LOCUS       NM_004878               1751 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens prostaglandin E synthase (PTGES), mRNA.
ACCESSION   NM_004878
VERSION     NM_004878.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1751)
  AUTHORS   Geng,S., Zhan,H., Cao,L., Geng,L. and Ren,X.
  TITLE     Targeting PTGES/PGE2 axis enhances sensitivity of colorectal cancer
            cells to 5-fluorouracil
  JOURNAL   Biochem Cell Biol 101 (6), 501-512 (2023)
   PUBMED   37358009
  REMARK    GeneRIF: Targeting PTGES/PGE2 axis enhances sensitivity of
            colorectal cancer cells to 5-fluorouracil.
REFERENCE   2  (bases 1 to 1751)
  AUTHORS   Murthy,D. and Attri,K.S.
  TITLE     PTGES Expression Is Associated with Metabolic and Immune
            Reprogramming in Pancreatic Ductal Adenocarcinoma
  JOURNAL   Int J Mol Sci 24 (8), 7304 (2023)
   PUBMED   37108468
  REMARK    GeneRIF: PTGES Expression Is Associated with Metabolic and Immune
            Reprogramming in Pancreatic Ductal Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1751)
  AUTHORS   Zhou,S., Zheng,F. and Zhan,C.G.
  TITLE     Clinical data mining reveals analgesic effects of lapatinib in
            cancer patients
  JOURNAL   Sci Rep 11 (1), 3528 (2021)
   PUBMED   33574423
  REMARK    GeneRIF: Clinical data mining reveals analgesic effects of
            lapatinib in cancer patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1751)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1751)
  AUTHORS   Wu,F., Wen,Z., Zhi,Z., Li,Y., Zhou,L., Li,H., Xu,X. and Tang,W.
  TITLE     MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3
            in the pathogenesis of Hirschsprung disease
  JOURNAL   J Pediatr Surg 54 (10), 2032-2037 (2019)
   PUBMED   30814036
  REMARK    GeneRIF: Studied the role that microsomal prostaglandin E
            synthase-1 (mPGES-1) derived prostaglandin E2 (PGE2) plays in cell
            migration in the pathogenesis of Hirschsprung disease. Results
            showed mPGES-1 derived PGE2 decreased the relative expression of
            EP2 and ARP2/3 and caused damage to cytoskeleton.
REFERENCE   6  (bases 1 to 1751)
  AUTHORS   Jakobsson,P.J., Morgenstern,R., Mancini,J., Ford-Hutchinson,A. and
            Persson,B.
  TITLE     Common structural features of MAPEG -- a widespread superfamily of
            membrane associated proteins with highly divergent functions in
            eicosanoid and glutathione metabolism
  JOURNAL   Protein Sci 8 (3), 689-692 (1999)
   PUBMED   10091672
REFERENCE   7  (bases 1 to 1751)
  AUTHORS   Giacomini,E., Giordani,L., di Modugno,F., Chersi,A. and
            Luzzati,A.L.
  TITLE     Increased PGE2 production mediates the in vitro inhibitory effect
            of the human immunodeficiency virus P24 immunosuppressive
            heptapeptide Ch7
  JOURNAL   Scand J Immunol 48 (3), 248-253 (1998)
   PUBMED   9743208
REFERENCE   8  (bases 1 to 1751)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
REFERENCE   9  (bases 1 to 1751)
  AUTHORS   Bastien,L., Sawyer,N., Grygorczyk,R., Metters,K.M. and Adam,M.
  TITLE     Cloning, functional expression, and characterization of the human
            prostaglandin E2 receptor EP2 subtype
  JOURNAL   J Biol Chem 269 (16), 11873-11877 (1994)
   PUBMED   8163486
REFERENCE   10 (bases 1 to 1751)
  AUTHORS   Funk,C.D., Furci,L., FitzGerald,G.A., Grygorczyk,R., Rochette,C.,
            Bayne,M.A., Abramovitz,M., Adam,M. and Metters,K.M.
  TITLE     Cloning and expression of a cDNA for the human prostaglandin E
            receptor EP1 subtype
  JOURNAL   J Biol Chem 268 (35), 26767-26772 (1993)
   PUBMED   8253813
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008280.1 and AL590369.18.
            
            On Nov 22, 2018 this sequence version replaced NM_004878.4.
