LOCUS       NM_001261836            3625 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens phosphotriesterase related (PTER), transcript variant
            3, mRNA.
ACCESSION   NM_001261836
VERSION     NM_001261836.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3625)
  AUTHORS   Wei,W., Lyu,X., Markhard,A.L., Fu,S., Mardjuki,R.E., Cavanagh,P.E.,
            Zeng,X., Rajniak,J., Lu,N., Xiao,S., Zhao,M., Moya-Garzon,M.D.,
            Truong,S.D., Chou,J.C., Wat,L.W., Chidambaranathan-Reghupaty,S.,
            Coassolo,L., Xu,D., Shen,F., Huang,W., Ramirez,C.B., Jang,C.,
            Li,L., Svensson,K.J., Fischbach,M.A. and Long,J.Z.
  TITLE     PTER is a N-acetyltaurine hydrolase that regulates feeding and
            obesity
  JOURNAL   Nature 633 (8028), 182-188 (2024)
   PUBMED   39112712
  REMARK    GeneRIF: PTER is a N-acetyltaurine hydrolase that regulates feeding
            and obesity.
REFERENCE   2  (bases 1 to 3625)
  AUTHORS   Feng,X., Zhou,Y., Pang,S., Yang,C. and Wang,S.
  TITLE     Phosphotriesterase-related protein as a novel prognostic predictor
            for hepatocellular carcinoma patients
  JOURNAL   Chin Clin Oncol 12 (4), 37 (2023)
   PUBMED   37699602
  REMARK    GeneRIF: Phosphotriesterase-related protein as a novel prognostic
            predictor for hepatocellular carcinoma patients.
REFERENCE   3  (bases 1 to 3625)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3625)
  AUTHORS   Cheng,C.W., Chang,L.C., Tseng,T.L., Wu,C.C., Lin,Y.F. and Chen,J.S.
  TITLE     Phosphotriesterase-related protein sensed albuminuria and conferred
            renal tubular cell activation in membranous nephropathy
  JOURNAL   J Biomed Sci 21 (1), 32 (2014)
   PUBMED   24750591
  REMARK    GeneRIF: Our findings reveal that PTER may sense albuminuria in the
            progression of Membranous nephropathy induce tubular cell
            activation and lead to end-stage renal disease .
            Erratum:[J Biomed Sci. 2016 Apr 04;23:37. doi:
            10.1186/s12929-016-0252-5.. PMID: 27044255]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3625)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   6  (bases 1 to 3625)
  AUTHORS   Morgan,A.R., Thompson,J.M., Murphy,R., Black,P.N., Lam,W.J.,
            Ferguson,L.R. and Mitchell,E.A.
  TITLE     Obesity and diabetes genes are associated with being born small for
            gestational age: results from the Auckland Birthweight
            Collaborative study
  JOURNAL   BMC Med Genet 11, 125 (2010)
   PUBMED   20712903
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3625)
  AUTHORS   Meyre,D., Delplanque,J., Chevre,J.C., Lecoeur,C., Lobbens,S.,
            Gallina,S., Durand,E., Vatin,V., Degraeve,F., Proenca,C., Gaget,S.,
            Korner,A., Kovacs,P., Kiess,W., Tichet,J., Marre,M.,
            Hartikainen,A.L., Horber,F., Potoczna,N., Hercberg,S.,
            Levy-Marchal,C., Pattou,F., Heude,B., Tauber,M., McCarthy,M.I.,
            Blakemore,A.I., Montpetit,A., Polychronakos,C., Weill,J.,
            Coin,L.J., Asher,J., Elliott,P., Jarvelin,M.R., Visvikis-Siest,S.,
            Balkau,B., Sladek,R., Balding,D., Walley,A., Dina,C. and Froguel,P.
  TITLE     Genome-wide association study for early-onset and morbid adult
            obesity identifies three new risk loci in European populations
  JOURNAL   Nat Genet 41 (2), 157-159 (2009)
   PUBMED   19151714
  REMARK    GeneRIF: In addition to FTO and MC4R, we detected significant
            association of obesity with three new risk loci in NPC1
            (endosomal/lysosomal Niemann-Pick C1 gene), near MAF (encoding the
            transcription factor c-MAF) and near PTER
            (phosphotriesterase-related gene).
REFERENCE   8  (bases 1 to 3625)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 3625)
  AUTHORS   Alimova-Kost,M.V., Imreh,S., Buchman,V.L. and Ninkina,N.N.
  TITLE     Assignment1 of phosphotriesterase-related gene (PTER) to human
            chromosome band 10p12 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 16-17 (1998)
   PUBMED   9925913
REFERENCE   10 (bases 1 to 3625)
  AUTHORS   Davies,J.A., Buchman,V.L., Krylova,O. and Ninkina,N.N.
