LOCUS       NM_001384253           25280 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens patched domain containing 4 (PTCHD4), transcript
            variant 3, mRNA.
ACCESSION   NM_001384253 XM_017010893
VERSION     NM_001384253.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 25280)
  AUTHORS   Chung,J.H., Larsen,A.R., Chen,E. and Bunz,F.
  TITLE     A PTCH1 homolog transcriptionally activated by p53 suppresses
            Hedgehog signaling
  JOURNAL   J Biol Chem 289 (47), 33020-33031 (2014)
   PUBMED   25296753
  REMARK    GeneRIF: Data indicate that tumor suppressor p53 can suppress
            canonical Hedgehog signaling via induction of patched domain
            containing 4 (PTCH53), a PTCH1 homolog.
REFERENCE   2  (bases 1 to 25280)
  AUTHORS   Guan,W., Steffen,B.T., Lemaitre,R.N., Wu,J.H.Y., Tanaka,T.,
            Manichaikul,A., Foy,M., Rich,S.S., Wang,L., Nettleton,J.A.,
            Tang,W., Gu,X., Bandinelli,S., King,I.B., McKnight,B., Psaty,B.M.,
            Siscovick,D., Djousse,L., Chen,Y.I., Ferrucci,L., Fornage,M.,
            Mozafarrian,D., Tsai,M.Y. and Steffen,L.M.
  TITLE     Genome-wide association study of plasma N6 polyunsaturated fatty
            acids within the cohorts for heart and aging research in genomic
            epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 7 (3), 321-331 (2014)
   PUBMED   24823311
REFERENCE   3  (bases 1 to 25280)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 25280)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353138.10, AL121973.2, AL161622.12 and KF458157.1.
            
            On Jun 12, 2020 this sequence version replaced XM_017010893.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1886947.1,
                                           SRR14038192.1638301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339488.9/ ENSP00000341914.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AL353138.10        57132-57280         c
            150-1123            AL353138.10        15036-16009         c
            1124-1535           AL353138.10        14313-14724         c
            1536-2016           AL121973.2         37539-38019         c
            2017-3848           AL161622.12        83362-85193         c
            3849-4211           KF458157.1         1-363               c
            4212-25280          AL161622.12        61930-82998         c
FEATURES             Location/Qualifiers
     source          1..25280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..25280
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /note="patched domain containing 4"
                     /db_xref="GeneID:442213"
                     /db_xref="HGNC:HGNC:21345"
                     /db_xref="MIM:616908"
     exon            1..149
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..1123
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1119..3650
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     patched domain-containing protein C6orf138; patched
                     domain-containing protein 4; p53-regulated patched
                     protein"
                     /codon_start=1
                     /product="patched domain-containing protein 4 isoform 3"
                     /protein_id="NP_001371182.1"
                     /db_xref="CCDS:CCDS93929.1"
                     /db_xref="GeneID:442213"
                     /db_xref="HGNC:HGNC:21345"
                     /db_xref="MIM:616908"
                     /translation="MRRPGAPASWIWWRMLRQVLRRGLQSFCHRLGLCVSRHPVFFLT
                     VPAVLTITFGLSALNRFQPEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDL
                     HTPGRYGRVILLSPTGDNILLQAEGILQTHRAVLEMKDGRNSFIGHQLGGVVEVPNSK
                     DQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQELQLYSLASFS
                     LWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITA
                     AGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVM
                     VTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAGQ
                     LEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLREH
                     YNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKY
                     FSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANNKS
                     DFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEVLE
                     KLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGN
                     FWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHT
                     RTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFV
                     ILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV"
