LOCUS       NM_001163788            7192 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens polypyrimidine tract binding protein 3 (PTBP3),
            transcript variant 2, mRNA.
ACCESSION   NM_001163788
VERSION     NM_001163788.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7192)
  AUTHORS   Zhao,C., Zhao,J.W., Zhang,Y.H., Zhu,Y.D., Yang,Z.Y., Liu,S.L.,
            Tang,Q.Y., Yang,Y., Wang,H.K., Shu,Y.J., Dong,P., Wu,X.S. and
            Gong,W.
  TITLE     PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in
            Gallbladder Cancer
  JOURNAL   Adv Sci (Weinh) 11 (38), e2406633 (2024)
   PUBMED   39116343
  REMARK    GeneRIF: PTBP3 Mediates IL-18 Exon Skipping to Promote Immune
            Escape in Gallbladder Cancer.
REFERENCE   2  (bases 1 to 7192)
  AUTHORS   Dong,D., Wei,J., Wang,W., Zhou,H., Hong,L., Ji,G. and Yang,X.
  TITLE     YTHDC1 promotes the malignant progression of gastric cancer by
            promoting ROD1 translocation to the nucleus
  JOURNAL   Cell Biol Toxicol 40 (1), 19 (2024)
   PUBMED   38573528
  REMARK    GeneRIF: YTHDC1 promotes the malignant progression of gastric
            cancer by promoting ROD1 translocation to the nucleus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7192)
  AUTHORS   Lu,N., Min,J., Peng,L., Huang,S., Chai,X., Wang,S. and Wang,J.
  TITLE     MiR-297 inhibits tumour progression of liver cancer by targeting
            PTBP3
  JOURNAL   Cell Death Dis 14 (8), 564 (2023)
   PUBMED   37633911
  REMARK    GeneRIF: MiR-297 inhibits tumour progression of liver cancer by
            targeting PTBP3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7192)
  AUTHORS   Dong,C., Wu,K., Gu,S., Wang,W., Xie,S. and Zhou,Y.
  TITLE     PTBP3 mediates TGF-beta-induced EMT and metastasis of lung
            adenocarcinoma
  JOURNAL   Cell Cycle 21 (13), 1406-1421 (2022)
   PUBMED   35323096
  REMARK    GeneRIF: PTBP3 mediates TGF-beta-induced EMT and metastasis of lung
            adenocarcinoma.
REFERENCE   5  (bases 1 to 7192)
  AUTHORS   Xie,C., Long,F., Li,L., Li,X., Ma,M., Lu,Z., Wu,R., Zhang,Y.,
            Huang,L., Chou,J., Gong,N., Hu,G. and Lin,C.
  TITLE     PTBP3 modulates P53 expression and promotes colorectal cancer cell
            proliferation by maintaining UBE4A mRNA stability
  JOURNAL   Cell Death Dis 13 (2), 128 (2022)
   PUBMED   35136024
  REMARK    GeneRIF: PTBP3 modulates P53 expression and promotes colorectal
            cancer cell proliferation by maintaining UBE4A mRNA stability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7192)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 7192)
  AUTHORS   Brazao,T.F., Demmers,J., van IJcken,W., Strouboulis,J.,
            Fornerod,M., Romao,L. and Grosveld,F.G.
  TITLE     A new function of ROD1 in nonsense-mediated mRNA decay
  JOURNAL   FEBS Lett 586 (8), 1101-1110 (2012)
   PUBMED   22575643
  REMARK    GeneRIF: ROD1 and UPF1 associate with a significant number of
            common transcripts.
REFERENCE   8  (bases 1 to 7192)
  AUTHORS   Sadvakassova,G., Dobocan,M.C., Difalco,M.R. and Congote,L.F.
  TITLE     Regulator of differentiation 1 (ROD1) binds to the amphipathic
            C-terminal peptide of thrombospondin-4 and is involved in its
            mitogenic activity
  JOURNAL   J Cell Physiol 220 (3), 672-679 (2009)
   PUBMED   19441079
  REMARK    GeneRIF: Regulator of differentiation 1 (ROD1) binds to the
            amphipathic C-terminal peptide of thrombospondin-4 and is involved
            in its mitogenic activity.
