LOCUS       NM_000956               2458 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens prostaglandin E receptor 2 (PTGER2), mRNA.
ACCESSION   NM_000956
VERSION     NM_000956.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2458)
  AUTHORS   Lavoie,J.C., Simard,M., Kalkan,H., Rakotoarivelo,V., Huot,S., Di
            Marzo,V., Cote,A., Pouliot,M. and Flamand,N.
  TITLE     Pharmacological evidence that the inhibitory effects of
            prostaglandin E2 are mediated by the EP2 and EP4 receptors in human
            neutrophils
  JOURNAL   J Leukoc Biol 115 (6), 1183-1189 (2024)
   PUBMED   38345417
  REMARK    GeneRIF: Pharmacological evidence that the inhibitory effects of
            prostaglandin E2 are mediated by the EP2 and EP4 receptors in human
            neutrophils.
REFERENCE   2  (bases 1 to 2458)
  AUTHORS   Salama,M.A., Anwar Ismail,A., Islam,M.S., K,G. AR, Al Kawas,S.,
            Samsudin,A.R. and A,C. SA.
  TITLE     Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors
            on osteoblast healing and organization of collagen
  JOURNAL   PLoS One 19 (5), e0303202 (2024)
   PUBMED   38753641
  REMARK    GeneRIF: Impact of Bone Morphogenetic Protein 7 and Prostaglandin
            receptors on osteoblast healing and organization of collagen.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2458)
  AUTHORS   Walker,A.R., Parkin,H.A., Hye Kim,S., Terzidou,V., Woodward,D.F.,
            Bennett,P.R. and Hanyaloglu,A.C.
  TITLE     Constitutive internalisation of EP2 differentially regulates G
            protein signalling
  JOURNAL   J Mol Endocrinol 73 (1), e230153 (2024)
   PUBMED   38639976
  REMARK    GeneRIF: Constitutive internalisation of EP2 differentially
            regulates G protein signalling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2458)
  AUTHORS   Desai,S., April,H., Nwaneshiudu,C. and Ashby,B.
  TITLE     Comparison of agonist-induced internalization of the human EP2 and
            EP4 prostaglandin receptors: role of the carboxyl terminus in EP4
            receptor sequestration
  JOURNAL   Mol Pharmacol 58 (6), 1279-1286 (2000)
   PUBMED   11093764
REFERENCE   5  (bases 1 to 2458)
  AUTHORS   Smock,S.L., Pan,L.C., Castleberry,T.A., Lu,B., Mather,R.J. and
            Owen,T.A.
  TITLE     Cloning, structural characterization, and chromosomal localization
            of the gene encoding the human prostaglandin E(2) receptor EP2
            subtype
  JOURNAL   Gene 237 (2), 393-402 (1999)
   PUBMED   10521663
REFERENCE   6  (bases 1 to 2458)
  AUTHORS   Stillman,B.A., Breyer,M.D. and Breyer,R.M.
  TITLE     Importance of the extracellular domain for prostaglandin EP(2)
            receptor function
  JOURNAL   Mol Pharmacol 56 (3), 545-551 (1999)
   PUBMED   10462542
REFERENCE   7  (bases 1 to 2458)
  AUTHORS   Duncan,A.M., Anderson,L.L., Funk,C.D., Abramovitz,M. and Adam,M.
  TITLE     Chromosomal localization of the human prostanoid receptor gene
            family
  JOURNAL   Genomics 25 (3), 740-742 (1995)
   PUBMED   7759114
REFERENCE   8  (bases 1 to 2458)
  AUTHORS   Regan,J.W., Bailey,T.J., Pepperl,D.J., Pierce,K.L., Bogardus,A.M.,
            Donello,J.E., Fairbairn,C.E., Kedzie,K.M., Woodward,D.F. and
            Gil,D.W.
