LOCUS       NM_000954                812 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens prostaglandin D2 synthase (PTGDS), mRNA.
ACCESSION   NM_000954
VERSION     NM_000954.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Chen,B., Guo,L., Wang,L., Wu,P., Zheng,X., Tan,C., Xie,N., Sun,X.,
            Zhou,M., Huang,H., Hao,N., Lei,Y., Yan,K., Wu,D. and Du,Y.
  TITLE     Leveraging cell death patterns to predict metastasis in prostate
            adenocarcinoma and targeting PTGDS for tumor suppression
  JOURNAL   Sci Rep 14 (1), 21680 (2024)
   PUBMED   39289451
  REMARK    GeneRIF: Leveraging cell death patterns to predict metastasis in
            prostate adenocarcinoma and targeting PTGDS for tumor suppression.
            Erratum:[Sci Rep. 2024 Nov 28;14(1):29593. doi:
            10.1038/s41598-024-81267-4.. PMID: 39609588]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Zhang,Q., Wang,F., Huang,Y., Gao,P., Wang,N., Tian,H., Chen,A.,
            Li,Y. and Wang,F.
  TITLE     PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and
            Stemness of Gastric Cancer Stem Cells and Prevents the Progression
            of Gastric Cancer
  JOURNAL   Comb Chem High Throughput Screen 27 (6), 933-946 (2024)
   PUBMED   37526190
  REMARK    GeneRIF: PGD2/PTGDR2 Signal Affects the Viability, Invasion,
            Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents
            the Progression of Gastric Cancer.
REFERENCE   3  (bases 1 to 812)
  AUTHORS   Iida,T., Nakatsuji,M., Teraoka,Y., Goto,Y., Yamamura,T. and Inui,T.
  TITLE     Thermodynamic stability of human lipocalin-type prostaglandin D
            synthase under various pH conditions
  JOURNAL   J Biochem 174 (1), 21-31 (2023)
   PUBMED   36762787
  REMARK    GeneRIF: Thermodynamic stability of human lipocalin-type
            prostaglandin D synthase under various pH conditions.
REFERENCE   4  (bases 1 to 812)
  AUTHORS   Shen,B.Q., Sankaranarayanan,I., Price,T.J. and Tavares-Ferreira,D.
  TITLE     Sex-differences in prostaglandin signaling: a semi-systematic
            review and characterization of PTGDS expression in human sensory
            neurons
  JOURNAL   Sci Rep 13 (1), 4670 (2023)
   PUBMED   36949072
  REMARK    GeneRIF: Sex-differences in prostaglandin signaling: a
            semi-systematic review and characterization of PTGDS expression in
            human sensory neurons.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 812)
  AUTHORS   Hu,S., Ren,S., Cai,Y., Liu,J., Han,Y., Zhao,Y., Yang,J., Zhou,X.
            and Wang,X.
  TITLE     Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell
            lymphoma by MYH9-mediated regulation of Wnt-beta-catenin-STAT3
            signaling
  JOURNAL   Cell Death Differ 29 (3), 642-656 (2022)
   PUBMED   34743203
  REMARK    GeneRIF: Glycoprotein PTGDS promotes tumorigenesis of diffuse large
            B-cell lymphoma by MYH9-mediated regulation of
            Wnt-beta-catenin-STAT3 signaling.
REFERENCE   6  (bases 1 to 812)
  AUTHORS   Zahn,M., Mader,M., Schmidt,B., Bollensen,E. and Felgenhauer,K.
  TITLE     Purification and N-terminal sequence of beta-trace, a protein
            abundant in human cerebrospinal fluid
  JOURNAL   Neurosci Lett 154 (1-2), 93-95 (1993)
   PUBMED   7689714
REFERENCE   7  (bases 1 to 812)
  AUTHORS   Harrington,M.G., Aebersold,R., Martin,B.M., Merril,C.R. and Hood,L.
  TITLE     Identification of a brain-specific human cerebrospinal fluid
            glycoprotein, beta-trace protein
  JOURNAL   Appl Theor Electrophor 3 (5), 229-234 (1993)
   PUBMED   7692978
REFERENCE   8  (bases 1 to 812)
  AUTHORS   White,D.M., Mikol,D.D., Espinosa,R., Weimer,B., Le Beau,M.M. and
            Stefansson,K.
  TITLE     Structure and chromosomal localization of the human gene for a
            brain form of prostaglandin D2 synthase
  JOURNAL   J Biol Chem 267 (32), 23202-23208 (1992)
   PUBMED   1385416
REFERENCE   9  (bases 1 to 812)
  AUTHORS   Kuruvilla,A.P., Hochwald,G.M., Ghiso,J., Castano,E.M., Pizzolato,M.
            and Frangione,B.