REFERENCE   9  (bases 1 to 7192)
  AUTHORS   Robinson,F., Jackson,R.J. and Smith,C.W.
  TITLE     Expression of human nPTB is limited by extreme suboptimal codon
            content
  JOURNAL   PLoS One 3 (3), e1801 (2008)
   PUBMED   18335065
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7192)
  AUTHORS   Yamamoto,H., Tsukahara,K., Kanaoka,Y., Jinno,S. and Okayama,H.
  TITLE     Isolation of a mammalian homologue of a fission yeast
            differentiation regulator
  JOURNAL   Mol Cell Biol 19 (5), 3829-3841 (1999)
   PUBMED   10207106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN371677.1, AK302558.1 and
            AL158824.11.
            
            On Nov 6, 2019 this sequence version replaced NM_001163788.3.
            
            Summary: The protein encoded by this gene binds RNA and is a
            regulator of cell differentiation. The encoded protein
            preferentially binds to poly(G) and poly(U) sequences in vitro.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence and uses an alternate in-frame splice junction at
            the 3' end of an exon compared to variant 6. The resulting isoform
            (2) is shorter at the N-terminus and contains an alternate short
            internal segment compared to isoform 6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.27654.1,
                                           SRR18074968.953916.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374257.6/ ENSP00000363375.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CN371677.1         46-86
            42-1841             AK302558.1         4-1803
            1842-7192           AL158824.11        51887-57237         c
FEATURES             Location/Qualifiers
     source          1..7192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..7192
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="polypyrimidine tract binding protein 3"
                     /db_xref="GeneID:9991"
                     /db_xref="HGNC:HGNC:10253"
                     /db_xref="MIM:607527"
     exon            1..150
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..235
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1776
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     fission yeast differentiation regulator; regulator of
                     differentiation 1; ROD1 regulator of differentiation 1"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 3 isoform
                     2"
                     /protein_id="NP_001157260.1"
                     /db_xref="CCDS:CCDS55332.1"
                     /db_xref="GeneID:9991"
                     /db_xref="HGNC:HGNC:10253"
                     /db_xref="MIM:607527"
                     /translation="MNSSTPSTGVYANGNDSKKFKRDRPPCSPSRVLHLRKIPCDVTE
                     AEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQY
                     SNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSPVLRIIIEN
                     LFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYN
                     ACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSP
                     YAGAAGFAPAIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVLLV
                     TNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRL
                     YGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLH
                     LSNIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHD
