LOCUS       NM_001261430            1543 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens prostaglandin E synthase 3 like (PTGES3L), transcript
            variant 5, mRNA.
ACCESSION   NM_001261430
VERSION     NM_001261430.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1543)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1543)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055866.19.
            
            On Oct 25, 2019 this sequence version replaced NM_001261430.1.
            
            Transcript Variant: This variant (5) represents the longest
            transcript and encodes the longest isoform (5).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.377717.1,
                                           SRR14038191.1601740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000591916.7/ ENSP00000467778.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC055866.19        164337-164371       c
            36-149              AC055866.19        163841-163954       c
            150-216             AC055866.19        163669-163735       c
            217-315             AC055866.19        163461-163559       c
            316-405             AC055866.19        155898-155987       c
            406-459             AC055866.19        154580-154633       c
            460-1543            AC055866.19        152394-153477       c
FEATURES             Location/Qualifiers
     source          1..1543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..1543
                     /gene="PTGES3L"
                     /note="prostaglandin E synthase 3 like"
                     /db_xref="GeneID:100885848"
                     /db_xref="HGNC:HGNC:43943"
     exon            1..35
                     /gene="PTGES3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..498
                     /gene="PTGES3L"
                     /note="isoform 5 is encoded by transcript variant 5;
                     putative protein PTGES3L; prostaglandin E synthase 3
                     (cytosolic)-like"
                     /codon_start=1
                     /product="putative protein PTGES3L isoform 5"
                     /protein_id="NP_001248359.2"
                     /db_xref="CCDS:CCDS92328.1"
                     /db_xref="GeneID:100885848"
                     /db_xref="HGNC:HGNC:43943"
                     /translation="MARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKN
                     ADGVELYNEIEFYAKVNSKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDIKPVWLSV
                     DFDNWRDWEGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLDDDSDSADDATSN"
     exon            36..149
                     /gene="PTGES3L"
                     /inference="alignment:Splign:2.1.0"
     exon            150..216
                     /gene="PTGES3L"
                     /inference="alignment:Splign:2.1.0"
     exon            217..315
                     /gene="PTGES3L"
                     /inference="alignment:Splign:2.1.0"
     exon            316..405
                     /gene="PTGES3L"
                     /inference="alignment:Splign:2.1.0"
     exon            406..459
                     /gene="PTGES3L"
                     /inference="alignment:Splign:2.1.0"
     exon            460..1543
                     /gene="PTGES3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGES3L"
                     /note="hexamer: AATAAA"
     polyA_site      920
                     /gene="PTGES3L"
     regulatory      1525..1530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGES3L"
                     /note="hexamer: AATAAA"
     polyA_site      1543
                     /gene="PTGES3L"
                     /note="major polyA site"
ORIGIN      
        1 aaatgccacc ctggagcggg agccgcaatg gcacggcagc acgcccggac cttgtggtac
       61 gacaggccca ggtatgtgtt catggagttt tgtgttgagg acagcaccga tgtccacgtg
      121 cttattgagg atcaccgcat tgtgttcagc tgcaagaatg ccgatggagt ggagttgtac
      181 aatgagattg agttctatgc caaagtgaac tccaaggact cccaggataa gcgctcttcc
      241 cgctctatta cttgttttgt gagaaaatgg aaggaaaagg tggcctggcc gcggcttacc
      301 aaggaggata tcaagccagt gtggctgtct gtggactttg ataactggag agactgggaa
      361 ggggatgaag agatggagct ggctcatgtg gaacattatg cagagctttt gaagaaggtc
      421 agcaccaaga gacctccacc tgccatggat gatttggatg atgattctga cagtgctgat
      481 gatgcaacaa gtaattaact ttctgtgacg caaagctggg aaggcagctg tggctatttt
      541 ccagttgttc tagaaagcta gcgcctaggc ctttgtcagc gctttggctg tgcaccaagt
      601 tcttctgaga tctctgaact ttcctagaag ctctttatta agggtcgtcc ttcaagcttg
      661 tcttcctcct aggcacttga ctatggctcc acatcagatg cagggtcggg gaggggtaga
      721 ctggtagggc ttctgatttc ttactgattg gtttctaatc tctgtgttta ggccacttga
      781 ttatttgagt atgtgtgtgt atgtggcaaa acaaaagcca aagaagaatg cagattatag
      841 aaatctctac tatgtgtgca tatggggcaa agcaaaaagc caaagaagaa acagattata
      901 ataaatctct aggaactgtt ctctgtctgt ttccttcttg tacttattcc tcctggtggc
      961 aagcctcttc tccctctagt aaccaagctg gggtgcttcc tcttgcccag atttgtgctc
     1021 tgatttctta cagctaattc tgtcatctct agaaccagcc acttcagctt cctgcacact
     1081 ctagaaatct ctttatactt tttttttttt tttccgagat ggagtcttgc tctgtcgccc
     1141 aggctggagt gcagtggtgc agtctctgtt cactgcaacc tccaccttct gggttcaagc
     1201 aattctcctg cctcagcctc ccaagtagat gggactacag atgtgcacca ccaggcccag
     1261 ctaatttttg tatttttagc agagatgggg tttcaccatg ttggccaggc tggtctcgaa
     1321 ctcctgacct caagtaatcc acccacctca gcctcccaaa gtgctaggat tacatgtatg
     1381 agccaccaca cccggccctc tttatacttt taaaactgat tgttactcta gttaatgtct
     1441 atgtttattt gtccaacagc tattctattt gtccataaac ttttttgagt gcctaatatg
     1501 tacagttgac tgtaacttaa acaaaataaa tgcattgcct ata
//
