LOCUS       NM_024754              11145 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens pentatricopeptide repeat domain 2 (PTCD2), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_024754
VERSION     NM_024754.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11145)
  AUTHORS   Baleva,M.V., Chicherin,I., Piunova,U., Zgoda,V., Patrushev,M.V.,
            Levitskii,S. and Kamenski,P.
  TITLE     Pentatricopeptide Protein PTCD2 Regulates COIII Translation in
            Mitochondria of the HeLa Cell Line
  JOURNAL   Int J Mol Sci 23 (22), 14241 (2022)
   PUBMED   36430722
  REMARK    GeneRIF: Pentatricopeptide Protein PTCD2 Regulates COIII
            Translation in Mitochondria of the HeLa Cell Line.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11145)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 11145)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 11145)
  AUTHORS   Lightowlers,R.N. and Chrzanowska-Lightowlers,Z.M.
  TITLE     Human pentatricopeptide proteins: only a few and what do they do?
  JOURNAL   RNA Biol 10 (9), 1433-1438 (2013)
   PUBMED   23635806
  REMARK    Review article
REFERENCE   5  (bases 1 to 11145)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 11145)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 11145)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 11145)
  AUTHORS   Xu,F., Ackerley,C., Maj,M.C., Addis,J.B., Levandovskiy,V., Lee,J.,
            Mackay,N., Cameron,J.M. and Robinson,B.H.
  TITLE     Disruption of a mitochondrial RNA-binding protein gene results in
            decreased cytochrome b expression and a marked reduction in
            ubiquinol-cytochrome c reductase activity in mouse heart
            mitochondria
  JOURNAL   Biochem J 416 (1), 15-26 (2008)
   PUBMED   18729827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC393817.1, AK056761.1, AI798903.1, AC026406.5 and AC093278.2.
            
            On Nov 22, 2018 this sequence version replaced NM_024754.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.96450.1,
                                           SRR1660807.208968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380639.10/ ENSP00000370013.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               DC393817.1         7-329
            324-1978            AK056761.1         994-2648
            1979-2103           AI798903.1         20-144              c
            2104-6195           AC026406.5         118613-122704
            6196-11145          AC093278.2         43435-48384
FEATURES             Location/Qualifiers
     source          1..11145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..11145
                     /gene="PTCD2"
                     /note="pentatricopeptide repeat domain 2"
                     /db_xref="GeneID:79810"
                     /db_xref="HGNC:HGNC:25734"
                     /db_xref="MIM:615484"
     exon            1..137
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1177
                     /gene="PTCD2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pentatricopeptide repeat-containing protein 2,
                     mitochondrial; CTC-365E16.1"
                     /codon_start=1
