LOCUS       NM_198719               2360 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens prostaglandin E receptor 3 (PTGER3), transcript
            variant 9, mRNA.
ACCESSION   NM_198719
VERSION     NM_198719.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Wang,S., Zhang,Y., Zhang,D., Meng,J., Che,N., Zhao,X. and Liu,T.
  TITLE     PTGER3 knockdown inhibits the vulnerability of triple-negative
            breast cancer to ferroptosis
  JOURNAL   Cancer Sci 115 (6), 2067-2081 (2024)
   PUBMED   38566528
  REMARK    GeneRIF: PTGER3 knockdown inhibits the vulnerability of
            triple-negative breast cancer to ferroptosis.
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Hu,C.J., Wang,Y.W., Huang,W.X. and Xia,Y.B.
  TITLE     E prostanoid receptor-3 promotes oxidized low-density
            lipoprotein-induced human aortic smooth muscle cells inflammation
  JOURNAL   ESC Heart Fail 10 (2), 1077-1089 (2023)
   PUBMED   36578105
  REMARK    GeneRIF: E prostanoid receptor-3 promotes oxidized low-density
            lipoprotein-induced human aortic smooth muscle cells inflammation.
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Singh,S., Rao,B.S. and Basu,S.
  TITLE     Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal
            Glands of Patients with Chronic Stevens-Johnson Syndrome
  JOURNAL   Ocul Immunol Inflamm 31 (2), 343-347 (2023)
   PUBMED   35113749
  REMARK    GeneRIF: Altered Prostaglandin E Receptor Subtype 3 Expression in
            Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome.
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Tao,X., Du,R., Guo,S., Feng,X., Yu,T., OuYang,Q., Chen,Q., Fan,X.,
            Wang,X., Guo,C., Li,X., Xue,F., Chen,S., Tong,M., Lazarus,M.,
            Zuo,S., Yu,Y. and Shen,Y.
  TITLE     PGE2 -EP3 axis promotes brown adipose tissue formation through
            stabilization of WTAP RNA methyltransferase
  JOURNAL   EMBO J 41 (16), e110439 (2022)
   PUBMED   35781818
  REMARK    GeneRIF: PGE2 -EP3 axis promotes brown adipose tissue formation
            through stabilization of WTAP RNA methyltransferase.
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Ye,Y., Peng,L., Chelariu-Raicu,A., Kuhn,C., Dong,X., Jeschke,U. and
            von Schonfeldt,V.
  TITLE     Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in
            unexplained recurrent pregnancy loss
  JOURNAL   Biol Reprod 106 (5), 910-918 (2022)
   PUBMED   35134851
  REMARK    GeneRIF: Prostaglandin E2 receptor 3 promotes M1 macrophages
            polarization in unexplained recurrent pregnancy loss.
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Kotelevets,L., Foudi,N., Louedec,L., Couvelard,A., Chastre,E. and
            Norel,X.
  TITLE     A new mRNA splice variant coding for the human EP3-I receptor
            isoform
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 77 (3-4), 195-201 (2007)
   PUBMED   18023986
  REMARK    GeneRIF: We identified a new mRNA splice variant of the EP3 gene in
            human gastric fundic mucosa, mammary artery and pulmonary vessels.
            This EP3-Ic transcript contains exons 1, 2, 3, 5 and 6 of the EP3
            gene and should be translated in the EP3-I isoform.
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Kotani,M., Tanaka,I., Ogawa,Y., Usui,T., Mori,K., Ichikawa,A.,
            Narumiya,S., Yoshimi,T. and Nakao,K.
  TITLE     Molecular cloning and expression of multiple isoforms of human
            prostaglandin E receptor EP3 subtype generated by alternative
            messenger RNA splicing: multiple second messenger systems and
            tissue-specific distributions
  JOURNAL   Mol Pharmacol 48 (5), 869-879 (1995)
   PUBMED   7476918
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Schmid,A., Thierauch,K.H., Schleuning,W.D. and Dinter,H.
  TITLE     Splice variants of the human EP3 receptor for prostaglandin E2
  JOURNAL   Eur J Biochem 228 (1), 23-30 (1995)
   PUBMED   7883006
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Duncan,A.M., Anderson,L.L., Funk,C.D., Abramovitz,M. and Adam,M.
  TITLE     Chromosomal localization of the human prostanoid receptor gene
            family
  JOURNAL   Genomics 25 (3), 740-742 (1995)
   PUBMED   7759114
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031429.11, D38297.1 and
            AI273491.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_198719.1.
            
            Summary: The protein encoded by this gene is a member of the
            G-protein coupled receptor family. This protein is one of four
            receptors identified for prostaglandin E2 (PGE2). This receptor may
            have many biological functions, which involve digestion, nervous
            system, kidney reabsorption, and uterine contraction activities.
