatatt cttctacgaa
     1261 aggctgtcct taagaatctc tataagcttg ccagtcaatg ctgtggagtg catgtcatca
     1321 gcttacatat ttgggagctt agttccatta aaaattcctt aaaggttgct gctatttctg
     1381 agtcaccagt tgcagagaaa tcagcaagca cctagcttaa taggacagta aatctgtgtg
     1441 gggctagaac aaaattaaga catgtttggc aatatttcag ttagttaaat acctgtagcc
     1501 taactggaaa attcaggctt catcatgtag tttgaagata ctattgtcag attcaggttt
     1561 tgaaatttgt caaataaaca ggataactgt acatttttca cttgtttttg ccaatgggag
     1621 gtagacacaa taaaataatg ccatgggagt cacactgaaa gcaattttga gcttatctgt
     1681 cttatttatg ctttgagtga atcatctgtt gaggtctaat gcctttactt ggcctatttg
     1741 ccagagaaca tcttaatgca gcctgcatag tgaaatggtt attttgagat caccgctctg
     1801 tagctaaccc ttataaacta ggctcagtaa aataaagcac tcttattttt tgatctggcc
     1861 tattttgccc ctcattgtgt agcctcaatt aacacatgca tggtcatgac acccagaatt
     1921 catgatggtt tgttataaca acctctgcat attccaggtc tggcagacag gttgcctgac
     1981 cctgcaatcc tatctagaat gggcccattc ttgtcatatt tgacaaatag gactgcctac
     2041 atttattatt atgaaggtcg attgttgttg gaagtgtttt ttcatgtcat agattagcaa
     2101 ttttcaaata attatttttt ctctgaaaat tttgtgtgtg attgcacaat aaataatttt
     2161 tagagaaaca aaggctcttt ctcagcacat tgatgggcaa ctagaattac agcagtttca
     2221 aaactctacc atggataatg caaacaaacc gaagctacat gccaatgata ggtgcaaaga
     2281 atattggcaa aaggtgcttt accttgagcc attatttgtg tcagagaaca aaagaaacag
     2341 aatcaatata taaaattcaa agactatctg cagctagtgt gtttcttctt tacacacata
     2401 tacacacaga catcagaaaa ttctgttgag agcaggttca ttaaatttgt aagatggcat
     2461 attctaaagc ctgtgctacc agtactaaga ggggaagact ggcaatttgc caagcacttg
     2521 gggattatta taacaattaa ctaggagatc aagagataat aatctctccc caaattttcc
     2581 aataataatt gagacttttt ctttgcttgt ttgtgtaatt caaccaaaag aatttcaata
     2641 cccattcaaa ttgtcctagg tctatcagaa attagggaag gtagtcctgc tttataatag
     2701 gaaaatgtat ttctgtataa gagttctttg ctttcattaa cttggattca tttaaaaatt
     2761 aatcttccct gttaggctga tttcagattc tctaggaaat ctgtgtaagt aaccagaaga
     2821 cctttcagat ggtttatttg ctttcagcag agaatttatt tcatacagtt acttaagagt
     2881 gttgatgtct tgtgaacaga gatataagga accattctcc atccttcctt atcatgctgg
     2941 gtacaatgct tctatgaata tttccatgta ttttgactgg ggagaggcat ggagaagaaa
     3001 ctctcattca ggggctccag gatccttctc cttgaggctt ctaaataaat ggcagaattc
     3061 ttgctgtatt gccatgatgt caccctggcc atgtgtactg acttgaggag atcttgcaac
     3121 atggccatgt gcaaggcttt aaggagtgag agagatgtgt acatatctta ggagggttat
     3181 ctatgttatc tgagtatatg tttgggtaac caaattggtc ttaaaaatga tgttaaccca
     3241 agaagtagac atcaaaaatt aaaaaaaaaa aaaggaatgt gttttcattg ttttaagttt
     3301 ttcttctgag taaaacaaaa ttatagaaaa caaatgcaac aatgtgcaca tctgacttaa