  TITLE     Isolation and amino terminal sequence of beta-trace, a novel
            protein from human cerebrospinal fluid
  JOURNAL   Brain Res 565 (2), 337-340 (1991)
   PUBMED   1726844
REFERENCE   10 (bases 1 to 812)
  AUTHORS   Nagata,A., Suzuki,Y., Igarashi,M., Eguchi,N., Toh,H., Urade,Y. and
            Hayaishi,O.
  TITLE     Human brain prostaglandin D synthase has been evolutionarily
            differentiated from lipophilic-ligand carrier proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 4020-4024 (1991)
   PUBMED   1902577
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807752.10.
            
            On Nov 22, 2018 this sequence version replaced NM_000954.5.
            
            Summary: The protein encoded by this gene is a
            glutathione-independent prostaglandin D synthase that catalyzes the
            conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2).
            PGD2 functions as a neuromodulator as well as a trophic factor in
            the central nervous system. PGD2 is also involved in smooth muscle
            contraction/relaxation and is a potent inhibitor of platelet
            aggregation. This gene is preferentially expressed in brain.
            Studies with transgenic mice overexpressing this gene suggest that
            this gene may be also involved in the regulation of non-rapid eye
            movement sleep. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005686.1, SRR5189655.211023.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371625.8/ ENSP00000360687.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AL807752.10        47466-47654
            190-329             AL807752.10        48955-49094
            330-406             AL807752.10        49185-49261
            407-523             AL807752.10        49908-50024
            524-625             AL807752.10        50145-50246
            626-648             AL807752.10        50795-50817
            649-812             AL807752.10        51541-51704
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..812
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /note="prostaglandin D2 synthase"
                     /db_xref="GeneID:5730"
                     /db_xref="HGNC:HGNC:9592"
                     /db_xref="MIM:176803"
     exon            1..189
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..648
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /EC_number="5.3.99.2"
                     /note="prostaglandin-H2 D-isomerase; beta-trace protein;
                     PGD2 synthase; lipocalin-type prostaglandin D synthase;
                     glutathione-independent PGD synthase; cerebrin-28;
                     glutathione-independent PGD synthetase; prostaglandin D2
                     synthase 21kDa (brain); testis tissue sperm-binding
                     protein Li 63n"
                     /codon_start=1
                     /product="prostaglandin-H2 D-isomerase precursor"
                     /protein_id="NP_000945.3"
                     /db_xref="CCDS:CCDS7019.1"
                     /db_xref="GeneID:5730"
                     /db_xref="HGNC:HGNC:9592"
                     /db_xref="MIM:176803"
                     /translation="MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWF
                     SAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSL
                     GSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELK
                     EKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ"
     exon            190..329
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..406
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..523
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..625
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..648
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..812
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      788..793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /note="hexamer: AATAAA"
     polyA_site      812
                     /gene="PTGDS"
                     /gene_synonym="L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcctg cacacctccc tcgctctccc acaccactgg caccaggccc cggacacccg
       61 ctctgctgca ggagaatggc tactcatcac acactgtgga tgggactggc cctgctgggg
      121 gtgctgggcg acctgcaggc agcaccggag gcccaggtct ccgtgcagcc caacttccag
      181 caggacaagt tcctggggcg ctggttcagc gcgggcctcg cctccaactc gagctggctc
      241 cgggagaaga aggcggcgtt gtccatgtgc aagtctgtgg tggcccctgc cacggatggt
      301 ggcctcaacc tgacctccac cttcctcagg aaaaaccagt gtgagacccg aaccatgctg
      361 ctgcagcccg cggggtccct cggctcctac agctaccgga gtccccactg gggcagcacc
      421 tactccgtgt cagtggtgga gaccgactac gaccagtacg cgctgctgta cagccagggc
      481 agcaagggcc ctggcgagga cttccgcatg gccaccctct acagccgaac ccagaccccc
      541 agggctgagt taaaggagaa attcaccgcc ttctgcaagg cccagggctt cacagaggat
      601 accattgtct tcctgcccca aaccgataag tgcatgacgg aacaatagga ctccccaggg
      661 ctgaagctgg gatcccggcc agccaggtga cccccacgct ctggatgtct ctgctctgtt
      721 ccttccccga gcccctgccc cggctccccg ccaaagcaac cctgcccact caggcttcat
      781 cctgcacaat aaactccgga agcaagtcag ta
//
