LOCUS       NM_001244898            8009 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens polypyrimidine tract binding protein 3 (PTBP3),
            transcript variant 6, mRNA.
ACCESSION   NM_001244898
VERSION     NM_001244898.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8009)
  AUTHORS   Zhao,C., Zhao,J.W., Zhang,Y.H., Zhu,Y.D., Yang,Z.Y., Liu,S.L.,
            Tang,Q.Y., Yang,Y., Wang,H.K., Shu,Y.J., Dong,P., Wu,X.S. and
            Gong,W.
  TITLE     PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in
            Gallbladder Cancer
  JOURNAL   Adv Sci (Weinh) 11 (38), e2406633 (2024)
   PUBMED   39116343
  REMARK    GeneRIF: PTBP3 Mediates IL-18 Exon Skipping to Promote Immune
            Escape in Gallbladder Cancer.
REFERENCE   2  (bases 1 to 8009)
  AUTHORS   Dong,D., Wei,J., Wang,W., Zhou,H., Hong,L., Ji,G. and Yang,X.
  TITLE     YTHDC1 promotes the malignant progression of gastric cancer by
            promoting ROD1 translocation to the nucleus
  JOURNAL   Cell Biol Toxicol 40 (1), 19 (2024)
   PUBMED   38573528
  REMARK    GeneRIF: YTHDC1 promotes the malignant progression of gastric
            cancer by promoting ROD1 translocation to the nucleus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8009)
  AUTHORS   Lu,N., Min,J., Peng,L., Huang,S., Chai,X., Wang,S. and Wang,J.
  TITLE     MiR-297 inhibits tumour progression of liver cancer by targeting
            PTBP3
  JOURNAL   Cell Death Dis 14 (8), 564 (2023)
   PUBMED   37633911
  REMARK    GeneRIF: MiR-297 inhibits tumour progression of liver cancer by
            targeting PTBP3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8009)
  AUTHORS   Dong,C., Wu,K., Gu,S., Wang,W., Xie,S. and Zhou,Y.
  TITLE     PTBP3 mediates TGF-beta-induced EMT and metastasis of lung
            adenocarcinoma
  JOURNAL   Cell Cycle 21 (13), 1406-1421 (2022)
   PUBMED   35323096
  REMARK    GeneRIF: PTBP3 mediates TGF-beta-induced EMT and metastasis of lung
            adenocarcinoma.
REFERENCE   5  (bases 1 to 8009)
  AUTHORS   Xie,C., Long,F., Li,L., Li,X., Ma,M., Lu,Z., Wu,R., Zhang,Y.,
            Huang,L., Chou,J., Gong,N., Hu,G. and Lin,C.
  TITLE     PTBP3 modulates P53 expression and promotes colorectal cancer cell
            proliferation by maintaining UBE4A mRNA stability
  JOURNAL   Cell Death Dis 13 (2), 128 (2022)
   PUBMED   35136024
  REMARK    GeneRIF: PTBP3 modulates P53 expression and promotes colorectal
            cancer cell proliferation by maintaining UBE4A mRNA stability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8009)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 8009)
  AUTHORS   Brazao,T.F., Demmers,J., van IJcken,W., Strouboulis,J.,
            Fornerod,M., Romao,L. and Grosveld,F.G.
  TITLE     A new function of ROD1 in nonsense-mediated mRNA decay
  JOURNAL   FEBS Lett 586 (8), 1101-1110 (2012)
   PUBMED   22575643
  REMARK    GeneRIF: ROD1 and UPF1 associate with a significant number of
            common transcripts.
REFERENCE   8  (bases 1 to 8009)
  AUTHORS   Sadvakassova,G., Dobocan,M.C., Difalco,M.R. and Congote,L.F.
  TITLE     Regulator of differentiation 1 (ROD1) binds to the amphipathic
            C-terminal peptide of thrombospondin-4 and is involved in its
            mitogenic activity
  JOURNAL   J Cell Physiol 220 (3), 672-679 (2009)
   PUBMED   19441079
  REMARK    GeneRIF: Regulator of differentiation 1 (ROD1) binds to the
            amphipathic C-terminal peptide of thrombospondin-4 and is involved
            in its mitogenic activity.
REFERENCE   9  (bases 1 to 8009)
  AUTHORS   Robinson,F., Jackson,R.J. and Smith,C.W.