            Studies of the mouse counterpart suggest that this receptor may
            also mediate adrenocorticotropic hormone response as well as fever
            generation in response to exogenous and endogenous stimuli.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.771059.1, X83858.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306666.10/ ENSP00000302313.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL031429.11        124147-124154       c
            9-1886              D38297.1           1-1878
            1887-2360           AI273491.1         2-475               c
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..2360
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /note="prostaglandin E receptor 3"
                     /db_xref="GeneID:5733"
                     /db_xref="HGNC:HGNC:9595"
                     /db_xref="MIM:176806"
     exon            1..1136
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1412
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /note="isoform 4 is encoded by transcript variant 9; PGE
                     receptor, EP3 subtype; prostaglandin receptor (PGE-2);
                     prostanoid EP3 receptor; prostaglandin E2 receptor EP3
                     subtype; PGE2 receptor EP3 subtype; prostaglandin E
                     receptor 3 (subtype EP3)"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP3 subtype isoform 4"
                     /protein_id="NP_942012.1"
                     /db_xref="CCDS:CCDS657.1"
                     /db_xref="GeneID:5733"
                     /db_xref="HGNC:HGNC:9595"
                     /db_xref="MIM:176806"
                     /translation="MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSG
                     EDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVG
                     QLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIR
                     APHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNG
                     TSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRI
                     TTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRL
                     ASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER"
     exon            1137..1316
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1408
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..2360
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /note="hexamer: AATAAA"
     polyA_site      2283
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /note="hexamer: AATAAA"
     polyA_site      2360
                     /gene="PTGER3"
                     /gene_synonym="EP3; EP3-I; EP3-II; EP3-III; EP3-IV;
                     EP3-VI; EP3e; lnc003875; PGE2-R"
                     /note="major polyA site"
ORIGIN      
        1 gcctcgccac cagaggtttc ccagagagga aggcgtggct ccctcccggg ccagtgagcc
       61 ctggcgccgc cgcggccgcg gtcccagcag cggagtaggg cggcggctgc gccccgcacc
      121 atggggggca gcccagcccc agccgcggta aacgccgacc tccgccgccg cccgcgccgc
      181 gtctgccccc tcccgctgcg gctctctgga cgccatcccc tcctcacctc gaagccaaca
      241 tgaaggagac ccggggctac ggaggggatg cccccttctg cacccgcctc aaccactcct
      301 acacaggcat gtgggcgccc gagcgttccg ccgaggcgcg gggcaacctc acgcgccctc
      361 cagggtctgg cgaggattgc ggatcggtgt ccgtggcctt cccgatcacc atgctgctca
      421 ctggtttcgt gggcaacgca ctggccatgc tgctcgtgtc gcgcagctac cggcgccggg
      481 agagcaagcg caagaagtcc ttcctgctgt gcatcggctg gctggcgctc accgacctgg
      541 tcgggcagct tctcaccacc ccggtcgtca tcgtcgtgta cctgtccaag cagcgttggg
      601 agcacatcga cccgtcgggg cggctctgca cctttttcgg gctgaccatg actgttttcg
      661 ggctctcctc gttgttcatc gccagcgcca tggccgtcga gcgggcgctg gccatcaggg
      721 cgccgcactg gtatgcgagc cacatgaaga cgcgtgccac ccgcgctgtg ctgctcggcg
      781 tgtggctggc cgtgctcgcc ttcgccctgc tgccggtgct gggcgtgggc cagtacaccg
      841 tccagtggcc cgggacgtgg tgcttcatca gcaccgggcg agggggcaac gggactagct
      901 cttcgcataa ctggggcaac cttttcttcg cctctgcctt tgccttcctg gggctcttgg
      961 cgctgacagt caccttttcc tgcaacctgg ccaccattaa ggccctggtg tcccgctgcc
     1021 gggccaaggc cacggcatct cagtccagtg cccagtgggg ccgcatcacg accgagacgg
     1081 ccattcagct tatggggatc atgtgcgtgc tgtcggtctg ctggtctccg ctcctgataa
     1141 tgatgttgaa aatgatcttc aatcagacat cagttgagca ctgcaagaca cacacggaga
     1201 agcagaaaga atgcaacttc ttcttaatag ctgttcgcct ggcttcactg aaccagatct
     1261 tggatccttg ggtttacctg ctgttaagaa agatccttct tcgaaagttt tgccagatca
     1321 ggtaccacac aaacaactat gcatccagct ccacctcctt accctgccag tgttcctcaa
     1381 ccttgatgtg gagcgaccat ttggaaagat aatgaaagaa cggagttgga cattttattg
     1441 caattcctgc ttccctgaat ttgcatattt cttcccacct gagaaggata attatatatt
     1501 ttaatttgga ttatttcttc atttttatct ttttatttta atgattgttt tgtcagtaat
     1561 acccatggag atcaacttta ttattataat ccatgcctct gaatattaga ttggtttctt
     1621 ggatgggatt ttgaatatgc atttaagaag ttgggaagaa tttcacagat gatgattgga
     1681 ggaaaagtga tgaaaagaaa gacctgtgtt ccaggagttt tctccaactt caaaccttta
     1741 cgtgaatctt aaccaaagtg gacatcttta catttcatga tagcttgctt ttgcaatatg
     1801 agtttgaaaa atcagtataa gcttatgatg gtgaaaagtc aacatattga gagtgataat
     1861 tcaattaata ggatatgaac ttaacgacat ataaaagcaa atgagggcag gagggaatcg
     1921 tgacaaaaaa tatttgtgcc caattatgat taatgtttta gagatgttgt gtccctgtgg
     1981 gcttagcatg gaactaaaag ttcctaagtc tcaattctag ttatgtgtca tttagtaact
     2041 caggaatctg cttaattgtt atttctaagc ttttgatgac aaaggagtga tgcagctaag
     2101 ggcatccttg gagtgtcata aaaaacaaat ttgaggttga atgattagct gcgcagttag
     2161 agtgataaaa aaatccaggt aggccttctg attcaccatg accaagtcag gatttcttaa
     2221 tatttctttt ctggcagcat atacaaaggc aaaattaata aataacagtt gttgaataac
     2281 aaactttatt acgtttttat aaaataaaag aatctatttt gtctgtatta aaataaaaaa
     2341 ctttgtggac ttctaaaaga
//
