LOCUS       NM_004778               2881 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens prostaglandin D2 receptor 2 (PTGDR2), mRNA.
ACCESSION   NM_004778
VERSION     NM_004778.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2881)
  AUTHORS   Kurz,M., Ulrich,M., Kirchhofer,S.B., Bittner,A., Daude,M.,
            Diederich,W.E., Pauck,K., Garn,H. and Bunemann,M.
  TITLE     Arachidonic Acid Directly Activates the Human DP2 Receptor
  JOURNAL   Mol Pharmacol 106 (5), 216-224 (2024)
   PUBMED   39284672
  REMARK    GeneRIF: Arachidonic Acid Directly Activates the Human DP2
            Receptor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2881)
  AUTHORS   Gress,C., Fuchs,M., Carstensen-Aureche,S., Muller,M. and
            Hohlfeld,J.M.
  TITLE     Prostaglandin D2 receptor 2 downstream signaling and modulation of
            type 2 innate lymphoid cells from patients with asthma
  JOURNAL   PLoS One 19 (7), e0307750 (2024)
   PUBMED   39052598
  REMARK    GeneRIF: Prostaglandin D2 receptor 2 downstream signaling and
            modulation of type 2 innate lymphoid cells from patients with
            asthma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2881)
  AUTHORS   Zhang,Q., Wang,F., Huang,Y., Gao,P., Wang,N., Tian,H., Chen,A.,
            Li,Y. and Wang,F.
  TITLE     PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and
            Stemness of Gastric Cancer Stem Cells and Prevents the Progression
            of Gastric Cancer
  JOURNAL   Comb Chem High Throughput Screen 27 (6), 933-946 (2024)
   PUBMED   37526190
  REMARK    GeneRIF: PGD2/PTGDR2 Signal Affects the Viability, Invasion,
            Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents
            the Progression of Gastric Cancer.
REFERENCE   4  (bases 1 to 2881)
  AUTHORS   Dash,P., Ghatak,S., Topi,G., Satapathy,S.R., Ek,F., Hellman,K.,
            Olsson,R., Mehdawi,L.M. and Sjolander,A.
  TITLE     High PGD2 receptor 2 levels are associated with poor prognosis in
            colorectal cancer patients and induce VEGF expression in colon
            cancer cells and migration in a zebrafish xenograft model
  JOURNAL   Br J Cancer 126 (4), 586-597 (2022)
   PUBMED   34750492
  REMARK    GeneRIF: High PGD2 receptor 2 levels are associated with poor
            prognosis in colorectal cancer patients and induce VEGF expression
            in colon cancer cells and migration in a zebrafish xenograft model.
REFERENCE   5  (bases 1 to 2881)
  AUTHORS   Liu,H., Deepak,R.N.V.K., Shiriaeva,A., Gati,C., Batyuk,A., Hu,H.,
            Weierstall,U., Liu,W., Wang,L., Cherezov,V., Fan,H. and Zhang,C.
  TITLE     Molecular basis for lipid recognition by the prostaglandin D2
            receptor CRTH2
  JOURNAL   Proc Natl Acad Sci U S A 118 (32) (2021)
   PUBMED   34341104
  REMARK    GeneRIF: Molecular basis for lipid recognition by the prostaglandin
            D2 receptor CRTH2.
REFERENCE   6  (bases 1 to 2881)
  AUTHORS   Hirai,H., Tanaka,K., Takano,S., Ichimasa,M., Nakamura,M. and
            Nagata,K.
  TITLE     Cutting edge: agonistic effect of indomethacin on a prostaglandin
            D2 receptor, CRTH2
  JOURNAL   J Immunol 168 (3), 981-985 (2002)
   PUBMED   11801628
  REMARK    GeneRIF: CRTH2 is involved in mediating some of the therapeutic
            and/or unwanted side effects of indomethacin, independently of
            cyclooxygenases and peroxisome proliferator-activated receptors.
REFERENCE   7  (bases 1 to 2881)
  AUTHORS   Hirai,H., Tanaka,K., Yoshie,O., Ogawa,K., Kenmotsu,K., Takamori,Y.,
            Ichimasa,M., Sugamura,K., Nakamura,M., Takano,S. and Nagata,K.
  TITLE     Prostaglandin D2 selectively induces chemotaxis in T helper type 2
            cells, eosinophils, and basophils via seven-transmembrane receptor
            CRTH2
  JOURNAL   J Exp Med 193 (2), 255-261 (2001)
   PUBMED   11208866
REFERENCE   8  (bases 1 to 2881)
  AUTHORS   Marchese,A., Sawzdargo,M., Nguyen,T., Cheng,R., Heng,H.H.,
            Nowak,T., Im,D.S., Lynch,K.R., George,S.R. and O'dowd,B.F.
