LOCUS       NM_000953               2957 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens prostaglandin D2 receptor (PTGDR), transcript variant
            1, mRNA.
ACCESSION   NM_000953
VERSION     NM_000953.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2957)
  AUTHORS   Xie,M., Zhang,L., Han,L., Huang,L., Huang,Y., Yang,M. and Zhang,N.
  TITLE     The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the
            RAS signaling in gastric cancer
  JOURNAL   Oncogene 42 (46), 3435-3445 (2023)
   PUBMED   37805663
  REMARK    GeneRIF: The ASH1L-AS1-ASH1L axis controls NME1-mediated activation
            of the RAS signaling in gastric cancer.
REFERENCE   2  (bases 1 to 2957)
  AUTHORS   Yang,X., Lu,L., Wu,C. and Zhang,F.
  TITLE     ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and
            inflammation by regulating miR-23a-3p/TLR4 axis
  JOURNAL   Allergol Immunopathol (Madr) 51 (2), 17-26 (2023)
   PUBMED   36916084
  REMARK    GeneRIF: ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and
            inflammation by regulating miR-23a-3p/TLR4 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2957)
  AUTHORS   Dash,P., Ghatak,S., Topi,G., Satapathy,S.R., Ek,F., Hellman,K.,
            Olsson,R., Mehdawi,L.M. and Sjolander,A.
  TITLE     High PGD2 receptor 2 levels are associated with poor prognosis in
            colorectal cancer patients and induce VEGF expression in colon
            cancer cells and migration in a zebrafish xenograft model
  JOURNAL   Br J Cancer 126 (4), 586-597 (2022)
   PUBMED   34750492
  REMARK    GeneRIF: High PGD2 receptor 2 levels are associated with poor
            prognosis in colorectal cancer patients and induce VEGF expression
            in colon cancer cells and migration in a zebrafish xenograft model.
REFERENCE   4  (bases 1 to 2957)
  AUTHORS   Frechette,L., Binda,C., Genier,S., Degrandmaison,J., Boisvert,M.
            and Parent,J.L.
  TITLE     GGA3 interacts with L-type prostaglandin D synthase and regulates
            the recycling and signaling of the DP1 receptor for prostaglandin
            D2 in a Rab4-dependent mechanism
  JOURNAL   Cell Signal 72, 109641 (2020)
   PUBMED   32334026
  REMARK    GeneRIF: GGA3 interacts with L-type prostaglandin D synthase and
            regulates the recycling and signaling of the DP1 receptor for
            prostaglandin D2 in a Rab4-dependent mechanism.
REFERENCE   5  (bases 1 to 2957)
  AUTHORS   He,Y., Zuo,C., Jia,D., Bai,P., Kong,D., Chen,D., Liu,G., Li,J.,
            Wang,Y., Chen,G., Yan,S., Xiao,B., Zhang,J., Piao,L., Li,Y.,
            Deng,Y., Li,B., Roux,P.P., Andreasson,K.I., Breyer,R.M., Su,Y.,
            Wang,J., Lyu,A., Shen,Y. and Yu,Y.
  TITLE     Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial
            Hypertension via mTORC1 Signaling
  JOURNAL   Am J Respir Crit Care Med 201 (10), 1263-1276 (2020)
   PUBMED   31917615
  REMARK    GeneRIF: Loss of DP1 Aggravates Vascular Remodeling in Pulmonary
            Arterial Hypertension via mTORC1 Signaling.
REFERENCE   6  (bases 1 to 2957)
  AUTHORS   Gervais,F.G., Cruz,R.P., Chateauneuf,A., Gale,S., Sawyer,N.,
            Nantel,F., Metters,K.M. and O'neill,G.P.
  TITLE     Selective modulation of chemokinesis, degranulation, and apoptosis
            in eosinophils through the PGD2 receptors CRTH2 and DP
  JOURNAL   J Allergy Clin Immunol 108 (6), 982-988 (2001)
   PUBMED   11742277
REFERENCE   7  (bases 1 to 2957)
  AUTHORS   Wright,D.H., Ford-Hutchinson,A.W., Chadee,K. and Metters,K.M.
  TITLE     The human prostanoid DP receptor stimulates mucin secretion in
            LS174T cells
  JOURNAL   Br J Pharmacol 131 (8), 1537-1545 (2000)
   PUBMED   11139429
REFERENCE   8  (bases 1 to 2957)
  AUTHORS   Kobayashi,T., Ushikubi,F. and Narumiya,S.