  TITLE     Expression of human nPTB is limited by extreme suboptimal codon
            content
  JOURNAL   PLoS One 3 (3), e1801 (2008)
   PUBMED   18335065
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8009)
  AUTHORS   Yamamoto,H., Tsukahara,K., Kanaoka,Y., Jinno,S. and Okayama,H.
  TITLE     Isolation of a mammalian homologue of a fission yeast
            differentiation regulator
  JOURNAL   Mol Cell Biol 19 (5), 3829-3841 (1999)
   PUBMED   10207106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC044585.1, AL158824.11 and
            BX097575.1.
            
            Summary: The protein encoded by this gene binds RNA and is a
            regulator of cell differentiation. The encoded protein
            preferentially binds to poly(G) and poly(U) sequences in vitro.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (6).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044585.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1969              BC044585.1         2-1970
            1970-7854           AL158824.11        51309-57193         c
            7855-8009           BX097575.1         1-155               c
FEATURES             Location/Qualifiers
     source          1..8009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..8009
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="polypyrimidine tract binding protein 3"
                     /db_xref="GeneID:9991"
                     /db_xref="HGNC:HGNC:10253"
                     /db_xref="MIM:607527"
     exon            1..243
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1860
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="isoform 6 is encoded by transcript variant 6;
                     fission yeast differentiation regulator; regulator of
                     differentiation 1; ROD1 regulator of differentiation 1"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 3 isoform
                     6"
                     /protein_id="NP_001231827.1"
                     /db_xref="CCDS:CCDS59141.1"
                     /db_xref="GeneID:9991"
                     /db_xref="HGNC:HGNC:10253"
                     /db_xref="MIM:607527"
                     /translation="MDASPSPFSLPKKLNELSARRGSDELLSSGIINGPFTMNSSTPS
                     TANGNDSKKFKRDRPPCSPSRVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQ
                     AFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAV
                     SAVQSGSLALSGGPSNEGTVLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKII
                     TFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKS
                     RDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAPAIGFPQATGLSVPAV
                     PGALGPLTITSSAVTGRMAIPGASGIPGNSVLLVTNLNPDLITPHGLFILFGVYGDVH
                     RVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQED
                     QGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFIEAGCSV
                     KAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI"
     exon            244..319
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..489
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..636
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..801
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..912
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1087
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1165
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1305
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1339
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1432
