LOCUS       NM_001244896            7742 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens polypyrimidine tract binding protein 3 (PTBP3),
            transcript variant 4, mRNA.
ACCESSION   NM_001244896
VERSION     NM_001244896.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7742)
  AUTHORS   Zhao,C., Zhao,J.W., Zhang,Y.H., Zhu,Y.D., Yang,Z.Y., Liu,S.L.,
            Tang,Q.Y., Yang,Y., Wang,H.K., Shu,Y.J., Dong,P., Wu,X.S. and
            Gong,W.
  TITLE     PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in
            Gallbladder Cancer
  JOURNAL   Adv Sci (Weinh) 11 (38), e2406633 (2024)
   PUBMED   39116343
  REMARK    GeneRIF: PTBP3 Mediates IL-18 Exon Skipping to Promote Immune
            Escape in Gallbladder Cancer.
REFERENCE   2  (bases 1 to 7742)
  AUTHORS   Dong,D., Wei,J., Wang,W., Zhou,H., Hong,L., Ji,G. and Yang,X.
  TITLE     YTHDC1 promotes the malignant progression of gastric cancer by
            promoting ROD1 translocation to the nucleus
  JOURNAL   Cell Biol Toxicol 40 (1), 19 (2024)
   PUBMED   38573528
  REMARK    GeneRIF: YTHDC1 promotes the malignant progression of gastric
            cancer by promoting ROD1 translocation to the nucleus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7742)
  AUTHORS   Lu,N., Min,J., Peng,L., Huang,S., Chai,X., Wang,S. and Wang,J.
  TITLE     MiR-297 inhibits tumour progression of liver cancer by targeting
            PTBP3
  JOURNAL   Cell Death Dis 14 (8), 564 (2023)
   PUBMED   37633911
  REMARK    GeneRIF: MiR-297 inhibits tumour progression of liver cancer by
            targeting PTBP3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7742)
  AUTHORS   Dong,C., Wu,K., Gu,S., Wang,W., Xie,S. and Zhou,Y.
  TITLE     PTBP3 mediates TGF-beta-induced EMT and metastasis of lung
            adenocarcinoma
  JOURNAL   Cell Cycle 21 (13), 1406-1421 (2022)
   PUBMED   35323096
  REMARK    GeneRIF: PTBP3 mediates TGF-beta-induced EMT and metastasis of lung
            adenocarcinoma.
REFERENCE   5  (bases 1 to 7742)
  AUTHORS   Xie,C., Long,F., Li,L., Li,X., Ma,M., Lu,Z., Wu,R., Zhang,Y.,
            Huang,L., Chou,J., Gong,N., Hu,G. and Lin,C.
  TITLE     PTBP3 modulates P53 expression and promotes colorectal cancer cell
            proliferation by maintaining UBE4A mRNA stability
  JOURNAL   Cell Death Dis 13 (2), 128 (2022)
   PUBMED   35136024
  REMARK    GeneRIF: PTBP3 modulates P53 expression and promotes colorectal
            cancer cell proliferation by maintaining UBE4A mRNA stability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7742)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 7742)
  AUTHORS   Brazao,T.F., Demmers,J., van IJcken,W., Strouboulis,J.,
            Fornerod,M., Romao,L. and Grosveld,F.G.
  TITLE     A new function of ROD1 in nonsense-mediated mRNA decay
  JOURNAL   FEBS Lett 586 (8), 1101-1110 (2012)
   PUBMED   22575643
  REMARK    GeneRIF: ROD1 and UPF1 associate with a significant number of
            common transcripts.
REFERENCE   8  (bases 1 to 7742)
  AUTHORS   Sadvakassova,G., Dobocan,M.C., Difalco,M.R. and Congote,L.F.
  TITLE     Regulator of differentiation 1 (ROD1) binds to the amphipathic
            C-terminal peptide of thrombospondin-4 and is involved in its
            mitogenic activity
  JOURNAL   J Cell Physiol 220 (3), 672-679 (2009)
   PUBMED   19441079
  REMARK    GeneRIF: Regulator of differentiation 1 (ROD1) binds to the
            amphipathic C-terminal peptide of thrombospondin-4 and is involved
            in its mitogenic activity.
REFERENCE   9  (bases 1 to 7742)
  AUTHORS   Robinson,F., Jackson,R.J. and Smith,C.W.