     exon            1124..1535
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..2016
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..25280
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4514..4519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /note="hexamer: AATAAA"
     polyA_site      4532
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /note="major polyA site"
     regulatory      17216..17221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /note="hexamer: ATTAAA"
     polyA_site      17238
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
     regulatory      25259..25264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /note="hexamer: ATTAAA"
     polyA_site      25280
                     /gene="PTCHD4"
                     /gene_synonym="C6orf138; dJ402H5.2; PTCH53; SLC65C2"
                     /note="major polyA site"
ORIGIN      
        1 agtgagaagt ctggccatcg gtagagggat gcagccacta ccaaccacag tatggcagag
       61 aagtagcaga gaagaaataa aagaaatccc ctctcactct ccaattctgt tgttgcctcc
      121 atgcgccaat ccaaaccgaa agccagaagg caaaactacc tggtgtgtct ggaagtgtct
      181 gtttctggaa ttccactcac aggggaaaat tagcctgaac cagatggctt gaaacagtcc
      241 tcatgggtga ggggtggaag gagacactgg aaaaggggac tgaaatcagc tttaggaact
      301 ttctgtcctt taatctcaag aatacagaaa gtgaatgtaa catgttatga gaaacctcat
      361 attgcctgta gatcttcact ttcaatacac acacacgcac acgcacacgc acacaggcta
      421 ctgctattgg caaatgcctc ctctccagcc atcagaggaa agaagctatc cagacggtcc
      481 caacgcacca gggatagatg gagtctccgc agccctcagc tgcagcggac tggtctgtgg
      541 aatcacagcg aggaaggtgt tgcgaggaaa tcccttgcat gctgtgtggt gtgttaaaaa
      601 tgcagcatca tcctctctgc tccttttctt cgctgaaaag cagaattcga gggcacaggg
      661 aaactggagg ggcgagaagg ctgtctcctg gagccctggg gctgtctccc tccatgcccc
      721 actccttggg ctctaattgc ccttgctcca atgggccagc agcaccttca ccatttattt
      781 cctcttcaat tcactccagc ggggagggaa gagggaacac aaaactctaa aaataactgt
      841 cagcatctta aaaaaagaaa aaagcttatc tgccccccca cccccaacgt gctcccgccc
      901 ttctccctcc tctccccccc tcagcccccc ccccctttat ggggcacatg tctgcttctt
      961 acaacaccga ggcacatggt tccagttagg caccgaaccc caccaagaca gagaggaaat
     1021 ccacatctgt gggacgctcc acacggaacc acctccagcg agggaggcca ggggactgca
     1081 gcaccgagat gaagggctag accgagggaa cgctgctcat gcgacggccg ggagcgcctg
     1141 cgagctggat ctggtggagg atgctgcggc aggtgcttcg cagagggctc cagtcgttct
     1201 gccacaggct gggtttgtgc gtgagccggc acccggtctt tttcctcacc gtgcccgcag
     1261 tcctgacaat caccttcggc ctcagcgcgc tcaaccgctt ccagcccgag ggcgacctgg
     1321 agcgcctggt cgctcccagc cacagcctgg ccaagatcga gcgcagcctg gccagcagcc
     1381 ttttccccct ggaccagtcc aaaagccagc tctattcgga cttacacacc cctgggaggt
     1441 atggcagggt gatcctcctc tccccaaccg gggacaatat tttgctccag gctgagggga
     1501 tcctgcagac ccaccgagcc gtgctggaaa tgaaggatgg gaggaacagt tttattggac
     1561 accaactggg cggggtagtg gaagtgccaa acagcaaaga tcagcgggtc aagtcagcca
     1621 gagccattca aatcacctac tacctccaga cctatggctc tgccacccaa gacctcatag
     1681 gggagaagtg ggagaatgag ttctgtaagc ttataaggaa gctccaggag gagcatcaag
     1741 aactccagct ctactcttta gcatccttta gcctctggag ggactttcat aagaccagca
     1801 tcctggccag aagcaaggtc ctggtgagcc tcgtgctgat cctgaccaca gccaccctct
     1861 ccagctccat gaaggactgc ttgcgcagta agcccttcct gggcctcctg ggggtgctca
     1921 cagtatgcat ctccatcatc acagcagcag ggatcttctt catcaccgat ggaaagtaca
     1981 actccaccct gctgggaatc ccgttcttcg ccatgggtca tggaactaaa ggagtgtttg
     2041 agcttctgtc cggatggcgg agaaccaaag agaacttgcc cttcaaagac aggatagcag
     2101 atgcctattc tgatgtgatg gtcacctata ccatgaccag ctccctgtac ttcatcactt
     2161 ttggcatggg tgccagccca ttcacaaaca tagaggctgt gaaggtcttc tgtcaaaaca
     2221 tgtgtgtctc tattctgttg aactacttct acattttctc cttctttggc tcctgtctgg
     2281 tctttgctgg ccaactagag caaaaccgct accacagcat cttttgctgt aagatccctt
     2341 ctgcagaata cctggatcgc aaacctgtgt ggttccagac agtgatgagt gatgggcatc
     2401 aacagacgtc ccatcatgag acgaacccct accagcacca cttcattcag cacttcctcc
     2461 gtgaacatta taatgaatgg attaccaata tatatgtgaa gccatttgtt gtcatcctct
     2521 atctcattta tgcctccttc tccttcatgg ggtgcttaca gatcagtgac ggagccaaca
     2581 tcatcaatct actagccagt gattcgccaa gtgtttccta tgccatggtt cagcagaaat
     2641 atttcagcaa ctatagccct gtgataggat tctacgtcta tgagccccta gagtactgga
     2701 acagcagcgt ccaggatgac ctaagaagac tctgtagtgg attcactgca gtgtcctggg
     2761 tggagcagta ctaccagttc ctgaaagtca gcaacgtcag tgccaataac aaaagtgact
     2821 tcatcagtgt cctgcaaagc tcatttttaa aaaagccaga attccagcat tttcgaaatg
     2881 atatcatctt ctccaaggca ggggatgaaa gcaatatcat tgcttctcgc ttgtatctgg
     2941 tggccaggac tagcagagac aagcagaaag aaatcacaga agtgttggaa aagctgaggc