                     /product="pentatricopeptide repeat-containing protein 2,
                     mitochondrial isoform 1"
                     /protein_id="NP_079030.3"
                     /db_xref="CCDS:CCDS4014.2"
                     /db_xref="GeneID:79810"
                     /db_xref="HGNC:HGNC:25734"
                     /db_xref="MIM:615484"
                     /translation="MVRDSMAAAFRPSNRVLLQALQILVYPGVGGSGSVSCRCPLGAK
                     RYLLTDNVVKLKEFQQKKVAVACNLSGTKETYFRNLKKKLTQNKLILKGELITLLHLC
                     ESRDHVELAKNVIYRYHAENKNFTLGEYKFGPLFVRLCYELDLEESAVELMKDQHLRG
                     FFSDSTSFNILMDMLFIKGKYKSALQVLIEMKNQDVKFTKDTYVLAFAICYKLNSPES
                     FKICTTLREEALLKGEILSRRASCFAVALALNQNEMAKAVSIFSQIMNPESIACINLN
                     IIIHIQSNMLENLIKTLKNAAEGNLSKFVKRHVFSEEVLAKVREKVKDVPALVAKFDE
                     IYGTLHITGQVTTDSLDAVLCHTPRDRKSHTLLLNKRMVSRRTFQPLSQSLLAE"
     exon            138..230
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..360
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..478
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..557
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..649
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..763
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..838
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..952
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..11145
                     /gene="PTCD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTCD2"
                     /note="hexamer: AATAAA"
     polyA_site      1984
                     /gene="PTCD2"
                     /note="major polyA site"
     regulatory      7133..7138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTCD2"
                     /note="hexamer: TATAAA"
     polyA_site      7167
                     /gene="PTCD2"
                     /note="major polyA site"
     regulatory      11126..11131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTCD2"
                     /note="hexamer: AATAAA"
     polyA_site      11145
                     /gene="PTCD2"
ORIGIN      
        1 agtagttggt atggtccgag acagtatggc tgctgcattt cggccctcga atcgagttct
       61 cctgcaggcg ctgcagattt tggtgtatcc tggggtggga ggctccggct ctgtcagctg
      121 ccgctgccct ctcggagcta aaagatacct acttacagat aatgtggtga aattaaaaga
      181 atttcaacaa aagaaagtgg ctgttgcatg taatctttct ggcactaaag aaacgtattt
      241 tagaaacttg aaaaagaaac tgacccagaa caagctcatc ttgaaggggg agttgataac
      301 cttactacat ttgtgtgagt ctcgggacca tgtggaactg gctaaaaatg tcatttacag
      361 gtaccatgca gagaacaaaa atttcacttt gggggagtat aaatttggac cgctttttgt
      421 gaggttgtgt tacgagttgg atctcgagga atctgcagtg gagctcatga aagaccagca
      481 tttacgaggt ttcttctcag actccacatc attcaatatt ttgatggata tgttatttat
      541 caaaggcaaa tataaaagtg ctttgcaagt attgatagag atgaaaaacc aagatgtgaa
      601 gttcaccaaa gatacctatg ttcttgcttt tgcaatttgc tacaaactga atagccctga
      661 gtctttcaaa atctgtacta cattaagaga agaagctcta ctcaaaggag aaattctctc
      721 caggagagca tcctgtttcg ctgtggcatt agctctgaat cagaatgaga tggcaaaagc
      781 tgtgtccatt ttttctcaaa tcatgaatcc agaaagcata gcctgcatta atttaaatat
      841 tataatccat atccagtcaa atatgttgga aaacctgata aagactctaa aaaatgctgc