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1649
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1727
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..7996
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7086..7091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="hexamer: ATTAAA"
     polyA_site      7107
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="major polyA site"
     regulatory      7244..7249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="hexamer: AATAAA"
     polyA_site      7276
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
ORIGIN      
        1 gaggtggggc gagcggccga cggcgggtgc acgcgtcggt acacgtctgg gcggcgacct
       61 ggtcgcaagc catggtccca cgcggggtcc cagggccgcc gcgggacttg gccgaggtct
      121 cccgacttgt gctgtgagat acgttaacgc tttctcgaca ccaggggtct ggacttagtg
      181 accatggacg cttccccctc acctttctct ctccccaaga aacttaatga attatctgcc
      241 cgtcggggat ctgatgagct tctttcttct ggcatcatta acggaccttt taccatgaat
      301 agttctactc cttctacagc taatgggaat gacagcaaga aatttaaacg agatagacct
      361 ccctgttcgc cttcccgtgt tctccatctt cgaaaaattc catgtgatgt caccgaagca
      421 gagatcatat cattaggtct accatttggc aaagtaacta atcttttgat gttgaaagga
      481 aaaagccagg ctttcttaga aatggcttct gaggaagctg ccgttactat ggtgaattat
      541 tacactccta ttactcctca ccttcgaagc cagcctgttt atattcagta ttccaatcac
      601 agagaactta agactgacaa tctacctaat caagctcgag cccaagctgc actgcaggct
      661 gtcagtgccg tccaatcagg aagcctggcc ctttctggag gtccttccaa tgaaggcaca
      721 gtcctacctg ggcagagccc tgtgcttcga ataattattg aaaacctctt ttaccctgtt
      781 accctggaag ttcttcatca gatattttct aaatttggca cagtcttgaa gattatcacc
      841 tttacaaaga ataatcagtt tcaagccttg cttcagtatg ctgacccagt aaatgcacat
      901 tatgccaaaa tggctctgga tggccagaat atctataatg catgctgcac tctgcgcatt
      961 gacttctcca agctcaccag ccttaatgtg aaatataata atgacaaaag cagagacttc
     1021 actcgcttag accttcctac tggtgatggc cagccatccc ttgaaccccc tatggctgct
     1081 gcttttggtg caccgggtat aatttcttca ccatatgcag gggctgctgg atttgcccca
     1141 gccattggat ttcctcaagc tacaggtcta tcagttccag ctgttcctgg agctcttggt
     1201 cctctcacaa tcacctcttc tgctgtcact ggaaggatgg ccattcctgg ggctagtggt
     1261 ataccaggaa attctgttct actcgtcaca aatctcaatc ctgatcttat cacaccacat
     1321 gggcttttta tcctatttgg agtctatggt gatgtacatc gagtgaagat tatgtttaat
     1381 aagaaagaaa atgccttggt tcagatggcg gatgcaaatc aagctcagct agcaatgaac
     1441 catctaagtg gtcagagact ttatgggaaa gtgcttcgtg ctacactgtc caaacatcaa
     1501 gcagtacagc ttcctcgaga gggacaagaa gaccaaggtc tgactaagga tttcagcaat
     1561 agtcctttgc atcgctttaa aaagccgggc tctaaaaact tccagaatat ctttccacca
     1621 tcagccactc tgcatctttc caacattccc ccttctgtta cagtggatga tctgaagaac
     1681 cttttcatag aagctggatg ttcagtgaag gcttttaaat tctttcagaa agatcgcaaa
     1741 atggcgctca ttcaattggg atctgtggaa gaagcaattc aggccctcat tgagcttcat
     1801 aaccatgacc ttggagaaaa tcaccacctc agagtttcct tctcaaaatc tacaatctga
     1861 cttttctgtg aatttttctc ctaaaactgg accataattt cagtaaaacc ttcagacata
     1921 gactgaagca gctcaagacc aattttgcct ctttcacaaa aataactctg agtttgatat
     1981 tcaagtatat tttaaaaatc aagggatttt ttttttttgt attccccctg cccccgccag
     2041 tcaaaggttt cttttccctt tttaccatgg tttctacaaa aataaccttc aggaaaaaga
     2101 aaatcaggaa aaaaattttt tttcaataat cttattccct atattaaatt agatttgaag
     2161 aggattaacg ttgttttagt ttgggtccag atcagcctta tacaacattt ctaaactcat
     2221 ttgtactttt aaaaaattta aacacagact tctaaaatta cttgatgtaa gtaatttaaa
     2281 tcacttatga ccaagttatt aaccttatga atcagaagtc tgacccttgt aggaaattat
