LOCUS       NP_001157260             524 aa            linear   PRI 29-APR-2025
DEFINITION  polypyrimidine tract-binding protein 3 isoform 2 [Homo sapiens].
ACCESSION   NP_001157260
VERSION     NP_001157260.1
DBSOURCE    REFSEQ: accession NM_001163788.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 524)
  AUTHORS   Zhao,C., Zhao,J.W., Zhang,Y.H., Zhu,Y.D., Yang,Z.Y., Liu,S.L.,
            Tang,Q.Y., Yang,Y., Wang,H.K., Shu,Y.J., Dong,P., Wu,X.S. and
            Gong,W.
  TITLE     PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in
            Gallbladder Cancer
  JOURNAL   Adv Sci (Weinh) 11 (38), e2406633 (2024)
   PUBMED   39116343
  REMARK    GeneRIF: PTBP3 Mediates IL-18 Exon Skipping to Promote Immune
            Escape in Gallbladder Cancer.
REFERENCE   2  (residues 1 to 524)
  AUTHORS   Dong,D., Wei,J., Wang,W., Zhou,H., Hong,L., Ji,G. and Yang,X.
  TITLE     YTHDC1 promotes the malignant progression of gastric cancer by
            promoting ROD1 translocation to the nucleus
  JOURNAL   Cell Biol Toxicol 40 (1), 19 (2024)
   PUBMED   38573528
  REMARK    GeneRIF: YTHDC1 promotes the malignant progression of gastric
            cancer by promoting ROD1 translocation to the nucleus.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 524)
  AUTHORS   Lu,N., Min,J., Peng,L., Huang,S., Chai,X., Wang,S. and Wang,J.
  TITLE     MiR-297 inhibits tumour progression of liver cancer by targeting
            PTBP3
  JOURNAL   Cell Death Dis 14 (8), 564 (2023)
   PUBMED   37633911
  REMARK    GeneRIF: MiR-297 inhibits tumour progression of liver cancer by
            targeting PTBP3.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 524)
  AUTHORS   Dong,C., Wu,K., Gu,S., Wang,W., Xie,S. and Zhou,Y.
  TITLE     PTBP3 mediates TGF-beta-induced EMT and metastasis of lung
            adenocarcinoma
  JOURNAL   Cell Cycle 21 (13), 1406-1421 (2022)
   PUBMED   35323096
  REMARK    GeneRIF: PTBP3 mediates TGF-beta-induced EMT and metastasis of lung
            adenocarcinoma.
REFERENCE   5  (residues 1 to 524)
  AUTHORS   Xie,C., Long,F., Li,L., Li,X., Ma,M., Lu,Z., Wu,R., Zhang,Y.,
            Huang,L., Chou,J., Gong,N., Hu,G. and Lin,C.
  TITLE     PTBP3 modulates P53 expression and promotes colorectal cancer cell
            proliferation by maintaining UBE4A mRNA stability
  JOURNAL   Cell Death Dis 13 (2), 128 (2022)
   PUBMED   35136024
  REMARK    GeneRIF: PTBP3 modulates P53 expression and promotes colorectal
            cancer cell proliferation by maintaining UBE4A mRNA stability.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 524)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (residues 1 to 524)
  AUTHORS   Brazao,T.F., Demmers,J., van IJcken,W., Strouboulis,J.,
            Fornerod,M., Romao,L. and Grosveld,F.G.
  TITLE     A new function of ROD1 in nonsense-mediated mRNA decay
  JOURNAL   FEBS Lett 586 (8), 1101-1110 (2012)
   PUBMED   22575643
  REMARK    GeneRIF: ROD1 and UPF1 associate with a significant number of
            common transcripts.
REFERENCE   8  (residues 1 to 524)
  AUTHORS   Sadvakassova,G., Dobocan,M.C., Difalco,M.R. and Congote,L.F.
  TITLE     Regulator of differentiation 1 (ROD1) binds to the amphipathic
            C-terminal peptide of thrombospondin-4 and is involved in its
            mitogenic activity
  JOURNAL   J Cell Physiol 220 (3), 672-679 (2009)
   PUBMED   19441079
  REMARK    GeneRIF: Regulator of differentiation 1 (ROD1) binds to the
            amphipathic C-terminal peptide of thrombospondin-4 and is involved
            in its mitogenic activity.
REFERENCE   9  (residues 1 to 524)
  AUTHORS   Robinson,F., Jackson,R.J. and Smith,C.W.
  TITLE     Expression of human nPTB is limited by extreme suboptimal codon
            content
  JOURNAL   PLoS One 3 (3), e1801 (2008)
   PUBMED   18335065
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 524)
  AUTHORS   Yamamoto,H., Tsukahara,K., Kanaoka,Y., Jinno,S. and Okayama,H.
  TITLE     Isolation of a mammalian homologue of a fission yeast
            differentiation regulator
  JOURNAL   Mol Cell Biol 19 (5), 3829-3841 (1999)
   PUBMED   10207106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN371677.1, AK302558.1 and
            AL158824.11.
            
            Summary: The protein encoded by this gene binds RNA and is a
            regulator of cell differentiation. The encoded protein
            preferentially binds to poly(G) and poly(U) sequences in vitro.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence and uses an alternate in-frame splice junction at
            the 3' end of an exon compared to variant 6. The resulting isoform
            (2) is shorter at the N-terminus and contains an alternate short
            internal segment compared to isoform 6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.27654.1,
                                           SRR18074968.953916.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374257.6/ ENSP00000363375.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     Protein         1..524
                     /product="polypyrimidine tract-binding protein 3 isoform
                     2"
                     /note="fission yeast differentiation regulator; regulator
                     of differentiation 1; ROD1 regulator of differentiation 1"
                     /calculated_mol_wt=56690
     Region          29..524
                     /region_name="hnRNP-L_PTB"
                     /note="hnRNP-L/PTB/hephaestus splicing factor family;
                     TIGR01649"
                     /db_xref="CDD:273733"
     CDS             1..524
                     /gene="PTBP3"
                     /gene_synonym="ROD1"
                     /coded_by="NM_001163788.4:202..1776"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS55332.1"
                     /db_xref="GeneID:9991"
                     /db_xref="HGNC:HGNC:10253"
                     /db_xref="MIM:607527"
ORIGIN      
        1 mnsstpstgv yangndskkf krdrppcsps rvlhlrkipc dvteaeiisl glpfgkvtnl
       61 lmlkgksqaf lemaseeaav tmvnyytpit phlrsqpvyi qysnhrelkt dnlpnqaraq
      121 aalqavsavq sgslalsggp snegtvlpgq spvlriiien lfypvtlevl hqifskfgtv
      181 lkiitftknn qfqallqyad pvnahyakma ldgqniynac ctlridfskl tslnvkynnd
      241 ksrdftrldl ptgdgqpsle ppmaaafgap giisspyaga agfapaigfp qatglsvpav
      301 pgalgpltit ssavtgrmai pgasgipgns vllvtnlnpd litphglfil fgvygdvhrv
      361 kimfnkkena lvqmadanqa qlamnhlsgq rlygkvlrat lskhqavqlp regqedqglt
      421 kdfsnsplhr fkkpgsknfq nifppsatlh lsnippsvtv ddlknlfiea gcsvkafkff
      481 qkdrkmaliq lgsveeaiqa lielhnhdlg enhhlrvsfs ksti
//
