LOCUS       NM_006601               1898 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens prostaglandin E synthase 3 (PTGES3), transcript
            variant 1, mRNA.
ACCESSION   NM_006601
VERSION     NM_006601.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1898)
  AUTHORS   Yin,Q., Ma,H., Dong,Y., Zhang,S., Wang,J., Liang,J., Mao,L.,
            Zeng,L., Xiong,X., Chen,X., Wang,J. and Zheng,X.
  TITLE     The integration of multidisciplinary approaches revealed PTGES3 as
            a novel drug target for breast cancer treatment
  JOURNAL   J Transl Med 22 (1), 84 (2024)
   PUBMED   38245717
  REMARK    GeneRIF: The integration of multidisciplinary approaches revealed
            PTGES3 as a novel drug target for breast cancer treatment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1898)
  AUTHORS   Jiang,W., Wei,Q., Xie,H., Wu,D., He,H. and Lv,X.
  TITLE     Effect of PTGES3 on the Prognosis and Immune Regulation in Lung
            Adenocarcinoma
  JOURNAL   Anal Cell Pathol (Amst) 2023, 4522045 (2023)
   PUBMED   37416927
  REMARK    GeneRIF: Effect of PTGES3 on the Prognosis and Immune Regulation in
            Lung Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1898)
  AUTHORS   Biebl,M.M. and Buchner,J.
  TITLE     p23 and Aha1: Distinct Functions Promote Client Maturation
  JOURNAL   Subcell Biochem 101, 159-187 (2023)
   PUBMED   36520307
  REMARK    GeneRIF: p23 and Aha1: Distinct Functions Promote Client
            Maturation.
            Review article
REFERENCE   4  (bases 1 to 1898)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1898)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1898)
  AUTHORS   Obermann,W.M., Sondermann,H., Russo,A.A., Pavletich,N.P. and
            Hartl,F.U.
  TITLE     In vivo function of Hsp90 is dependent on ATP binding and ATP
            hydrolysis
  JOURNAL   J Cell Biol 143 (4), 901-910 (1998)
   PUBMED   9817749
REFERENCE   7  (bases 1 to 1898)
  AUTHORS   Zou,J., Guo,Y., Guettouche,T., Smith,D.F. and Voellmy,R.
  TITLE     Repression of heat shock transcription factor HSF1 activation by
            HSP90 (HSP90 complex) that forms a stress-sensitive complex with
            HSF1
  JOURNAL   Cell 94 (4), 471-480 (1998)
   PUBMED   9727490
REFERENCE   8  (bases 1 to 1898)
  AUTHORS   Dittmar,K.D., Demady,D.R., Stancato,L.F., Krishna,P. and Pratt,W.B.
  TITLE     Folding of the glucocorticoid receptor by the heat shock protein
            (hsp) 90-based chaperone machinery. The role of p23 is to stabilize
            receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70
  JOURNAL   J Biol Chem 272 (34), 21213-21220 (1997)
   PUBMED   9261129
REFERENCE   9  (bases 1 to 1898)
  AUTHORS   Dittmar,K.D. and Pratt,W.B.
  TITLE     Folding of the glucocorticoid receptor by the reconstituted
            Hsp90-based chaperone machinery. The initial
            hsp90.p60.hsp70-dependent step is sufficient for creating the
            steroid binding conformation
  JOURNAL   J Biol Chem 272 (20), 13047-13054 (1997)
   PUBMED   9148915
REFERENCE   10 (bases 1 to 1898)
  AUTHORS   Johnson,J.L., Beito,T.G., Krco,C.J. and Toft,D.O.
  TITLE     Characterization of a novel 23-kilodalton protein of unactive
            progesterone receptor complexes
  JOURNAL   Mol Cell Biol 14 (3), 1956-1963 (1994)
   PUBMED   8114727
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP194632.1, BC003005.1 and
            BG927063.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006601.6.