     2341 attcacatat aaagtacatc agatctttgc catatattga tggttattat gcataaacac
     2401 attgagttgt gttggaagca gatttataaa cctgcatgtt ttctttgaat gatttctttt
     2461 tttcactgta agacactcct ttaaataatg cctatcttta actttttaag actatttgga
     2521 aaaatgcagt gtctcagctg tccccaggga aattaagtgg aattcaacta agatctgtta
     2581 ataagatgtc agaataacta ataattttat taggaaaaaa tcatgtttta aatttcaaaa
     2641 tgacacttat ttgtcaagta atatgatctt ggaaaatttt aaagaaaaat aatcctactt
     2701 ataaactact tttttataat tgttttcaga aaaaaagttt acagtcttaa ggaaaatatt
     2761 caggtctatc atatggtttg acagattttt taaaagttat ttttggtaag gtcttctttt
     2821 agaaaaaaat taatctcaag ggttttttgt accactataa tctctaatac ttactcagaa
     2881 ttactgtgta tttacttaat ttcttattat gtgccttatt atgtgcttaa gatacaatag
     2941 gttagagttt aatctaaata tcttgaaagc tatattgtgg gcttggtaag cattttgttt
     3001 tttctttctc tgttttggta aggatttaaa atttttttca ttgcaatttt aagtggtttt
     3061 caataagtaa tagtttttat caaatttttg gtgcttggtg cagagacggt gtggggaagg
     3121 gtgaatggtt ttgggaataa ttcagtgcac acctgtaggc ctctttacat tgtgactgat
     3181 aggggttatt gcatatcaat ttggggctgt agagtgcaat ctcagtttca tctttttcac
     3241 ccatcagaat ttgtctcagg attacttggt ttttctcagt cctcaagcga gaacttgctt
     3301 ttctttgtta atgtgacttt cattactgag tacccacgta tttggagtat gagaaggtgg
     3361 gttatttctc atactctgtc cctctctttt tcattgaatg taagagtaca ttttaatgtt
     3421 gcttcagtga ttgtataatg taaaattgtt tctttttaat aagaaacttt gctattattt
     3481 cttcaattgt tgatcagaat tttttaaagc agaatttgtc aaaagggtca tttttttgtc
     3541 tacccctttt acacttttca gattctcaaa gtgtctcatc tcaactttta aaagaataaa
     3601 gaatatcttg ctgggcatgg tggtgtgcgc ctgtgcgcct gtagtcccag ctacaggctg
     3661 agcctgtagg caggaggcta caggcaggag gatcacttga gcccaggagt tcaaggctgc
     3721 agtgcgctat gatcacattt gtgaatagcc acttcactcc agccctggaa catagtgtga
     3781 ccccttctct taaaagtaaa aattaagaaa atctcaatct ctttgctgta ttccagtgat
     3841 taatttgaac atagggaggt ttttacagaa gaaattttac caaaaaatag agactgcaag
     3901 agatgataca gattgtttaa aaagcagaat tcactcacca ctgagcaaca cttagttggt
     3961 agaatagaaa ggagggatac taagttaaga cttttcaaat ggatcagttt ggctgaatag
     4021 atagatatac tcatgtatgt agttgtggga gtttttagtt ttttgttttt ttacttatga
     4081 aataagtttt gacctagaca caaggggtat atgaaggagg aaaaaaattt ctttgcaaaa
     4141 tctcccaaaa cttgcttttt tttcccttcc acacaggcac tattataatt ttcagtgcca
     4201 tgttaaattg gattatttca tttactttaa gttaggaatt actgtgtaat ttattaattc
     4261 atgattctca taacattcag cataagtgta gcaaagttgc taataacgga aggggatcat
     4321 agtggtgttg aatgtaactt tgaagtaggg aatggccttt taagtctgag agagaacatt
     4381 tgaatccttt tcagggattt gtgtaggggt gtgtttgtgt gtgtgtgtga atgtgtgtgt
     4441 gtgtagataa gtgtatatac ataaatacac tcttctaaag ttgtatatac atatgcacat
     4501 tacatacatt ttaatttatt gacaaaatta accaaattaa gatttggaga tgtgggatgt
     4561 tcttgtttta aaatagcatg tttgaaacca tcagtttgtg tctaaaatta gctgtagcac
     4621 atggatgttg tccatattaa gctatttgct gtttgaatta tagaggtcta cagtatttgt
     4681 gttggcatag tttttgtaaa aaaaagatta aaaaatatca ggatggtgga aaaactagat
     4741 ctgtgtatct ctgttttggc atgcatttat tcagtatctt ctagcaatgg tttttctctg
     4801 ttgatctacc gtagtatcct atttttaagt ttattttatt tttaaggagt attgtcatca
     4861 cttttcaagg tgtcttgact tctacacaaa gtatatatat tcaggacttt aaaaaatagc
     4921 agtacacatt taacagtagc gaattacacc aaaatgattt actttgagat ttgaataatt
     4981 tgcatagcag taaaatgtgt tttgtgtaac atacaaatag aaaaatgacc cagtatctta
     5041 attgatactt actggagagt atcagaatta cccagcagct cttacagaat gccataaatt
     5101 ctttaagact aaatattgaa atcaattatt tgaagtaatg tttctgattt actgttaaaa