      901 agaaggaaat ttatcaaaat ttgtgaaaag acatgtgttc tcggaggaag tgctggccaa
      961 agtgagggaa aaagtgaagg atgtgcctgc ccttgtggcc aaatttgatg agatctatgg
     1021 gacactgcac atcactggcc aggtcaccac tgattctttg gatgctgtgc tctgccacac
     1081 ccccagggac aggaaatctc acacgttgct attaaacaag aggatggtca gccgtcgcac
     1141 cttccagcca ctcagccagt ccctgttggc tgagtaaccc tggtttcagt ccacctatgg
     1201 atctgagggg cctgcttcta gtgagttatt acctttccta agaagccagg tatcgcactt
     1261 cagcagacag tgtgctgaca cttggtcttc tcctgaaatt cccaaattca ctgaatggta
     1321 ccatgccgat ctctgagaag ttatgttgca ccactgtgaa ggtctagatg caagcttggc
     1381 tccctcagaa aggcgcttcc cttttgcatg gctgaggatc cttgaaggaa cctggtcagt
     1441 ctccggttca gcttccgaca ccagagtgga acccagtaag caccatcagg aatgaatttc
     1501 actacaagtg tggataactc tgattttcaa aggagtagtt acttgcaaat tacatccttg
     1561 ctgaattcag gaggtatgaa accctatttt accatgttag aaaacagccc aggattttct
     1621 cattgctctg ccatcatata tgtctatgac ttgagccctt atttttccat ctgcaaaaca
     1681 ataatgccta tgtgtctttg catatagatt tgaaatcttc attcaaggtt tagtaggatc
     1741 atattttctc aaaaataaga gaaataaggt tcataaggaa acttgctggg attgtggttg
     1801 ttttgttttc tcagcagcac aaacaaaacc agaatttagc ctttaggact gctgagtaag
     1861 ccaaatttaa atgactactg ctttgttcat gggtaagcca tgtgcttttc aaaataagtg
     1921 ccactaaaaa ccacataatg ctttggtttc tatgtggata ataaatattt agtcctatag
     1981 tttatcttat ttgttaatga tttttctctc ttgaatgcct catattaaaa aaaaatgtgc
     2041 catgagagca gttcaaagct gcttcatact tatggtctca aatatagtat gtgttgaatt
     2101 ttaccgtgtc tggtcaccag tgagcagaag atacacagtg accccacctc acttgctcct
     2161 tttgtttcag aaagcccaga gggttgctca gacctcagga gctgtctgcc aagattgctg
     2221 cagactcttc attgccacct ccaaaactaa gactgttcac ttggttgttg ttctaaggca
     2281 aggattatag agtcagaaat tgtagactag gagaagtctt ctgagtctcc taattaattc
     2341 cttcatcttt caggttaagg aaacgatcca tgcaagagag gcccaatctc aactgtagac
     2401 tgtgtcccag taagagagtc acagcttcag gtgtttgctg aatccaggtc tgagatcaca
     2461 atcccacctg aggacaggat ccgcatatga gagtcgcaca ttggtataat tgatttgtgg
     2521 tagagctgag attagaatcc agattcctag tctagtatcc ttcccactgt accacattat
     2581 ctcttttcag aggggaaaaa ggagcagctc ttaagaaaca gaatactaag ggcccccatt
     2641 actgtgtggc cctgggcatc ctcagtttcc tcatttggta aatggggata atggtaccga
     2701 cctcttaggc ttggtgtgag gatgaaatga gatagggaat ataaagcaag cagatagtgg
     2761 ctggcacata gtacatgcaa tatgtttgaa actagttaag gaattataaa aacaaatgag
     2821 ttcttccttc tgctcaaaaa tattgaattt cttgtccttg tgctctgtga aacattgaac
     2881 agccccattt agagaaacaa attctctgcc ctcatagaat cctaattgtt tctgtatgtg
     2941 tctggtgttt tgcacatgca aaaaaaaaaa aaaaagtgct tggatttctc cactttcagt
     3001 cttagggaat aatagggcat gcttcctgtc cccccagctt acttttcatc ttctccaact
     3061 ctcacagttc aaatggctcc agtgctgtgg gtgagtgtgg ccttggttgt tagctaacaa
     3121 ccattcatta gcgaaataac caaattttgt gagcagtaaa tagcaacaag cttcccaatc
     3181 cctgctgccc agccgactgg aaaaactggt ccattccacc tgttcccaga aacctcagta
     3241 cagaggtagc tatatgcata atgttcaccc caaagtaata gatgatttta aagtcttaaa
     3301 agtccaataa aacagtgttc agtataggtt atgataggca tttcattctt taaaactcag
     3361 taattccttt gaaaaaatga tgtttcttta taagcagtag tttgcctaca tcatttactt
     3421 gtttttttct gctttggggt tttttttttt ttgagacaca atttcactct gtcgcccagg