            
            Summary: This gene encodes an enzyme that converts prostaglandin
            endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein
            functions as a co-chaperone with heat shock protein 90 (HSP90),
            localizing to response elements in DNA and disrupting
            transcriptional activation complexes. Alternative splicing results
            in multiple transcript variants. There are multiple pseudogenes of
            this gene on several different chromosomes. [provided by RefSeq,
            Feb 2016].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.246689.1,
                                           SRR3476690.449259.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262033.11/ ENSP00000262033.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               BP194632.1         125-303
            180-1649            BC003005.1         1-1470
            1650-1898           BG927063.1         270-518
FEATURES             Location/Qualifiers
     source          1..1898
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1898
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /note="prostaglandin E synthase 3"
                     /db_xref="GeneID:10728"
                     /db_xref="HGNC:HGNC:16049"
                     /db_xref="MIM:607061"
     exon            1..287
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..768
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /EC_number="5.3.99.3"
                     /note="isoform a is encoded by transcript variant 1;
                     unactive progesterone receptor, 23 kD; telomerase-binding
                     protein p23; progesterone receptor complex p23; Hsp90
                     co-chaperone; prostaglandin E synthase 3 (cytosolic);
                     cytosolic prostaglandin E synthase; cytosolic
                     prostaglandin E2 synthase"
                     /codon_start=1
                     /product="prostaglandin E synthase 3 isoform a"
                     /protein_id="NP_006592.3"
                     /db_xref="CCDS:CCDS31836.1"
                     /db_xref="GeneID:10728"
                     /db_xref="HGNC:HGNC:16049"
                     /db_xref="MIM:607061"
                     /translation="MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGS
                     DNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVD
                     FNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
                     "
     exon            288..401
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            402..471
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            472..570
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            571..660
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            661..723
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            724..748
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1898
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1630..1635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /note="hexamer: AATAAA"
     polyA_site      1649
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /note="major polyA site"
     regulatory      1876..1881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /note="hexamer: ACTAAA"
     polyA_site      1898
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /note="major polyA site"
ORIGIN      
        1 ctcaccaccc ctcgtttgca cgcacgcacg ttcattctcc gtcctcgcgc cccttttcct
       61 acactttcct cttctccccg accggaggag ccgctctttc cgcgcggtgc attctggggc
      121 ccgaggtcga gcccgccgct gccgccgtcg cctgagggaa gcgagaagag gccgcgaccg
      181 gagagaaaaa gcggagtcgc caccggagag aagtcgactc cctagcagca gccgccgcca
      241 gagaggcccg cccaccagtt cgcccgtccc cctgccccgt tcacaatgca gcctgcttct
      301 gcaaagtggt acgatcgaag ggactatgtc ttcattgaat tttgtgttga agacagtaag
      361 gatgttaatg taaattttga aaaatccaaa cttacattca gttgtctcgg aggaagtgat
      421 aattttaagc atttaaatga aattgatctt tttcactgta ttgatccaaa tgattccaag
      481 cataaaagaa cggacagatc aattttatgt tgtttacgaa aaggagaatc tggccagtca
      541 tggccaaggt taacaaaaga aagggcaaag cttaattggc ttagtgtcga cttcaataat
      601 tggaaagact gggaagatga ttcagatgaa gacatgtcta attttgatcg tttctctgag
      661 atgatgaaca acatgggtgg tgatgaggat gtagatttac cagaagtaga tggagcagat
      721 gatgattcac aagacagtga tgatgaaaaa atgccagatc tggagtaagg aatattgtca
      781 tcacctggat tttgagaaag aaaaataact tctctgcaag atttcataat tgagagaatt
      841 cctgagttga tagctctaaa ggcagatatg ctgtatttgc ctactttaac ccatttttca
      901 acctgtttgt tttttaaaag gcttcactaa gggttgatat gtaccattgt atggggcaat
      961 tttaagtcag ctaaggcaat aaccttatgc atgaacattt cccagacttt catgaagctg
     1021 ttgaggtcct aggcaattaa tgcagcagtt gcgataaata aaaacatctc acctaagtct
     1081 ccttttcttc ataacataga tactgacatg ataggaagct ctcagcttag ggaaagagaa
     1141 taaattttag attatagaac atggattcaa aagtgactgg aacaaattgg ctgacacctt
     1201 actggtaacc tgctattctt ctggtgttat ccttcaggat tgttccacta aaatttattt
     1261 ttcaaaaaat ttacttcaca ttattctatg taagtgatga cttgtcagtg ttccaggtgt
     1321 atcttagcta aaactagaga atgccctaac ttagatggtt tttgaagcct atacaattgg
     1381 tattgtttga cccttaagct tttacatctc ttagcatgga ggacgaagaa agctgtacat
     1441 tgttgcttga gagtctgtac atttagtcca gatttgtatt tgcactgtca gtatggcaaa
     1501 tgagtgaaaa atgtttaata cactattgga ttttttattt cctttttttg attcagctta
     1561 tacccgggct gaaaacctca atttatgttc atgacagtgg ggattttttt aaatgtctac
     1621 attctttcta ataaactgtt ggaagacttc ttggctgtcc ttttaagtgt ctggcttact
     1681 gtaattttta tgtatttacc atttactgga atggagttta tttgaggaag aatttgggat
     1741 tattcctctg tttgaaaaaa gaggcttgct gtaatgtcac aggaaacctt ttaaaagtgg
     1801 atctgtaata gcatattgta gatgcacttt gcagcagttg gaaaagaaag tgttgtgtga
     1861 tttgattgaa ataaaactaa atgtgttgtc ctcctaaa
//