            
            Summary: The protein encoded by this gene is a
            glutathione-dependent prostaglandin E synthase. The expression of
            this gene has been shown to be induced by proinflammatory cytokine
            interleukin 1 beta (IL1B). Its expression can also be induced by
            tumor suppressor protein TP53, and may be involved in TP53 induced
            apoptosis. Knockout studies in mice suggest that this gene may
            contribute to the pathogenesis of collagen-induced arthritis and
            mediate acute pain during inflammatory responses. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008280.1, SRR3476690.724992.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340607.5/ ENSP00000342385.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               BC008280.1         6-677
            673-1685            BC008280.1         684-1696
            1686-1751           AL590369.18        122764-122829       c
FEATURES             Location/Qualifiers
     source          1..1751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..1751
                     /gene="PTGES"
                     /gene_synonym="MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1;
                     PGES; PIG12; PP102; PP1294; TP53I12"
                     /note="prostaglandin E synthase"
                     /db_xref="GeneID:9536"
                     /db_xref="HGNC:HGNC:9599"
                     /db_xref="MIM:605172"
     exon            1..156
                     /gene="PTGES"
                     /gene_synonym="MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1;
                     PGES; PIG12; PP102; PP1294; TP53I12"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..489
                     /gene="PTGES"
                     /gene_synonym="MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1;
                     PGES; PIG12; PP102; PP1294; TP53I12"
                     /EC_number="2.5.1.18"
                     /EC_number="5.3.99.3"
                     /note="microsomal glutathione S-transferase 1-like 1;
                     tumor protein p53 inducible protein 12; p53-induced
                     apoptosis protein 12; MGST1-like 1; microsomal
                     prostaglandin E synthase-1; p53-induced gene 12 protein;
                     glutathione peroxidase PTGES; glutathione transferase
                     PTGES"
                     /codon_start=1
                     /product="prostaglandin E synthase"
                     /protein_id="NP_004869.1"
                     /db_xref="CCDS:CCDS6927.1"
                     /db_xref="GeneID:9536"
                     /db_xref="HGNC:HGNC:9599"
                     /db_xref="MIM:605172"
                     /translation="MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAF
                     ANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMH
                     FLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL"
     exon            157..239
                     /gene="PTGES"
                     /gene_synonym="MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1;
                     PGES; PIG12; PP102; PP1294; TP53I12"
                     /inference="alignment:Splign:2.1.0"
     exon            240..1751
                     /gene="PTGES"
                     /gene_synonym="MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1;
                     PGES; PIG12; PP102; PP1294; TP53I12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1731..1736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGES"
                     /gene_synonym="MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1;
                     PGES; PIG12; PP102; PP1294; TP53I12"
                     /note="hexamer: ATTAAA"
     polyA_site      1751
                     /gene="PTGES"
                     /gene_synonym="MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1;
                     PGES; PIG12; PP102; PP1294; TP53I12"
                     /note="major polyA site"
ORIGIN      
        1 acacccacag ttgagctgcg ctggccagag atgcctgccc acagcctggt gatgagcagc
       61 ccggccctcc cggccttcct gctctgcagc acgctgctgg tcatcaagat gtacgtggtg
      121 gccatcatca cgggccaagt gaggctgcgg aagaaggcct ttgccaaccc cgaggatgcc
      181 ctgagacacg gaggccccca gtattgcagg agcgaccccg acgtggaacg ctgcctcagg
      241 gcccaccgga acgacatgga gaccatctac cccttccttt tcctgggctt cgtctactcc
      301 tttctgggtc ctaacccttt tgtcgcctgg atgcacttcc tggtcttcct cgtgggccgt
      361 gtggcacaca ccgtggccta cctggggaag ctgcgggcac ccatccgctc cgtgacctac
      421 accctggccc agctcccctg cgcctccatg gctctgcaga tcctctggga agcggcccgc
      481 cacctgtgac cagcagctga tgcctccttg gccaccagac catgggccaa gagccgccgt
      541 ggctatacct ggggacttga tgttccttcc agattgtggt gggccctgag tcctggtttc
      601 ctggcagcct gctgcgcgtg tgggtctctg ggcacagtgg gcctgtgtgt gtgcccgtgt
      661 gtgtgtatgt gtgtgtgtat gtttcttagc cccttggatt cctgcacgaa gtggctgatg
      721 ggaaccattt caagacagat tgtgaagatt gatagaaaat ccttcagcta aagtaacaga
      781 gcatcaaaaa catcactccc tctccctccc taacagtgaa aagagagaag ggagactcta
      841 tttaagattc ccaaacctaa tgatcatctg aatcccgggc taagaatgca gacttttcag
      901 actgacccca gaaattctgg cccagccaat ctagaggcaa gcctggccat ctgtattttt
      961 ttttttccaa gacagagtct tgctctgttg cccaagctgg agtgaagtgg tacaatctgg
     1021 ctcactgcag cctccgcctc ccgggttcaa gcgattctcc cgcctcagcc tcctgagtag
     1081 ctgggattac aggcgcgtat caccataccc agctaatttt tgtattttta gtagagacgg
     1141 gttcaccatg ttgcccagga gggtctcgaa ctcctggcct caagtgatcc accggcctcg
     1201 gcctcccaaa gtgctgggat gacaggcatg aatcactgtg ctcagccacc atctggagtt
     1261 ttaaaaggct cccatgtgag tccctgtgat ggccaggcca ggggacccct gccagttctc
     1321 tgtggaagca aggctggggt cttgggttcc tgtatggtgg aagctgggtg agccaaggac
     1381 agggctggct cctctgcccc cgctgacgct tcccttgccg ttggctttgg atgtctttgc
     1441 tgcagtcttc tctctggctc aggtgtgggt gggaggggcc cacaggaagc tcagccttct
     1501 cctcccaagg tttgagtccc tccaaagggc agtgggtgga ggaccgggag ctttgggtga
     1561 ccagccactc aaaggaactt tctggtccct tcagtatctt caaggtttgg aaactgcaaa
     1621 tgtccccttg atggggaatc cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1681 tgtgtgtgtt ttctcctaga cccgtgacct gagatgtgtg atttttagtc attaaatgga
     1741 agtgtctgcc a
//