     3481 ctggagtgca gtggtgtgat ctcagctcac tgcaacttct gcctcctggg ttcaagcaat
     3541 tctcatgccc cagcctccca agtagctggg aatacagttg tgtgccacca cactggctta
     3601 ttttttgtat ttttttagta gagatggggt ttcaccatgt tggccaggct ggtctctaac
     3661 tcttatcctc aagtgatctg cctgccttgg cctcccaaag tgctgggatt acaggcatga
     3721 gccaccgcac ctggcctact tatcctgtta atgaaaatat ttgattggac agaacatctt
     3781 attccttaac tctgttatgt gcttttgtag attgttttta cttactgtag atatctgttg
     3841 ctccagagtc ccagaaatca gtatgatgag ttcagcacag ttactagaag gagacaaaaa
     3901 gatatcttct taattaggtg atatcaggga tagttctggt tattgattgc tgtgtggaaa
     3961 acactccaaa actcagtgac tttaaacaac accagtcatt gtgttatttc tcattatcct
     4021 aagtactgac tgggctcagc cagacagttc ttattcgggt tctcatgcag ttatagtcat
     4081 catcagattg tggccgcgac tggcataatc tcaaaggctt ccttagtatt tctggcagtt
     4141 gatgctagga cctcagctag tgctggggct ggaacatgtc tacacatagc ttccccacag
     4201 catggtggct aggtactagg agtgactgtc ccaagaggac caggcagaag cagttacatt
     4261 ttatgaccta gtctcagaag tctcataaca tcacttccac taaagtccca agccccccca
     4321 gattcaaatg gagggagcat atatcccatc tcagtggtag gaatttcaaa gaataaattc
     4381 tgtgaaactg tagtagatag tctgttttct cccctgttta aaacctcctg aggacctcac
     4441 atgcttctgg ataaagctca ggctcttcaa catggtttag aaggtccttc ctaatctggc
     4501 ccacatttgt ccatccagct ccaactcttg ctactctacg cccctcttcc cctcttgtgg
     4561 aatggctaat tcctactcat cattcaggtc ttggcttaga catcttttca tctgagaagg
     4621 ctttctggtc tagtctcacc tggttaggtg aactccccat gtgccccatg tacctcattt
     4681 atcaaagtgc ttatcatatg cctgtcactg tctgttttct tcactagact caggtgccat
     4741 gtctgtcctt tctgctctgt ttgctgggtg cctagcatgg taggggatgt atcagaggat
     4801 tagtacttat ttaactcacc agctcattta actatattgt ataacaatgt tggtggtcat
     4861 attggtcccc catggacagc ttttcgtctc taataccata cactcagtgc agggtctgaa
     4921 tgtcccccca aactcatatg ttgaactcca aatccccaag gtgttggtat tagatgatgt
     4981 agcctttggg aaggaattag ggtggtgccc tcatgaatgg gatttgtgtc attataaaac
     5041 aagcccaaag aaatttggtc accccttcct ttaagcgagg tcatggcaaa aagacgctgt
     5101 ctatgaacca gaaaatgggc tctcactaga caccaaatgc tggtgtcttg ttcttggatt
     5161 tcccagcctt cagaactgtg agaaatatat ttctgttatt tataagccac ccagtttttg
     5221 gtattttgtt atagcagcct gaagagacta agacagccag tcccaacctt ccacatttag
     5281 acctgactcc aagttttgct cagcccactg tgtatccctt cctcctccca accaaagtgt
     5341 ccccactctt tctctattct gttctgccta ttattcaagg tctaacttgt gtcacttttt
     5401 caatgaggca tttgcaagct ctttaaattc tcaaggattc tccattaatt caccatatct
     5461 attttgagaa tctacaaagg acaaggcact acgaaagact ctacatgcca cagggaaaag
     5521 acagacaaga tctctgtccc aacacagaaa attttagcct gccatgttga ctcccaggga
     5581 tctttttgtt tctgtaggag gtgctcatta cagagtggcc aaattcctac tgaagaatgg
     5641 acttggttgt gaaataaaac aatcctgggc aatatttgtt gatagttttg ttgaggatga
     5701 ttcaggaaat aaatacaaac ttttaactac tcataatgaa tattgttggg atattataat
     5761 gaggaggtaa ggatttacct gctacaattt gggtaggcaa aaatgtaggc ttctctgttt
     5821 ctttgcagtg aactaaaact tcttatgaac tctggttata ctgaaaacag gagtcatggg
     5881 agacttgatc ttgcttaaag gatattttag tctttgattt ctttgaggta aatgttcaat
     5941 ctttttgcgt atcttcctcc taccttttca tagccaagat gacagctgaa caggctctca
     6001 tcttaaacct gaacaggcat cagaatcact tggagagctt gttaaaatac agattgatgg