                     LGENHHLRVSFSKSTI"
     exon            236..405
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..552
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..717
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..828
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1003
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1081
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1221
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1255
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1348
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1565
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1643
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..7192
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7002..7007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="hexamer: ATTAAA"
     polyA_site      7023
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="major polyA site"
     regulatory      7160..7165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /note="hexamer: AATAAA"
     polyA_site      7192
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
ORIGIN      
        1 actctccttc cacctcggac cggccggggc tccgcagagc caaagctcgc ttgtccccgg
       61 aaccgccctg ctgccgccgc ctgcttcctc tgctcgcggt tagcccgtca gtccctgctc
      121 tgtgcgcgcc tccatctggg ccatggatgg cggggatctg atgagcttct ttcttctggc
      181 atcattaacg gaccttttac catgaatagt tctactcctt ctacaggtgt gtatgctaat
      241 gggaatgaca gcaagaaatt taaacgagat agacctccct gttcgccttc ccgtgttctc
      301 catcttcgaa aaattccatg tgatgtcacc gaagcagaga tcatatcatt aggtctacca
      361 tttggcaaag taactaatct tttgatgttg aaaggaaaaa gccaggcttt cttagaaatg
      421 gcttctgagg aagctgccgt tactatggtg aattattaca ctcctattac tcctcacctt
      481 cgaagccagc ctgtttatat tcagtattcc aatcacagag aacttaagac tgacaatcta
      541 cctaatcaag ctcgagccca agctgcactg caggctgtca gtgccgtcca atcaggaagc
      601 ctggcccttt ctggaggtcc ttccaatgaa ggcacagtcc tacctgggca gagccctgtg
      661 cttcgaataa ttattgaaaa cctcttttac cctgttaccc tggaagttct tcatcagata
      721 ttttctaaat ttggcacagt cttgaagatt atcaccttta caaagaataa tcagtttcaa
      781 gccttgcttc agtatgctga cccagtaaat gcacattatg ccaaaatggc tctggatggc
      841 cagaatatct ataatgcatg ctgcactctg cgcattgact tctccaagct caccagcctt
      901 aatgtgaaat ataataatga caaaagcaga gacttcactc gcttagacct tcctactggt
      961 gatggccagc catcccttga accccctatg gctgctgctt ttggtgcacc gggtataatt
     1021 tcttcaccat atgcaggggc tgctggattt gccccagcca ttggatttcc tcaagctaca
     1081 ggtctatcag ttccagctgt tcctggagct cttggtcctc tcacaatcac ctcttctgct
     1141 gtcactggaa ggatggccat tcctggggct agtggtatac caggaaattc tgttctactc
     1201 gtcacaaatc tcaatcctga tcttatcaca ccacatgggc tttttatcct atttggagtc
     1261 tatggtgatg tacatcgagt gaagattatg tttaataaga aagaaaatgc cttggttcag
     1321 atggcggatg caaatcaagc tcagctagca atgaaccatc taagtggtca gagactttat
     1381 gggaaagtgc ttcgtgctac actgtccaaa catcaagcag tacagcttcc tcgagaggga
     1441 caagaagacc aaggtctgac taaggatttc agcaatagtc ctttgcatcg ctttaaaaag
     1501 ccgggctcta aaaacttcca gaatatcttt ccaccatcag ccactctgca tctttccaac
     1561 attccccctt ctgttacagt ggatgatctg aagaaccttt tcatagaagc tggatgttca
     1621 gtgaaggctt ttaaattctt tcagaaagat cgcaaaatgg cgctcattca attgggatct
     1681 gtggaagaag caattcaggc cctcattgag cttcataacc atgaccttgg agaaaatcac
     1741 cacctcagag tttccttctc aaaatctaca atctgacttt tctgtgaatt tttctcctaa