  TITLE     Expression of human nPTB is limited by extreme suboptimal codon
            content
  JOURNAL   PLoS One 3 (3), e1801 (2008)
   PUBMED   18335065
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7742)
  AUTHORS   Yamamoto,H., Tsukahara,K., Kanaoka,Y., Jinno,S. and Okayama,H.
  TITLE     Isolation of a mammalian homologue of a fission yeast
            differentiation regulator
  JOURNAL   Mol Cell Biol 19 (5), 3829-3841 (1999)
   PUBMED   10207106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN371677.1, AK001685.1,
            AL158824.11 and BX097575.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001244896.1.
            
            Summary: The protein encoded by this gene binds RNA and is a
            regulator of cell differentiation. The encoded protein
            preferentially binds to poly(G) and poly(U) sequences in vitro.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            coding sequence, uses an alternate in-frame splice junction at the
            3' end of an exon, and lacks an alternate coding exon compared to
            variant 6. The resulting isoform (4) has a shorter and distinct
            N-terminus compared to isoform 6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2303796.1,
                                           SRR7346977.2420583.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CN371677.1         46-86
            42-722              AK001685.1         7-687
            723-723             AL158824.11        84491-84491         c
            724-1281            AK001685.1         689-1246
            1282-1282           AL158824.11        60976-60976         c
            1283-1715           AK001685.1         1248-1680
            1716-7600           AL158824.11        51309-57193         c
            7601-7742           BX097575.1         14-155              c
FEATURES             Location/Qualifiers
     source          1..7742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..7742
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="polypyrimidine tract binding protein 3"
                     /db_xref="GeneID:9991"
                     /db_xref="HGNC:HGNC:10253"
                     /db_xref="MIM:607527"
     exon            1..150
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..235
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1606
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     fission yeast differentiation regulator; regulator of
                     differentiation 1; ROD1 regulator of differentiation 1"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 3 isoform
                     4"
                     /protein_id="NP_001231825.1"
                     /db_xref="CCDS:CCDS59140.1"
                     /db_xref="GeneID:9991"
                     /db_xref="HGNC:HGNC:10253"
                     /db_xref="MIM:607527"
                     /translation="MAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKTD
                     NLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSPVLRIIIENLFYPVTLEV
                     LHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDF
                     SKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAP
                     AIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVLLVTNLNPDLIT
                     PHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATL
                     SKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVT
                     VDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRV
                     SFSKSTI"
     exon            236..382