     3001 ccctatccct ctcaaagagc atccgattca tcgtgttcaa cccctccttt gtcttcatgg
     3061 accattacag cttgtctgtc acagtgcctg ttctgattgc aggctttggt gttctcctgg
     3121 tgttaatcct gacttttttc ctagtgatcc accctctggg aaacttctgg ctaattctta
     3181 gcgtcacctc aattgagctg ggcgttctgg gcttaatgac attatggaac gtcgacatgg
     3241 attgcatttc tatcttgtgc cttatctaca ccttgaattt cgccattgac cactgtgcac
     3301 cactgctttt cacatttgta ttagcaactg agcacacccg aacacaatgt ataaaaagct
     3361 ccttgcaaga ccatgggaca gccattttgc aaaatgttac ttcttttctt attgggttag
     3421 tcccccttct atttgtgcct tcgaacctga ccttcacact gttcaaatgc ttgctgctca
     3481 ctgggggttg cacacttctg cactgttttg ttattttacc tgtgttccta acgtttttcc
     3541 ccccttccaa aaagcaccac aagaaaaaga aacgtgccaa gcgaaaggag agagaggaaa
     3601 ttgaatgcat agaaattcaa gagaacccgg atcacgtcac cacagtatga ggggtataga
     3661 ccagtggatt atttttcttt tccagtattg cacaatgatg cagggcaagt aaagctcaga
     3721 cctcagctgc ttgggctggc caggggtaac aaggcaagtc agatcaagag tgcattattc
     3781 atgacacttc aaggtgcctg cttcttgggg ggaagaggga ataaaaaaag aggaaaaagt
     3841 tatttgcaac cttgttctcc tctaaaaaca agtttctgga tgtaatctga gagctcttcc
     3901 aaggaatgga tgaatcaatg gagtgttaag atagaaggcc aaaataacca gcttctttta
     3961 aaaataaaat gcttaggagt gatggagaag caaggaaagg tgtccttcaa atagggggaa
     4021 agacatggga aatgtgccat ggcacttttc atgcttgttt tttgaacagg ttggtcaaag
     4081 gaaacctatg cacttgggaa gtacatattt aatactgtct aaaccaaagg acttcccaat
     4141 ccattttatg tgtacatata tatgtatata tcccgtatat acatatactt agttttgtct
     4201 ttagggtaca ttgacgttta tgtggaggga gctgtccatt tgaagatagg ctggcttttc
     4261 cctagaaagt caaatcaacc ttagccaaat ttatagattc attaatagcc gttctaaatc
     4321 aacccaagtg tctcagcagt cagtgtgtca ttcaactgtg ggatgagcaa aataaacaga
     4381 gatgtgagtt cattagatta tgcatatcat gtcagcagtc atctagactt ttgctttgga
     4441 tgacttcaca agaaaacaca aaaggcattt gaattaatta ccacatggac aaggtttact
     4501 gtttcatatt agaaataaac agttgatatg gattttcgtt ggcttttact gtatttggaa
     4561 gactgatatg gctgctttca gtgagctcac ccaattgcaa atgagcgctt tacacagatt
     4621 atccatacat gagtctaagg gtgcacaagt atgtgtatgt gagttggggt actccatagt
     4681 tacaccgttc ttattttaga tagggaaaat aactgtcatg gaatatagat aattaacata
     4741 ggagaaagga gacataacta ggaaactcgt agagtgaaat agaataaaat ggaccatacc
     4801 cactcatcac atgccatcta ctagttctta gcataaggaa actattctaa tcctataaac
     4861 tctagtgtat tccttgcatt agtatttgga acataaccca ggccatgatc actatagtag
     4921 tgttcactac acctactgca gtaccatttg tagcttctca caatagtgtt gctcttgtta
     4981 cctggaaagt gctcctcggt tggcccacct cctagggtga tcgcagctct ccacaggtgg
     5041 gatattaact ataactgctg ctgaattctt tctcaaacaa aagtactgag gtaaatgttt
     5101 tcattaagtt aaagtttaaa actactccca agcacctgtt gggtgcttac ttggactatt
     5161 gctgtgcctc ctgtcacagg aaattactag aaaatgcctt ttcccatgcc aagcagtaac
     5221 ataatttatt tccaggtagg acagaataaa tgtccgatga ttataaaatc tgctagtaag
     5281 ctcttttacc tagaagaaag ctactacttc ccatcaactt tggttctatg ttttaatcaa
     5341 attaataata cctaaaataa caaaactcct tgactcaatt atgttcagaa aaaaggtaca
     5401 aaccattcca ttctcgttat agtctctgga aatgaagttg atagactaat gaagtaacaa
     5461 aacaagtata cttagacata taactttcca gaatataaag gggaaaggga acagacccta
     5521 aaatgaaaac atttaagtaa tatttcattt attaaatgga gtttgttttg ttttaccttg
     5581 aggtaattgg gtttcaacag gaaatgatct atgtcttctc cattgtgtca gtttcagtgc
     5641 aatatctata gatttgagtg gggaaaatta ttgcccataa tcatagggtt attgttttta
     5701 cattatttgt aaagtcatgt cacaaatact cctagccttt tgcctcatga actgctgtac
     5761 tagaatgaac tggtatttgg tacgagtagc ctccagacca tgatctcata tctgaagtag
     5821 aagtttcaga ggaggttttt ggttgggttt tgattttttg tttgggtggg agttttgtag
     5881 tgggggtgca gggaggagga gaattcctct tacagattac ccatcatttg taaagatttg
     5941 atatggaaga tttttatctc ccatatcaaa atatgggaga taatcactga gaaagttaat
     6001 taactatcac tccttttctt cccattgtgt gccatgctcc actcattcac ctatttttta
     6061 aaagattggc tattggggtt ggttttttct tggttcctat agaccattct gcatgcaaag
     6121 aagaatggca ggctgattta cagggaaaga atcaagcatg ccagttgtca aaagcacatg
     6181 gaggaaatgg tatacactgc caaatgacca gggcagatct aatattatgt ctccatccag
     6241 atagtctctg tttagatagg gaaaaacagt tcttttttag tttatgtctt caaggatcaa
     6301 agtgtctaag ataaatatga atttctcatt gttcgagtga ctagagggca ttttggaagg
     6361 aacattatct tttccaggac accgtagtac tctttagaga actgtagcaa taatttactg
     6421 aaatggaatt atttgttctg gaagagttaa tataccacct aaagtgtctt aatgcagtcc
     6481 taggaagtaa tttaatccta agaagaatct aacagagcat cgtctgacct cccaacctca
     6541 ctgtgaaaca gatgtttcca agaattccat ttcctgaata ctaagataca tcctaagata
     6601 tgagatcatg acttgcaggt cacccccaat cccaaccttt tttggtagct tgtatgcacc
     6661 tctccctagt ttttccagtt tgcactcatt gttttgttca tttatgaagt actaatgcca