     5161 gttgctgagc tcagtttttg gagatatcat ttatgcctgc ctgttccctt atgacagtga
     5221 ggccttcttt ggctccacct agtatgataa tcatgggttc tgttttagtt gatgagaagt
     5281 ggctcctatg aatgcctctg ctcaatttct ttttatttta ctttatttta tttttagggg
     5341 tctcgccaac tcctgggctc aagtgattct cctgcttcca cctccccaca gtgctgggat
     5401 tacaggcatg agccaccacg cctggctctc tgttcttttc agtgtctccg tgccatcagt
     5461 cagcagtgct tacatgttta gcatattgtc atgcagtttc tcttctgttc ccacgagata
     5521 tttttggaca aaaaattgac aaaagtacat gtgtttttcc ccacctatcc cttagaaaac
     5581 ctaatgtgta ctgctatttt taaaaccaaa aagagacagc gtgacgatgc gtaaagcatt
     5641 tttcttagcc tttcctttgt cttgatctgt taatgagaac aaaactgcca gactcaaaat
     5701 actctactat tgtgctgaaa gaaatacaat ttagattgca caaaatttga aaatataact
     5761 cagctgtctt ttaaaagagt tgtgttgtta tctacaagac tattagcagt cttttttcag
     5821 agcaaatttt aacagctagt tgtgagtggt ttaaaatata gaaaattatt aaaatcttag
     5881 tttgaggggt tttatagtgg gagaaaaaac aggaccaaag tttatgtgcc ttcttcagta
     5941 gtcttaattg accttttctt cctatttgag actaaagtag tatcagtatt ctggttttca
     6001 ggaaatatgt actatatagt tttaaaagaa tgttgtccca ccaactattc atccaagcaa
     6061 agaattgtaa ctataaataa agtctcagtt acacttttgc ctttatcaca taatattcat
     6121 tgtagagcat tgtgcaggtc caagaataga gctgctcaaa atctttgtgg tagtttcctt
     6181 agtttttgta acctgaggca tatgttccag agaacaggga tatttgtctg gtccagtgac
     6241 cttggtgatc atagtcataa ttgaaagatg cctatggcat gcttaaatca gcattgtcaa
     6301 ctgatttgtt gttgtattat tttcacttct tggatctatg tagtagttgt aataacaaat
     6361 atttaaatag ctattttttt gatgccatta aaaaaatcat actctggcct tttttccccc
     6421 ttactgttgt ttcccagatc ttttaaaaat tcatcccata tccagaaagt accagttata
     6481 aagattgctg accaagcaaa gttttgcatc aaagtgtcac ctcattgctc tgaccaaaga
     6541 ctgactgttg tggttttaac tcctctctgt aaagcatttt gcattttccc caagctcctt
     6601 tctgaaagaa gaaccagtgc agagcggcct ttactttcaa tttctactgc tgaatagact
     6661 acttagagaa aatgtgagtt tcagtgtgaa cagaatggat taggatgacg agtttgatgg
     6721 gcattttcag tactgtatct aagaaaaaaa aaatagcaca gctaggagcc tctgacattg
     6781 tctggtgttt tacgtggtct gttcatcaaa attccccttt tcagttttta agaatgttcg
     6841 tctaacagaa gaaaatgctg taaatatttg taacaacatt ttttttaaca aggccaaaaa
     6901 agaaaaaaag gtttttggga acaaatgaac ttataaagtg gttttatata aaacatcaat
     6961 tgtcttgtat attttggata agcagcagta ccagctttca tttgtaacag tctgtggcat
     7021 tggaaaaaaa ggagtctgtg attgttgaag tgaattatgt tataaatgca aagagaagat
     7081 aaaatattaa aaaacatatt ttctaaatgc gtagtgcatg gttaattcaa gcttctgtac
     7141 actacagtat attccatttt cgttcagttt gtatatttgc tgactattac ttgatatctc
     7201 taatctcttt tcctaacaaa tatagcattg tagcatgcct tttaataaat gtcatgacat
     7261 ctgtactctc ttaaaatttt tctgtgttct tgtctgtact ttgggtttcc ctttgtctta
     7321 cctgtaattc taatgatgtc ctattttctt ttcttttcca tagccatcca tctaaacgtg
     7381 tcatggttag tgaatagtga gcacatattc aaacaatgtt caaaatggga aaaacacaaa
     7441 atctattaac tgtctctgtc ttcatttagg aataattctc gttttgagga gcaaagtgct
     7501 ttcctaatct tcctatgatg caccttctct ggcactgccc cgtaatgcag gggcatggcg
     7561 gcatgctttc ttgcttgcac actcactctc ctttttcttt ctctctttct ccccatatgt
     7621 gcagtgccaa actacagttg gaacactatt tccagttttg ttcagtattt ggcttcccta
     7681 cggcattagt atacatacac tttgagacac aaggtgtgat ctcaaaccaa atttgtgtcc
     7741 tctttaaaaa ggtagcacag atactagctg atgctacatt ccttttcctt agacaaacgt
     7801 tttacttctc agatctttaa agaattgttg gattgcagaa gtctagactt agcgttcatt
     7861 gtatatttta gtctcctgga agtgggaatt tattttgaat ggaatagaaa attaggtaat
     7921 cactactaat ctttgctggc ttacctgtaa aatctgtggt ctccataaat actgggaaaa
     7981 taaataggta tttttaaaaa aaaaaaaaa
//