  TITLE     Molecular cloning and expression pattern of rpr-1, a
            resiniferatoxin-binding, phosphotriesterase-related protein,
            expressed in rat kidney tubules
  JOURNAL   FEBS Lett 410 (2-3), 378-382 (1997)
   PUBMED   9237666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314910.1 and AL360230.20.
            
            On Aug 14, 2020 this sequence version replaced NM_001261836.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648556.1, SRR11853567.3388.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535784.7/ ENSP00000439485.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1136              AK314910.1         68-1203
            1137-3625           AL360230.20        154674-157162
FEATURES             Location/Qualifiers
     source          1..3625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..3625
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /note="phosphotriesterase related"
                     /db_xref="GeneID:9317"
                     /db_xref="HGNC:HGNC:9590"
                     /db_xref="MIM:604446"
     exon            1..38
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            39..518
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1136
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     resiniferatoxin-binding, phosphotriesterase-related;
                     phosphotriesterase-related protein; parathion
                     hydrolase-related protein; N-acetyltaurine hydrolase"
                     /codon_start=1
                     /product="N-acetyltaurine hydrolase isoform 1"
                     /protein_id="NP_001248765.1"
                     /db_xref="CCDS:CCDS7111.1"
                     /db_xref="GeneID:9317"
                     /db_xref="HGNC:HGNC:9590"
                     /db_xref="MIM:604446"
                     /translation="MSSLSGKVQTVLGLVEPSKLGRTLTHEHLAMTFDCCYCPPPPCQ
                     EAISKEPIVMKNLYWIQKNAYSHKENLQLNQETEAIKEELLYFKANGGGALVENTTTG
                     ISRDTQTLKRLAEETGVHIISGAGFYVDATHSSETRAMSVEQLTDVLMNEILHGADGT
                     SIKCGIIGEIGCSWPLTESERKVLQATAHAQAQLGCPVIIHPGRSSRAPFQIIRILQE
                     AGADISKTVMSHLDRTILDKKELLEFAQLGCYLEYDLFGTELLHYQLGPDIDMPDDNK
                     RIRRVRLLVEEGCEDRILVAHDIHTKTRLMKYGGHGYSHILTNVVPKMLLRGITENVL
                     DKILIENPKQWLTFK"
     exon            519..784
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..925
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..3625
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3312..3317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /note="hexamer: AATAAA"
     polyA_site      3334
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /note="major polyA site"
     regulatory      3598..3603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
                     /note="hexamer: AATAAA"
     polyA_site      3625
                     /gene="PTER"
                     /gene_synonym="HPHRP; RPR-1"
ORIGIN      
        1 ggaagttccc agggagaagg cagcgcgttg tacccgagaa aaaagaaatc ctctttttag
       61 aacatctctt ggtggtacca tcagaaatgt cttccttaag tggaaaagtc caaaccgttt
      121 tgggccttgt agagccaagc aaactgggcc gtaccctgac ccatgaacac ctggccatga
      181 cctttgactg ctgttactgt ccacctcccc cgtgccagga agctatttcc aaagaaccta
      241 tcgtgatgaa aaatttatat tggattcaga aaaacgccta ttcccataaa gaaaaccttc
      301 aattaaatca ggagacagaa gccataaagg aagaactgtt gtattttaaa gctaatggtg
      361 gaggggcttt ggtggaaaac acaaccactg ggattagccg agacacacag acgttgaaga
      421 ggcttgcaga agagactggc gtccatatca tatctggagc cgggttttat gtggatgcaa
      481 ctcactcctc agagaccagg gccatgtcag tggagcagct taccgatgtc cttatgaatg
      541 aaattctcca tggagctgat ggaaccagta tcaagtgtgg cattattgga gaaattggtt
      601 gctcctggcc tttgactgag agtgaaagaa aggttctcca ggccacagct catgcccagg