     3361 gagtttcatt tctgttatta tatgtgttgc atgtagcttg gcgatttact gtgtaatgaa
     3421 taatagactg gaacatctac caataacttt cacataaatg ttcaaaatag aagtgtattt
     3481 tttcaggttt ctggaaataa atagtaaaat aaatggcaca aatagtttca ataaatttac
     3541 caatttgagt gttttcagct ctatttcaaa actcataact aatcttcaga attactgaat
     3601 ttccttttga actgggtaag gcattatcca agcaacttca catactattt aaacatgatt
     3661 tctcggtaat tatatattct gggcaaataa cataaacatg tcaggatttt tacaggtgtt
     3721 agtgaatttt tctaaaaaga tgagacaaaa gcaaaaatat cacacatagg tttttatgac
     3781 tatgaataca aagataatgc tgattcacaa ttagctatgg gtaagtccaa aacatcagac
     3841 cttttactga tgggttaact aggtgaaaga aatgggccct tatttttttt tttccctaga
     3901 ggcagaaagt tacttctaat gatctatata gctaaaacga aaaatacctg aaagttaata
     3961 catacatatg tagatatatt ttgttatgtg ataaatgttt cttgtttgca cacttttgga
     4021 cttgagaaat ctgcttttgt tttgtgccta ctctgagttt agaacccaaa taagaggact
     4081 tgttaaatat agagtgtact ttttgttaaa actattgcta gcttcacctg tataccatca
     4141 ttgttccaaa ttaaataact gttttgggtc agaatataaa tgctgggaat atacatttta
     4201 ttacttctta atctgggtgt caaagatttt accacctggt aaataatgtt ggacttcaac
     4261 ttgttactgg cacattttaa tagtagatga aacatgtttt tcttggttat gtgaataaat
     4321 gtatgttgtg ctcttcatac ttgttggatt gtatagagat taaatagtga tatgtatatt
     4381 ttgttgtttg ctttggtatg caactcatgt aattttagtg ctttgactag cttaaaactt
     4441 caaacaagta attttataat aaagttggac taatgttttt caagagtgat tatttttaga
     4501 aggaccatat aaaacttgaa acgcttgaac ctaaactccc gttttatctg ctactggatg
     4561 agaagaattt caacttaatt tccattatta ccttttgctc tcccaccctg cccaatcttc
     4621 tgtgatatct tctctctttt acctgtgtct caacttacct aggcaagtca taatttagat
     4681 agaaatctga tttcccaaac ctccaggttt agatatatca ttcagaaaag cctcaatgtg
     4741 tctgtaataa gaaacaatct ccaaattaca gcgccataaa cttcacaaaa gtttgtatct
     4801 cccacatggt tcctgtccac tctgaagggg agctctgctg ttgtaatcac tcagagaact
     4861 caggtgaaaa aacagccacc attatatgtg gctgtttctc aaactacaga gcatggtgaa
     4921 tcacacacag gctgttagaa tatccatctg gaggcaacac acatttgcat acacttctcc
     4981 agctaacata aataatgtgg ctttactaac ttcccagggg gcagctaagt gcaatactat
     5041 atgttaggaa aacggaaact aatttgtaga cagcactaat gatttccaca ttaggtaaaa
     5101 aaaattttca ttcttgtctt cctaatagca tttaaacaga aacgattttt aaaagttgtt
     5161 ttaaacattt agaaacatca tggcatagaa acatttagga ctcactcttt gtaagtactg
     5221 acaagcatgg tcttgtaatc tgtaaagata aggtagaata aatgaactaa aagaaatttt
     5281 agatgactaa aaggactata taatagaaag agggaaatct tggttcttaa aaattcaggc
     5341 aattgaaaca tttctgtata ataccaagca ttgttgcagt attgtctgaa atggttgctt
     5401 ttctaataaa tgaaaatgac taaaatgta
//