     6721 ttcaaattag gaacttatct gttgtcagca gatgaccaat caactcctag aagagaagaa
     6781 atttgtggga aatatgttag ctttgtgtaa tattttattt aattgaaaca tatatgccct
     6841 taaagtaaga ggttataaag tttgaaaaaa ctactctttt tctgtatgta aactggaatg
     6901 tggatttatt tccttccatc agaatttaaa tttgaattgg aaagtgccat gtgagctcca
     6961 ctctctttga tgttaataaa cttcaaagag gtactcacct aaattacaga gagatcagct
     7021 aaaagatttt ttaccgttta tggttaaagg taatcatacc ttagagattt gattctttag
     7081 accagcctta attcttttta atgaaagtca tgtttagatg tcttcccagg aattcttgca
     7141 gttactatga acctctttga aggctgtgca tgagtattct atgaaagaac tattctcctc
     7201 tgttgttgta tcatgtaagt ggccctttcc tatttgattc ccatttattt ccacagaatt
     7261 taggttttta ccttgtgagg tgagaagaat aatgatgaca aatgttttat gatgctatta
     7321 tagttattct tgaatgttaa attcaagaca gtaaaagctt tgtccatttt gtaattatct
     7381 atcacatttc cccgtaataa gctaatcctt ctaggcttgt ggttagagct aaggattaac
     7441 tattgccatt cagaattaca tgtattttta taagttgact gtaaatatca taattacagt
     7501 cacatatttt tatgaccaaa tagttatgaa tgcacggcac tatgcatgct ttgttattaa
     7561 tagtacatag gttattaaag acactatttt cagggttatt gcaactttta ttaaaatttc
     7621 ttacatcacc tattcataaa tgcctcatgg cttttggtct taagggccta aagtccacag
     7681 aaagttccat ccccaggtaa gcaatttaag aattgccttc cctgggtatc agtaacaacc
     7741 acctcttcta gaatggactt cggaaaatct cagaagtgaa atctggcttc caggcaaagg
     7801 gcctagtata ttctgtattg gttagtaaat aaacataatt ttatgtcttg tgtttgctaa
     7861 tcttatggtg aagcagaaaa tacaatgcca tgagactgac atttagatat tgtctcttag
     7921 agattggaga agtcaatgat ttgctcggca tcctactaca gggatctttc tgttcagtct
     7981 ggtttgttgg tgtctgcgaa ggatattggc aatctttgca aaagtgaatc tgaaaactgt
     8041 tacttattcc aaaagagcct cagaagcact tttcttccct ttacaaacaa aaaacaaaca
     8101 aaaaaagttt tagctttttc tcaattacca aaattttgtg acaattttat gacattgacc
     8161 caaaacatat ttatggctga attggtatgc ccttgctatt tccccatctt caatctcaat
     8221 atgaaattga acatcatcac tgtggtgcgg acctttatgc taatatttta aatcagtgag
     8281 ctgcagatat ataggatagg gaaaaatcaa gttttttact actttgtcta caaaataact
     8341 acaatgatat tgacccaaat gaaagcagca aaatcataag tgaaagcaac aaagccacac
     8401 tgcatgagat ccagcagggg agggactgtg tatgggtata gcagcagtaa attaccttga
     8461 tttatcaact aaaggaccaa gattaatcca ccatcacgtt taacttagga gcacaagagg
     8521 tggtgttctg tgtttgaagt gttgtggagt tagatcaggc aacatttgaa atgacactgg
     8581 aaggatattg agagatgagc ccacatctca gaaatcaaga tgtctgtaag taggtgtgat
     8641 agaacaagtg gaataatacc acatattctg tgatttagaa tacagcagag agaatcacgt
     8701 ggtgttgcaa aactatagat tctcaactgc tagcaaactt gatcataggc aaatacattg
     8761 cacttgaaga ctgggttctc atttgttaga ttcataacct aatctttgca gtgggaggtg
     8821 ctcctgaatt tccaagcaca aaggaagagc cgtagaccct tttgttagtg aaagtgaaaa
     8881 gctagggaga ctctttgtaa agaagcttaa agtaagcacc gacataagca tcattcattc
     8941 ccagagtggc tctcattgac tatattttgt gagtctttga gtcataatga acactttttc
     9001 taatcagttt ttttcatact taatgaggac tctctattgc tgatagagaa gccacttgct
     9061 tttcttataa aacggaaaac aactcaaaag agcaatatat agggttaaga atatatttat
     9121 agtataactt cctagtctac aaatcacatt ttatgtcttc tgcatctcta aagatgtaaa
     9181 aattaaatgg gagtgtacct taaactgaaa acctctataa ggtagatatt tttaatataa
     9241 taaagtattt ataaaggaaa ctatcactga ttttgcacta tcttaaatta tagaaagcca
     9301 gcttctacta tttttcccca gttgaaaatt tcccttaaga aaggtctcac aggtcatggt
     9361 aattataaaa tcttaaaaat cagaaagaaa ctttaggaac agagtaggaa tcaccactga
     9421 tggtgtgtga ttcctgctgt gtatgatttc attgcactta tctgagctga ggtttttaga
     9481 agccatttgt agctgagctc tggtttccca acagctaatg gcatggtcta atagaggagc
     9541 attacggttt tctttccctc tgttgccaca gtttgtagag taagcacatt gcccacaagg
     9601 ctctgtcaaa ccagaggggg aaaaaaattc taatgctttg gaagactgca ttgaagaatt
     9661 tcctaggaat aactaggaaa cactctcatg gacgaaagat tactggtgtt taataaaaat
     9721 gtataacttt tcagtgctat ataaatttaa cttatattct cagtagcggc agtctacagt
     9781 atgttatggg gagcatttaa attatctaat gtaatatggt tactagaatc tctccctgga
     9841 cacggaaaca ccttctatca ttttatctga tgaattcact ggttgttggt agcaacactg
     9901 atagagctgg ggaaaaaaaa aaaagaataa gccgtcatat tcttgcatct cctggtacag
     9961 tctgtagcat ctattttcaa gtagaataag ggaattctgg catcttttct tcacaaacat
    10021 aaatgtgcta caaactgata aactagacct taaactagtc aatgcaaata tcccaaagtt
    10081 ttagtagttt aagcaacaac tttattatac tttcctgtta attatgcata tttttcagca
    10141 gtagactttt ttgctctgaa ctaggaaatc tgtcacagat tgaaaagggc agagatctct
    10201 ccaagctacc tcataagggt atttaaagac aaaatggcat gcaatctttg attaaatggc
    10261 aatatattaa agccacaaag caatattatt tatcaccttt ccttgatgct cattcacttt
    10321 atcaaattag acaaggcaaa atgtaaaatg agcactccta tatgcagtcc cacttataca
    10381 ttctggttaa cataatattc attaatatga aatctttcaa ggcagttgtt agttgtctcc