  TITLE     Amino acid residues conferring ligand binding properties of
            prostaglandin I and prostaglandin D receptors. Identification by
            site-directed mutagenesis
  JOURNAL   J Biol Chem 275 (32), 24294-24303 (2000)
   PUBMED   10827082
REFERENCE   9  (bases 1 to 2957)
  AUTHORS   Boie,Y., Sawyer,N., Slipetz,D.M., Metters,K.M. and Abramovitz,M.
  TITLE     Molecular cloning and characterization of the human prostanoid DP
            receptor
  JOURNAL   J Biol Chem 270 (32), 18910-18916 (1995)
   PUBMED   7642548
REFERENCE   10 (bases 1 to 2957)
  AUTHORS   Senior,J., Sangha,R., Baxter,G.S., Marshall,K. and Clayton,J.K.
  TITLE     In vitro characterization of prostanoid FP-, DP-, IP- and
            TP-receptors on the non-pregnant human myometrium
  JOURNAL   Br J Pharmacol 107 (1), 215-221 (1992)
   PUBMED   1422574
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365475.1, BC040968.1 and
            AK026202.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000953.2.
            
            Summary: This gene encodes a member of the guanine
            nucleotide-binding protein (G protein)-coupled receptor (GPCR)
            superfamily. The receptors are seven-pass transmembrane proteins
            that respond to extracellular cues and activate intracellular
            signal transduction pathways. This protein is reported to be a
            receptor for prostaglandin D2, which is a mediator of allergic
            inflammation and allergic airway inflammation in asthma.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040968.1, DRR138528.202482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306051.3/ ENSP00000303424.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL365475.1         104071-104085       c
            16-1443             BC040968.1         1-1428
            1444-1884           AL365475.1         96132-96572         c
            1885-2957           AK026202.1         397-1469
FEATURES             Location/Qualifiers
     source          1..2957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..2957
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /note="prostaglandin D2 receptor"
                     /db_xref="GeneID:5729"
                     /db_xref="HGNC:HGNC:9591"
                     /db_xref="MIM:604687"
     exon            1..963
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1197
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /note="isoform 1 is encoded by transcript variant 1; PGD2
                     receptor"
                     /codon_start=1
                     /product="prostaglandin D2 receptor isoform 1"
                     /protein_id="NP_000944.1"
                     /db_xref="CCDS:CCDS9707.1"
                     /db_xref="GeneID:5729"
                     /db_xref="HGNC:HGNC:9591"
                     /db_xref="MIM:604687"
                     /translation="MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARS
                     GLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDN
                     SLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFS
                     LAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCN
                     LGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTM
                     CSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIF
                     FHKIFIRPLRYRSRCSNSTNMESSL"
     exon            964..2957
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1259..1264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /note="hexamer: ATTAAA"
     polyA_site      1278
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /note="major polyA site"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /note="hexamer: CATAAA"
     polyA_site      1620
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
