LOCUS       NM_000955               1413 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens prostaglandin E receptor 1 (PTGER1), mRNA.
ACCESSION   NM_000955
VERSION     NM_000955.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Salama,M.A., Anwar Ismail,A., Islam,M.S., K,G. AR, Al Kawas,S.,
            Samsudin,A.R. and A,C. SA.
  TITLE     Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors
            on osteoblast healing and organization of collagen
  JOURNAL   PLoS One 19 (5), e0303202 (2024)
   PUBMED   38753641
  REMARK    GeneRIF: Impact of Bone Morphogenetic Protein 7 and Prostaglandin
            receptors on osteoblast healing and organization of collagen.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Bryson,T.D. and Harding,P.
  TITLE     Prostaglandin E2 EP receptors in cardiovascular disease: An update
  JOURNAL   Biochem Pharmacol 195, 114858 (2022)
   PUBMED   34822808
  REMARK    GeneRIF: Prostaglandin E2 EP receptors in cardiovascular disease:
            An update.
            Review article
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Zhu,J., Mayr,D., Kuhn,C., Mahner,S., Jeschke,U. and von
            Schonfeldt,V.
  TITLE     Prostaglandin E2 receptor EP1 in healthy and diseased human
            endometrium
  JOURNAL   Histochem Cell Biol 149 (2), 153-160 (2018)
   PUBMED   29134301
  REMARK    GeneRIF: No significant differences in EP1 intensity were detected
            for histological, stage, grading, metastatic and recurrent subtypes
            in endometrial cancer.
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Yang,H.J., Jiang,J.H., Yang,Y.T., Yang,X.D., Guo,Z., Qi,Y.P.,
            Zeng,F.H., Zhang,K.L., Chen,N.Z., Xiang,B.D. and Li,L.Q.
  TITLE     Cyclooxygenase-2 expression is associated with initiation of
            hepatocellular carcinoma, while prostaglandin receptor-1 expression
            predicts survival
  JOURNAL   World J Gastroenterol 22 (39), 8798-8805 (2016)
   PUBMED   27818595
  REMARK    GeneRIF: COX-2 expression appears to be linked to early
            hepatocellular carcinoma events (initiation), while EP1 receptor
            expression may participate in tumor progression and predict
            survival
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Plaza-Seron Mdel,C., Ayuso,P., Perez-Sanchez,N., Dona,I.,
            Blanca-Lopez,N., Flores,C., Galindo,L., Molina,A., Perkins,J.R.,
            Cornejo-Garcia,J.A., Agundez,J.A., Garcia-Martin,E., Campo,P.,
            Canto,G. and Blanca,M.
  TITLE     Copy number variation in ALOX5 and PTGER1 is associated with
            NSAIDs-induced urticaria and/or angioedema
  JOURNAL   Pharmacogenet Genomics 26 (6), 280-287 (2016)
   PUBMED   26959713
  REMARK    GeneRIF: Copy number variation in PTGER1 is associated with
            NSAIDs-induced urticaria and/or angioedema
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Kurihara,Y., Endo,H. and Kondo,H.
  TITLE     Induction of IL-6 via the EP3 subtype of prostaglandin E receptor
            in rat adjuvant-arthritic synovial cells
  JOURNAL   Inflamm Res 50 (1), 1-5 (2001)
   PUBMED   11235015
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Duncan,A.M., Anderson,L.L., Funk,C.D., Abramovitz,M. and Adam,M.
  TITLE     Chromosomal localization of the human prostanoid receptor gene
            family
  JOURNAL   Genomics 25 (3), 740-742 (1995)
   PUBMED   7759114
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Coleman,R.A., Smith,W.L. and Narumiya,S.
  TITLE     International Union of Pharmacology classification of prostanoid
            receptors: properties, distribution, and structure of the receptors
            and their subtypes
  JOURNAL   Pharmacol Rev 46 (2), 205-229 (1994)
   PUBMED   7938166
  REMARK    Review article
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Funk,C.D., Furci,L., FitzGerald,G.A., Grygorczyk,R., Rochette,C.,
            Bayne,M.A., Abramovitz,M., Adam,M. and Metters,K.M.
  TITLE     Cloning and expression of a cDNA for the human prostaglandin E
            receptor EP1 subtype
  JOURNAL   J Biol Chem 268 (35), 26767-26772 (1993)
   PUBMED   8253813
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Lee,T.Y. and Watanabe,Y.
  TITLE     A nonlinear regression model as applied to the comparison of
            axis-angles of electrocardiographic systems
  JOURNAL   Jpn Heart J 16 (3), 243-256 (1975)
   PUBMED   1160156
  REMARK    GeneRIF: Functional analysis of the mouse counterpart.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC051286.1 and BC039034.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000955.2.