    10441 ctacagatat cccagagctc aaaaattgac tcagaaagag agtaatctga ctttgattag
    10501 aggcagcagt ctacccagta agatgcacaa ataatctgtg aataacttca gaaaaattcc
    10561 aagtgcattt cacttatcac ttttcttgga ggaaaaaatc tgttcgggtg tttgtttgtt
    10621 tattctaggc aaatagaaag agacaaagtt accattattt ggcattttac ttaagttttc
    10681 ttttcctctg gaaggcattg ctattatttt ctgctaaatc ggggttttta aaacacaagt
    10741 cacttacgga aacattagca tcagtgaaaa gaaaactcct agggagaaac agtcttcacc
    10801 catgcataga caaattgtag aaatgagagt aaaagttgag catttttatt ttctttccta
    10861 aaacaaaacc cacttgttct taatcctagc tagacaaaat accagtttct acagcaaaga
    10921 agggtgacta aatgtatgaa attatgaaac tttgatgtat taacactaca aacctcatgg
    10981 caaaccatca attccagatg tctttaccca taacaatatt ccttctaaaa tactctatta
    11041 catataggtt catcccattc atgaaaacag cctcatttat cactcccaaa atagtacaaa
    11101 caaagccatt ttaggtttct gctctgtagt tctgtacctt gggctctaca actaaagcta
    11161 ccttactgag gaaagcttaa aaacgaattg tgaacaaaaa tgtcaaatca aaaaaacatt
    11221 acccaagttg tatttccatc caaaaatatc tcctgtgaaa tagaagactg ctgtgtagcc
    11281 attttagatc tcacaaagaa gaaaatattc taaaagtacc tatttttgat cttactaaga
    11341 acccaaacca aaagtccttc caaagtttcc aaagtttcca attcacctga atttggtcca
    11401 ttatcaaaat ttacctctat gttgatcagt gaaaaaacat tttgcaaaac aggtttttct
    11461 taactataat agaaacaaat aaagaacaaa ttatttccca tagatttgca tgtgtaaaca
    11521 cacatttaat aattaaatga atctcatacc tcagtcaagg gaaattatgt tccaaatatt
    11581 tccttgttcg gttcatcatt attttcatgt tttggacaca ctgaaataca ataattttag
    11641 ttaaattgct cataatttat ctgcatgaca aatctattat ctaaagctta caggtacaaa
    11701 tcttaagaaa aataacaatt aaatcttagc tacttggaaa aaaaagtcat caaaatcata
    11761 tttactacag tgccactagg caaagttaaa cagcatttct ggctatctca actttttatt
    11821 ttaacaacaa aagaaatcta gttccattag tcataataat agaaataatt tatatattaa
    11881 agtagtgata aattatacag gtgtatattc tatagttctt agggtcaaat atgaggtctt
    11941 ttaaaatcac aatcacaaat gctgtaaaag ctaggttatt cttaaattcg ccagattttt
    12001 cttcattctt tattgttagt attaaatgcc ccacagaata ttataatatg caacttattc
    12061 ctctaacctc agtgagaact tcgagcatgc taccttttaa ttctaggcta agaattaaac
    12121 ttcctaaaca aaacatctta taacatcaca atgtaaaata acataatcta tgttttttta
    12181 gtattttatt gaatcacaag ttctaaaact tataatgtaa ttttttatcc tttaaacatt
    12241 caagaataca tacattaaaa taatactgtg atgatatata tcaattatct ctccgtggtt
    12301 aagataaagc attctgaagc aaatacaaaa tgtcttggca ttcctgagag atatttttat
    12361 gaatccctaa gttcacaaat gtctctaaaa cacataaatt actaaagcat tactaaaaga
    12421 ttcagatagc actttaacac cccttaataa ttatgttacc ttcaaatcta cagcaattta
    12481 taatcgggtc aaataaattc tacctaaaat ttatcactgc attacattgc attattgtag
    12541 taatattaac tataaaaata cttgaaccaa catttttctc accatatgag agctgcagaa
    12601 gatggagaca atgagtgagc cagcggctcc tcagtagtac ccagagatta atcacaaagc
    12661 acatcccttt ggctgcacgc tatacagttt caagctgggg cataattgtt caggggctat
    12721 cagcaccact tctaagtcac taaaaccaat catgttaaat atttcaatat ccaagtccac
    12781 tgtattttga tgaataatgt ggtggcatta tacataacgc atagataacc aacattcaaa
    12841 atatgtaagg tcacttgatg ccaaaattat acttaaacaa tttaatattc cacaagccac
    12901 ttcaaaagct ttatcattgc aaagctctcc tcattattga cgtatgatga ggagaccaaa
    12961 gaagtcttag taatatttca ttttatatag tttgccgtat gttttcttaa aaacaaggat
    13021 gcctttatgt ctttcctgga aatgtttgga cttattcaat agccattttc ctgtccaaat
    13081 ttagtatttt aattattaat tttattctgc ttttttcctt taaatatgtt caacttttat
    13141 catttctaaa ataacttttc tttagagtaa ttaagcatgt tttctccttt acataaaaat
    13201 aagcatggct agaaaggaat gaaataagaa ctcagaaaaa ttaagctgga catttggaac
    13261 ctatttgcaa atactaaata aagtttgcaa aagtactatt tattgtcatt tatatgtgct
    13321 tcaagttgaa attctccact gattttattt taaaaatggc aactgacatg ccaaactatg
    13381 aagcacacaa tgtctgcttt gcagacgttc agtaattatc cattcagtga agaaaaatat
    13441 aaaagacttc tccagcttat cagttgcctg ctcatgacct aatgaaaagg aggttattta
    13501 ataatttcaa tctttgagag cccatattca gaagcttttg ttgttgtttt gtttcatttt
    13561 cttgaatttt cctatatagc cagttacaca ataataaggc cccatataaa ggaagaattt
    13621 caagtttgtt ggtaataact gtcctttcct ataagttgaa atgctacaac ctagagctat
    13681 acacatcttg atagtaaaat aagggagaat gtgatccaac ataaagaaaa attaaggaca
    13741 agggtgtttt tttaaaaaaa aaggtaaagt gagaaaaaat tttaaaacgg atctaaaact
    13801 gttgaagaag ggactaaaca actgaactga aacctttttt ttatttagtt tctgttcatt
    13861 agcttagtta ggctttaaaa acaaaggaac acattggaaa gtttcagaaa aaccctgaca
    13921 tatctaagtc tccaaaaagt ttgttactct ttaaaaagat agaactagaa attcagtccc
    13981 attttaggat caagatttga tgtagatggg tttctgaagt acccctagat ggcttgtgat
    14041 tgtacctatt tacttacctc atatttagga gcacctatat tggtctctgt gctaggctca
    14101 gaagaaaata ccactaaact attcatagtt cctgactttg aggtatgcat gatctgttga