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..547
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..658
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..833
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..911
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1051
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1085
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1178
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1395
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1473
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..7742
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6832..6837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="hexamer: ATTAAA"
     polyA_site      6853
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="major polyA site"
     regulatory      6990..6995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="hexamer: AATAAA"
     polyA_site      7022
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
ORIGIN      
        1 actctccttc cacctcggac cggccggggc tccgcagagc caaagctcgc ttgtccccgg
       61 aaccgccctg ctgccgccgc ctgcttcctc tgctcgcggt tagcccgtca gtccctgctc
      121 tgtgcgcgcc tccatctggg ccatggatgg cggggatctg atgagcttct ttcttctggc
      181 atcattaacg gaccttttac catgaatagt tctactcctt ctacaggtgt gtatggcttt
      241 cttagaaatg gcttctgagg aagctgccgt tactatggtg aattattaca ctcctattac
      301 tcctcacctt cgaagccagc ctgtttatat tcagtattcc aatcacagag aacttaagac
      361 tgacaatcta cctaatcaag ctcgagccca agctgcactg caggctgtca gtgccgtcca
      421 atcaggaagc ctggcccttt ctggaggtcc ttccaatgaa ggcacagtcc tacctgggca
      481 gagccctgtg cttcgaataa ttattgaaaa cctcttttac cctgttaccc tggaagttct
      541 tcatcagata ttttctaaat ttggcacagt cttgaagatt atcaccttta caaagaataa
      601 tcagtttcaa gccttgcttc agtatgctga cccagtaaat gcacattatg ccaaaatggc
      661 tctggatggc cagaatatct ataatgcatg ctgcactctg cgcattgact tctccaagct
      721 caccagcctt aatgtgaaat ataataatga caaaagcaga gacttcactc gcttagacct
      781 tcctactggt gatggccagc catcccttga accccctatg gctgctgctt ttggtgcacc
      841 gggtataatt tcttcaccat atgcaggggc tgctggattt gccccagcca ttggatttcc
      901 tcaagctaca ggtctatcag ttccagctgt tcctggagct cttggtcctc tcacaatcac
      961 ctcttctgct gtcactggaa ggatggccat tcctggggct agtggtatac caggaaattc
     1021 tgttctactc gtcacaaatc tcaatcctga tcttatcaca ccacatgggc tttttatcct
     1081 atttggagtc tatggtgatg tacatcgagt gaagattatg tttaataaga aagaaaatgc
     1141 cttggttcag atggcggatg caaatcaagc tcagctagca atgaaccatc taagtggtca
     1201 gagactttat gggaaagtgc ttcgtgctac actgtccaaa catcaagcag tacagcttcc
     1261 tcgagaggga caagaagacc aaggtctgac taaggatttc agcaatagtc ctttgcatcg
     1321 ctttaaaaag ccgggctcta aaaacttcca gaatatcttt ccaccatcag ccactctgca
     1381 tctttccaac attccccctt ctgttacagt ggatgatctg aagaaccttt tcatagaagc
     1441 tggatgttca gtgaaggctt ttaaattctt tcagaaagat cgcaaaatgg cgctcattca
     1501 attgggatct gtggaagaag caattcaggc cctcattgag cttcataacc atgaccttgg
     1561 agaaaatcac cacctcagag tttccttctc aaaatctaca atctgacttt tctgtgaatt
     1621 tttctcctaa aactggacca taatttcagt aaaaccttca gacatagact gaagcagctc
     1681 aagaccaatt ttgcctcttt cacaaaaata actctgagtt tgatattcaa gtatatttta
     1741 aaaatcaagg gatttttttt ttttgtattc cccctgcccc cgccagtcaa aggtttcttt
     1801 tcccttttta ccatggtttc tacaaaaata accttcagga aaaagaaaat caggaaaaaa
     1861 attttttttc aataatctta ttccctatat taaattagat ttgaagagga ttaacgttgt
     1921 tttagtttgg gtccagatca gccttataca acatttctaa actcatttgt acttttaaaa
     1981 aatttaaaca cagacttcta aaattacttg atgtaagtaa tttaaatcac ttatgaccaa