  TITLE     Discovery of three novel orphan G-protein-coupled receptors
  JOURNAL   Genomics 56 (1), 12-21 (1999)
   PUBMED   10036181
REFERENCE   9  (bases 1 to 2881)
  AUTHORS   Nagata,K., Tanaka,K., Ogawa,K., Kemmotsu,K., Imai,T., Yoshie,O.,
            Abe,H., Tada,K., Nakamura,M., Sugamura,K. and Takano,S.
  TITLE     Selective expression of a novel surface molecule by human Th2 cells
            in vivo
  JOURNAL   J Immunol 162 (3), 1278-1286 (1999)
   PUBMED   9973380
REFERENCE   10 (bases 1 to 2881)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000777.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004778.2.
            
            Summary: This gene encodes a G-protein-coupled receptor that is
            preferentially expressed in CD4+ effector T helper 2 (Th2) cells.
            This protein is a prostaglandin D2 receptor that mediates the
            pro-inflammatory chemotaxis of eosinophils, basophils, and Th2
            lymphocytes generated during allergic inflammation. Single
            nucleotide polymorphisms in the 3' UTR of this gene have been
            associated with asthma susceptibility.[provided by RefSeq, Mar
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF144308.1, AB008535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332539.5/ ENSP00000332812.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AP000777.4         83541-83622         c
            83-2881             AP000777.4         78605-81403         c
FEATURES             Location/Qualifiers
     source          1..2881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2881
                     /gene="PTGDR2"
                     /gene_synonym="CD294; CRTH2; DL1R; DP2; GPR44"
                     /note="prostaglandin D2 receptor 2"
                     /db_xref="GeneID:11251"
                     /db_xref="HGNC:HGNC:4502"
                     /db_xref="MIM:604837"
     exon            1..82
                     /gene="PTGDR2"
                     /gene_synonym="CD294; CRTH2; DL1R; DP2; GPR44"
                     /inference="alignment:Splign:2.1.0"
     exon            83..2881
                     /gene="PTGDR2"
                     /gene_synonym="CD294; CRTH2; DL1R; DP2; GPR44"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1279
                     /gene="PTGDR2"
                     /gene_synonym="CD294; CRTH2; DL1R; DP2; GPR44"
                     /note="chemoattractant receptor homologous molecule
                     expressed on T helper type 2 cells; chemoattractant
                     receptor-homologous molecule expressed on TH2 cells;
                     putative G-protein coupled receptor 44"
                     /codon_start=1
                     /product="prostaglandin D2 receptor 2"
                     /protein_id="NP_004769.2"
                     /db_xref="CCDS:CCDS7994.1"
                     /db_xref="GeneID:11251"
                     /db_xref="HGNC:HGNC:4502"
                     /db_xref="MIM:604837"
                     /translation="MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASL
                     LGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTT
                     FCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAV
                     LNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVP
                     LAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANP
                     GLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELG
                     GAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSS
                     TSS"
     regulatory      2856..2861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGDR2"
                     /gene_synonym="CD294; CRTH2; DL1R; DP2; GPR44"
                     /note="hexamer: AATAAA"
     polyA_site      2881