    14161 ggaaatttgc agctggagta ttcaaggaaa gtaaggaagg aattatgaac tgatccacat
    14221 tgaagtgtgg gtaagattct aatagataga gatggaggat gggctcaaca gtcagggaga
    14281 aaaagtgaaa tatacaaggg caggaaagca ggttgtccag gatgaaggct ataacagatg
    14341 agatgatagc aacccagaag agacttgtta cagatgggaa taaaaaggaa gcgcccattg
    14401 tgagtggtat tataaagcat tgccaggata tggggagtta cttggatttt ggagagggat
    14461 cataaagaaa aagctctttt tatgatgtat ccttgggctt aaatgcagtg aatggtttac
    14521 aaaatgtaaa tacacagtct ctatttttga attttaactg ttaaaatcaa ggatcccaaa
    14581 actgagcaat atcacataaa tttataatct ctcttgcttt gaaatgtagt ggttgcaaga
    14641 gccagtttag agcatgagtt tgattctcct gatgatggaa caccgtccac gttctggcac
    14701 aaaagccctc aaagtgtgag agtaagagac tgacatggat tgctgggaac ccaaactctc
    14761 cagaacaaac agctcaaact aatacactcc aattaactat ctctgttaat attattttaa
    14821 ttaacaattc aaataatacc tgcctaatag aataggtatt attgtccctg atttatagat
    14881 tgttcccaga aagaaaacat tgtaaacaag tactatgtcc ctatggtaaa atatatcatc
    14941 ttttcatcat aaatcagtat gaaaggtgca tgtacagaga agtccaaatg taaattatat
    15001 gtgatgaaaa ataactgcat agattttctc cccatctatc cttttctaaa tgtaaatttt
    15061 aagacaatga gtttgttaaa atgcttaaaa ctatttttta aattcacttc cttatgattc
    15121 actgatgctt tctttgaaga tcacataagg tacatatgca cttagttttt aagcataaac
    15181 ctaactgatt tatacattac ccttgtcctt tttaatagtt aaagttttaa ttataatagt
    15241 ggtgctcccc aaaaccagca atcatattac aagatgtttg gaggaatata ttttaaactt
    15301 taaacctgaa aaaagcattt cctaattatg ctttttagag ttatagataa ggttggagtt
    15361 ggcctgggga ggccccattt tccaactggt tcacgaggag gacatctgtt cacagaagta
    15421 gaatggagat aaatccaaca accaagtggc catacgagac catggtcaac aaacacactc
    15481 taagagacat tttggataac cctaggagta acaaagctag tggttctcaa aatttgctgt
    15541 actttggaat gacctagaga gatgtttaaa gtctcaatgc ccagacttca tgccagacta
    15601 cttaaatcaa tatatcctat agcgagaccc aacctcagta cttctgggag ttcccatagt
    15661 gatttcaatg tgtggctcaa tttgaaaaac agtggcttag acaaccaagt caacacattt
    15721 aatccaataa atactgatag agccttttat taagtgaagt tttaaaaagt cacaagacaa
    15781 aagcgtctgt gacatctata actagaatat aagccagaac ttgtacagag tccaaaagga
    15841 gatatccaga gggtagagag atgatttcta gtagagccaa acctggtatg agtgtgttgc
    15901 attaagatag cacttaagat gaggtaagat tattggcctg agcaccccat gtgacgggac
    15961 cagactgagc aaagccataa catgcaacaa aagcacagaa tatgttcctg ggtcaacgaa
    16021 ctcaatttag cttgagggta catttccagt acaggagttg aatttgtaca aaccagaaag
    16081 tttcatataa ggacctgcaa acatcatgct gcagaattta tatttgattt gatggactca
    16141 gattactttt tattattatt attattagat tcaaaattta gaagtattaa tctgcaatgt
    16201 tctaagtgta ggttagactg gagatgagag acctgaacca aagaattaag ttaggaggct
    16261 gttgtggtca tcagcaatga aggtaatatt ggcctgaaat agagttgtgg cactgaatat
    16321 aaaaaggaag aaataaatac aattcacaaa acttatatct gtaagatggc ctgaacaccc
    16381 aagaactttg agtgtctaaa acacaacaat attcacatta gtgaatttaa tgtggtataa
    16441 cagtaactag ttattagctc tgtgtgatct atttactaca atactctaat gtatagttta
    16501 atcttcacat tcctgtggtt ttgacatgca gcgtggccca tttttataac atttgtaaag
    16561 ctttaccaca aattttcagg aaattgcttt atctttacag aacagttgat ttggttttct
    16621 gcatatctaa cttggggaaa aatggtttat attgcattaa ttaaattcag taaataaaag
    16681 atgagtcaaa gaggaagaaa cgaatatctt aggaacataa ataggcagtc taatctttta
    16741 tacttttttc catgtaaaat tactggatac tcaggtatat ataactctta tctacatgca
    16801 cgtattatag ctagagacac tacaatagta tctagattaa tctacatata taaacatcaa
    16861 tttaattagc aaataattct tgagatttat ttgcatttca gggaatttag cagttcaggt
    16921 gatttatgct tagaaacaag atcactgttc ctcccacaat cagagatctg ctctgcagtc
    16981 atcttctatg aaagttatgt ataaggcaca tgcttttatt ctaccataaa gatgtagtat
    17041 tgcaatgtta tgtcagcact ggacaaagat ggatatatat gtaaaatgta attttcacaa
    17101 catatcctta cacatagtta cacattcatt ggatggcctg tctctaattc aaaacttttc
    17161 ctatggtata attgtcctgt caaatatttc acacatacat ggttttaaca ttagcattaa
    17221 aatgacctgt gaaaataatc catatgaact ctttgtattc ttctacagtc atagaactaa
    17281 aatacgtgag gatgaggaag cagataacaa cttgagaaaa tgtaaaagag ttggaacttg
    17341 gagccacagt gccatgcaat ggggccacac agcagcttga tcatccacgt agctttatgc
    17401 gatgcccttt gggtcatggc tttcaccagg tagcttactc aaaaaaaatg taattatcta
    17461 ttaacccctt tattctccaa atctttcatt caagaagaat tttaaacatc ttctatgtgc
    17521 cagacacata gagagtaaat gcaaagagaa atgagaggca gccactaccc atcaaggatt
    17581 ttagcaaagc aaactagtag gtgaaatagc catatatata tatgtgtgtg tgtgtgtata
    17641 tatatatctc aaaaataatg ggctccattt atagagcagc gattctccca cttaagcatg
    17701 tatcaaaatc acctggaggg cttgtcaaag cacagcctgc atatccccat ctccagaggt
    17761 tctgattcaa tagatctgga gtgaggcctg aaaatttaca tttctaacaa gttttcaggt
    17821 gatgctaatg ctactagtct gaggaaccac acttggactt tgaaaatctc tgaaatctaa