     2041 gttattaacc ttatgaatca gaagtctgac ccttgtagga aattatattc acatataaag
     2101 tacatcagat ctttgccata tattgatggt tattatgcat aaacacattg agttgtgttg
     2161 gaagcagatt tataaacctg catgttttct ttgaatgatt tctttttttc actgtaagac
     2221 actcctttaa ataatgccta tctttaactt tttaagacta tttggaaaaa tgcagtgtct
     2281 cagctgtccc cagggaaatt aagtggaatt caactaagat ctgttaataa gatgtcagaa
     2341 taactaataa ttttattagg aaaaaatcat gttttaaatt tcaaaatgac acttatttgt
     2401 caagtaatat gatcttggaa aattttaaag aaaaataatc ctacttataa actacttttt
     2461 tataattgtt ttcagaaaaa aagtttacag tcttaaggaa aatattcagg tctatcatat
     2521 ggtttgacag attttttaaa agttattttt ggtaaggtct tcttttagaa aaaaattaat
     2581 ctcaagggtt ttttgtacca ctataatctc taatacttac tcagaattac tgtgtattta
     2641 cttaatttct tattatgtgc cttattatgt gcttaagata caataggtta gagtttaatc
     2701 taaatatctt gaaagctata ttgtgggctt ggtaagcatt ttgttttttc tttctctgtt
     2761 ttggtaagga tttaaaattt ttttcattgc aattttaagt ggttttcaat aagtaatagt
     2821 ttttatcaaa tttttggtgc ttggtgcaga gacggtgtgg ggaagggtga atggttttgg
     2881 gaataattca gtgcacacct gtaggcctct ttacattgtg actgataggg gttattgcat
     2941 atcaatttgg ggctgtagag tgcaatctca gtttcatctt tttcacccat cagaatttgt
     3001 ctcaggatta cttggttttt ctcagtcctc aagcgagaac ttgcttttct ttgttaatgt
     3061 gactttcatt actgagtacc cacgtatttg gagtatgaga aggtgggtta tttctcatac
     3121 tctgtccctc tctttttcat tgaatgtaag agtacatttt aatgttgctt cagtgattgt
     3181 ataatgtaaa attgtttctt tttaataaga aactttgcta ttatttcttc aattgttgat
     3241 cagaattttt taaagcagaa tttgtcaaaa gggtcatttt tttgtctacc ccttttacac
     3301 ttttcagatt ctcaaagtgt ctcatctcaa cttttaaaag aataaagaat atcttgctgg
     3361 gcatggtggt gtgcgcctgt gcgcctgtag tcccagctac aggctgagcc tgtaggcagg
     3421 aggctacagg caggaggatc acttgagccc aggagttcaa ggctgcagtg cgctatgatc
     3481 acatttgtga atagccactt cactccagcc ctggaacata gtgtgacccc ttctcttaaa
     3541 agtaaaaatt aagaaaatct caatctcttt gctgtattcc agtgattaat ttgaacatag
     3601 ggaggttttt acagaagaaa ttttaccaaa aaatagagac tgcaagagat gatacagatt
     3661 gtttaaaaag cagaattcac tcaccactga gcaacactta gttggtagaa tagaaaggag
     3721 ggatactaag ttaagacttt tcaaatggat cagtttggct gaatagatag atatactcat
     3781 gtatgtagtt gtgggagttt ttagtttttt gtttttttac ttatgaaata agttttgacc
     3841 tagacacaag gggtatatga aggaggaaaa aaatttcttt gcaaaatctc ccaaaacttg
     3901 cttttttttc ccttccacac aggcactatt ataattttca gtgccatgtt aaattggatt
     3961 atttcattta ctttaagtta ggaattactg tgtaatttat taattcatga ttctcataac
     4021 attcagcata agtgtagcaa agttgctaat aacggaaggg gatcatagtg gtgttgaatg
     4081 taactttgaa gtagggaatg gccttttaag tctgagagag aacatttgaa tccttttcag
     4141 ggatttgtgt aggggtgtgt ttgtgtgtgt gtgtgaatgt gtgtgtgtgt agataagtgt
     4201 atatacataa atacactctt ctaaagttgt atatacatat gcacattaca tacattttaa
     4261 tttattgaca aaattaacca aattaagatt tggagatgtg ggatgttctt gttttaaaat
     4321 agcatgtttg aaaccatcag tttgtgtcta aaattagctg tagcacatgg atgttgtcca
     4381 tattaagcta tttgctgttt gaattataga ggtctacagt atttgtgttg gcatagtttt
     4441 tgtaaaaaaa agattaaaaa atatcaggat ggtggaaaaa ctagatctgt gtatctctgt
     4501 tttggcatgc atttattcag tatcttctag caatggtttt tctctgttga tctaccgtag
     4561 tatcctattt ttaagtttat tttattttta aggagtattg tcatcacttt tcaaggtgtc
     4621 ttgacttcta cacaaagtat atatattcag gactttaaaa aatagcagta cacatttaac
     4681 agtagcgaat tacaccaaaa tgatttactt tgagatttga ataatttgca tagcagtaaa
     4741 atgtgttttg tgtaacatac aaatagaaaa atgacccagt atcttaattg atacttactg
     4801 gagagtatca gaattaccca gcagctctta cagaatgcca taaattcttt aagactaaat
     4861 attgaaatca attatttgaa gtaatgtttc tgatttactg ttaaaagttg ctgagctcag