            
            Summary: The protein encoded by this gene is a member of the G
            protein-coupled receptor family. This protein is one of four
            receptors identified for prostaglandin E2 (PGE2). Through a
            phosphatidylinositol-calcium second messenger system, G-Q proteins
            mediate this receptor's activity. Knockout studies in mice
            suggested a role of this receptor in mediating algesia and in
            regulation of blood pressure. Studies in mice also suggested that
            this gene may mediate adrenocorticotropic hormone response to
            bacterial endotoxin. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051286.1, L22647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292513.4/ ENSP00000292513.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1108              BC051286.1         9-1116
            1109-1413           BC039034.1         1066-1370
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1413
                     /gene="PTGER1"
                     /gene_synonym="EP1"
                     /note="prostaglandin E receptor 1"
                     /db_xref="GeneID:5731"
                     /db_xref="HGNC:HGNC:9593"
                     /db_xref="MIM:176802"
     exon            1..93
                     /gene="PTGER1"
                     /gene_synonym="EP1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..1052
                     /gene="PTGER1"
                     /gene_synonym="EP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1319
                     /gene="PTGER1"
                     /gene_synonym="EP1"
                     /note="prostanoid EP1 receptor; PGE receptor, EP1 subtype;
                     prostaglandin E receptor 1 (subtype EP1), 42kD;
                     prostaglandin E receptor 1, subtype EP1; PGE2 receptor EP1
                     subtype; prostaglandin E receptor 1 (subtype EP1), 42kDa"
                     /codon_start=1
                     /product="prostaglandin E2 receptor EP1 subtype"
                     /protein_id="NP_000946.2"
                     /db_xref="CCDS:CCDS12309.1"
                     /db_xref="GeneID:5731"
                     /db_xref="HGNC:HGNC:9593"
                     /db_xref="MIM:176802"
                     /translation="MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMT
                     LGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAG
                     RAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAA
                     VAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAA
                     LVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFF
                     GGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLF
                     LAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLR
                     SSRHSGLSHF"
     exon            1053..1413
                     /gene="PTGER1"
                     /gene_synonym="EP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGER1"
                     /gene_synonym="EP1"
                     /note="hexamer: AATAAA"
     polyA_site      1413
                     /gene="PTGER1"
                     /gene_synonym="EP1"
                     /note="major polyA site"
ORIGIN      
        1 gagggaggaa gcggcttgcc ggagagccag ggcgcagtgg gcggcagggc tgagcggccg
       61 gtgatgggga ccccacatcc caggcagtgc cggcacccct ggcgcctgac atgagccctt
      121 gcgggcccct caacctgagc ctggcgggcg aggcgaccac atgcgcggcg ccctgggtcc
      181 ccaacacgtc ggccgtgccg ccgtcgggcg cttcgcccgc gctgcccatc ttctccatga
      241 cgctgggcgc cgtgtccaac ctgctggcgc tggcgctgct ggcgcaggcc gcgggccgcc
      301 tgcgacgccg ccgctcggcc gccaccttcc tgctgttcgt ggccagcctg ctggccaccg
      361 acctggcggg ccacgtgatc ccgggcgcgc tggtgctgcg tctgtacact gcggggcgcg
      421 ctccggccgg cggggcctgc cacttcctgg gcggctgcat ggtcttcttc ggcctgtgcc
      481 cgctgctgct gggctgtggc atggccgtgg agcgctgcgt gggcgtcacg cggccgctgc
      541 tccacgccgc gcgggtctcg gtcgcccgcg cgcgcctggc gctggccgcg gtggccgcgg
      601 tggccttggc cgtggcgctg ctgccgctgg cgcgcgtggg ccgctatgag ctgcagtacc
      661 cgggcacgtg gtgcttcatc ggcctgggtc ccccgggcgg ctggcgccag gcactgcttg
      721 ctggcctctt cgccagcctc ggcctggtcg cgctcctcgc cgcgctggtg tgcaacacgc
      781 tcagcggcct ggccctgcta cgcgcccgct ggcgacgccg ctcccgacgg cctcccccgg
      841 cctcaggccc cgacagccgg cgtcgctggg gggcgcacgg accccgctcg gcctccgcct
      901 cgtccgcctc gtccatcgct tcggcctcca ccttctttgg cggctctcgg agcagcggct
      961 cggcacgcag agctcgcgcc cacgacgtgg agatggtggg ccagcttgtc ggtatcatgg
     1021 tggtgtcgtg catctgctgg agcccaatgc tggtgttggt ggcgctggcc gtcggcggct
     1081 ggagctctac ctccctgcag cggccactgt tcctggccgt gcgccttgcc tcctggaacc
     1141 agatcctgga cccttgggtg tacatcctac tgcgccaggc cgtgctgcgc caactgcttc
     1201 gcctcttgcc cccgagggcc ggagccaagg gcggccccgc ggggctgggc ctaacaccga
     1261 gcgcctggga ggccagctcg ctgcgcagct cccggcacag cggcctcagc cacttctaag
     1321 cacaaccaga ggcccaacga ctaagccagc ccaccctggg ctgggcccag gtgcgcggcg
     1381 cagagccttt gggaataaaa agccattctg cga
//