     1801 aactggacca taatttcagt aaaaccttca gacatagact gaagcagctc aagaccaatt
     1861 ttgcctcttt cacaaaaata actctgagtt tgatattcaa gtatatttta aaaatcaagg
     1921 gatttttttt ttttgtattc cccctgcccc cgccagtcaa aggtttcttt tcccttttta
     1981 ccatggtttc tacaaaaata accttcagga aaaagaaaat caggaaaaaa attttttttc
     2041 aataatctta ttccctatat taaattagat ttgaagagga ttaacgttgt tttagtttgg
     2101 gtccagatca gccttataca acatttctaa actcatttgt acttttaaaa aatttaaaca
     2161 cagacttcta aaattacttg atgtaagtaa tttaaatcac ttatgaccaa gttattaacc
     2221 ttatgaatca gaagtctgac ccttgtagga aattatattc acatataaag tacatcagat
     2281 ctttgccata tattgatggt tattatgcat aaacacattg agttgtgttg gaagcagatt
     2341 tataaacctg catgttttct ttgaatgatt tctttttttc actgtaagac actcctttaa
     2401 ataatgccta tctttaactt tttaagacta tttggaaaaa tgcagtgtct cagctgtccc
     2461 cagggaaatt aagtggaatt caactaagat ctgttaataa gatgtcagaa taactaataa
     2521 ttttattagg aaaaaatcat gttttaaatt tcaaaatgac acttatttgt caagtaatat
     2581 gatcttggaa aattttaaag aaaaataatc ctacttataa actacttttt tataattgtt
     2641 ttcagaaaaa aagtttacag tcttaaggaa aatattcagg tctatcatat ggtttgacag
     2701 attttttaaa agttattttt ggtaaggtct tcttttagaa aaaaattaat ctcaagggtt
     2761 ttttgtacca ctataatctc taatacttac tcagaattac tgtgtattta cttaatttct
     2821 tattatgtgc cttattatgt gcttaagata caataggtta gagtttaatc taaatatctt
     2881 gaaagctata ttgtgggctt ggtaagcatt ttgttttttc tttctctgtt ttggtaagga
     2941 tttaaaattt ttttcattgc aattttaagt ggttttcaat aagtaatagt ttttatcaaa
     3001 tttttggtgc ttggtgcaga gacggtgtgg ggaagggtga atggttttgg gaataattca
     3061 gtgcacacct gtaggcctct ttacattgtg actgataggg gttattgcat atcaatttgg
     3121 ggctgtagag tgcaatctca gtttcatctt tttcacccat cagaatttgt ctcaggatta
     3181 cttggttttt ctcagtcctc aagcgagaac ttgcttttct ttgttaatgt gactttcatt
     3241 actgagtacc cacgtatttg gagtatgaga aggtgggtta tttctcatac tctgtccctc
     3301 tctttttcat tgaatgtaag agtacatttt aatgttgctt cagtgattgt ataatgtaaa
     3361 attgtttctt tttaataaga aactttgcta ttatttcttc aattgttgat cagaattttt
     3421 taaagcagaa tttgtcaaaa gggtcatttt tttgtctacc ccttttacac ttttcagatt
     3481 ctcaaagtgt ctcatctcaa cttttaaaag aataaagaat atcttgctgg gcatggtggt
     3541 gtgcgcctgt gcgcctgtag tcccagctac aggctgagcc tgtaggcagg aggctacagg
     3601 caggaggatc acttgagccc aggagttcaa ggctgcagtg cgctatgatc acatttgtga
     3661 atagccactt cactccagcc ctggaacata gtgtgacccc ttctcttaaa agtaaaaatt
     3721 aagaaaatct caatctcttt gctgtattcc agtgattaat ttgaacatag ggaggttttt
     3781 acagaagaaa ttttaccaaa aaatagagac tgcaagagat gatacagatt gtttaaaaag
     3841 cagaattcac tcaccactga gcaacactta gttggtagaa tagaaaggag ggatactaag
     3901 ttaagacttt tcaaatggat cagtttggct gaatagatag atatactcat gtatgtagtt
     3961 gtgggagttt ttagtttttt gtttttttac ttatgaaata agttttgacc tagacacaag
     4021 gggtatatga aggaggaaaa aaatttcttt gcaaaatctc ccaaaacttg cttttttttc
     4081 ccttccacac aggcactatt ataattttca gtgccatgtt aaattggatt atttcattta
     4141 ctttaagtta ggaattactg tgtaatttat taattcatga ttctcataac attcagcata
     4201 agtgtagcaa agttgctaat aacggaaggg gatcatagtg gtgttgaatg taactttgaa
     4261 gtagggaatg gccttttaag tctgagagag aacatttgaa tccttttcag ggatttgtgt
     4321 aggggtgtgt ttgtgtgtgt gtgtgaatgt gtgtgtgtgt agataagtgt atatacataa
     4381 atacactctt ctaaagttgt atatacatat gcacattaca tacattttaa tttattgaca
     4441 aaattaacca aattaagatt tggagatgtg ggatgttctt gttttaaaat agcatgtttg