     4921 tttttggaga tatcatttat gcctgcctgt tcccttatga cagtgaggcc ttctttggct
     4981 ccacctagta tgataatcat gggttctgtt ttagttgatg agaagtggct cctatgaatg
     5041 cctctgctca atttcttttt attttacttt attttatttt taggggtctc gccaactcct
     5101 gggctcaagt gattctcctg cttccacctc cccacagtgc tgggattaca ggcatgagcc
     5161 accacgcctg gctctctgtt cttttcagtg tctccgtgcc atcagtcagc agtgcttaca
     5221 tgtttagcat attgtcatgc agtttctctt ctgttcccac gagatatttt tggacaaaaa
     5281 attgacaaaa gtacatgtgt ttttccccac ctatccctta gaaaacctaa tgtgtactgc
     5341 tatttttaaa accaaaaaga gacagcgtga cgatgcgtaa agcatttttc ttagcctttc
     5401 ctttgtcttg atctgttaat gagaacaaaa ctgccagact caaaatactc tactattgtg
     5461 ctgaaagaaa tacaatttag attgcacaaa atttgaaaat ataactcagc tgtcttttaa
     5521 aagagttgtg ttgttatcta caagactatt agcagtcttt tttcagagca aattttaaca
     5581 gctagttgtg agtggtttaa aatatagaaa attattaaaa tcttagtttg aggggtttta
     5641 tagtgggaga aaaaacagga ccaaagttta tgtgccttct tcagtagtct taattgacct
     5701 tttcttccta tttgagacta aagtagtatc agtattctgg ttttcaggaa atatgtacta
     5761 tatagtttta aaagaatgtt gtcccaccaa ctattcatcc aagcaaagaa ttgtaactat
     5821 aaataaagtc tcagttacac ttttgccttt atcacataat attcattgta gagcattgtg
     5881 caggtccaag aatagagctg ctcaaaatct ttgtggtagt ttccttagtt tttgtaacct
     5941 gaggcatatg ttccagagaa cagggatatt tgtctggtcc agtgaccttg gtgatcatag
     6001 tcataattga aagatgccta tggcatgctt aaatcagcat tgtcaactga tttgttgttg
     6061 tattattttc acttcttgga tctatgtagt agttgtaata acaaatattt aaatagctat
     6121 ttttttgatg ccattaaaaa aatcatactc tggccttttt tcccccttac tgttgtttcc
     6181 cagatctttt aaaaattcat cccatatcca gaaagtacca gttataaaga ttgctgacca
     6241 agcaaagttt tgcatcaaag tgtcacctca ttgctctgac caaagactga ctgttgtggt
     6301 tttaactcct ctctgtaaag cattttgcat tttccccaag ctcctttctg aaagaagaac
     6361 cagtgcagag cggcctttac tttcaatttc tactgctgaa tagactactt agagaaaatg
     6421 tgagtttcag tgtgaacaga atggattagg atgacgagtt tgatgggcat tttcagtact
     6481 gtatctaaga aaaaaaaaat agcacagcta ggagcctctg acattgtctg gtgttttacg
     6541 tggtctgttc atcaaaattc cccttttcag tttttaagaa tgttcgtcta acagaagaaa
     6601 atgctgtaaa tatttgtaac aacatttttt ttaacaaggc caaaaaagaa aaaaaggttt
     6661 ttgggaacaa atgaacttat aaagtggttt tatataaaac atcaattgtc ttgtatattt
     6721 tggataagca gcagtaccag ctttcatttg taacagtctg tggcattgga aaaaaaggag
     6781 tctgtgattg ttgaagtgaa ttatgttata aatgcaaaga gaagataaaa tattaaaaaa
     6841 catattttct aaatgcgtag tgcatggtta attcaagctt ctgtacacta cagtatattc
     6901 cattttcgtt cagtttgtat atttgctgac tattacttga tatctctaat ctcttttcct
     6961 aacaaatata gcattgtagc atgcctttta ataaatgtca tgacatctgt actctcttaa
     7021 aatttttctg tgttcttgtc tgtactttgg gtttcccttt gtcttacctg taattctaat
     7081 gatgtcctat tttcttttct tttccatagc catccatcta aacgtgtcat ggttagtgaa
     7141 tagtgagcac atattcaaac aatgttcaaa atgggaaaaa cacaaaatct attaactgtc
     7201 tctgtcttca tttaggaata attctcgttt tgaggagcaa agtgctttcc taatcttcct
     7261 atgatgcacc ttctctggca ctgccccgta atgcaggggc atggcggcat gctttcttgc
     7321 ttgcacactc actctccttt ttctttctct ctttctcccc atatgtgcag tgccaaacta
     7381 cagttggaac actatttcca gttttgttca gtatttggct tccctacggc attagtatac
     7441 atacactttg agacacaagg tgtgatctca aaccaaattt gtgtcctctt taaaaaggta
     7501 gcacagatac tagctgatgc tacattcctt ttccttagac aaacgtttta cttctcagat
     7561 ctttaaagaa ttgttggatt gcagaagtct agacttagcg ttcattgtat attttagtct
     7621 cctggaagtg ggaatttatt ttgaatggaa tagaaaatta ggtaatcact actaatcttt
     7681 gctggcttac ctgtaaaatc tgtggtctcc ataaatactg ggaaaataaa taggtatttt
     7741 ta
//