                     /gene="PTGDR2"
                     /gene_synonym="CD294; CRTH2; DL1R; DP2; GPR44"
                     /note="major polyA site"
ORIGIN      
        1 gtctgcccgc tgcctcttgt ctagctgctg tcaggagctg actgcctcca gggctggaat
       61 cctgtgctcc ctctgtgccc agagccccac gatgtcggcc aacgccacac tgaagccact
      121 ctgccccatc ctggagcaga tgagccgtct ccagagccac agcaacacca gcatccgcta
      181 catcgaccac gcggccgtgc tgctgcacgg gctggcctcg ctgctgggcc tggtggagaa
      241 tggagtcatc ctcttcgtgg tgggctgccg catgcgccag accgtggtca ccacctgggt
      301 gctgcacctg gcgctgtccg acctgttggc ctctgcttcc ctgcccttct tcacctactt
      361 cttggccgtg ggccactcgt gggagctggg caccaccttc tgcaaactgc actcctccat
      421 cttctttctc aacatgttcg ccagcggctt cctgctcagc gccatcagcc tggaccgctg
      481 cctgcaggtg gtgcggccgg tgtgggcgca gaaccaccgc accgtggccg cggcgcacaa
      541 agtctgcctg gtgctttggg cactagcggt gctcaacacg gtgccctatt tcgtgttccg
      601 ggacaccatc tcgcggctgg acgggcgcat tatgtgctac tacaatgtgc tgctcctgaa
      661 cccggggcct gaccgcgatg ccacgtgcaa ctcgcggcag gtggccctgg ccgtcagcaa
      721 gttcctgctg gccttcctgg tgccgctggc gatcatcgcc tcgagccacg cggccgtgag
      781 cctgcggttg cagcaccgcg gccgccggcg gccaggccgc ttcgtgcgcc tggtggcggc
      841 cgtcgtggcc gccttcgcgc tctgctgggg gccctaccac gtgttcagcc tgctggaggc
      901 gcgggcgcac gcaaacccgg ggctgcggcc gctcgtgtgg cgcgggctgc ccttcgtcac
      961 cagcctggcc ttcttcaaca gcgtggccaa cccggtgctc tacgtgctca cctgccccga
     1021 catgctgcgc aagctgcggc gctcgctgcg cacggtgctg gagagcgtgc tggtggacga
     1081 cagcgagctg ggtggcgcgg gaagcagccg ccgccgccgc acctcctcca ccgcccgctc
     1141 ggcctcccct ttagctctct gcagccgccc ggaggaaccg cggggccccg cgcgtctcct
     1201 cggctggctg ctgggcagct gcgcagcgtc cccgcagacg ggccccctga accgggcgct
     1261 gagcagcacc tcgagttaga acccggccca cgtagggcgg cactcacacg cgaaagtatc
     1321 accagggtgc cgcggttcaa ttcgatatcc ggactcctgc cgcagtgatc aaagtccgag
     1381 gggcgggacc caggcacctg cattttaaag cgccccggga gactctgaat ctttttcaga
     1441 aacagtgagt taaagcagtg cttctcaaac cttgatgtgc ctgtgaatca cctaggggtc
     1501 ttgttaagtg cagtctgatc caggaggccg gggccgggta ctgagagtct gcacttaaca
     1561 agctcccagg ccgagaagcc agtgcggcag gttcacaggc gaggcctgga gtaacacaaa
     1621 gtgaaactca taatagactt cccactctag ggcagtggag tcggaagggc acacggggtg
     1681 cgtctccccg gagttcagtt ttaccagatg atgggggagg ggggaaggag ttttatgtta
     1741 aaccatccat gtatttttgg agaagagaga ggaaaggttt gagaagcact gttccagcct
     1801 gccctcttca tttagccaat gcttactgcg ctagacgctt catcccacaa tcttaagggg
     1861 cagcttctat tagccagtct ttacagctga gcacattctg gctcagggag gttaagtgac
     1921 ttgcccagtt tcagggctaa cgaccacagg gtctgcactc taaccctagg catcacatgc
     1981 tcaatgactc tctggtgagc gaggacattc tctgacctac tcgagggact taagatgcta
     2041 ccttgtgacc cagcactgcc caaagtgctt ccaaggcaga agcagcaggg gatggcgtgg
     2101 tcaagcactc gggaaacctg gggctaatca aatccaatgg gggaaatgac taaaagtctt
     2161 cggtcgttag aagttgaatg ggcacagcaa ctctaagact acagcacacg tcatttctta
     2221 gctaagcgga ccagcctccc tgtcggcctg gtgttctgtg ggatccctct gggcactggt
     2281 aatcccaaga tctgtgcagc cccgcctcca ggccacatgg ggctgggcag ctaccatttc
     2341 ccttttgcgg atgggagggg taacttgcac ctctgaccta tcacttccac tgcaccccgt
     2401 ctcattcctc cacctgccgt ggacttgggg tcagagactg ctgtgtttga gctctgcagc
     2461 ccagggaccg aaaagttggt gtcaatgaat tttgcttggt ggatgaaatg tcagtggaag
     2521 aagcagatga gaaactcttg agatcttggt cctgtgtttt ttctgccacc aaaggccagg
     2581 gtcactgaag gcctggccca cagcaggtgc tgagcaaagg gaacagtgag gtgcccagct
     2641 agctgcagag ccaccctgtg ttgacacctc gcccctgctc cctcccatcc cttccccctt
     2701 tactcatagc acttccccca ttggacacgt ggtgcatttt gcttgtttat tatgttttct
     2761 ctccatcaga atgaaagctc ctcgagggca gggactttgg tctattgtct gtatttgccg
     2821 gtgcctagga ttgtgcctgt atgcaacagg cactcaataa atatttttgc tgtagactgg
     2881 a
//