  TITLE     Cloning of a novel human prostaglandin receptor with
            characteristics of the pharmacologically defined EP2 subtype
  JOURNAL   Mol Pharmacol 46 (2), 213-220 (1994)
   PUBMED   8078484
REFERENCE   9  (bases 1 to 2458)
  AUTHORS   Bastien,L., Sawyer,N., Grygorczyk,R., Metters,K.M. and Adam,M.
  TITLE     Cloning, functional expression, and characterization of the human
            prostaglandin E2 receptor EP2 subtype
  JOURNAL   J Biol Chem 269 (16), 11873-11877 (1994)
   PUBMED   8163486
REFERENCE   10 (bases 1 to 2458)
  AUTHORS   An,S., Yang,J., Xia,M. and Goetzl,E.J.
  TITLE     Cloning and expression of the EP2 subtype of human receptors for
            prostaglandin E2
  JOURNAL   Biochem Biophys Res Commun 197 (1), 263-270 (1993)
   PUBMED   8250933
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR977661.1, CN484094.1,
            BC093927.1, CF132756.1, BE739744.1, U19487.1 and BM986745.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000956.3.
            
            Summary: This gene encodes a receptor for prostaglandin E2, a
            metabolite of arachidonic acid which has different biologic
            activities in a wide range of tissues. Mutations in this gene are
            associated with aspirin-induced susceptibility to asthma. [provided
            by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.277466.1, U19487.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245457.6/ ENSP00000245457.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               CR977661.1         15-179
            166-311             CN484094.1         157-302
            312-1397            BC093927.1         128-1213
            1398-1522           CF132756.1         184-308
            1523-1756           BE739744.1         19-252              c
            1757-2076           U19487.1           1676-1995
            2077-2458           BM986745.1         23-404              c
FEATURES             Location/Qualifiers
     source          1..2458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..2458
                     /gene="PTGER2"
                     /gene_synonym="EP2"
                     /note="prostaglandin E receptor 2"
                     /db_xref="GeneID:5732"
                     /db_xref="HGNC:HGNC:9594"
                     /db_xref="MIM:176804"
     exon            1..1080
                     /gene="PTGER2"
                     /gene_synonym="EP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1314
                     /gene="PTGER2"
                     /gene_synonym="EP2"
                     /note="prostanoid EP2 receptor; PGE receptor EP2 subtype;
                     PGE2 receptor EP2 subtype; prostaglandin E receptor 2
                     (subtype EP2), 53kD; prostaglandin E receptor 2 (subtype
                     EP2), 53kDa"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP2 subtype"
                     /protein_id="NP_000947.2"
                     /db_xref="CCDS:CCDS9708.1"
                     /db_xref="GeneID:5732"
                     /db_xref="HGNC:HGNC:9594"
                     /db_xref="MIM:176804"
                     /translation="MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALA
                     LLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVAL
                     APESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVI
                     YAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSV
                     ILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVC
                     SLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRI
                     SLRTQDATQTSCSTQSDASKQADL"
     exon            1081..2458
                     /gene="PTGER2"
                     /gene_synonym="EP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGER2"
                     /gene_synonym="EP2"
                     /note="hexamer: AATAAA"
     polyA_site      2458
                     /gene="PTGER2"
                     /gene_synonym="EP2"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtaggc gcgggagcct cgagcgccgc tcggatgcag cagccgagcc gccactcggc
       61 gcgcggcggg agacccaggg caagccgccg tcggcgcgct gggtgcggga agggggctct
      121 ggatttcggt ccctcccctt tttcctctga gtctcggaac gctccggctc tcagaccctc
      181 ttcctcccag gtaaaggccg ggagaggagg gcgcatctct tttccaggca ccccaccatg
      241 ggcaatgcct ccaatgactc ccagtctgag gactgcgaga cgcgacagtg gcttccccca
      301 ggcgaaagcc cagccatcag ctccgtcatg ttctcggccg gggtgctggg gaacctcata
      361 gcactggcgc tgctggcgcg ccgctggcgg ggggacgtgg ggtgcagcgc cggccgcagg
      421 agctccctct ccttgttcca cgtgctggtg accgagctgg tgttcaccga cctgctcggg
      481 acctgcctca tcagcccagt ggtactggct tcgtacgcgc ggaaccagac cctggtggca
      541 ctggcgcccg agagccgcgc gtgcacctac ttcgctttcg ccatgacctt cttcagcctg
      601 gccacgatgc tcatgctctt cgccatggcc ctggagcgct acctctcgat cgggcacccc
      661 tacttctacc agcgccgcgt ctcgcgctcc gggggcctgg ccgtgctgcc tgtcatctat
      721 gcagtctccc tgctcttctg ctcgctgccg ctgctggact atgggcagta cgtccagtac
      781 tgccccggga cctggtgctt catccggcac gggcggaccg cttacctgca gctgtacgcc
      841 accctgctgc tgcttctcat tgtctcggtg ctcgcctgca acttcagtgt cattctcaac
      901 ctcatccgca tgcaccgccg aagccggaga agccgctgcg gaccttccct gggcagtggc
      961 cggggcggcc ccggggcccg caggagaggg gaaagggtgt ccatggcgga ggagacggac
     1021 cacctcattc tcctggctat catgaccatc accttcgccg tctgctcctt gcctttcacg
     1081 atttttgcat atatgaatga aacctcttcc cgaaaggaaa aatgggacct ccaagctctt
     1141 aggtttttat caattaattc aataattgac ccttgggtct ttgccatcct taggcctcct
     1201 gttctgagac taatgcgttc agtcctctgt tgtcggattt cattaagaac acaagatgca
     1261 acacaaactt cctgttctac acagtcagat gccagtaaac aggctgacct ttgaggtcag
     1321 tagtttaaaa gttcttagtt atatagcatc tggaagatca ttttgaaatt gttccttgga
     1381 gaaatgaaaa cagtgtgtaa acaaaatgaa gctgccctaa taaaaaggag tatacaaaca
     1441 tttaagctgt ggtcaaggct acagatgtgc tgacaaggca cttcatgtaa agtgtcagaa
     1501 ggagctacaa aacctaccct cagtgagcat ggtacttggc ctttggagga acaatcggct
     1561 gcattgaaga tccagctgcc tattgattta agctttcctg ttgaatgaca aagtatgtgg
     1621 ttttgtaatt tgtttgaaac cccaaacagt gactgtactt tctattttaa tcttgctact
     1681 accgttatac acatatagtg tacagccaga ccagattaaa cttcatatgt aatctctagg
     1741 aagtcaatat gtggaagcaa ccaagcctgc tgtcttgtga tcacttagcg aaccctttat
     1801 ttgaacaatg aagttgaaaa tcataggcac cttttactgt gatgtttgtg tatgtgggag
     1861 tactctcatc actacagtat tactcttaca agagtggact cagtgggtta acatcagttt
     1921 tgtttactca tcctccagga actgcaggtc aagttgtcag gttatttatt ttataatgtc
     1981 catatgctaa tagtgatcaa gaagacttta ggaatggttc tctcaacaag aaataataga
     2041 aatgtctcaa ggcagttaat tctcattaat actctttatt tatcctattt ctgggggagg
     2101 atgtacgtgg ccatgtatga agccaaatat taggcttaaa aactgaaaaa tctggttcat
     2161 tcttcagata tactggaacc cttttaaagt tgatattggg gccatgagta aaatagattt
     2221 tataagatga ctgtgttgta ccaaaattca tctgtctata ttttatttag ggaacatggt
     2281 ttgactcatc ttatatggga aaccatgtag cagtgagtca tatcttaata tatttctaaa
     2341 tgtttggcat gtaaatgtaa actcagcatc aaaatatttc agtgaatttg cactgtttaa
     2401 tcatagttac tgtgtaaact catctgaaat gttacaaaaa taaactataa aacaaaaa
//