      661 ctcagcttgg ttgtcctgtt attatccatc ctggacggag ctccagggca ccatttcaga
      721 ttatccgaat attgcaagaa gcaggcgcag acatctccaa aacagtcatg tcacacctgg
      781 ataggactat tcttgataag aaagagctct tggagtttgc tcaacttggc tgctacttgg
      841 aatatgatct ctttggtact gaactacttc attaccaact cggcccagat attgacatgc
      901 ctgatgataa caaaagaatt agaagggtgc gtctcctggt ggaagagggc tgtgaagatc
      961 gaattctggt agcacatgac atacatacga aaacccggct gatgaaatat ggaggtcacg
     1021 gctattctca tatactcacc aatgttgttc ctaaaatgtt gctgagaggc ataactgaga
     1081 atgtgcttga taagattcta atagagaacc ctaagcaatg gctaactttc aaataggatg
     1141 gttgcttatg aattcacacc ttgagtataa aacttgcaga gaacattcag cgatttccag
     1201 tccactgtga gatattaatc agttacctag gactaatgac agatcatttc cttctgatga
     1261 gaactaggag ggtttgcctt ctctgagacc agctattaca actgtgcctc tagggagtta
     1321 ctcagcctaa ttgagcccta ttattttaac ttaacaaaat aaatacagaa gtacctattt
     1381 ctaaacaatg atttaaagtc tatatcccct aagcggagtt gttgtttttc tccctaatct
     1441 atcagctgca ctacttgaga aaatttaaag tgtttctagt taaattattt ccttcttgag
     1501 cgatctaatg tttcttgtaa tattgatgat cctactaatt atcctgctgt tctttaatta
     1561 atgcttaatg aataatatgg cactgtaaaa tagcttctgc aacaagggaa gttaaatttt
     1621 gagacttttt tccccaaagg atactgactg taatacaatt accaattcac aatgataaaa
     1681 atattttgaa aggttaattt tatactgtcc acctatctat atattcttct actgaaatga
     1741 ttttgatatc tttggctttc cggtatctat ttttgccata cattttgctg ttttgcaaag
     1801 tttgtataag aacacataac actactgaat tataaaaatt caatcataaa agtcaaaata
     1861 tattacataa tatagtttaa tgaatcatta catttataat aacaaaggcc acaatttaat
     1921 taattggtaa gatataatgc aaaaaaaaaa agagaaatgt ttgccttatg tatattccct
     1981 ttatttcctt taccttttgt ttttccttgg acctaaacag agaaaataat gcttatgtat
     2041 ctgaagaaaa ggtcagatct attggaaatg acagcccgat acttgagcct cctctttaaa
     2101 aggtatccag ccctgatatt ttgtgtaaat aaaatgtttt taaaacctgt tagttaaaac
     2161 acttaggtga tgggcactgc tgcttataaa ttcatctttt ggttgaatcc tcactatgct
     2221 atttggtacc taaaaatatt ctccaaaccc ttgctgccag ttcctctttg ataaatatat
     2281 agttaattcg aaataaaatc cattgcaatt catttatgag ttatcttaca tatcacaaag
     2341 accaattaga attagtcatt attcttgatg aagagtctgt ttttaatcat aaaaatcatg
     2401 acagttactc agacccaggc atttcaacag agctaacacc accttcagat aggcacacca
     2461 tgcataactc ttgggaagtt gagctttgct aaataaaaga tatttctgct gatcaaagat
     2521 gatcaagctt tctgtgtatt ggaacagaaa gtaacaaaga ggaatgagcc aggagaacaa
     2581 actaattcct ttaaataaat aaaaaaaaaa aatgcaaatg tccttcacca gtaaagcaag
     2641 caaattttta aaatctctgt ttttgaaatc tactcgtcaa agagttttca gaggcaatga
     2701 aaggggaaca gatttttcat tgtaatagtg gaagttgtgt gatagttagg agatatcaac
     2761 atgcattttt aatcttttcc ttagatgaaa gagatggctt ttggcagtgt gttctaacca
     2821 gaaagaaagg atttgtatta ctctccaaat ctactgtact gtcagcttca ctccacctga
     2881 gaaaaaagaa aaaaaaattg atagctcaaa tgcatgtaat tcataaacac tgcaaaggag
     2941 agccacttgg tgtctgcagt cctcatatta acagtctgtc acagaatgca gttaaagtat
     3001 tgattggcat atggtaatag agcaaccata gccttaactt acagacctgt gaaataaagg
     3061 gcattttgac ctaatacaat taattttctg gataactctt aaagagaagt cattttaact
     3121 gtttttgcta ctccatatat tgtcattcaa aatatatttt aacccaaaat aagttaaata
     3181 atttgtgcat gtttgtgtgt gtatatatgc atacactttt ttatattaaa attttgaggc
     3241 tatacagcca ctgtgccctg tggaataaag ccatatatat aaatgtttta tatgtatatg
     3301 ttttatacat aaataaaaca tttcatctaa tatatatatg tgtgtgtgag tatatgtgtg
     3361 catgtttagc agatatttgt ataaaatata aacactctgt tgtcatatag gctatatgcg
     3421 aaattgttaa ttttaaaata acctcaggcc acagacttgt agtaatcatt tgaaggcctc
     3481 acctagtgtc cccttggtga cgtatgcagc agctcaaatt aaacctttgt gcattgggtt
     3541 atgaataatc ttttcttcca aagatggcaa aagcctcggt ttgatttgat actaaagaat
     3601 aaatttctct gactttccca gtgaa
//