     4501 aaaccatcag tttgtgtcta aaattagctg tagcacatgg atgttgtcca tattaagcta
     4561 tttgctgttt gaattataga ggtctacagt atttgtgttg gcatagtttt tgtaaaaaaa
     4621 agattaaaaa atatcaggat ggtggaaaaa ctagatctgt gtatctctgt tttggcatgc
     4681 atttattcag tatcttctag caatggtttt tctctgttga tctaccgtag tatcctattt
     4741 ttaagtttat tttattttta aggagtattg tcatcacttt tcaaggtgtc ttgacttcta
     4801 cacaaagtat atatattcag gactttaaaa aatagcagta cacatttaac agtagcgaat
     4861 tacaccaaaa tgatttactt tgagatttga ataatttgca tagcagtaaa atgtgttttg
     4921 tgtaacatac aaatagaaaa atgacccagt atcttaattg atacttactg gagagtatca
     4981 gaattaccca gcagctctta cagaatgcca taaattcttt aagactaaat attgaaatca
     5041 attatttgaa gtaatgtttc tgatttactg ttaaaagttg ctgagctcag tttttggaga
     5101 tatcatttat gcctgcctgt tcccttatga cagtgaggcc ttctttggct ccacctagta
     5161 tgataatcat gggttctgtt ttagttgatg agaagtggct cctatgaatg cctctgctca
     5221 atttcttttt attttacttt attttatttt taggggtctc gccaactcct gggctcaagt
     5281 gattctcctg cttccacctc cccacagtgc tgggattaca ggcatgagcc accacgcctg
     5341 gctctctgtt cttttcagtg tctccgtgcc atcagtcagc agtgcttaca tgtttagcat
     5401 attgtcatgc agtttctctt ctgttcccac gagatatttt tggacaaaaa attgacaaaa
     5461 gtacatgtgt ttttccccac ctatccctta gaaaacctaa tgtgtactgc tatttttaaa
     5521 accaaaaaga gacagcgtga cgatgcgtaa agcatttttc ttagcctttc ctttgtcttg
     5581 atctgttaat gagaacaaaa ctgccagact caaaatactc tactattgtg ctgaaagaaa
     5641 tacaatttag attgcacaaa atttgaaaat ataactcagc tgtcttttaa aagagttgtg
     5701 ttgttatcta caagactatt agcagtcttt tttcagagca aattttaaca gctagttgtg
     5761 agtggtttaa aatatagaaa attattaaaa tcttagtttg aggggtttta tagtgggaga
     5821 aaaaacagga ccaaagttta tgtgccttct tcagtagtct taattgacct tttcttccta
     5881 tttgagacta aagtagtatc agtattctgg ttttcaggaa atatgtacta tatagtttta
     5941 aaagaatgtt gtcccaccaa ctattcatcc aagcaaagaa ttgtaactat aaataaagtc
     6001 tcagttacac ttttgccttt atcacataat attcattgta gagcattgtg caggtccaag
     6061 aatagagctg ctcaaaatct ttgtggtagt ttccttagtt tttgtaacct gaggcatatg
     6121 ttccagagaa cagggatatt tgtctggtcc agtgaccttg gtgatcatag tcataattga
     6181 aagatgccta tggcatgctt aaatcagcat tgtcaactga tttgttgttg tattattttc
     6241 acttcttgga tctatgtagt agttgtaata acaaatattt aaatagctat ttttttgatg
     6301 ccattaaaaa aatcatactc tggccttttt tcccccttac tgttgtttcc cagatctttt
     6361 aaaaattcat cccatatcca gaaagtacca gttataaaga ttgctgacca agcaaagttt
     6421 tgcatcaaag tgtcacctca ttgctctgac caaagactga ctgttgtggt tttaactcct
     6481 ctctgtaaag cattttgcat tttccccaag ctcctttctg aaagaagaac cagtgcagag
     6541 cggcctttac tttcaatttc tactgctgaa tagactactt agagaaaatg tgagtttcag
     6601 tgtgaacaga atggattagg atgacgagtt tgatgggcat tttcagtact gtatctaaga
     6661 aaaaaaaaat agcacagcta ggagcctctg acattgtctg gtgttttacg tggtctgttc
     6721 atcaaaattc cccttttcag tttttaagaa tgttcgtcta acagaagaaa atgctgtaaa
     6781 tatttgtaac aacatttttt ttaacaaggc caaaaaagaa aaaaaggttt ttgggaacaa
     6841 atgaacttat aaagtggttt tatataaaac atcaattgtc ttgtatattt tggataagca
     6901 gcagtaccag ctttcatttg taacagtctg tggcattgga aaaaaaggag tctgtgattg
     6961 ttgaagtgaa ttatgttata aatgcaaaga gaagataaaa tattaaaaaa catattttct
     7021 aaatgcgtag tgcatggtta attcaagctt ctgtacacta cagtatattc cattttcgtt
     7081 cagtttgtat atttgctgac tattacttga tatctctaat ctcttttcct aacaaatata
     7141 gcattgtagc atgcctttta ataaatgtca tgacatctgt actctcttaa aa
//