    17881 gtttgtgaac agcaacagac attctgagaa tagttggatt aaatctgtcc agggaagaag
    17941 gtgaggacaa aggtcagctt ctcaccacta ggcctgaaag gctgcatagt tgaagagtgc
    18001 aaagacattc cagtttgaag aaaagaaatt acctgaacta aggccatatc tgacaagtct
    18061 acctgttggt agaactcatc tagaagactt tttaaactct tgaagggatg gccttagtaa
    18121 tctctatttg taataagttg ctctggacag tcttttcatg aagaaaattt aggaacatgg
    18181 aaccaaggcg tagagtataa aagaatgtgt cattttcaga gaagtcctgt tatagactgg
    18241 tttaactaga accactgtat actagaacta gcactctata ctagaactag attcatgtag
    18301 gacatgagtt aagtttgaat ttccaataat cagtgaatga aatttttagt acaagtatgt
    18361 ttcatgcaat atttggaatc tactatacta aaaatacttg tttctctgaa attcaaattt
    18421 aactgggcat attgcatttt tacttgctaa atctcacaac cctaagaatg tagggtatgt
    18481 gtcaggtgga gaaaagaacc agaaataatg aggctgaaac actattatat tattaggcca
    18541 aataatagta aagtactatt tttcatgtgg gatatgcaag tgtagcatgt agctaatgaa
    18601 gcttaaattt ctgagcccat tgcttacata agtcttttgg aggccctagg acagtcctta
    18661 gcagtatgtt cacatcttat gtttatataa aattttcaaa tgtatgatat ttttgcattc
    18721 ttttccttaa aaggggactc caaaaatgta tacacttcag gctcaacaaa attttgatct
    18781 gcccctgcat gtgggaccac ataagtctca gatacaacac aaaaatcata ttgataaata
    18841 ccaactctta agtaaaaagt taagtacaat gaatgcccag agaatttgaa gatctttttg
    18901 ttcctatatt atcacgaaat gctacttgaa attaaaatgg cttcaacact ggcaaaatga
    18961 agcctattct ttgaattacc ctcaatgtgt gaaattaatg ttccagtagc ataaagacag
    19021 tatttgattt cccagatata attgaccatg ggtcattatg ttcatggagc atcttaaaga
    19081 actagtgttc caggaagcaa acattgataa tgtcatgtta gagaagcctg tctttgttac
    19141 tgaagagcag atgagtatta caattccaaa ggaaacagta ttaatgggtc tgtgtggaaa
    19201 tcagttctta ttttctaaac aatattgctg atttctagct atttgagtaa tttataacct
    19261 aatagaagaa aagaatactt aaggaaaaat gattcatcag catgaatttc aattaaaata
    19321 acacagaact aatttttccc ttctgtccca gtacaatttc agggaatgag aagtaagcaa
    19381 atggaaacca agttaaacta gaccataaat agtaaaatat gaagaaaaaa attgacaaat
    19441 ggccaggaaa ccaaataaat aaacaggttg atattttatt tttcattctt ttgaaaatga
    19501 tatagcattc tagaataatt gaaaaatttt gatcttgaat aaaagacttc aggaaggtta
    19561 tttcttggag aacttcaatg aagggaaaag ggggaaagca gcctacaaaa aaaatttagt
    19621 atgtgttgaa aatggttgta agtagatctt tggtcccaac agcacagcta ctaaactatg
    19681 atatacgcca gacccaagat attaaaaaaa aagccataat gcaacaaaag taatgattgg
    19741 caaaaccgat aattcattaa aaatccatca ggcctcctaa aggccaactt ggtcatacct
    19801 atacaataaa gaagtgctga aactccaatc agagttacac acaatatgta agtcaaatat
    19861 ctcttaccaa atgttccaat agattttctt tttgtattaa attcgaatac ttagagtact
    19921 gggttatgtt caataatagg aagtcacagc taaaagtcga caaagagaat aactgattgg
    19981 aagaactttt tcgataacag gaaatatgga cagttaccta ggaactagga aaataaaatg
    20041 acctgatgaa ctagccatat cattcattca ttaatccatc caacaaacat ggattaagaa
    20101 cctataatgt gccaagtgat gtacaaagtc ctgtgtgagg gacaaagcag ttcaaattgc
    20161 tcagcggaat actttaatgt ctcataaaaa gaagaaagta actatttgct ttcactgaaa
    20221 catttgttat gagacattgg caaaactaga gttattattt atttgcctgc tattaaccta
    20281 attaacctgc tattaatcta aaaattgttc aagattctta gttaacatgt cttccataat
    20341 aaatagaagt tgctatactg atttttttgt ttgttggaca taaatgtcaa tgagtactag
    20401 atgtgttttg gacaaaatgg taagatagga aggcaaggat gcctaatgat tgattagtgt
    20461 attaaacaca gcagatacag ccttgagggt atacatcttt ttgtttgaaa ttaatacact
    20521 taaacaaatt agtgaatgta agtgtaaata ggttcccaaa ctcataattt tacccaaaag
    20581 aaataaatac tagtaagtaa acagtcaggc aagaattgag acacaaataa aattttttta
    20641 aaaaatagtt ttatgaaaga acatcagcaa ggagtgttaa tgagtcgttt tctaccctgt
    20701 tgccacctct tctatttagc acagcaatga ctaagacata tttagaagga tggcctaaag
    20761 aaaaatcagg actaagtagt ttaggtaaaa agaagaattc atctacagat ggagaaaaac
    20821 aatcttgccc ttcttcacgc caagttccaa catgtttgaa atttagcact ggagggattg
    20881 ggagagctca ataattagac tgcgattgaa atgttccact aaaataatga ttagagaggc
    20941 atccaggggc actttctatc ttcttcattc gacctcagca tggagcacat caactctgtt
    21001 tcttagttgg actatactac cttagataca gaactgattt ttaaaagtat ataaaattat
    21061 ttcaagtcta aaaatcataa agagtttatc tcaggataaa taatttttat gaaagtattt
    21121 tatcgccagt tcatttgtaa cctaattgct ttgcttaagt agataaatcc caagcaatga
    21181 gtgaaataaa ctagtagact agtgggtttt taaccctcta cctatgtctc tcaaatgttt
    21241 ataatttctg ctccactaat agccctgacc ctgctaggta acaatactct aggaaattga
    21301 agatatgagt tcagagaaaa aaaatcataa aggaagatag acattgtgaa gaatgggcag
    21361 tagtgctaat gtaaagaaag aaagaaggct gcatggatga gggattacat tttctgtagg
    21421 acaggaagaa gagatctaca gatgtatagg tataagctct aagttgggat aagcaatgat
    21481 gtagattact aaacaaaatc agatcatgtg tcttatccac tgagttctac cttaatgttt
    21541 ttgttttcat ggctatattc tcaaaatacc tgaatttgtt tttagagtca tatatttctt