     6061 gccccacccc cagaatatct gattccatac atatgagtca gggcccaaga atttgcatta
     6121 caaatgcatt ctcagatgat gcctttgcta gtctgggcaa cacactttaa gaatagttgg
     6181 tataacagaa agcttgtgtg tcttgtgtgt ctatgtggac aggagttgtg ggcttcagat
     6241 tcatcctctg tgtcctctgg tctcagttgt gaggaggggg aagagtggga agtctggcct
     6301 tgtctctgga ctcctgagta aataatgtgc tgatgcagtg ttgggcccag caggcctttt
     6361 agagggtcat gccagcaccc actgctgagg tctgtagtct ctaccatctg ccctacacat
     6421 aataagtacc cttcctctgc tattctctct tgctgacccc aagcccacca atgaattaat
     6481 tgaatcaaga gttccaaggc attaggttaa agacattgaa aaatatatcc atttattttt
     6541 tcaaatatac ataaagaaat ccatacaaac taaggccaat tgtggcaaaa ctacatgaga
     6601 cttgactaaa ataacccaca attcaaattt ccttcataac atttctacct ataaatttga
     6661 ttcagagaaa ttacacttca tagataaact agccataaaa aagattacag cggcaaaagc
     6721 tatcatcagt aatatttgat atgcataaga aaccgtgagg aaccaaatca tggtaaaatt
     6781 gattctaagg aaatggttgc acaaaaataa aagtgaaatg gtatttttta aaaggaagtg
     6841 gttcaactgt attgcataga aaatgaatca aggaattaca ttggcttaaa tggcattagc
     6901 tcaaaaaagt gttctcaaaa attaatggaa attggtgtat tctgattgag atatgtttta
     6961 ttcaataaca tggagtcaaa acaagaagat tttttaaatg tcctctgttc ccatggagct
     7021 tgcattctgc aagagcaaca gacatcaaaa agataactgg gcaaatgacc acatgattgc
     7081 agttgggata agtgctaagt ctagggtaat cttcatatca ccctgtggca tgtataaagg
     7141 aagacctttt gctggtgttt tgtaaaacca gttgtctgtg tcatttattt taacatgtaa
     7201 agtacactgc cttgtattgt tacagatctt tttctccata tccggtctct cctgaagaac
     7261 agagtattct acatttgttt tatatgaccc caaggtgctt atgtagcata ttatttatac
     7321 atctaatgag gtcttaatat tttttgaaag agtgatttca ttaattaacg gcagatttta
     7381 gttaatatgt acagtctgcc acaatatact ttaggcattt cacagttttc tcataaactg
     7441 gttgctgttt ctgtcccggt tttacacatg acagagccaa gacacagaca agtagaatga
     7501 cttgcctgtg cgggggtcct gggttggcca gtgcattcat gtactggacc agggcccctg
     7561 tatcttgcag taatgtatcc gtgggcgttt ccccccagac attcgaagca cacagctaat
     7621 ctgagaaaga agtgatttgg cgaggggttg ggggagtagg cggtgggcac aacggttcca
     7681 ggtgactttc aagttgctaa tgaaagagga tcaaagcgct gctgaactgc tcacctcccc
     7741 gcttggcctg ccttgcccag ctgactttct tccaagggcc tcagaggcag cattaccaca
     7801 ggcattaaag atggggatgg ggaaagaagg cccagaggga aagggaacca catgcttacc
     7861 tgctaatcac tgccctgcag ctgaaacact gcagagctgg ctgctctggg ataggagagg
     7921 aaggcctcat ttaatcagga gaagaaagag aaccaggggc ctctgagatg gcctgcaagg
     7981 catcacggtc tgtgaactgg tctgtgaact gcgggcctgc ctggaaatgc attgtcagag
     8041 tagagtgatg ctttctttgt aaatcccttg tcttccctga ttcctttttc ctgactgaat
     8101 caggccaaga tgctcaccca gaagagcaca gcatcaccct gtctttcaat ccccaaagta
     8161 gcccttaccc ctagacagca acatcatctg ttacaattga cagcatgaag gaaggcataa
     8221 cccctgcaaa gtgactgccc tacaactcaa tttgattttg aatccgcaag tgcaagtctc
     8281 attcctggta actaatagta acagaatctg ctgatgtatt ctaccgcatc ccagggagac
     8341 tcatgtagcc atgaagactg aagaggatta agttaacctt ccattttata gctgcaaatt
     8401 actgggttga tgtcaggtag ggtgaggagt atgttccggt tatagctggt agcaagatgg
     8461 ctgcatgcat catgaggctt tggcctaaaa agcttgtcat tatataaaaa agctatagag
     8521 agcagagaaa atgtcatttc caatttagaa gatcataatc gatttttaac acattggtcc
