LOCUS       NM_001136042            2184 bp    mRNA    linear   PRI 10-JUL-2022
DEFINITION  Homo sapiens PTGES3L-AARSD1 readthrough (PTGES3L-AARSD1),
            transcript variant 1, mRNA.
ACCESSION   NM_001136042
VERSION     NM_001136042.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Deng X, Sabino EC, Cunha-Neto E, Ribeiro AL, Ianni B, Mady C, Busch
            MP and Seielstad M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295447.1, AF039235.1 and AI312767.1.
            
            On Dec 13, 2008 this sequence version replaced NM_001136042.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring PTGES3L (prostaglandin E
            synthase 3 (cytosolic)-like) and AARSD1(alanyl-tRNA synthetase
            domain containing 1) genes on chromosome 17. The readthrough
            transcript encodes a fusion protein that shares sequence identity
            with each individual gene product. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295447.1, SRR1660807.79346.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 80755,
                                      100885848
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-927               AK295447.1         1-927
            928-1334            AF039235.1         633-1039
            1335-2150           AK295447.1         1335-2150
            2151-2184           AI312767.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2184
                     /gene="PTGES3L-AARSD1"
                     /note="PTGES3L-AARSD1 readthrough"
                     /db_xref="GeneID:100885850"
                     /db_xref="HGNC:HGNC:43946"
     exon            1..483
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..2107
                     /gene="PTGES3L-AARSD1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="PTGES3L-AARSD1 protein isoform 1"
                     /protein_id="NP_001129514.2"
                     /db_xref="GeneID:100885850"
                     /db_xref="HGNC:HGNC:43946"
                     /translation="MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAM
                     ARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAK
                     VNSKDSQDKRSSRSITCFVRKWKEKVAWPRLTKEDIKPVWLSVDFDNWRDWEGDEEME
                     LAHVEHYAELLKKVSTKRPPPAMDDLDFTTTVVSCCPAELQTEGSNGKKEVLSGFQVV
                     LEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPGSQVLVRVDWERR
                     FDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNE
                     KIRDRLPVNVRELSLDDPEVEQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLS
                     DLQVIKILGTEKGKKNRTNLIFLSGNRVLKWMERSHGTEKALTALLKCGAEDHVEAVK
                     KLQNSTKILQKNNLNLLRDLAVHIAHSLRNSPDWGGVVILHRKEGDSEFMNIIANEIG
                     SEETLLFLTVGDEKGGGLFLLAGPPASVETLGPRVAEVLEGKGAGKKGRFQGKATKMS
                     RRMEAQALLQDYISTQSAKE"
     exon            484..597
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..664
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..763
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..853
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..907
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1039
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1199
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1257
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1414
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1531
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1662
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1729
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1821
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1876
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1971
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2174
                     /gene="PTGES3L-AARSD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2158..2163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGES3L-AARSD1"
                     /note="hexamer: AATAGA"
     polyA_site      2174
                     /gene="PTGES3L-AARSD1"
                     /note="major polyA site"
ORIGIN      
        1 gcaacggcgc ggtggcctgg aaccccaggg gagtggtggg cggggcctga agtacccaag
       61 tccccgaggg cgcgccttcc ccgggaattt aattcaggac aataatgttt tattgagcgc
      121 ctattgtgaa tcagacactg agcagtaagc gtcggagaaa caggtgaatg ataccgggga
      181 aaagtcattc cctgtgtgta gcgtctaggg cagcctttgc cctggttcca gcagatgggt
      241 tgtctcttca tagtctatgc atttctgaag accccacggt gaagggctgc aaggatgaag
      301 ctgtcccaga gtatctccag agtgcagatc ccttggctgc caggtcatgt tctctcttcc
      361 tctcaactgc tctcccgacc atataaggag aggcagctgc tgggggcgtc cccaggatct
      421 aaagatagcg gcccctgcct ggaactctaa atgccaccct ggagcgggag ccgcaatggc
      481 acggcagcac gcccggacct tgtggtacga caggcccagg tatgtgttca tggagttttg
      541 tgttgaggac agcaccgatg tccacgtgct tattgaggat caccgcattg tgttcagctg
      601 caagaatgcc gatggagtgg agttgtacaa tgagattgag ttctatgcca aagtgaactc
      661 caaggactcc caggataagc gctcttcccg ctctattact tgttttgtga gaaaatggaa
      721 ggaaaaggtg gcctggccgc ggcttaccaa ggaggatatc aagccagtgt ggctgtctgt
      781 ggactttgat aactggagag actgggaagg ggatgaagag atggagctgg ctcatgtgga
      841 acattatgca gagcttttga agaaggtcag caccaagaga cctccacctg ccatggatga
      901 tttggatttc accaccaccg tggtctcctg ctgtcccgcg gagctgcaga ctgaagggag
      961 caacggcaag aaagaagtgc tgagcggttt ccaagtggtg ctggaagaca cagtgctttt
     1021 ccctgagggc gggggacagc ctgatgaccg tggtacaatc aatgacatct ctgtgctgag
     1081 agtgactcgc cgtggggaac aggctgatca tttcacccag acacccctgg atccaggaag
     1141 ccaggttctg gtccgggtag attgggagcg gaggtttgac cacatgcagc agcattcagg
     1201 gcagcatctc atcacggcag ttgctgacca tctatttaag ctgaagacaa catcatggga
     1261 gttagggaga tttcggagtg cgattgagct ggacaccccc tctatgactg cagagcaagt
     1321 agctgccatt gagcagagcg tcaatgaaaa aatcagagat cggctgcctg tgaatgtccg
     1381 agaactgagc ctggatgatc ctgaggtgga gcaggtgagt ggccggggtt tgcctgatga
     1441 tcatgctggg cccattcggg ttgttaacat cgagggcgtt gattccaaca tgtgctgtgg
     1501 gacccatgtg agcaatctca gtgaccttca ggtcattaag attctgggca ctgagaaggg
     1561 gaaaaagaac agaaccaacc tgatatttct gtctgggaac cgggtgctga agtggatgga
     1621 gagaagtcat ggaactgaaa aagcactgac tgctctgctt aagtgtggag cagaggatca
     1681 tgtggaagca gtgaaaaagc tccagaactc caccaagatc ctgcagaaga ataacctgaa
     1741 tctgctcaga gacctggctg tgcacattgc ccatagcctc aggaacagtc cagactgggg
     1801 aggtgtggtc atattacaca ggaaggaggg tgattcagag ttcatgaata tcattgccaa
     1861 tgagattggg tcagaggaga ccctcctgtt cttaactgtg ggcgatgaga aaggtggtgg
     1921 actcttctta ctggcagggc cacctgcgtc tgtggagacc ctggggccca gggtggctga
     1981 ggtcctggaa ggcaaaggag cagggaagaa aggccgtttt cagggcaagg ccaccaagat
     2041 gagccggcgg atggaggcgc aggcgcttct ccaggactac atcagcacgc agagtgctaa
     2101 ggagtgaggg cttagggcac tcacctcctg tttccacagg aatcttttgg tcaataaaat
     2161 agattgactc agaaaaaaaa aaaa
//