    21601 tgtcttttct taattgacag ttttatatat ttctttcatt tctttcttga ttaccttgag
    21661 tttaacatca tgtgctatat gggatgaaga aaaagtatga tgtgttttct acctttaaat
    21721 tgcttgcaat ctctttaaag atgctgacag aagaaatagt cactcacaat aaagcacaag
    21781 aaatgattgc atgattcata ctttagagtt aagagaatct gggtataggg aactattggc
    21841 attaaagggg aatacttcaa gaaggaaatg cagcttcaaa taggccttga agaaggcatt
    21901 ttatctgcct aaacaaaaga accatctctt cacagacatt aacttgggtg ggagattcac
    21961 gaaagagggg aagccccacc cagtctgttc ccctgtctcc tgctctgacc acttctccag
    22021 ccactgcccc ctttgttctc tctgcatcaa ccatgcaccc cctttggtct tttgtcattg
    22081 cagttcccac caccctgaat gctcttcttc ccccagttag ccacagatct tcctccctca
    22141 catctttttg gtttcttctt aaatattaaa taagtatgca ttagagaggc ctttcctgac
    22201 aatctcatga aaatatagta aatctcctcc cttctttcat atttgtcatg ggatttgttt
    22261 attgtctgtc tgtccccagt aaattgaaag ctctaagggg gcagagatat ttttctgctc
    22321 tgtaaactgc tataagccca gtaccctgaa gggtgccagg cacatgttag gcattcaata
    22381 aatatttgac aaaggaagga aggaaaggag ggagggaggg aagaaattag ttcaggtaga
    22441 ccttgaaagc ttcaagtgtt tcagttgcaa atatattaga tgtatctcat tatctagtaa
    22501 gtcattttaa ggtaaactta ctgatacatt tgaaagttgt ttgcccatga attctttgct
    22561 aggtaatatt aacatctacc cctgcactcc cttaaatatt tatcagtagc ttaaacttta
    22621 acaaaagaca tggtttcctt tggcagagca gggactgtgc tcgtatccta gcttgtcaat
    22681 ggaaagaaaa agaaatactg ctgaacaagt gaaagattat catggcagcc acatccttaa
    22741 atgggagcaa ttggtagcct gctgcttctc aggcttaaag aagtaaaaga tactgcccca
    22801 agccattttc agctggaatt gtaagagtat gcacacaaat acacaaagtt accctgacat
    22861 aagcgtgaat aaaatatatt atctgatgct caggaacatt tccttcttcc ctcaaaatga
    22921 ataatttatt ggttttctac ctgctgtttc caagctcaca ttaatgattc attgattagt
    22981 ctcaaaaaca gatgcttgta attaaatcat aggttctgta agatcattaa ctggttctct
    23041 aatggctgaa agaattaagg agaaatgggg tagtttaaat tcatagattc aagaaggatt
    23101 ataggaagca tattctgtac aaatgtgaca tttgctgtat tgttttcctt tctgatagaa
    23161 atttctcacc ttctaaattt tcatttgtat ggaacttgtt ttagttttct taacatcagc
    23221 aggtttatta tttattccac ccacagaaat tctgactcag atggctagtg cagtgtagcc
    23281 ttgttacttg tgttcagatt tcttattgct ctttgtttta tgccttagtt tatccttatt
    23341 agaatctctc caaaataatt gataatttat gttggtcaag tagcattcca ttatctgtgg
    23401 taaaaaatgc tttattaatt ataccacata ggtttcagca tgtgcaaagt cttctgaaag
    23461 tatcataaat gatagttgtt tgggagatgt gataactttt atttccatta atgtttacat
    23521 ttctgcctca ttctcagctg agattgttac ttatattttt atccacttga atcttgaagt
    23581 taaggtaagc tgaatatatc taattgtctt tcatacacat tactttgttc tacagaagaa
    23641 atttattaat ggagtaaggt gaatatgata aactcaaatc agattttctt cttatgtctg
    23701 cccctgaatc caaaattggg ggtgcctgct ataaaatcaa gtatgtttat gaaaaccttc
    23761 cctctcctat aattgctgga gtattcattc agagctctca cttgctatat aatttctaac
    23821 caaacacttt ccagggaatg tacaacaagg aagtacatgg acaacactca aattcaaatg
    23881 tccatagatg gtggaatttt accactcttt agcttacaag ctcaatcaac tgaaacgttt
    23941 cagaaatgtt tgtgtttggg gtttgggttt gagatgtgaa acaaatgaca tccttaaaca
    24001 tgttattgtt agtcttcaag gtacatatgt gtaccttgat atagaactat ttatagttac
    24061 agtttgctaa aaaattatta taatgaaatt aactttggga ggtagatgtt aaagtaccag
    24121 cttgtaaaaa gaatgtttaa tgccaatcat ttgtatgttt aatacctgtg tgctcaatgt
    24181 agtgtcatct ttactagatg atttacttca caatgttttc attcctgttc cccaaatgaa
    24241 aataagtagt ctattaacta atttacagct cttagttttg gatactattg cagagacaca
    24301 ggagcacttt taactcaaac actatggttt accatagttt tgcggtggta tgaaattgag
    24361 ttagcactgc aatgcaatat tgaaaaaatc agaatgcaat aaagaaatgt agatatcacc
    24421 tgtgactact tcatgtacta cccagactcc tcatttattg tttgaaccca agggttagtt
    24481 ttttatcttg ccaaaaggac atgatcagga agtcagtgtg ataccgtctt gctgcagtgc
    24541 agaagtttta agaagcaaga tactttttaa tgatgtacta tcacaggata gaagttatgc
    24601 cctacatgaa actacgtatt cgcagaaact ttgtgtcgtc aatgtgcatc tgttcttact
    24661 agtctggagg gaaacaaata agatttccag ttttctgctg atccaacacc atttcccata
    24721 ggcagcacaa tacaccagca cacagttagc agcactttgg gacaaaactg ttgaaaggaa
    24781 agaaacagtg attattctga aaacatgtaa agcaacactg atcataagta atttttgtta
    24841 ggtgggacaa tactatataa tatgatttct tgtgtctaaa ttttctctaa aagattattt
    24901 gggctgggtc cagaaggctc caatttccct aagcaacctt gatcatcaat gttgtcatgc
    24961 ttcagctttt ggcagttttg attcattacc aattattaat atcattattt aaatatgaat
    25021 attgtccctt cccattatga aaagctatta caaacatata tggatttata taaaggttga
    25081 tgactatatg cttttttata ttagaaaatc atgtgaaaac aaaattaatc tgatgaatgc
    25141 tgttaattat tttaactttt ttattaggta taaaatgttc ataaaattat tctctctata
    25201 acttaccaag atttattagc ttgtgtaatt tttataatca gaggagtctg gttttctaat
    25261 taaagttttg tcaaagaaaa
//