     8581 ttaggtgata cagaattcaa caaaaacggg gcttataaaa agccagggtt cataaaatta
     8641 caaagattat agacaaaaat agataacata taagacttac cagctgggca aggtagctca
     8701 agtttgtaat cccagcactt agggaggccg aggcaggcag atcacctgag gtcaggggtt
     8761 ctagaccagc ctggccagca tggtgaaacc ccatctctac taaaaataca aaaaaattag
     8821 ccaggcgtgg tggcgggcat ctgtaatttc agctactcag gaggttgaga cgggagaatt
     8881 gcttgaacct gggagacgga ggttacagtg agcctagact gcgccattgc actctagcct
     8941 aggcgacaag agcgaaacta tgtttcaaat aataataata ataataagac ttaccatttg
     9001 ccaggtcctg tgcaaagcac tttatctcat ttgatccctg ggaaacccca taaagtacta
     9061 ttatgccatt tctcagataa agaaactgaa gctcagagac gtttagttgc ttgcctgtgg
     9121 atataacact agagagcggg agagcacagt atttgaaccc aggaggtctg atgctggagg
     9181 tcatgttttt aaccttatct ctgtattgcc tgcccaagtg ctggctgtgt gcatgtattc
     9241 tcaataatcc ctggccaact tcctgctttg ctgtcagtag cagagctgaa gaacttacaa
     9301 tagacggcag agggcgtcca gagtcactat ttttaaaagg tgctagtttt caaaagcatt
     9361 tctggaattc agagagaaca gaggtccaca tagcaggcta gacaggaaag gtagctgtag
     9421 atagacttta gggagtatat agaatattgc cttcacgcag gttaagaaat atttagtgtt
     9481 gaaaggatac ttttaaaaga gagaaagcag taaagttgat cctctgcaga aagtagacca
     9541 atgtaagtat catgcaatgt gtccatgtgc gtgtacacgt gagcacacat gcacacacac
     9601 attagatgtt ttgtgagaaa acatacactc agtttcttat gaaagaaaaa ggatggtcat
     9661 ttgtctcact tgggaaaggg tttcctccca aattgagaag gaaaatcccc ccaattaact
     9721 gtttgccttt attaactaaa atcacatttg tgtgtgaaag aagtaaaaag gaattaggat
     9781 cttggttatt ttgattgtct ctctaccctt ccagattcat caaatgatag tcaaccttac
     9841 tgtctcttcc tgccatcatc aggaatgact aaatcttgga gcgttctcca tttaagtgag
     9901 ggaaatgttg gattcccggt gtatttatca ctgcccatct ctaagaatag gtcaaagatg
     9961 aaattcccat tatcatgaaa ctttaatata tattgagact tcacagagca ctaactatac
    10021 tggggctggg atggggattc tgatgagaga tatccctgac agagaccaga gctcaggagg
    10081 aagaaaggac agatgccctt gttcaagatg acttcttcat gggcatcgat agatacattc
    10141 ttgaaaacca cccaaagtac ctagaggaga ccctagtgca actgtgcatt gtacaacaac
    10201 tgatgaggta aaagaaacaa actgttaatg actctaaaca atgtggccca cagagttggt
    10261 atggtttggc cacaccagct cagggataaa ggtactagaa aaaatcttgg ggaaaatcct
    10321 attgtacata ttccttacat aatgtctgtg atttacctca cttatcaaat gaaaaaaacc
    10381 caaaacacct ggttgatggc catttggtca aacacctcta ggagtctgga gttgagtggc
    10441 cagaactcag tctttcttta catgctgtgt taagcaggct tttatctcat tcaggtgtta
    10501 gaagtggagg gaggaacaca gttaggctgt gttctactgc actgcatagg gaggcagggt
    10561 atcacccagg cacaacgccc actttgcaag taaataatca gtagcatgaa gctcacttct
    10621 gcaggaccca ccatgacaaa gtggagagct gggcggttaa ccagtgaacc aattgagtgg
    10681 ctctgggctc ctatacccct ttcattccac agcctgtgat acacccttag agtcaaaata
    10741 tcaaattcag tgggccatga gtcttgccca aaagtataaa tctttttttc atatggacta
    10801 tttgggtcta ttttcaaaaa tccctttttc ttctctaaac tatctcaatt ccacatttca
    10861 ctttgcaggt gtagacatga cttttaggtt gttgatgatt taatgctatt gaaatgttct
    10921 tatatgcaaa acacctagat agatgcagag tgtgggacaa agacaaccag cacattgcta
    10981 agcccaagta gcaaatttcc tgaccccatt ttaaaggttc tgagacagat aggcggaata
    11041 ggtccccctg tctttgagta gaagagttgg caagcaagct ggactaaatg ggccatgtgc
    11101 aattttgctg tctgttcaca tttcaaataa actaatgtgt tatga
//