     regulatory      2941..2946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /note="hexamer: AATATA"
     polyA_site      2957
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgcagc ttctccgccc gagccgcgcg cggagctgcc gggggctcct tagcacccgg
       61 gcgccggggc cctcgccctt ccgcagcctt cactccagcc ctctgctccc gcacgccatg
      121 aagtcgccgt tctaccgctg ccagaacacc acctctgtgg aaaaaggcaa ctcggcggtg
      181 atgggcgggg tgctcttcag caccggcctc ctgggcaacc tgctggccct ggggctgctg
      241 gcgcgctcgg ggctggggtg gtgctcgcgg cgtccactgc gcccgctgcc ctcggtcttc
      301 tacatgctgg tgtgtggcct gacggtcacc gacttgctgg gcaagtgcct cctaagcccg
      361 gtggtgctgg ctgcctacgc tcagaaccgg agtctgcggg tgcttgcgcc cgcattggac
      421 aactcgttgt gccaagcctt cgccttcttc atgtccttct ttgggctctc ctcgacactg
      481 caactcctgg ccatggcact ggagtgctgg ctctccctag ggcacccttt cttctaccga
      541 cggcacatca ccctgcgcct gggcgcactg gtggccccgg tggtgagcgc cttctccctg
      601 gctttctgcg cgctaccttt catgggcttc gggaagttcg tgcagtactg ccccggcacc
      661 tggtgcttta tccagatggt ccacgaggag ggctcgctgt cggtgctggg gtactctgtg
      721 ctctactcca gcctcatggc gctgctggtc ctcgccaccg tgctgtgcaa cctcggcgcc
      781 atgcgcaacc tctatgcgat gcaccggcgg ctgcagcggc acccgcgctc ctgcaccagg
      841 gactgtgccg agccgcgcgc ggacgggagg gaagcgtccc ctcagcccct ggaggagctg
      901 gatcacctcc tgctgctggc gctgatgacc gtgctcttca ctatgtgttc tctgcccgta
      961 atttatcgcg cttactatgg agcatttaag gatgtcaagg agaaaaacag gacctctgaa
     1021 gaagcagaag acctccgagc cttgcgattt ctatctgtga tttcaattgt ggacccttgg
     1081 atttttatca ttttcagatc tccagtattt cggatatttt ttcacaagat tttcattaga
     1141 cctcttaggt acaggagccg gtgcagcaat tccactaaca tggaatccag tctgtgacag
     1201 tgtttttcac tctgtggtaa gctgaggaat atgtcacatt ttcagtcaaa gaaccatgat
     1261 taaaaaaaaa aagacaactt acaatttaaa tccttaaaag ttacctccca taacaaaagc
     1321 atgtatatgt attttcaaaa gtatttgata tcttaacaat gtgttaccat tctatagtca
     1381 tgaacccctt cagtgcattt tcattttttt attaacagca actaaaattt tatatattgt
     1441 aaccagtgtt aaaagtctta aaaaacaatg gtattaattg tccctacatt tgtgcttggt
     1501 ggccctattt ttttttttta gagaggcctt gagacataca ggtcttttaa aatacagtag
     1561 aaacaccact gtttacgatt atacgatgga cattcataaa aagcataatt tcttacccta
     1621 ttcatttttt ggtgaaacct gattcattga ttttatatca ttgccgatgt ttagttcatt
     1681 tctttgccaa ttgatctaag catagcctga attatgatgt tcctcagaga agtgaggtgg
     1741 gaaatatgac caggtcaggc agttggaggg gcttccccag ccaccatcgg ggagtacttg
     1801 ctgcctcagg tggagacctg aagctgtaac tagatgcaga gcaagatatg actatagccc
     1861 acaacccaaa gaagcaaaaa ttcgttttta tcttttgaaa tccagtttct tttgtattga
     1921 gtcaagggtg tcagtaggaa tcaaaagttg ggggtgggtt gcaaaatgtt ctttcagttt
     1981 ttagaacctc cattttataa aagaattatc ctatcaatgg attctttagt ggaaggattt
     2041 atgcttcttt gaaaaccagt gtgtgactca ctgtagagcc atgtttactg tttgactgtg
     2101 tggcacaggg gggcatttgg cacagcaaaa agcccaccca ggacttagcc tcagttgacg
     2161 atagtaacaa tggccttaac atctacctta acagctacct attacagccg tattctgctg
     2221 tccgtggaga cggtaagatc ttaggttcca agattttact tcaaattaca ccttcaaaac
     2281 tggagcagca tatagccgaa aaggagcaca actgagcact ttaatagtaa tttaaaagtt
     2341 ttcaagggtc agcaatatga tgactgaaag ggaaaagtgg aggaaacgca gctgcaactg
     2401 aagcggagac tctaaaccca gcttgcaggt aagagctttc acctttggta aaagaacagc
     2461 tggggaggtt caaggggttt cagcatctct ggagttcctt tgtatctgac aatctcagga
     2521 ctccaaggtg caaagcctgc tgcatttgcg tgatctcaag acctccagcc agaagtccct
     2581 tccaaatata agagtactca tgtttattta tttccaactg agcagcaacc tcctttgttt
     2641 cacttatgtt ttttccagta tctgagataa tataaagctg ggtaattttt tatgtaattt
     2701 tttggtatag caaaactgtg aaaaagccaa attaggcata caaggagtat gatttaacag
     2761 tatgacatga tgaaaaaaat acagttgttt ttgaaattta acttttgttt gtaccttcaa
     2821 tgtgtaagta catgcatgtt ttattgtcag aggaagaaca tgttttttgt attctttttt
     2881 tggagaggtg tgttaggata attgtccagt taatttgaaa aggccccaga tgaatcaata
     2941 aatataattt tatagta
//
